Alpha-linolenic acid is a plant-based source of omega-3 fatty acids. Like fish oil, which provides eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), it helps to maintain a healthy balance of omega-3 and omega-6 fatty acids.
Omega-3 fatty acids help reduce inflammation in the body and can also lower risk factors related to heart disease and arthritis. There is also evidence that omega-3 fatty acid and alpha-linolenic acid benefits can improve cardiovascular health and reduce risk factors for strokes, heart attacks, and high blood pressure. [2]
Alpha-linolenic acid can be found in walnut oil, perilla, soy, canola oil and flaxseed oil. It is considered to be a good source of omega 3’s for vegetarians and vegans who might otherwise be deficient in these important fatty acids.
However, research shows that not all the benefits of fish or krill oil can be replicated by using alpha-linolenic acid. Research is under way to determine the differences between these two sources of omega-3 fatty acids. [1]



- Exhibits anti-inflammatory effects
- Supports mood, memory & brain health
- Promotes cardiovascular health
Alpha Linolenic Acid
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There are three different kinds of omega fatty acids: omega-3, omega-6 and omega-9. Omega-3 and omega-6 fatty acids are polyunsaturated fats whereas omega-9 is a monounsaturated fat.
Each of these types of fats has a role to play in the body, but problems can occur when they are not properly balanced.
The Western diet tends to contain an over-abundance of omega-6 and not enough omega-3 fatty acids. To restore a healthy valance, supplements like alpha linolenic acid and fish oil are used. [3]
Alpha linolenic acid can be purchased as a dietary supplement or consumption can be increased by choosing foods such as perilla seeds, walnuts, pumpkin seeds, canola (rapeseed oil), flaxseeds and soybeans. ALA is also found in cooking oils, such as canola oil and soybean oil, as well as flaxseed oil supplements.
Adults are recommended to consume between 1 – 2 g of alpha-linolenic acid per day for maximum benefit. Flaxseeds contain approximately 2.2 g of ALA per tablespoon, flaxseed oil provides 8.5 g per tablespoon and canola oil provides 1.3 g per tablespoon.
Alpha Linolenic Acid Benefits
Maintaining a healthy diet rich in sources of alpha linolenic acid may reduce risk factors for heart disease. In one study, individuals who consumed more ALA were less likely to die of a heart attack than those who consumed less of the unsaturated fat.
Women who consumed at least 1.5 g of ALA per day had a 46% lower chance of experiencing sudden cardiac death compared to those who only consumed 0.5 g or less per day. In other population studies, individuals who ate higher amounts of this omega 3 fatty acid had a lower risk of death caused by heart disease. [4]
It has yet to be determined whether ALA supplements can provide the same benefits as eating a diet diet high in omega-3 fatty acids, such as the Mediterranean Diet.
In other studies, higher consumption of ALA is associated with lower cholesterol and triglyceride levels. Walnuts provide an excellent source of ALA and have been shown to reduce LDL (“bad”) cholesterol levels in people with high cholesterol.
Studies using flaxseed oil as a source of ALA have been less conclusive than studies using ALA supplements. In some studies flaxseed lowered cholesterol and in others it produced no change. [5]
Additional studies have looked at the benefits of alpha linolenic acid for reducing blood pressure – a significant risk factor in cardiovascular disease. Diets rich in omega-3 fatty acids have been shown to lower blood pressure slightly in individuals with hypertension.
Eating sources of this polyunsaturated fat may be able to reduce the risk of high blood pressure by as much as 30%. [6] Finally, this fatty acid has been shown to decrease inflammation in the lungs and improve breathing in individuals with asthma. [7]
Is Alpha Linolenic Acid Safe?
There are few side effects associated with alpha linolenic acid supplementation, but some precautions may be necessary for certain individuals. If you are currently being treated with blood thinning medications, you should not use this supplement before consulting with your doctor.
Omega-fatty acids in ALA, Fish Oil or Krill Oil can increase the blood-thinning effects of drugs including warfarin (Coumadin), clopidogrel (Plavix), and aspirin. Due to the increased risk of bleeding, alpha-linolenic acid and fish oil supplementation should be stopped at least two weeks before surgery. Inform your surgeon if you are using these supplements.
If you are currently taking medication to lower cholesterol levels, the use of ALA supplements may be contraindicated. Omega-3 fatty acids can lower cholesterol levels and may cause side effects when used with statin drugs, such as: Atorvastatin (Lipitor); Rosuvastatin (Crestor); Fluvastatin (Lescol); Lovastatin (Mevacor); Simvastatin (Zocor); and Pravastatin (Pravachol).
Individuals who have been diagnosed with diabetes or schizophrenia may have a condition where they are unable to convert alpha-linolenic acid into other forms of omega-3 fatty acids, such as EPA and DHA. These individuals should avoid ALA and instead use a fish or krill oil supplement.
It is unclear whether this fatty acid reduces or increases the risk of macular degeneration and prostate cancer. So far studies have found results suggesting both of these outcomes. Until more research can be done, speak to your doctor to learn more about alpha-linolenic acid benefits and find out if you have risk factors for prostate cancer or macular degeneration.
- Wang C, et al n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review . Am J Clin Nutr. (2006)
- Bernstein AM, et al A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease . J Nutr. (2012)
- Stark KD, et al Comparison of bloodstream fatty acid composition from African-American women at gestation, delivery, and postpartum . J Lipid Res. (2005)
- Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr. 2004;134:919-922.
- Caron MF, White CM. Evaluation of the antihyperlipidemic properties of dietary supplements. Pharmacotherapy. 2001;21(4):481-487.
- Pan A, Chen M, Chowdhury R, et al. a-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. Am J Clin Nutr. 2012; 96(6):1262-1273.
- Okamoto M, Misunobu F, Ashida K, Mifune T, Hosaki Y, Tsugeno H, et al. Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. Int Med. 2000;39(2):107-111.
- Zatonski W, Campos H, Willett W. Rapid declines in coronary heart disease mortality in Eastern Europe are associated with increased consumption of oils rich in alpha-linolenic acid. Eur J Epidemiol. 2008;23(1):3-10.
- Du Q, Martin JC, Agnani G, Pages N, Leruyet P, Carayon P, Delplanque B. Dairy fat blends high in alpha-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. J Nutr Biochem. 2012
- Wiggins AK, Mason JK, Thompson LU. Growth and gene expression differ over time in alpha-linolenic acid treated breast cancer cells. Exp Cell Res. 2015
- Petzinger C, Larner C, Heatley JJ, Bailey CA, MacFarlane RD, Bauer JE. Conversion of alpha-linolenic acid to long-chain omega-3 fatty acid derivatives and alterations of HDL density subfractions and plasma lipids with dietary polyunsaturated fatty acids in Monk parrots (Myiopsitta monachus). J Anim Physiol Anim Nutr (Berl). 2014
- Lemaitre RN, Sitlani C, Song X, King IB, McKnight B, Spiegelman D, Sacks FM, Djoussé L, Rimm EB, Siscovick DS, Mozaffarian D. Circulating and dietary alpha-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. Am J Clin Nutr. 2012
- Ebrahimi M, Rajion MA, Goh YM. Effects of oils rich in linoleic and alpha-linolenic acids on fatty acid profile and gene expression in goat meat. Nutrients. 2014
- Pal M, Ghosh M. Prophylactic effect of alpha-linolenic acid and ?-eleostearic acid against MeHg induced oxidative stress, DNA damage and structural changes in RBC membrane. Food Chem Toxicol. 2012
- Hadjighassem M, Kamalidehghan B, Shekarriz N, Baseerat A, Molavi N, Mehrpour M, Joghataei MT, Tondar M, Ahmadipour F, Meng GY. Oral consumption of alpha-linolenic acid increases serum BDNF levels in healthy adult humans. Nutr J. 2015
- Umesha SS, Naidu KA. Vegetable oil blends with alpha-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats. Food Chem. 2012
Article last updated on: May 12th, 2018 by Nootriment