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Looking for a good source of legal Adrafinil for sale in Canada?
Adrafinil is a compound which acts like a mental stimulant but without the jittery anxiousness many people experience with traditional amphetamine and methylphenidate based stimulants.
It belongs to a class of drugs called eugeroics. or wakefulness producing agents.
It was originally tested as a treatment for narcolepsy and some studies have been done on increasing alertness in elderly patients.
Adrafinil has been used in some European countries since the 1980s.
Adrafinil acts as a prodrug to Modafinil. What this means is, once it is inside the body, it is metabolized by the liver and converted to Modafinil.
However, once it became possible to produce the metabolite, Modafinil, directly, much of the market for Adrafinil was usurped.
However, the fact that Modafinil requires a prescription and Adrafinil can be purchased without a prescription means that many people who want to use Modafinil will sometimes turn to this legal alternative instead.
Generic Adrafinil is also significantly cheaper per dosage in comparison to both generic and name brand Modafinil capsules like Provigil, Alertec, Modiodal, or Modalert.
Focus
Wakeful- ness
Thinking- Converted into Modafinil by the liver
- Increases energy, wakefulness & motivation
- Boosts mental performance & focus
The History of Adrafinil and Modafinil
Related Topics
Adrafinil was first developed by scientists at the French pharmaceutical company Lafon Laboratories in 1974. Research on developing new analgesics by experimental medicine professor Michel Jouvet and another scientists led to the development of a group of benzhydryl sulfinyl compounds, of which Adrafinil was one.
In testing, it was found that Adrafinil did not have pain-relieving effects, but instead stimulant-like, wakefulness promoting effects. First tests in animals showed psychostimulant effects, causing vigilance and increased locomotor activity at lower dosages, and hyperactivity at higher dosages.
It was during testing to determine what Adrafinil’s mechanism of action in the body was that Modafinil was discovered in 1976. When it is ingested, Adrafinil travels to the liver, where it is metabolized. The compound is broken down into its component parts, namely the inactive modafinilic acid, and the active Modafinil.
Modafinil was determined to be the primary active compound in Adrafinil, and what causes Adrafinil’s effects in the body.
Because of the wakefulness producing effects seen in animal trials, Adrafinil and later Modafinil were first tested in humans as a treatment for the sleep disorder narcolepsy. Narcolepsy causes excessive daytime sleepiness regardless of the quality and quantity of nighttime sleep; as well, people with this condition often fall asleep randomly multiple times per day.
In multiple double-blind placebo-controlled research trials, both Adrafinil and Modafinil have been seen to significantly reduce excessive daytime sleepiness and increase wakefulness in people with narcolepsy, compared to results from a placebo.
Adrafinil was first tested as a treatment for narcolepsy in 1977-78. It was eventually approved as a drug for human use in 1986 for narcolepsy in France.
In 2001, Lafon was purchased by Cephalon Inc. Cephalon was later acquired by Teva Pharmaceutical Industries in 2011. Acting as a subsidiary of Teva, Cephalon still produces the original name brand version of Modafinil, Provigil. In 2011, Cephalon ceased production of their brand name version of Adrafinil Olmifon. It is now produced as a generic product by a variety of manufacturers.
Modafinil vs Adrafinil Overview
While many of the effects of these two drugs are the same, there are a few specific differences between them.
One difference is that it takes the body about one hour to metabolize Adrafinil, so there is a brief period after ingestion before it becomes effective.
Another difference is that although both drugs have known side effects, Adrafinil may affect liver enzyme levels in a negative way with consistent use and so Modafinil is generally considered to be safer.
Users typically cycle Adrafinil with regularity, and people should not take Adrafinil for extended periods of time without having their liver enzymes regularly monitored by a doctor.
Adrafinil was originally sold under the name Olmifon or CRL-40028 and now is sold under the generic name of Adrafinil. It is available in many countries without a prescription, whereas Modafinil can only be prescribed by a doctor for a limited number of medical purposes.
Modafinil is a prescription only medication that is approved to treat narcolepsy and shift-work sleep disorder, and as an adjunct treatment for obstructive sleep apnea/hypopnea syndrome. In some countries it is also prescribed for idiopathic hypersomnia, another sleep disorder similar to narcolepsy.
What is the legal status of Adrafinil in Canada? Is it legal to buy? What happens if I am found in possession of it? Is it legal to use? If you plan to buy and use Adrafinil in Canada, there are some guidelines about which you will want to be aware.
- Increases energy, wakefulness and motivation
- Boosts mental performance and focus
- Supports memory and cognition
Legal Status of Adrafinil in Canada
Canada issues Drug Identification Numbers (DIN) for all controlled or scheduled substances within the country. Adrafinil has not been issued a Drug Identification Number nor has it been officially been approved by Health Canada.
Drugs falling into this category are in a grey area wherein they are allowed to be purchased for personal use, but they are not recognized, nor approved, for any specific treatment or use. When purchasing Adrafinil or other Nootropics by mail in Canada, citizens buying three-month supplies or less seem to have very few issues with importation.
Dosage recommendations vary a bit because individual bodies process Adrafinil at differing rates and potencies. As mentioned earlier, Adrafinil is the prodrug of Modafinil. What this means is that Adrafinil is an inactive substance until it is taken into the body.
Once ingested, the liver metabolizes it and it becomes Modafinil. Metabolic rates can vary, but in general, a healthy person’s liver should metabolize Adrafinil similarly to another healthy person’s liver, offering a standard recommendation for dosage.
Dosage is recommended at 100mg – 300mg (although dosages as high as 600-1200 mg per day were recommended for people taking Olmifon for narcolepsy). New users should start with 100mg and allow the body to process it fully. Users should bear in mind the possibility of elevated liver enzymes and seek to use the lowest dose possible to achieve the desired results.
Where Canadians Can Buy Adrafinil Online
Before deciding to buy Adrafinil, potential users should make themselves aware of the benefits and risks of this drug.
It can provide mental alertness and acuity for those who work abnormal shifts or for people facing an overnight study session while cramming for exams. Situational or occasional use is recommended over long-term usage.
If you live in Canada, it is probably easiest to buy Adrafinil from a reputable online company. Adrafinil comes in a powder form and sometimes is encapsulated. To take advantage of reasonable shipping rates, Canadian buyers do best to purchase from a US based company versus one from overseas.
For example, Absorb Health is a reputable company with a history of quality products. Their prices are average and offer a good idea of cost.
You can purchase Adrafinil in bulk powder form in quantities of 10 or 20 grams, making the price per dose somewhere between .40 cents and $1.20, depending on your final dosage requirement.
Adrafinil Side Effects
Adrafinil is generally well tolerated by most adults who take it at recommended levels. However, some mild side effects have been reported by a number of users.
Some of the most commonly reported side effects from user reviews online include:
- headaches
- anxiety/nervousness
- nausea
- stomach pain
- skin rash
- insomnia
- weight/appetite loss
- dizziness
- dry mouth
In many cases, mild side effects are common in the first few weeks of taking a new medication as the body adjusts. If your side effects still persist after 2-3 weeks, then consider taking a lower dosage and noticing if there is a reduction in side effects.
Insomnia is a commonly reported side effect with Adrafinil and Modafinil that is typically not a true adverse reaction to the compound, but rather is often due to poor timing of dosages. Because it has a long half-life of about 12-15 hours, the effects of Adrafinil can be felt long after it is ingested.
It is therefore recommended to take the drug early in the morning to avoid sleep disturbances.
There is the possibility of developing a series of serious cutaneous reactions when taking Adrafinil, including Stevens-Johnson syndrome. There is some strong scientific evidence suggesting that some people have a genetic predisposition and are more susceptible to these conditions when they take certain medications, including Adrafinil and Modafinil.
If you develop a fever and a spreading/blistering rash, then stop taking Adrafinil and speak with your doctor immediately.
It has been hypothesized that continual use of Adrafinil could lead to a buildup of hepatotoxic enzymes in the liver. Like with any other compound that is metabolized in the liver, certain enzymes are necessary for the process, but elevated levels can cause hepatic strain or eventual injury.
Increases in hepatic alkaline phosphatase, SGPT, GGPT, and SGOT, can all indicate possible liver injury or strain. It is therefore recommended that Adrafinil only be taken on an occasional basis when needed.
If Adrafinil is taken more regularly, or at higher than normal dosages, then it is recommended that liver enzyme levels be check periodically by your doctor. If levels are too high, or signs of damage are noted, then Adrafinil usage should be stopped.
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Other Nootropic Options
While many Canadians take Adrafinil responsibly and do not have any issues with liver toxicity, some people may, and others may simply prefer to avoid the compound. Whatever the reason, there are some other nootropic alternatives that people use instead of Adrafinil, most commonly one of the Racetams.
The Racetams are a family of compounds that are all based off of the parent compound Piracetam. Piracetam was first developed in the 1960s by Corneliu Giurgea, working for UCB Pharma in Belgium.
Piracetam has been observed in studies to have positive effects on levels and activity of the neurotransmitter Acetylcholine in the brain and central nervous system. Higher levels of Acetylcholine have been linked to improved executive function, enhanced learning ability, and greater memory formation, retention, and recall.
The other Racetams are all more potent derivatives of their parent compound that have been created over the years since Piracetam was developed. These derivatives include Aniracetam, Oxiracetam, Phenylpiracetam, and Pramiracetam.
In addition to the effects these derivatives have on Acetylcholine, they have also been observed to have other nootropic effects. For example, Aniracetam has been observed to be a stronger AMPA receptor agonist than Piracetam. Oxiracetam increases levels of ATP, which leads to greater mental energy.
Phenylpiracetam is essentially Piracetam with a phenyl ring attached, with makes it fat soluble and up to 60 times as powerful as Piracetam. Considered one of the strongest Racetams, it is said to have effects on learning capacity, memory, concentration, and mental energy.
Like Adrafinil, the Racetams are unscheduled, unregulated compounds in Canada that do not have DINs. They are available for sale from a number of specialized online nootropic stores.
Adrafinil Canada Summary
Canada has clear guidelines for drugs which are regulated and those which have schedules attached to them. Drugs falling outside this area are allowed to be purchased for personal use, but they may not be purchased or imported for commercial sale or for distribution.
When purchasing Adrafinil, select a company which is reputable and whose products are known to be pure. Importing in smaller quantities of 30-90 days worth seems to be a common practice and is less likely to cause any unnecessary delays in customs.
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- Rambert FA, Pessonnier J, de Sereville JE, Pointeau AM, Duteil J. [A unique psychopharmacologic profile of adrafinil in mice]. J Pharmacol. 1986
- Rao RN, Maurya PK, Shinde DD. Development of a validated LC method for enantiomeric separation and determination of adrafinil and its related substances on a Chiralcel OJ-H column connected to PDA and polarimetric detectors in series. Biomed Chromatogr. 2010
- Milhaud CL, Klein MJ. [The effect of adrafinil on the nocturnal activity of the rhesus monkey (Macaca mulatta)]. J Pharmacol. 1985
- Rao RN, Shinde DD, Talluri MV, Agawane SB. LC-ESI-MS determination and pharmacokinetics of adrafinil in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2008
Article last updated on: April 13th, 2018 by Nootriment