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Ampamet is a European brand name for Aniracetam – a nootropic drug used to treat cognitive impairment. This Racetam compund was initially discovered in the 1970s by Hoffmann-La Roche.
Ampamet is manufactured by the Menarini Group in Italy. It is sold in the form of 750 mg satchets of Aniracetam granules for oral administration.
Aniracetam is a fat soluble Ampakine and Racetam used both for cognitive enhancement purposes and as an anxiolytic. It is purported to have more powerful nootropic effects than Piracetam.
Studies have shown it to be effective for anxiety, improving memory and learning abilities, alleviating depression, protecting brain cells and increasing motivation.
While the effects vary for different individuals, user reviews have reported benefits for mental performance, mood enhancement and brain health.
Ampamet is sold under the generic name Aniracetam and can be purchase in either pill or bulk powder formulations.
Continue reading for a closer look at how Ampamet/Aniracetam works, its “smart drug” benefits, possible side effects and usage advice. Buy Aniracetam online at this link.
Motivation
Memory
Mood- Heightens focus & motivation
- Supports memory formation & recall
- Shown to enhance mood & reduce anxiety
How Ampamet Works
Related Topics
- What is Aniracetam?
- User Reviews
- Effects and Benefits
- Aniracetam for Anxiety
- Dosage Suggestions
- Using Aniracetam Powder
- Best Way to Take
- Side Effects
- Aniracetam for Sale
- Buyer's Guide
- Is Aniracetam Legal?
- Stacking with Piracetam
- Stacking with Choline
- Comparison to Piracetam
- Comparison to Oxiracetam
- Comparison to Pramiracetam
- Comparison to Noopept
Ampamet functions in a similar fashion to other racetams by influencing the pathways for two neurotransmitters – acetylcholine and glutamate.
Like Piracetam (Nootropil), it is believed to facilitate cholinergic neurotransmission. This refers to communication between neurons that respond to the neurotransmitter acetylcholine.
Ampamet stimulates increased cholinergic activity in the hippocampus by causing more acetylcholine to be released form your neurons and by modulating the sensitivity of neural receptors.
The hippocampus is the structure in your brain most closely tied to memory formation as well as recall and acetylcholine is used in many of the cognitive processes that involve storing and accessing memories.
By increasing acetylcholine activity, Ampamet is purported to improve information retention and allow you to make more connections between stored memories.
Ampamet is also a positive allosteric modulator of the AMPA and NMDA receptors for the neurotransmitter glutamate. This is the most abundant excitatory neurotransmitter in the brain.
AMPA receptors (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors) are ionotropic transmembrane receptors that mediate fast synaptic transmission in the Central Nervous System.
NMDA receptors are highly involved in the growth of new synapses which are connections between neurons. They play a role in Long-Term Potentiation, which is the process by which memories are stored.
Greater NMDA stimulation has the potential to lead to more plasticity in the brain as your neurons are able to form more synapses at which neurotransmitters will be transmitted.
While our brains become less plastic over time, a drug like Ampamet has been theorised to increase neuroplasticity and combat signs of memory loss or cognitive decline with aging.
This drug has been used in the treatment of Senile Dementia-type Alzheimer’s disease (SDAT), Age-Related Cognitive Decline, memory impairment of a vascular origin and cognitive dysfunction following a stroke.
- Improves memory and learning
- Heightens focus and motivation
- Enhances mood and reduces anxiety & stress
Ampamet Effects on Mood & Brain Function
In addition to its purported benefits for cognitive function, Ampapet has also been used to promote improved mood and general health and well-being.
Clinically, this drug has been used to treat post-stroke depression and anxiety.
The mood enhancement effects of Ampamet are likely due to the stimulation of nicotinic acetylcholine receptors as well as the D2 receptors for Dopamine.
The neurochemical dopamine is associated with feelings of happiness and pleasure and it also plays a role in focusing our attention and impulse control.
Individuals with low dopamine activity may suffer from depression and other mood disorders. Increasing dopamine stimulation can lead to feelings of well-being and reduce anxiety and stress symptoms.
Aniracetam has also been observed to stimulate GABA and Serotonin receptors in the brain as well as increasing the release of noradrenaline in the cerebrum. This may explain the stimulatory and anxiolytic effects of this nootropic agent.
There are additional neuroprotective benefits of Ampamet as this nootropic supplement can increase blood flow and oxygenation of your brain tissue. It may also help to remove toxins from your neurons and act as an anti-oxidant. Studies have further found that it can increase the expression of BDNF which is a protein that is responsible for the growth and maintenance of your neurons.
These positive nootropic effects of Ampamet on neuronal health and basic cell function may provide the groundwork for long-term improvements to your brainpower when using this drug.
Ampamet Benefits
The benefits of the nootropic drug Ampamet extend beyond those listed above. The primary off-label reason for taking this cognitive enhancer is to improve intellect, as a concentration aid, and as a mood booster.
Your specific benefits may be stronger in one of these areas than another and this may also vary depending on other supplements that you stack Ampamet with.
Below are some of the most common benefits attributed to Ampamet from user reviews and experience ratings as posted online:
- Improves memory & learning
- Reduces brain fog
- Increases alertness and attention span
- Good concentration and focus booster
- Raises perceptual awareness – especially with music
- Better sleep quality and lucid dreams
- Lower anxiety levels
- May reduce depression symptoms
- Enhanced verbal processing & communication
- Reduces social anxiety
- Improves creative though & problem solving
It has also been used off-label to address ADHD symptoms, but is not approved for this use. There is no clinical research available on its effects for Attention Deficity Hyperactivity Disorder.
While it is approved and used as a treatment for Alzheimer’s disease and dementia in some European countries, it has never been approved for any medicinal or therapeutic purporses in the United States.
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Ampamet Side Effects
Based on research results from clinical trials, Aniracetam powder and pills are considered safe with a low frequency of adverse effects.
There are no serious side effects attributed to Ampamet and the nootropic agent is considered non-toxic. However, some user reviews do report side effects that are generally mild and temporary.
As a racetam, it can put added demand on your acetylcholine stores which may lead to headaches, irritability, and unclear thoughts. You can prevent this by using a choline supplement such as Alpha GPC or Citicoline with your Ampamet dosage.
It is best to use a high quality acetylcholine precursor rather than Choline Bitartrate or Phosphatidylcholine as these have lower conversion into acetylcholine.
Other side effects are uncommon but may include insomnia, stomach pain, diarrhea, nausea, irritability or a rash.
Using Ampamet
Ampamet is sold in the form of powdered granules with a dosage of 750 mg or 1500 mg per satchet. This smart drug is also sold as an oral capsule, tablet or a bulk powder. For medical use, it has also been administered as an intravenous solution.
The standard Ampamet dosage is 750 mg taken three or four times per day. Because Aniracetam has a short half-life, it is important to repeat your dose multiple times during the day to experience the full benefits
It is a fat soluble nootropic and should be ingested with food or with milk such as in a protein shake. This will ensure that the Ampamet binds to a lipid and gets absorbed properly into the blood.
The absoprtion of this drug from the gut is rated between 97-100% and it has a half-life of 2 hours.
Purchasing Aniracetam in powder format tends to be the cheapest way to acquire this supplement, but you can also find Ampamet tablets for sale online if this is your preferred method of administration.
Currently Ampamet is regulated as a prescription medication in much of Europe and in Australia. In the United States and Canada, it is not considered a prescription drug and is not scheduled as a controlled substance.
In some countries, Aniracetam can be purchased online or as an over-the-counter drug or supplement. Check with local regulations before deciding to buy this nootropic agent.
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- Martin JR, Moreau JL, Jenck F. Aniracetam reverses memory impairment in rats. Pharmacol Res. 1995
- Saletu B, Grünberger J. The hypoxia model in human psychopharmacology: neurophysiological and psychometric studies with aniracetam i.v. Hum Neurobiol. 1984
- Vincent G, Verderese A, Gamzu E. The effects of aniracetam (Ro 13-5057) on the enhancement and protection of memory. Ann N Y Acad Sci. 1985
- Nakamura K, Tanaka Y. Antidepressant-like effects of aniracetam in aged rats and its mode of action. Psychopharmacology (Berl). 2001
- Ventra C, Grimaldi M, Meucci O, Scorziello A, Apicella A, Filetti E, Marino A, Schettini G. Aniracetam improves behavioural responses and facilitates signal transduction in the rat brain. J Psychopharmacol. 1994
- Toide K. Effects of aniracetam on one-trial passive avoidance tests and cholinergic neurons in discrete brain regions of rats. Arch Int Pharmacodyn Ther. 1989
- Lee CR, Benfield P. Aniracetam. An overview of its pharmacodynamic and pharmacokinetic properties, and a review of its therapeutic potential in senile cognitive disorders. Drugs Aging. 1994
Article last updated on: March 13th, 2018 by Nootriment