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Alertex is a form of the drug Modafinil which is manufactured by Saval Pharmaceuticals Company in Chile. Alertex is a drug developed for and prescribed to treat patients with specific sleep disorders that cause extreme fatigue and lack of energy during the day.
Some examples of conditions for which it is used include narcolepsy, obstructive sleep apnea and shift worker sleep disorder (SWSD). It works by activating certain parts of the brain that control how awake we feel and keep us from falling asleep.
Besides being used for these medical diagnoses, Alertex is used off-label for lifestyle purposes as a cognitive enhancer or smart drug. The primary reasons for taking Alertex without a prescription relate to decreasing fatigue and increasing mental acuity and focus.
Alertness
Mental Acuity
Focus- Stimulates wakefulness in the brain
- Promotes mental acuity & processing
- Enhances focus, motivation & energy
How Alertex Works
Related Topics
- What is Modafinil? (Provigil)
- How Does Provigil Work?
- Effects and Benefits
- User Reviews
- Typical Experiences
- Recommended Dosages
- How to Take
- Provigil Uses
- Use for ADHD
- Effects on Weight Loss
- Negative Side Effects
- Abuse Warnings & Dangers
- Comparison to Adrafinil
- Comparison to Armodafinil
- Comparison to Adderall
- Where to Buy
- Generic Modafinil Brands
- Is Modafinil Legal?
- How to Get Modafinil
- Review of Online Sources
Alertex is only sold in South America, though you will see the active component in this stimulant – Modafinil – marketed under other names across the globe. Modafinil is frequently referred to as Provigil, the brand name used for the same medication within the USA.
Modafinil is also sold in other countries under the brand names Modavigil, Modasomil, Alertec, and Modiodal. Other versions of the drug are manufactured in India under the names Modalert, Modapro and Modvigil. Estimates are that some 10 million plus individuals have used Modafinil since its development.
Alertex is a psychostimulant which affects the central nervous system (CNS). Alertex belongs to a class of drugs that are referred to as eugeroics, or wakefulness promoting compounds. Although the exact mechanism of action remains elusive, there are some pretty good indications of how it works in the brain and which systems it is affecting.
Modafinil has been seen to affect Dopamine, Serotonin, Norepinephrine, Histamine, and Orexin (Hypocretin) levels and transport in the brain and central nervous system.
Smart drug users report the drug does not ‘feel’ like other CNS stimulant drugs (amphetamines). Indeed, Modafinil is noted for its lack of CNS stimulant side-effects, such as elevated blood pressure and increased heart rate.
This is because Modafinil is working on different brain processes than amphetamines, giving the user a keen sense of being awake but without the offensive stimulant effects replete with jitters and jaw-clenching.
It is thought that Alertex works, in part, by affecting the Dopamine and Norepinephrine neurotransmitters, but that it does not strongly affect the neurotransmitter Epinephrine, thereby skirting those unwanted amphetamine side-effects.
One of the main theories that supports Modafinil’s wakefulness promoting effects concerns the drug’s interaction with Orexin and Histamine. Orexin is a neuropeptide that helps regulate sleep and wake response system, appetite, and arousal. Histamine is a neurotransmitter that is involved in the same processes in the brain.
Alertex has been seen to strongly activate Orexin neurons and Orexin-secreting neurons in the hypothalamus. This in turn stimulates the release of Histamine. Together the elevated levels of these compounds leads to an overall alert state of mind.
Adrafinil and Modafinil
Modafinil was first discovered because of another related compound, Adrafinil. First developed in 1974 in France at Lafon Laboratories, Adrafinil is a benzhydryl sulfinyl compound that is classified as a eugeroic. Adrafinil and Modafinil share a high degree of similarity in their molecular structure, only differing by one hydroxyl group that Adrafinil has and Modafinil lacks.
The reason for this similarity is because Adrafinil is in fact the prodrug of Modafinil. In the body, Adrafinil is metabolized in the liver into its component parts, modafinilic acid and Modafinil. During testing to determine its mechanism of action, it was found that the primary active compound in Adrafinil is Modafinil.
After its discovery, research and development commenced to be able to produce Modafinil on its own without conversion from Adrafinil first. Once this was possible, the production of Adrafinil decreased, and eventually was stopped. Lafon was bought by Cephalon Inc (who are now a subsidiary of Teva Pharmaceutical Industries) who still make the most popular brand name of Modafinil, Provigil; they still no longer produce Adrafinil, however it is now produced again today by other manufacturers.
Adrafinil was first tested in animals and seen to have stimulating, alertness-promoting effects that caused vigilance and increased locomotor activity. In later trials, Modafinil was obviously seen to produce similar results.
Adrafinil was first tested for use in humans as a treatment for narcolepsy sleep disorder. Likewise, Modafinil was first tested for this use as well.
- Increases energy, wakefulness and motivation
- Boosts mental performance and focus
- Supports memory and cognition
Alertex for Sleep Disorders
Narcolepsy is a neurological sleep disorder that affects the ability to maintain wakefulness. People with narcolepsy often fall asleep multiple times per day, often without warning, and experience excessive sleepiness throughout the day, regardless of the quality and quantity of sleep they have at night. It is thought that a cause of narcolepsy may be a reduced number of Orexin neurons in the brain.
In many different double-blind placebo-controlled clinical trials, when compared to a placebo, Alertex was seen to significantly improve wakefulness and reduce sleepiness, as measured by a variety of sleep tests, including the Epworth Sleepiness Scale, the Maintenance of Wakefulness test, and the Multiple Sleep Latency test.
Modafinil is approved as a treatment for narcolepsy in many countries around the world. It has also been approved to treat some other serious sleep disorders, including shift-work sleep disorder and obstructive sleep apnea/hypopnea syndrome. It is also approved to treat hypersomnia (excessive sleepiness and bouts of falling asleep, similar to narcolepsy) in some countries.
While the cause of it is different in these various conditions, all involve excessive sleepiness. As seen in narcoleptics, Modafinil is able to reduce excessive sleepiness in people with these conditions significantly better than a placebo.
In people with shift-work sleep disorder work performance is improved, and attention lapses are fewer and shorter than when not on Modafinil. People with obstructive sleep apnea/hypopnea syndrome who are being treated for their condition but still experience residual excessive sleepiness have been seen to have improved wakefulness when taking Alertex.
Modafinil for ADHD
Any use of Alertex that is not an approved use is considered off-label. It is believed that as many as 9 out of 10 prescriptions for Modafinil are in fact used for off-label purposes.
It is legal for doctors to write off-label prescriptions. There is sometimes a reluctance to do so because of a fear of repercussions from medical boards, but there are some doctors who will in fact write these prescriptions when it is in the best interest of their patients.
One of the most popular off-label uses of Modafinil that doctors will write prescriptions for is for managing the symptoms of attention-deficit disorder (ADD) or attention-deficit hyperactivity disorder (ADHD).
In many different studies done on all age groups (children, adolescents, and adults) it has been found that compared to a placebo, Alertex significantly improves symptoms of ADHD on a variety of tests including the ADHD Rating Scale-IV School and Home Versions, Conners Rating Scales, and the Clinical Global Impressions-Improvement scale.
Modafinil has even been tested against a traditional amphetamine based ADHD medication, detroamphetamine (Dexedrine) to test its efficacy. It was found that both active medications improved performance on the DSM-IV ADHD Behavior Checklist for Adults significantly compared to a placebo.
Similar improvement of results were seen between Modafinil and dextroamphetamine, and the scientists suggested that it should be considered a viable alternative ADHD medication.
Off-Label Alertex Nootropic Uses
As seen in people with sleep disorders, Alertex helps people to stay awake and to be both mentally and physically alert and active. It works to make the user’s mind crisp and clear. This is particularly noticeable in situation where the user would normally be experiencing fatigue or sleep deprivation.
Students putting in long hours while studying hard for final exams, for example, are often able to concentrate and retain information more easily while not having to fight fatigue and the need for sleep. Your brain may also seem like it is working faster and your thoughts have a greater degree of clarity to them.
Most users report a direct increase in their ability to focus on whatever it is they decide to do. The intensity of focus seems to vary in degree from user to user, but nearly every report includes increased focus as a primary benefit.
Another potential benefit which may actually be a byproduct of the enhanced focus is an increase in motivation. Some individuals say it is impossible to not be productive when using Alertex or other types of Modafinil tablets.
Modafinil has been seen in research to be a good alternative to amphetamines for improving mood and cognitive performance in sleep deprived military subjects. Knowing this, some researchers wanted to test effects of Modafinil on cognitive performance in non-sleep deprived individuals.
The research team made healthy, non-sleep deprived subjects complete a battery of cognitive tests before drug ingestion. The subjects were then giving a dose of either a placebo or Modafinil and asked to complete the tests at 90 and 180 minutes post ingestion.
Compared to the placebo, Modafinil was seen to significantly increase motivation levels, reduce fatigue levels, improve reaction time, and enhance vigilance compared to baseline results.
Dosage Information
Alertex comes in tablets of 100mg or 200mg. Your doctor will prescribe one or two doses over the course of the day. People taking Alertex for nootropic purposes usually take just one dose first thing in the morning.
The half-life of Alertex is about 12 hours, so taking your dose at 7am or 8am should be effective to carry you though the majority of your day.
Most people report that taking Alertex later in the day (after lunchtime or beyond) can result in sleep problems, so unless you plan to be working or studying though the night, taking just the single daily dose should be enough.
Interestingly, smart drug users share that taking higher doses does not increase the effects. In fact, because you can build tolerance to Alertex, it is recommended you find the lowest possible dose with which you can achieve the beneficial effects and take only that.
It is also recommended you cycle this drug with other nootropics in order to avoid tolerance from occurring, if possible. Stacking Alertex with other supplements like Piracetam or Aniracetam may help you to amplify the effectiveness.
Side Effects
Alertex is generally well tolerated, however minor side effects are common. The most commonly reported minor side effects include headaches, nausea, anxiety, nervousness, back pain, heartburn, indigestion, vomiting, diarrhea, dry skin, dry mouth, and insomnia.
For some people, there is an adjustment period necessary when they first start taking Alertex, where they need to give their body time to adjust. Side effects that occur when the medication is first taken can subside or cease after about two weeks of adjustment.
In some cases, a normal dosage of 200 mg can be too much for certain people and cause side effects. It is recommended that you lower your dosage for a few weeks to see if side effects subside. If they do and you are still getting the benefits you need, then some people will just continue with the lower dosage.
If the benefits are not what they should be, then it is recommended to slowly increase the dosage back to normal levels, keeping track if any side effects occur. If they do, then this drug may not be right for your physiology and needs.
While quite rare, there is the possibility of developing one of a group of serious skin and mucous membrane conditions, including Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN), or drug reaction with eosinophilia and systemic symptoms (DRESS). There has been research done showing strong evidence that some people have a genetic predisposition making them susceptible to these conditions when they take certain drugs, including Alertex.
These conditions can be life-threatening, and it is important that you stop taking Alertex and speak with your doctor immediately if you develop a fever, flu-like symptoms, and a red or purple blistering rash on the skin and mucous membranes of the mouth, eyes, nose, and/or genitals.
Alertex Prescription Information
Modafinil is categorized by the Food and Drug Administration (FDA) in the United States as a Schedule IV prescription drug. Alertex is considered a prescription-only drug in nearly every country. India and Mexico are two known exceptions, here Modafinil is legally sold as an over-the-counter medication.
Because getting a prescription for off-label uses can be very difficult, some people will turn to the “gray market” and buy Modafinil online from online pharmacies based in countries where it is not a prescription drug. There are two main issues with buying from these places.
First, there is often not strict quality assurance and good manufacturing practices in place at some international manufacturers and distributors, making it difficult to determine if the product is pure and uncontaminated.
Second, even if the product is actually Modafinil, it may never actually reach you. Customs agents are often trained to look for packages containing medications from foreign countries, and could seize the product and not release it to you without proof of a prescription (and in other countries like Canada where importation of prescription drugs is not allowed, you will definitely not receive the product, even with a prescription).
If you are lucky than you will just not receive your shipment, but you could also be placed on a watch list by agencies like the Drug Enforcement Agency (DEA). Because of these reasons, some people will turn to legal non-prescription alternatives such as Adrafinil or one of the Racetam family of nootropics.
A non-prescription alternative to Alertex is a Adrafinil which is available from many reputable online nootropic providers. As described previously, Adrafinil is converted by the body into Modafinil. While it does take a bit longer to take effect, it is said that the effects of Adrafinil are comparable to Modafinil.
Bear in mind that because the liver must metabolize Adrafinil into Modafinil, continuous use hypothetically may result in elevated hepatotoxic enzyme levels and damage to the liver. Smart drug users therefore usually keep Adrafinil as a special purpose drug, using it for those occasions when they know wakefulness and mental focus will be especially needed.
Another non-prescription Alertex alternative is using one of the Racetam nootropics. Based off of the original nootropic, Piracetam, developed in the 1960s, the Racetams positively affect levels and activity of the neurotransmitter Acetylcholine in the brain and central nervous system. This has been seen to cause improvements to general cognition, and increased memory formation, retention, and recall.
The derivatives of Piracetam – including Aniracetam, Oxiracetam, Pramiracetam, and Phenylpiracetam – are all more potent than their parent compound, with Phenylpiracetam believed to be up to 50-60 times more powerful than Piracetam.
These derivatives have the same Acetylcholine effects as Piracetam, but often stronger, as well as specialized effects unto themselves. For example, Pramiracetam and Phenylpiracetam are both said to increase mental energy and alertness, making them ideal substitutes for Modafinil.
Both Adrafinil and the Racetams are classified as unscheduled, unregulated compounds in the United States and many other countries. While laws on the sale of compounds like these can make it difficult to find suppliers, they are fully legal to buy, own, and use, and can often be found at specialized online nootropic stores.
Alertex Review
Alertex is a drug used to promote a natural, subtle sense of wakefulness in the user. It is the brand name for Modafinil in Chile and is sometimes sold in other South American countries under this name, as well.
It is available by prescription-only and should be monitored by a doctor. You can buy Alertex online from some offshore pharmacies only if you have a valid prescription. A non-prescription alternative is called Adrafinil, a drug which is turned into Modafinil by the liver.
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Article last updated on: April 11th, 2018 by Nootriment
1 Comment
Estoy tomando Alertex de 200mg una todas las mañanas a las 8am y me quita el cansancio y sueño que tenia pero me altera los tendones siento molestias hasta fuertes por ejemplo en un brazo en una pierna y en los tendones detras de la cabeza y baja hasta el cuello.
Porque tengo esos sintomas despues de tomar alertex?.