- Alpha GPCCholinergic SupplementMemoryAttentionNeuro- protective
How It Works:
Top Alpha GPC Products* ❯View User Ratings* ❯*Affiliate LinksOVERVIEW: Alpha GPC is a phospholipid form of choline derived from soy lecithin. It is a precursor to the neurotransmitter acetylcholine. READ MORE...USED FOR: Memory, Learning, Focus, Brain Health, Mood, Depression, Cognitive Decline, Alzheimer's Disease, Dementia, Stroke Recovery.MECHANISM: Highly bioavailable source of choline to increase acetylcholine synthesis in the brain. READ MORE...DOSAGE: 300mg to 1,200mg per day; Taken 2-3 times a day.SIDE EFFECTS: Generally Regarded as Safe (GRAS) Status from the FDA. Some users report heartburn, upset stomach, nausea, diarrhea, dizziness, skin rash, and headache. READ MORE...INTERACTIONS: Scopalamine; No Known Supplement Interactions.RELATED SUPPLEMENTS: Choline, Citicoline, Phosphatidylcholine, DMAE, Lecithin, Centrophenoxine, Phosphatidylserine, UridineTop Alpha GPC Supplements
- Choline source to support memory function
- Increases attention, focus & energy
- Neuroprotective for brain cell health
Okay, the articles helped. However, what is unclear to me is, if both CDP Choline, Cognizin or Alpha GPC lead to or aid in the production of Acetylcholine, why not just take Acetylcholine and cut to the chase?
Good question! Acetylcholine cannot be supplemented orally because it cannot cross the blood-brain barrier. This is the filtration system that separates your circulating blood flow from brain tissue. Since the acetylcholine molecule won’t penetrate this barrier, you wouldn’t be able to increase its levels in the brain directly, which means it wouldn’t be able to bind to cholinergic receptors on your neurons.
Choline supplements (particularly alpha GPC) are able to penetrate this barrier and then they can be made into acetylcholine once they are inside the brain.
I’d go with CDP Choline / Citicoline any day over GPC.
There is an science article out reviewing GPC and free range choline and it’s increase in lethal prostate cancer and it is all bad news for GPC first then free change choline.
We observed 695 events of lethal prostate cancer during 879,627 person-years. In multivariate analyses, men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer.
In addition, intakes of free choline and glycerophosphocholine (GPC) were positively associated with risk of lethal prostate cancer, but the relations between phosphatidylcholine, sphingomyelin, and phosphocholine intake and lethal prostate cancer were not statistically significant. Betaine intake was not associated with risk of lethal prostate cancer.
Thanks for linking the article, very informative.
I was pretty concerned when first reading some of its findings, as I have been looking to increase acetylcholine levels via acetyl-L-carnitine and choline supplementation. Although the article does raise concerns about choline intake – this study points to greatest concern being present FOLLOWING a prostate cancer diagnosis, as choline utilization by cancer cells is abnormally high compared to normal cells. This does not point to causation by any means. Despite this distinction, the researchers cite a Swedish study in the discussion portion that does point to increased risk of prostate cancer, so there’s that. I don’t have access to that article – but it would be interesting to see if they also make any distinction between types of choline and increased risk.
I think the take aways from this article are:
1) Caution should be taken with choline supplementation if you are a male with a higher risk of prostate cancer (age, family hx, etc.) or obviously diagnosed with prostate cancer.
2) A weighing of cost vs. benefits must be taken with choline supplementation and dietary intake (as with anything). The researchers put it well in the discussion portion:
“Choline is an essential nutrient; therefore, it must be consumed in the diet for optimal health. Low concentrations of choline are associated with the development of fatty liver and liver damage (34, 35). In addition, animal data suggest that choline intake may be beneficial to cognitive function and memory (36–39), and cytidinediphosphocholine—the intermediate produced in the conversion of choline to phosphatidylcholine—has been associated with improved memory in elderly persons in short-term randomized controlled trials (40). Thus, future studies need to examine whether the benefits of choline intake outweigh the potential risks among men.”
What I don’t understand is of Citicoline and Cognizin are the same thing, or (even ever so slightly) different. Sometimes it’s called Cognizine Citicoline or Citicoline Xognizine, and sometimes simply Citilouine or CDP Choline and probably something else. Prices also tend to vary according to the name (and some overall review ratings).
Could you clear this up, please?