Alpha GPC (L-Alpha Glycerylphosphorylcholine, Choline Alfoscerate) is a natural Choline supplement that is considered one of the best precursors to acetylcholine.
Choline is found in the human body naturally, and we consume it regularly in foods such as milk, other dairy products, soy, and a number of plants.
Alpha GPC is a fat soluble supplement also considered to be a Nootropic, due to a number of cognitive enhancing effects and benefits.
Many people take Alpha GPC as a way to boost memory and mental performance, enhance athleticism, and support brain health and neuron protection.
Alpha GPC supplements are also almost entirely devoid of toxicity with only mild side effects reported.
You can find this source of choline in several high quality nootropic stacks like Alpha Brain or you may want to build your own stack using Alpha GPC supplements and other compounds such as Racetams or Noopept.



- Choline source to support memory function
- Increases attention, focus & energy
- Neuroprotective for brain cell health
Alpha GPC Supplements for Cognition
Related Topics
- Alpha Glycerylphosphorylcholine
- What is Choline?
- Alpha GPC Choline Content
- Health Benefits
- Dosages to Take
- User Reviews
- Side Effects
- Uses for Memory
- Effects on the Brain
- Increasing Growth Hormone
- Using Alpha GPC Powder
- Where to Buy Online
- Best Supplement Sources
- Comparison to CDP Choline
- Choline Alfoscerate
- Stacking with Piracetam
Can Alpha GPC really improve the amount of activity in your brain?
This derivative of purified soy lecithin is noted for rapidly supplying the brain with additional amounts of choline.
We need choline in order to make the neurotransmitter Acetylcholine which is implicated in many areas of brain function.
While most other choline sources are inefficient, slow to work, and only partially cross the blood brain barrier, Alpha GPC has a vastly higher rate of conversion into Acetylcholine.
CDP Choline is another Acetylcholine supplement that is often praised for its high degree of effectiveness, but Alpha GPC is actually twice as powerful as this compound by weight.
The fast-acting delivery mechanism of Alpha GPC for choline makes this nootropic a natural complement to Racetams like Piracetam, Aniracetam, Oxiracetam, Pramiracetam or Phenylpiracetam, but it also provides nootropic effects on its own.
One of the areas where this is especially noticeable is in terms of memory formation and recall. You may feel like you retain more information that you learn either from reading, listening to lectures, or just going about your day.
Other people say that taking Alpha GPC supplements gives them better access to their memories and makes it easier to come up with the right answer at test time or when at work.
In addition to memory, learning capacity may be expanded along greater clarity of thought and better ability to understand difficult topics. Many users will also experience a noticeable increase in their mental energy, leading to a feeling of well-being and increased drive.
This is due to the fact that the supplement helps to increase blood circulation to the brain along with improved oxygen uptake and glucose metabolism. This may lead to an increased attention span, better concentration, and focused thinking in most users.
Alpha GPC Supplements for Athletes
This supplement may also be beneficial to athletes or as part of a pre-workout stack. This is especially true for weight training and bodybuilders.
One of the reasons for this is that as Acetylcholine is produced and released into the bloodstream a chain of reactions begins. These cholinergic transmissions and reactions actually release more energy which helps to sustain longer and more intense work outs.
For more academic individuals, this may also translate to better mental stamina for times when you really need to study hard.
Another interesting health benefit of Alpha GPC supplements for athletes is the fact that this may stimulate the release of human growth hormone (HGH).
Alpha GPC is thought to work together with the pituitary gland to enhance the secretion of HGH. As there is more HGH available, the body can more easily develop and build muscle mass, helping athletes to become stronger in less time.
Alpha GPC for Overall Brain Health
Part of the chemical make-up of Alpha GPC is a material known as a phospholipid. This is actually very similar to what makes up the membranes within human cells, particularly in neurons and other brain cells.
Taking Alpha GPC can play a significant role in the synthesis of new cell membranes. This means that it may help to repair existing damage to these cells, prevent cell death, and even give them new life.
There is also evidence that suggests Alpha GPC supplements help to promote nerve cell expansion. This is vital in the protection of the neurons and other brain cells.
The supplement actually bonds to the omega-3 fatty acids, building new cell membranes. As basic cell function improves, they communicate better with each other and work much more efficiently.
Research on the effects of Alpha GPC is promising, however more studies need to be done, especially large-scale human trials. At this point time, Alpha GPC is available as a health supplement only, and the FDA has not approved Alpha GPC as a drug to prevent or treat any conditions.
Alpha GPC Dosage
Proper dosage is dependent on many different factors including age, weight, personal physiology, and the reason for taking a supplement. The below dosage recommendations are general guidelines, and your dosage may be different. It is always recommended that you speak with your doctor to determine the best dosage for your needs.
The most typical daily dosage range for Alpha GPC supplements is somewhere between 300 and 1200 mg.
Of course, this can be broken down it several equal administrations throughout the day, normally in the morning and the middle of the day (taking it too late in the afternoon may cause difficulties falling and staying asleep at night).
It is also advisable to always start out at the lower end of the dosage range and only increase the amount of Alpha GPC supplements as needed.
Alpha GPC Side Effects
While there have been some side effects associated with Alpha GPC supplements, they are normally very mild and well-tolerated.
Reported side effects include possible headaches, fatigue, nervousness, dizziness, nausea, diarrhea, and other GI issues.
Once again, these side effects are not common and they are usually mild even when they do appear. The best way to counter or avoid any of these listed side effects is to follow the recommended dosage levels.
Normally side effects will occur when doses much higher than recommended levels are used. Simply reduce back down, or even avoid taking your Alpha GPC supplements for a few days and they should normalize.
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Article last updated on: March 13th, 2018 by Nootriment
1 Comment
The following questions remain to be answered: How much acetylcholine should I take with say three or more racetams if I have a stack? How should I take it, on an empty stomach or not despite it being water-soluable? What happens if you compeletely leave choline out?
/Magnum