7
4.33
4
Aniracetam and Oxiracetam are two nootropics with some similar effects, but slightly different mechanisms of action. Both belong to the Racetam family of Nootropic drugs and are more potent derivatives of Piracetam.
While Aniracetam is used for memory enhancement as well as mood-boosting benefits, Oxiracetam is considered beneficial for focus, logical thinking and productivity.
Aniracetam promotes a positive state of mind, alertness, verbal fluency, memory formation and anti-anxiety effects. Oxiracetam also enhances memory and has a psychostimulatory effect as well as supporting neuron health and general mental performance.
Aniracetam is fat-soluble and has a rapid onset of effects, but a short duration in the body. Oxiracetam is water-soluble, takes longer to achieve peak levels in the body and stays active for a longer period of time.
This makes it natural to want to stack Aniracetam with Oxiracetam so you can benefit from both. The two are believed to potentiate each other resulting in stronger effects than if you were to take either one in isolation. How should you be using an Aniracetam Oxiracetam Stack?
In this article, we will compare the effects and mechanisms of Aniracetam and Oxiracetam. We will also discuss the purported benefits of stacking these two racetam nootropic supplements and the best way to take them. Below, you will also find user reviews of their results with the Aniracetam Oxiracetam Nootropic Stack.
Aniracetam Oxiracetam Stack Summary:
- 1:1 Dosage ratio of Aniracetam to Oxiracetam
- Take 750 mg of each up to twice per day
- Add 200 – 300 mg of Alpha GPC or CDP Choline per dose
- Oxiracetam is water-soluble and should be taken 20 minutes before food
- Aniracetam is fat-soluble and should be taken after a meal
Motivation
Memory
Mood- Heightens focus & motivation
- Supports memory formation & recall
- Shown to enhance mood & reduce anxiety
Comparing Aniracetam and Oxiracetam
Related Topics
- What is Aniracetam?
- User Reviews
- Effects and Benefits
- Aniracetam for Anxiety
- Dosage Suggestions
- Using Aniracetam Powder
- Best Way to Take
- Side Effects
- Aniracetam for Sale
- Buyer's Guide
- Is Aniracetam Legal?
- What is Oxiracetam?
- Dosage Guide
- Reviews
- Oxiracetam Effects
- Side Effects & Safety
- Experience Reports
- Where to Purchase
- Is Oxiracetam Legal?
Aniracetam (N-anisoyl-2-pyrrolidinone) was the first ever analogue to Piracetam (Nootropil) developed in the 1970’s.
It was originally code-named RO 135057 by researchers at Hoffmann-La Roche who identified it to be 3-6x more potent than Piracetam.
Following significant human research, it was introduced to clinical practice in parts of Europe and Japan to treat Senile Dementia, Age-Related Cognitive Decline, Alzhemier’s Disease and other forms of memory loss.
One of the unique benefits of this nootropic agent is its anxiolytic properties. In addition to enhancing cognitive function, it was found to improve mood, reduce anxiety and improve depression in patients with cerebrovascular disorder.
As a nootropic supplement, Aniracetam is favored by many users for its ability to reduce anxiety and lift mood. Some describe it as improving their social anxiety and helping them to feel more confident and happier.
It is thought to promote activity at serotonin and dopamine receptors in the brain. Low levels of these two neurotransmitters may play a role in both mood and anxiety disorders.
One of the benefits of Aniracetam compared to Piracetam is that it is more bio-accessible and better absorbed from the gastrointestinal tract. This has to do with the fact that Aniracetam is fat-soluble (lipophilic) while Piracetam is water-soluble (hydrophilic).
Molecules that are fat-soluble are transported across the intestinal barrier into the bloodstream more easily. They also cross the blood-brain barrier more readily.
Because Aniracetam is fat soluble, it works best if taken with a meal. This nootropic has a short half-life of less than two hours, meaning the benefits are experienced during a window of about 2-4 hours.
Oxiracetam is a cognitive enhancer that is also derived from Piracetam, but it has a different chemical structure compared to Aniracetam.
This nootropic substance is sometimes referred to as “hydroxypiracetam” because it has an additional hydroxy group in its molecule. It has a chemical structure of (RS)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetamide.
As a result of this chemical modification, Oxiracetam is 2-4 times stronger than Piracetam and requires a lower dosage. It is water soluble, which makes it different from Aniracetam.
Many of the mechanisms that produce the nootropic effects of this drug are similar to those involved in mediating Aniracetam’s benefits. Both are believed to increase choline uptake into neurons and to modulate acetylcholine and glutamate receptors.
Oxiracetam does not have the same effect of Aniracetam on mood balance, anxiety or depression. It does not appear to significantly affect dopamine or serotonin neurotransmission in the brain.
Oxiracetam is described as working more like a mild psycho-stimulant without the side effects associated with most amphetamines. It appears to increase mental alertness, arousal and attention span.
In anecdotal user reviews, it is described as having energy-boosting properties. Users say that it supports memory and learning, technical thinking ability and sensory perception. It also enhances concentration, but does not cause the same single-track focus as some of the other more powerful racetams.
Based on preliminary data from clinical trials involving patients with cognitive disorders, this nootropic is believed to be adept at enhancing skills related to abstraction, logical thinking, analytical processing and comprehending difficult mathematical or scientific concepts.
There is limited research into the use of both Aniracetam and Oxiracetam in healthy adults who have not been diagnosed with some form of cognitive dysfunction. There are also no comparative studies available to directly contrast therapeutic efficacy of these drugs.
Most of what we know about the cognitive enhancement effects of these nootropic agents comes from user reviews and experience logs. Based on these reviews, there does appear to be a perception of increased efficacy when stacking Aniracetam with Oxiracetam.
Alertness
Memory
Cognitive Function- Heightens focus, alertness & perception
- Promotes analytical thinking & memory
- Boosts energy & reduces mental fatigue
Aniracetam Oxiracetam Stack
The racetam family of smart drugs are purported to have a positive effect when they are stacked together. It is believed that combining their use can promote greater potentiation of effects compared to using one racetam individually.
The method of action for racetams isn’t fully understood, but all work to enhance cognitive function in various ways by acting on certain neurotransmitters and receptors.
Each racetam exhibits unique effects which may be heightened if stacked with another racetam.
These substances also have different half-lives and some may take longer for their effects to kick in than others. It is typical to stack a fast-acting racetam like Aniracetam with slower acting substances that remain in the body for a longer period of time. Stacking racetams together can allow the user to benefit from a longer duration of effects before dosing again.
You should bear in mind that the potency and effects of each are synergistically potentiated by each other in the brain, meaning their effects may be increased when they are taken together. Lower doses may be required to achieve beneficial results when combining racetams.
In addition to the potential for stronger benefits with combined use, one of the main reasons for taking Aniracetam with Oxiracetam is to enhance the range of effects experienced.
The anxiolytic effects of Aniracetam are said to counter Oxiracetam’s mild stimulating effects on the central nervous system. This stack can help during periods while working on a big project, studying for exams and even for taking examinations.
Some people find that Aniracetam improves their mood and helps them to focus, but reduces mental drive to complete tasks. Using Oxiracetam with Aniracetam may minimize this and result in greater motivation and goal-directed behavior.
Oxiracetam is purported to have benefits for tasks involving memorization and for handling complex calculations or data analysis. But it causes muscle tension, jaw clenching and over-excitation in some users. Others say it leaves them feeling emotionally blunted. Aniracetam may help to balance mood and eliminate the potentially over-stimulating nature of Oxiracetam’s effects.
- Improves memory and learning
- Heightens focus and motivation
- Enhances mood and reduces anxiety & stress
User Experiences
In the section below, we have collected user reviews on the Aniracetam Oxiracetam Stack from Reddit and Longecity.
These comments should give you an idea of how this nootropic stack makes some people feel. Your results may be different; responses to racetam nootropic agents are highly variable.
If you have used Oxiracetam with Aniracetam, please share your experience in the comment section below.
But if you’ve not taken either one before, give each one a trial of a few days separately before taking them together.” – MizTen [1]
Dosage: A bit more Aniracetam then before, try 1500mg Aniracetam, 750mg Oxiracetam, and 10-20mg Noopept. Don’t go much above that for Aniracetam, but again you can play with the Oxiracetam. I never go over 30mg Noopept though, and I wouldn’t recommend it.” – TripTipper [2]
When I’m using racetams, I like to take aniracetam + oxiracetam in the morning, again around noon, and again at reduced doses in the late afternoon.” – jadamgo [5]
- Heightens focus, alertness and perception
- Promotes better analytical thinking and memory
- Boosts energy and reduces mental fatigue
Dosage and Cycles
As mentioned earlier, combining racetams is believed to increase the potency of each individual racetam in the user’s stack due to the synergistic effects.
It is important to start taking this stack at a low dosage and gradually increase the dose over time to find the right stack for your individual needs and brain chemistry,
It is common to use Aniracetam and Oxiracetam in a 1:1 dosing ratio, taking between 750 mg to 1500 mg of each per day. Because Aniracetam has a shorter half-life, you may find that you need to take it more frequently in smaller doses. Some may split Aniracetam into 3 doses a day while taking the longer-lasting Oxiracetam only twice.
Experimentation with each of the racetams, individually, prior to combining them in a stack, is recommended. This is important to learn your own optimal dose for each, as well as making sure the racetam works in a beneficial way for you without producing any side effects.
Some people find they do not respond to one racetam, yet respond quite well to another. Everyone is different, making it difficult to set a standard dosage which will work for all users.
You may find that a stack of 1500 mg of Aniracetam with 750 mg of Oxiracetam produces the best results. Or it may be that 1550 mg of Oxiracetam to 750 mg of Aniracetam is more effective for you.
Some individuals report taking Oxiracetam in the morning and switching to Aniracetam in the afternoon to minimize the potential for side effects linked to over-excitation.
- Focus longer, clear brain fog & feel more motivated
- Boost energy, alertnes & memory
- Contains 12 safe and natural nootropic ingredients
How to Take Aniracetam and Oxiracetam
Aniracetam and Oxiracetam are sold in the form of oral capsules, tablets, powder and liquid solutions. Purchasing in bulk powder or in pill form is most common.
Aniracetam is fat-soluble requiring lipids, or a meal containing some fat source in order to maximize absorption from the gastrointestinal tract.
While research shows it is well absorbed from the gut even on an empty stomach, many users report that they feel the effects are more pronounced if they combine their dosage it with fish oil, olive oil, coconut oil, MCT oil or milk.
Oxiracetam is water-soluble and can be dissolved in water easily and dosed on an empty stomach. You may want to take Oxiracetam 20 – 30 minutes before eating a meal and then consume Aniracetam after the meal.
Oxiracetam has a longer kick-in time compared to Aniracetam’s effects, but it remains active in the body for a longer period of time. Staggering dosages may be the best way to combine these nootropic agents.
It is not necessary to take your dosages at the same time in order to experience the synergistic effects of these nootropics. You could take Oxiracetam first thing in the morning and add Aniracetam at breakfast or lunchtime, allowing a period for both racetams to work together.
Some people start their day with Oxiracetam first thing in the morning because of its slight stimulant effect, then Aniracetam in the evening to help them relax.
If taking a few interval doses throughout the day, do not take Oxiracetam later in the afternoon unless you plan to work through the night. Use of this nootropic drug in the evening can cause insomnia or sleep disturbances.
Some research suggests that Oxiracetam and Aniracetam may become more effective with long-term use for the treatment of conditions including Senile Dementia, Age-Related Cognitive Decline, Alzheimer’s Disease, or other forms of memory loss.
However, in anecdotal user reviews there is a strong suggestion of developing a tolerance to the effects of these nootropics over time. Individuals taking nootropics for the purpose of mental performance enhancement may find that they become less effective with continuous use.
Cycling racetams to avoid tolerance build-up can be done with a 2 weeks on/1 week off followed by 1 week on/2 weeks off type of cycle. The idea is to not let your body become adjusted to Aniracetam or Oxiracetam so your neurons remain sensitive to their effects.
Other nootropics can be added to this stack to increase the benefits for brain function. Racetams have a cholinosensitizing effect and are typically combined with a choline source to promote adequate acetylcholine levels.
If you take racetams without using choline in your stack and are prone to experiencing headaches, this may be the result of choline depletion.
Based on anecdotal evidence, these headaches can be minimized or eliminated with the addition of a choline supplement. Choline is the dietary precursor to the neurotransmitter acetylcholine.
This nutrient can be found abundantly in egg yolks as well as in meat, poultry, certain fish and some nuts and vegetables like broccoli. You can also use choline bitartrate supplements or look for higher quality choline sources like Alpha GPC, CDP Choline and Centrophenoxine.
In addition to acetylcholine precursors, Oxiracetam and Aniracetam are sometimes stacked with the following nootropic supplements and smart drugs:
- Piracetam
- Pramiracetam
- Phenylpiracetam
- Nefiracetam
- Coluracetam
- Noopept
- Sulbutiamine
- Phenibut
- Picamilon
- Adderall
- Modafinil (Provigil/Modalert)
- Adrafinil (Olmifon)
- Armodafinil (Nuvigil/Waklert)
- Caffeine
- Huperzine A
- Bacopa Monnieri
- Vinpocetine
- Bacopa Monnieri
- L-Theanine
Stacking can be very effective for those who respond well to both Oxiracetam and Aniracetam. But not everyone will need to stack nootropics in order to achieve their desired effects and some people may experience more side effects when combining racetams.
It is best to experiment with several different stacks to determine what works best for your goals. If you experience a worsening of side effects when using a stack, you may want to eliminate some of the co-ingested substances you are taking alongside Oxiracetam and Aniracetam.
Free shipping
- oxiracetam and aniracetam together. Longecity.
- Racetams and you: A guide of the popular Racetam family. Reddit.
- Thoughts on Aniracetam + Oxiracetam combo? Reddit.
- Favorite Racetam & why? Reddit.
- Aniracetam + Oxiracetam Stack. Longecity.
- Yu S, Cai J. Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study. Neurosci Lett. 2003
- Nakamura K, Kurasawa M. Aniracetam restores motivation reduced by satiation in a choice reaction task in aged rats. Pharmacol Biochem Behav. 2001
- Papandreou G, Zorpas K, Archontaki H. Development and validation of a liquid chromatographic method for the simultaneous determination of aniracetam and its related substances in the bulk drug and a tablet formulation. J Pharm Biomed Anal. 2011
- Fallarino F, Genazzani AA, Silla S, L'Episcopo MR, Camici O, Corazzi L, Nicoletti F, Fioretti MC. [3H]aniracetam binds to specific recognition sites in brain membranes. J Neurochem. 1995
- Galeotti N, Ghelardini C, Bartolini A. Piracetam and aniracetam antagonism of centrally active drug-induced antinociception. Pharmacol Biochem Behav. 1996
- Foltyn P, Lücker PW, Schnitker J, Wetzelsberger N. [A test model for cerebrally-active drugs as demonstrated by the example of the new substance aniracetam]. Arzneimittelforschung. 1983
- Wijayawardhane N, Shonesy BC, Vaglenova J, Vaithianathan T, Carpenter M, Breese CR, Dityatev A, Suppiramaniam V. Postnatal aniracetam treatment improves prenatal ethanol induced attenuation of AMPA receptor-mediated synaptic transmission. Neurobiol Dis. 2007
- Koliaki CC, Messini C, Tsolaki M. Clinical efficacy of aniracetam, either as monotherapy or combined with cholinesterase inhibitors, in patients with cognitive impairment: a comparative open study. CNS Neurosci Ther. 2012
- Johansen TH, Chaudhary A, Verdoorn TA. Interactions among GYKI-52466, cyclothiazide, and aniracetam at recombinant AMPA and kainate receptors. Mol Pharmacol. 1995
- Lee CR, Benfield P. Aniracetam. An overview of its pharmacodynamic and pharmacokinetic properties, and a review of its therapeutic potential in senile cognitive disorders. Drugs Aging. 1994
- Consolo S, Salmoiraghi P, Amoroso D, Kolasa K. Treatment with oxiracetam or choline restores cholinergic biochemical and pharmacological activities in striata of decorticated rats. J Neurochem. 1990
- Mondadori C, Schmutz M. Synergistic effects of oxiracetam and piracetam in combination with antiepileptic drugs. Acta Neurol Scand Suppl. 1986
- Gabryel B, Trzeciak HI, Pudełko A, Cieślik P. Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro. Pol J Pharmacol. 1999
- Cavoy A, Van Golf-Racht B, Delacour J. Relationships between arousal and cognition-enhancing effects of oxiracetam. Pharmacol Biochem Behav. 1994
- Gschwind HP, Schütz H, Wigger N, Bentley P. Absorption and disposition of 14C-labelled oxiracetam in rat, dog and man. Eur J Drug Metab Pharmacokinet. 1992
- Wang C, Li F, Guan Y, Zhu L, Fei Y, Zhang J, Pan Y. Bone marrow stromal cells combined with oxiracetam influences the expression of B-cell lymphoma 2 in rats with ischemic stroke. J Stroke Cerebrovasc Dis. 2014
- Sansone M, Castellano C, Battaglia M, Ammassari-Teule M. Effects of oxiracetam-nicotine combinations on active and passive avoidance learning in mice. Pharmacol Biochem Behav. 1991
Article last updated on: March 16th, 2018 by Nootriment
7 Comments
Currently I’m taking the following stack 2 per day:
1. oxiracetam 600mg
2. oxiracetam 750mg
3. alpha gpc 250mg
I also eating 6 eggs per day. From what I’ve been reading it might be too much choline.
However, I don’t feel any signs of depression, but I do get a headache and fogginess, which would point to choline deficiency.
Looking forward to your feedback.
-RS
Hey RS,
Thanks for your question!
One egg has around 100 mg of choline, so you’re getting approximately 600 mg of choline from dietary sources and then 250 mg from Alpha GPC.
In some studies, as much as 1,200 mg of Alpha GPC is used per day, so I don’t think it’s necessarily the case that you’re getting too much choline. However, since we have limited information on the optimal dosage for stacking, titration might be the best way to determine the right dose for you.
In the response of the Admin above, it was stated that up to 1,200 mg per day of Alpha GPC have been studied. I learned the hard way that Alpha GPC is absolutely terrible about absorbing moisture right out of the air ( hygroscopic) the first time I bought some. Since then I’ve been buying from a source that has a 50/50 mixture of Alpha GPC and silicon dioxide that eliminates the clumping. Is it safe to assume that this 50/50 mixture would require 2,400 mg to get 1,200 mg of Alpha GPC?
Hi Larry,
Yes that’s correct. I’ve switched to using a 50% Alpha GPC supplement myself due to the hygroscopic nature of the bulk powder and I’ve doubled my dosage to account for the lower effective dose of choline per serving. I split this dosage into three administrations as in some cases taking a high dosage of Alpha GPC 50% can cause stomach discomfort.
I hope that answers your question!
It sure does. Thanks! I’ll keep in mind the suggestion about splitting up the dosage. So far, I’ve only taken as much as 1,200 mg of the 50% mix at one time on only a couple of occasions without incidence. However, I’ll consider myself lucky and go with smaller multiple doses instead. Part of my problem in scheduling is because I get up around 3:30 am Mon-Fri for my job that starts at 5:00 am. It seems that no matter how tired I am or how late I stay up, I only sleep 5-6 hours, so I don’t go to bed until 9:00 pm. I’m kind of a night-owl so when Friday rolls around and I want to stay up and do some extra reading or watch a little TV, I’m more likely to use adrafinil (or other ‘similar’ products ;) ), phenylpiracetam, oxiracetam, or some of the other stimulant-like racetams and stay up until 2-3 am (22-23+ hours). At that point it becomes more of how much of ____ do I take every ___ hours? #nightowlproblems Thanks again!
It sure does, thanks! I’ve not had any problems with as high as 1,200 mg of the 50% mix however, I’ve only done that two or three times. I think I’ll back it off to 3x 800 mg to be safe.
My biggest problem is my work/sleep schedule. My day is much longer than the average day; just under 18 hours…and that’s just Mon-Thursday. I get up around 3:30 am Mon-Fri (job starts at 5) and since I can’t seem to sleep much more than 5-6 hours despite how tired/how late I’ve stayed up, I don’t go to bed until 9 pm. On Fridays, I usually stay up until 2-3 am to catch up on reading and a couple of TV shows. Since there’s not much physical exertion going on, I take a bit more racetams like Oxi, Phenyl P, and Sulbutiamine so I never quite know how to figure how much Alpha GPC/day since my days are so long. Along with the racetams, I often include caffeine/theanine and adrafinil or “similar” substances. ;) Any suggestions? Should I go for more of a “how much/hour” amount instead of a per day amount? Thanks again!
Hey Larry,
So I typically take my Alpha GPC earlier in the day to avoid sleep disturbances :). To keep thinks simple, I personally take a morning stack around 8:30 AM, a second dose at 11:30 AM and then a final dose at 2:30 PM. I just use an even split dosage at each administration, but sometimes will take more in the morning if I wake up feeling tired or low on energy, I’ll front-load my stack to take more in the morning :). Everyone’s results are different though and you may find your optimal stack is different/