What is Alpha GPC?: Alpha GPC is a choline supplement that is capable of easily crossing the blood-brain barrier and delivering choline to the brain.
It is a water soluble compound that is purified from soy lecithin and is a very powerful Nootropic supplement.
Alpha GPC (also known as choline alfoscerate or L-Alpha glycerylphosphorylcholine) is also a phospholipid metabolite that is actually found in concentrated form within neuronal membranes.
Whatever nootropic you are using, Alpha GPC is a great addition to your cognitive enhancement stack for improving memory, learning and brain health.
Choline is a critical nutrient in a number of cognitive and other brain related functions and processes.
It is a natural precursor to Acetylcholine, a powerful neurotransmitter that is responsible for learning, memory, and other important cognitive functions.
Ongoing research is also continuing to study the possibility of this supplement as a treatment for conditions such as Alzheimer’s disease.
Alpha GPC is considered one of the best choline sources that you can buy as a nootropic.



- Choline source to support memory function
- Increases attention, focus & energy
- Neuroprotective for brain cell health
Mechanisms Of Action:
Related Topics
- Alpha Glycerylphosphorylcholine
- What is Choline?
- Alpha GPC Choline Content
- Health Benefits
- Dosages to Take
- User Reviews
- Side Effects
- Uses for Memory
- Effects on the Brain
- Increasing Growth Hormone
- Using Alpha GPC Powder
- Where to Buy Online
- Best Supplement Sources
- Comparison to CDP Choline
- Choline Alfoscerate
- Stacking with Piracetam
The main way that this supplement works is by increasing the amount of available choline, which then naturally converts to, and influences the production of, Acetylcholine.
It is this powerful brain chemical that has been largely determined to influence a number of cognitive processes within the mind and is one of the reasons Alpha GPC is considered to be a Nootropic.
It is also important to understand that most people do not receive enough choline in their diets through natural means. Basically, this supplement is a way of helping to support natural bodily functions through a very pure and highly effective choline to Acetylcholine conversion process.
Alpha GPC works by delivering the choline and then breaking down, producing Acetylcholine as a by-product. There are other sources of choline supplementation that end up having similar effects, although they work by acting as an intermediary to the produced Acetylcholine.
Benefits Of Alpha GPC:
Since it has been estimated that around 90 percent of the population does not get the recommended levels of choline in their diet, this supplement should see extensive benefits for almost everyone.
There are even researchers who feel that a lack of choline can be one of the leading cause of cognitive decline, memory problems, and low energy levels. Therefore, one of the first benefits may just be restoring your body back to the condition that it should be in already.
There are a number of cognitive benefits associated with Alpha GPC. Most users notice increased memory and even learning abilities along with enhanced concentration, focus and clarity.
Mood may also be improved along with a general feeling of increased mental energy and sharpness.
This supplement is also seen as a key neuroprotectant. It helps to protect neurons from damage, maintain their health and even improve signal transmissions between nerves and synapses. This occurs by the choline acting as a precursor to membrane phospholipids.
The pituitary glands appear to work in conjunction with Alpha GPC as well, increasing the secretion of Human Growth Hormone. This can help athletes to recover quicker and train more intensely, building muscle tissues much faster.
Alpha GPC Side Effects & Safety:
This supplement is very safe and does not have any side effects at all if taken at the recommended dosage levels.
On the other hand, if you are not careful about the source of the choline supplement there could be an unintended reaction, especially if the choline source is impure.
On the other hand, it is also possible to overdo things by taking too much Alpha GPC. Some people who go beyond the recommended dosage may notice a slight fishy smell, which is the result of choline breakdown. Simply lower the dose if this happens.
In high doses it is also possible to experience increased sweating and salivation, nausea and stomach issues, and decreased appetite. Once again, simply reduce the dosage if any of these occur.
Alpha GPC Dosage:
Since this supplement is water soluble it is easy to take Alpha GPC powder and also extremely fast-acting. Therefore, many experts suggest a daily dosage range of between 400 and 1200 mg, normally with breakfast and/or lunch.
It is a bit stimulating, so it is recommended to not take this supplement any later than the early to mid-afternoon. In a pinch, it can be used as an effective energy booster.
It is great at helping to thwart the effects of jet lag. Another interesting use is to take Alpha GPC Choline as a pre-workout supplement.
Alpha GPC Stacks:
When taking almost any type of Racetam, Alpha GPC should definitely be included to support your extra need for a quality choline source. This means Piracetam, Aniracetam, Pramiracetam, Oxiracetam, and even Noopept.
Adding Alpha GPC into a Racetam stack is even more important if you begin to experience headaches. This indicates (normally) a need for additional choline, so give the brain what it is craving.
The extra choline may also help to potentiate the normal Nootropic effects as well, increasing any expected cognitive benefits.
You will also find a small amount of Alpha GPC in a number of nootropic products such as Alpha Brain by Onnit Labs.
The amount in these products may not be enough to give you the full range of benefits which is why you might want to buy Alpha GPC bulk powder online to build your own stack.
- Kawamura T, Okubo T, Sato K, Fujita S, Goto K, Hamaoka T, Iemitsu M. Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults. Nutrition. 2012
- Plangár I, Szabó ER, T?kés T, Mán I, Brinyiczki K, Fekete G, Németh I, Ghyczy M, Boros M, Hideghéty K. Radio-neuroprotective effect of L-alpha-glycerylphosphorylcholine (GPC) in an experimental rat model. J Neurooncol. 2014
- Abbiati G, Fossati T, Lachmann G, Bergamaschi M, Castiglioni C. Absorption, tissue distribution and excretion of radiolabelled compounds in rats after administration of [14C]-L-alpha-glycerylphosphorylcholine. Eur J Drug Metab Pharmacokinet. 1993
- Bronzetti E, Felici L, Zaccheo D, Amenta F. Age-related anatomical changes in the rat hippocampus: retardation by choline alfoscerate treatment. Arch Gerontol Geriatr. 1991
Article last updated on: March 13th, 2018 by Nootriment