Alpha GPC, also known by its chemical name of L-Alpha Glycerylphosphorylcholine, is a natural Choline compound found in the brain, milk, and a few other food sources.
Choline is a water-soluble vitamin-like nutrient that is similar to the B Vitamin family. It is essential to good health and brain function, taking part in many different bodily processes and functions.
As a nutritional supplement, Alpha GPC 300 mg tablets are considered to be a Nootropics, meaning that they positively affect memory and of other cognitive processes.
Alpha GPC is a precursor to acetylcholine which means once it is ingested it is capable of converting into and raising levels of this powerful neurotransmitter.
Alpha GPC tablets are considered superior to other forms of Choline because they experience a greater rate of transportation across the blood-brain barrier.
Choline itself has a difficult time crossing this barrier because its positive charge is repelled by the filtration system that keeps blood separated from brain tissues.
Any source of Choline has to enter into the central nervous system in order to be converted into acetylcholine since this neurotransmitter is also incapable of penetrating the BBB. Most versions of Alpha GPC 300 mg supplements are produced from highly purified forms of soy lecithin.



- Choline source to support memory function
- Increases attention, focus & energy
- Neuroprotective for brain cell health
Alpha GPC Uses
Related Topics
- Alpha Glycerylphosphorylcholine
- What is Choline?
- Alpha GPC Choline Content
- Health Benefits
- Dosages to Take
- User Reviews
- Side Effects
- Uses for Memory
- Effects on the Brain
- Increasing Growth Hormone
- Using Alpha GPC Powder
- Where to Buy Online
- Best Supplement Sources
- Comparison to CDP Choline
- Choline Alfoscerate
- Stacking with Piracetam
There are a number of researchers very excited by some of the additional possibilities for this supplement. This includes continuing research into using Alpha GPC to help with Alzheimer’s disease and other cognitive related damage.
There has also been some research suggesting that using Alpha GPC 300 mg tablets may promote better overall neuron function and communication while also working to repair damaged cells.
But most people who take this nootropic are healthy adults who want to improve their mental faculties and perform better at work, school or in their daily life. Alpha GPC is a favorite supplement to stack with other nootropics such as Piracetam, Aniracetam, Pramiracetam and Noopept.
Why Take Alpha GPC 300 mg Tablets
Alpha GPC is considered to be a nootropic because it satisfies two main requirements.
Firstly, it has a positive effect on cognitive functioning and mental processing as it relates to memory, learning, planning, concentration, reasoning and executive function.
Secondly, it also serves to help protect neurons and/or other brain systems by increasing membrane fluidity and by enhancing synaptic plasticity.
One of the first things new users notice about Alpha GPC 300 mg tablets is that they tend to improve their information retention in terms of memory formation as well as retrieval. It also leads to enhanced learning capacity, faster speed of memory recall, and even faster overall cognition and problem-solving skills.
Some of these changes are thought to be affected by an increase in blood flow to the brain caused by this supplement. This would certainly increase the supply of nutrients and glucose to working brain cells.
This may also lead to an increase in the amount of oxygen supplied to the brain as well as energy metabolism production. As a result of these changes, many people report that they see improved attention span, alertness, and the ability to concentrate.
Since Alpha GPC itself is a phospholipid – the same material that makes up the cell membranes – there are a number of neuronal and brain cell protection abilities inherent in this supplement.
It supports the development of new, healthy cell membranes as well as helping to repair past damage. This improves the overall functioning of neurons as well as the communication between brain cells.
Oftentimes, when your neurons are running short of choline in order to make Acetylcholine, they will start to auto-cannibalize your cell membrane walls in order to derive choline stored within certain phospholipids.
Over time, this process of stripping cell walls may contribute to impaired cell function and has been theorized as a potential cause of Alzheimer’s. Alpha GPC 300 mg tablets can prevent this by ensuring that there is enough choline available to make Acetylcholine. It can also repair damage to previously stripped areas of the cell membrane to ensure cell function is restored back to normal.
Research on Choline and Alpha GPC is very promising, however, more research on supplemental Choline use is still needed. At this time, Choline is available as a health supplement only, and the FDA has not approved Choline as a drug to prevent or treat any conditions.
Using Alpha GPC 300mg Tablets
There are a wide variety of different dosage recommendations on the books for using Alpha GPC. The below dosage recommendations are general guidelines only, and your personal dosage may differ. It is always recommended that you speak with your doctor before beginning any new supplements.
Some studies suggest that taking 300 mg two or three times per day is sufficient to achieve optimal results. However, other studies recommend taking 400 mg to 1,200 mg per day, which would mean taking anywhere from 1.3 to 4 tablets a day.
These suggestions are subject to a lot of room for accommodating your personal biochemistry and in most cases the best way to find out what works for you is trial and error.
Any new users should always begin with a lower dosage level, find their lowest effective dose, and remain there until having become thoroughly familiar with all of the effects. Only at this point should you consider increasing your dosage in a controlled and thoughtful manner.
You will want to take this supplement with a liquid, since it is water-soluble. It may be split into two or three administrations throughout the day, if you are so inclined, however taking it evening may interfere with your ability to fall and stay asleep, as the effects can sometimes be stimulating.
While Alpha GPC 300 mg tablets are convenient from a dosing standpoint, they do inherently limit the potential for flexibility with your dosages. These pills are also more expensive than other sources such as buying powdered Alpha GPC.
In some cases, the cost of encapsulating the supplement represents as much as 80% of the price tag you are paying. Most experienced nootropic users will buy the powder alongside a cheap measuring scale to achieve greater dose accuracy and control, while also saving a lot of money.
Some companies also sell Alpha GPC 200 mg tablets, but these are even less cost effective from a price per dosage standpoint.
Alpha GPC Side Effects
This supplement has a very safe user profile with extremely low risk of dangerous side effects. In fact, choline is a natural component of breast milk – a sign of its incredibly high tolerability.
While there are a few noted side effects, these are somewhat rare and usually mild. There is also no toxicity associated and no one has ever reported any serious side effects or suffered an overdose.
Generally speaking, if the recommended dosage level was exceeded, you might find yourself experiencing headaches, fatigue, nervousness, nausea, diarrhea, GI issues, dizziness, and lowered blood pressure.
The way to cope with any of these possible side effects is by reducing the dosage back down to under the recommended level and keeping it there. Sometimes, taking a few days break from supplementation can also help relieve possible symptoms.
Possible Alpha GPC Stacks
While Alpha GPC 300 mg tablets offer a lot of benefits on their own, many people will choose to use them together with other synergistic nootropics that work on different or complementary pathways.
Alpha GPC is one of the most efficient sources of Choline and a very potent Acetylcholine precursor. As such, stacking this with something that helps to increase the effectiveness of Acetylcholine itself can be very effective.
In this light, consider stacking Alpha GPC 300 mg tablets with any of the Racetam Nootropic family members, like Piracetam, Aniracetam, and Oxiracetam. The benefits will be exponential as opposed to merely additive, meaning that you will get more out of your Alpha GPC tablets than if you were to use them on their own.
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Article last updated on: March 14th, 2018 by Nootriment