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Aniracetam powder is used as an off-label smart drug to boost brainpower and promote mental focus.
As one of the most well-known Nootropic supplements, there has been a lot of interest in Aniracetam recently. This cognitive enhancer is said to have benefits for memory, learning, concentration, energy, sensory perception, anxiety and depression.
It has been well-researched in both animal studies and human clinical trials. Aniracetam has been used in some European countries to treat the cognitive symptoms of Alzheimer’s disease and to improve memory performance and behavioral issues.
But before you buy Aniracetam powder online to use on yourself, it is important that you understand how this nootropic drug works and what the right way to use it is.
Many former Piracetam users simply take Aniracetam powder the same way, but it actually requires a different style of administration.
Continue reading to discover the benefits, method of action, proper dosage, and the right way to use Aniracetam powder.
Motivation
Memory
Mood- Heightens focus & motivation
- Supports memory formation & recall
- Shown to enhance mood & reduce anxiety
What is Aniracetam Powder?
Related Topics
- What is Aniracetam?
- User Reviews
- Effects and Benefits
- Aniracetam for Anxiety
- Dosage Suggestions
- Using Aniracetam Powder
- Best Way to Take
- Side Effects
- Aniracetam for Sale
- Buyer's Guide
- Is Aniracetam Legal?
- Stacking with Piracetam
- Stacking with Choline
- Comparison to Piracetam
- Comparison to Oxiracetam
- Comparison to Pramiracetam
- Comparison to Noopept
Aniracetam is a synthetic nootropic drug that is used to promote cognitive enhancement, better memory function, improved vigilance and a positive mood.
It is also known as 1-(4-Methoxybenzoyl)-2-pyrrolidinone, 1-(4-Methoxybenzoyl)pyrrolidin-2-one, 1-p-Anisoyl-2-pyrrolidinone, Ampamet, Aniracetamun, Aniran, Conectol, Draganon, Memodrin, Referan, Pergamid, Sarpol and Sarpul.
Aniracetam is a more powerful derivative of Piracetam, the first Nootropic drug ever synthesized. It was developed by Hoffmann-La Roche in the 1970’s as a stronger analogue to Piracetam.
Aniracetam powder is considered to be 5-10 times stronger than a comparable dose of its parent compound and it works in a slightly different way.
Both are in the racetam family of nootropic agents. Members of this class share a similar chemical structure with a 2-pyrrolidinone chemical backbone. Small differences in the molecular structure of racetams result in different therapeutic effects and chemical properties.
Unlike Piracetam, Aniracetam is lipophilic or fat-soluble. Most other racetams are hydrophilic or water-soluble (except for Pramiracetam which is also lipophilic).
This property changes the way that Aniracetam is absorbed by the body and affects its metabolization. Lipophilic substances are generally better absorbed from the gut.
While all racetams are capable of penetrating the blood-brain barrier, Piracetam requires a higher dosage than Aniracetam to achieve therapeutic effects.
In addition to being more potent than the original Racetam nootropic agent, Aniracetam also exerts some different effects than its related compounds. It is the only racetam that has been clinically used for the treatment of mood disorders and anxiousness.
In Japan, three 200 mg dosages were previously prescribed to treat post-stroke depression and anxiety. This nootropic is commonly taken by individuals who want to experience both increased mental performance as well as mood enhancement.
Neurological Effects:
The exact method of action for Aniracetam is still not fully understood, despite the fact that this smart drug has been on the market since 1979.
However, existing research points to Aniracetam influencing activity in the glutamatergic and cholinergic systems which are highly involved in functions related to learning and memory.
Aniracetam is rapidly and almost completely absorbed into the bloodstream through the intestinal tract after you consume it. Because this supplement is fat soluble, it needs to be ingested with some type of lipid in order for it to be properly absorbed by the body.
Aniracetam powder actually has a lower bioavailability in comparison to Phenylpiracetam or Oxiracetam which is why you will typically need a larger dosage of this substance. It reaches maximum concentration within the bloodstream after about 20 to 30 minutes and crosses the blood-brain barrier.
Research shows that this compound undergoes extensive first-pass hepatic metabolism, which means that most of it is metabolized by the liver following ingestion. It gets converted into the following primary metabolites: N-anisoyl-GABA, 2-pyrrolidinone, p-anisic acid, and anisamide butyrate.
More recent research suggests that it is these metabolites that exert most of the effects on cognitive function, and not Aniracetam directly. In research studies, administration of N-anisoyl-GABA and p-anisic acid has mimicked many of the benefits linked to this nootropic drug.
Aniracetam (and its metabolites) then pass through the blood-brain barrier and bind to acetylcholine receptor sites. Acetylcholine is a brain chemical known as a neurotransmitter which your neurons use to send signals to each other and form new connections.
Acetylcholine is an excitatory neurochemical believed to play a vital role in a number of mental and cognitive processes. It is involved in memory consolidation (the transformation of short-term memories into long-term memories), dreaming, verbal and logical reasoning, synaptogenesis, muscle movement as well as rapid eye movement (REM) sleep.
Racetams have been shown to inhibit the desensitization of cholinergic receptors, especially in the hippocampus where new memories are formed. It is believe to amplify signals at the receptors, potentiating neuronal transmission that is already occurring.
This is thought to promote the development of synapses and connections, improving communication between brain cells.
Aniracetam has also been shown to bind to the AMPA and Kainate receptors for the neurotransmitter glutamate. It is considered to be a positive allosteric modulator of these receptors, making your synapses more sensitive to glutamate.
AMPA receptor activation is necessary for Long-Term Potentiation, which is the cellular mechanism underlying the formation of memories. LTP refers to a signal between two synapses becoming stronger.
This is one way in which Aniracetam is unique among the Racetams because it works on more glutamate receptors than related nootropics like Piracetam. This is another reason why you might see Aniracetam being called an AMPAkine while Piracetam is not.
There are additional neurotransmitters affected by this cognitive enhancer. It has been shown to increase the release of noradrenaline and to stimulate GABA receptors.
It also affects two brain chemicals involved in mood. These are Dopamine, thought to play a significant role in feelings of pleasure and rewards, and Serotonin, which plays a role in relaxation and regulation of stress and sleep cycles.
Aniracetam seems to increase levels of these neurotransmitters in the prefrontal cortex due to its stimulation of the Cholinergic systems. As a result, Aniracetam is considered to have effects on mood regulation and has been studied for its potential role in treating anxiety and depression, personality disorders, post-traumatic stress disorder, fear and impulsive behavior.
- Improves memory and learning
- Heightens focus and motivation
- Enhances mood and reduces anxiety & stress
Benefits & Uses
There are a number of nootropic effects and benefits attributed to Aniracetam in user reviews, both cognitive and otherwise.
This product is said to increase memory and learning capacity by improving the plasticity of the brain. It has been shown to promote the formation of new neuronal synapses in the brain, as well as enhancing Long-Term Potentiation, which is how our brain stores memories.
Aniracetam has also been observed to improve reasoning and judgment skills, resulting in less impulsive behavior in one study.
These effects may present themselves differently from person to person. Most users will see some improvements, ranging from subtle to very noticeable. However, others experience no benefits from taking this nootropic or feel like their mental capacities are made less sharp.
In user reviews, some state that use of Aniracetam bulk powder makes it easier to remember conversations, details, facts, and figures. You may not have to think as hard to understand difficult new concepts and you may find it easier to make connections between different concepts.
A common experience when taking Aniracetam powder is a boost in cognitive function through higher levels of mental energy. You may find yourself experiencing less fatigue after studying or working for several hours at a time.
In research studies, administration of Aniracetam has resulted in an increase in attention span, focus, and concentration as well as positively affecting motivation levels. Many people enjoy these benefits even more than the improvements to intellect, claiming that their overall clarity of thought is greatly improved and they become more productive.
This also may affect communication fluidity, making things like reading, writing, and holding conversations much easier.
Aniracetam has also been found to improve mood in some individuals, helping to relieve stress and nervousness. People with anxiety (and specifically social anxiety) say that this supplement makes them feel much more in control and motivated again, producing a relaxed sensation.
In animal studies, administration of this nootropic has resulted in an increase in social behavior. It also exhibited anti-depressant effects in a forced swim test model of depression in aged rats.
- Focus longer, clear brain fog & feel more motivated
- Boost energy, alertnes & memory
- Contains 12 safe and natural nootropic ingredients
How to Take Aniracetam Powder
Since this compound is more powerful than Piracetam (the original Nootropic), it does not require as high a dose. Most sources recommend a dosage range of 600 to 3,000 mg per day of bulk Aniracetanm powder.
In research studies, it is typically used at a maximum dosage of 1,500 mg per day. New users are advised to start with a low dosage and titrate upwards until desired effects are achieved. Taking higher dosages may not increase the benefits and may cause more adverse effects to occur.
Aniracetam powder dosages are typically broken into two or three equal administrations spread throughout the day.
The reason for this is to overcome the short half-life of this nootropic. However, even though Aniracetam is quickly eliminated from the body, its metabolites have a longer active half-life.
It is typical to use this compound with some type of Choline supplement, such as Centrophenoxine, Citicoline, Alpha GPC or Phosphatidylserine.
In user reviews, the powder formulation of Aniracetam is said to produce effects more quickly compared to taking oral capsules. This has not been demonstrated in research studies.
It is likely to be true considering that in order for the ingredients in capsules or tablets to be absorbed into the bloodstream, the capsule or tablet must first be broken down. This will inevitably cause some delay in its absorption from the gut.
Aniracetam is most commonly taken in oral form via a liquid suspension. It can be administered intravenously, but this form is not widely used anymore and is not more effective than oral administration in research studies.
Manufacturers generally recommend users take Aniracetam powder with a fat source to improve absorption from the gut. This nootropic is fat soluble and will not form a solution if mixed into water or juice.
You may also want to take your dosage along with food or together with a fish oil pill to ensure that the maximum amount is absorbed into your bloodstream. Consuming it with a meal can minimize stomach-related side effects like nausea or gastrointestinal distress.
In research studies, sachets of Aniracetam granules have been administered by mixing it with distilled or salinated water along with emulsifiers sodium carboxymethylcellulose or carboxymethylcellulose (CMC). 1-2 drops of the Sigma-Aldrich product TWEEN® 80 (Sigma-P4780) have also been used.
These emulsifiers help to keep the lipophilic aniracetam powder in a solution, since it would not naturally dissolve into water or juice without the presence of an emulsifier.
The powder has an extremely bitter, chemical-like taste that is off-putting to many who take it for the first time. As a result, oral capsules have become a more popular method for consuming this cognitive enhancer.
How to Use Nootropic Powder Stacks
Aniracetam is commonly used in stacks because some of its nootropic effects are distinct than what we see with other Racetams. This supplement is also believed to potentiate some of the benefits of Piracetam and related compounds.
The Piracetam Aniracetam Stack is one of the most used stacks out there today, but another interesting combination is Aniracetam with Oxiracetam powder.
You can also use a PAO stack with combines Aniracetam with Oxiracetam powder and Piracetam. Ideally, you should use this alongside some type of choline supplement such as Alpha GPC.
To avoid building a tolerance to Aniracetam, some individuals will cycle this compound by taking Oxiracetam in the morning for enhanced focus and Aniracetam in the evening to relax. You may need to experiment with several different combinations and regimens to determine which one works best for you.
Should you Buy Bulk Aniracetam Powder Online?
You can buy Aniracetam as a bulk powder from many nootropic vendors online. Some of the websites that sell this compound include:
- New Star Nootropics
- Nootropics Depot
- PowderCity
- LiftMode (no longer sells Aniracetam)
- Peak Nootropics
- Nootropics City
- Pure Nootropics
- Absorb Health
- Smart Drugs for Thought
- NutriVita Shop
- SmartPowders.com
- Nootrico (no longer operating)
- Sun Nootropic
- Nootropic Source
Use of a bulk powder is generally cheaper than buying oral capsules and will allow you to be more flexible with customizing dosages.
However, Aniracetam does have a very bitter taste when consumed orally and some prefer tablets to mask the taste.
This compound is legal to posses in the United States as well as in Canada. It does not require a prescription to buy and is currently not scheduled as a controlled substance.
However, it has not been approved as a drug for the treatment of any medical condition. While it does not qualify as a dietary supplement, it is commonly included as an ingredient in supplements and is widely distributed as such.
If you purchase aniracetam bulk powder online, you will often see it labelled as “For Research Purposes Only” or “Not for Human Consumption”. Note that if you buy this product from research vendors and then use it as a supplement, you may not have legal recourse should you experience side effects.
It is recommended to purchase Aniracetam from a well-established vendor that has a long history of positive reviews from customers. Look for suppliers that provide a Certificate of Authenticity demonstrating that they test every batch of product with a third-party certified lab
Beware of overly cheap prices of this nootropic in bulk powder form. There have been fake or mislabelled Nootropics sold in the North American market.
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- Ogiso T, Uchiyama K, Suzuki H, Yoshimoro M, Tanino T, Iwakai M, Uno S. Pharmacokinetics of aniracetam and its metabolites in rat brain. Biol Pharm Bull. 2000
- Nishizaki T, Matsumura T. The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway. Brain Res Mol Brain Res. 2002
- Nakamura K, Shirane M. Activation of the reticulothalamic cholinergic pathway by the major metabolites of aniracetam. Eur J Pharmacol. 1999
- Petkov VD, Grahovska T, Petkov VV, Konstantinova E, Stancheva S. Changes in the brain biogenic monoamines of rats, induced by piracetam and aniracetam. Acta Physiol Pharmacol Bulg. 1984
- Nakamura K, Kurasawa M. Serotonergic mechanisms involved in the attentional and vigilance task performance of rats and the palliative action of aniracetam. Naunyn Schmiedebergs Arch Pharmacol. 2000
- Rao Y, Xiao P, Xu S. Effects of intrahippocampal aniracetam treatment on Y-maze avoidance learning performance and behavioral long-term potentiation in dentate gyrus in rat. Neurosci Lett. 2001
- Papandreou G, Zorpas K, Archontaki H. Development and validation of a liquid chromatographic method for the simultaneous determination of aniracetam and its related substances in the bulk drug and a tablet formulation. J Pharm Biomed Anal. 2011
Article last updated on: March 13th, 2018 by Nootriment
2 Comments
Hi,
thanks for all the great info.
I am interested in trying a Piracetam and Aniracetam stack.
If Piracetam is water soluble, and Aniracetam is fat soluble,
How do you take them together ???
Thanks again,
Bill
Hi Bill,
Thanks for your question. One way to do this would be to spread out your dosages for these nootropics. For example, some individuals report taking Piracetam in the morning when they first wake up, eating breakfast and then taking Aniracetam after their meal.
Even if not consumed with food, Aniracetam demonstrates very high absoprtion from the gut so it is possible to consume them both at the same time.