Arcalion (a brand-name version of generic Sulbutiamine) is a nootropic supplement that is known for boosting energy, strength, mood, and focus, without having the side effects of a stimulant.
Arcalion is a synthetic dimer of Thiamine (Vitamin B1), which is one of the nutrients involved in turning fuel into energy within your cells.
Arcalion was designed to be more powerful than Thiamine; it also possesses unique properties such as improving memory, rational thinking, visual perception, and even sexual performance. Arcalion is typically sold in 200 mg pills, but the actual dosage you should use depends on why you are taking it as well as personal biochemistry.
What is the best Arcalion dosage to take and what is the right way to use this supplement?



- Heightened alertness, focus & energy
- Supports memory & mental performance
- Promotes mood through dopaminergic activity
How Arcalion Works in the Body
Related Topics
- What is Sulbutiamine?
- What is Arcalion?
- User Reviews
- Effects and Benefits
- Why Take Sulbutiamine?
- Sulbutiamine for Energy
- Effects on Dopamine
- Dosage Guidelines
- Sulbutiamine for Anxiety
- Possible Side Effects
- Bulk Sulbutiamine Suppliers
- Buying Sulbutiamine Online
- Arcalion Uses
- How to Take Arcalion
- Is Arcalion Safe?
- Buy Arcalion
Arcalion was developed in Japan where widespread Thiamine deficiency was causing a high incidence of beriberi (a nervous system disorder) in the general population.
Because Thiamine itself has a poor ability to cross the blood-brain divide, you would need to take megadoses of it in order to improve brain function.
Sulbutiamine is essentially two Thiamine molecules connected by a sulfur bond. Sulbutiamine, or Arcalion, is lipophilic which means more of it can be taken up by brain cells and it has a greater net effect on the Central Nervous System.
Although it is not known exactly when Arcalion was first developed, the earliest literature refers to this supplement in 1973. Researchers noted that they had developed a substance that in addition to having higher oral bioavailability than Vitamin B1, also had a broader range of interactions with neurotransmitters.
So how exactly does Arcalion work? We know that because it is highly lipophilic (fat-soluble), it more readily penetrates the blood-brain barrier.
Once it is taken up by neurons, it aids in the production of energy in your cell mitochondria. Arcalion can raise levels of ATP in the brain which is an energy molecule used to power all of your many cellular functions.
Another effect of taking Arcalion tablets is that levels of Acetylcholine are increased in the brain. This neurotransmitter is responsible for a number of cognitive processes like memory storage and consolidation, working memory capacity, the ability to manipulate data and make connections, as well as synaptic plasticity and learning.
Users report that taking Arcalion dosages has an effect on their creativity and sensory perceptions along with enhancing the attention span and ability to focus intently. This supplement also affects the levels of Dopamine within the brain. This is another key neurotransmitter which affects and regulates things like mood and movement.
Arcalion is known for boosting activity at Dopamine receptors, but it does this in such a way that does not cause these receptors to become less sensitive over time.
Some antidepressants and mood boosting chemicals cause higher levels of Dopamine to be released by your neurons which results in receptor down-regulation as your receptors learn to tolerate greater amounts of this neurochemical.
Arcalion actually increases the sensitivity of receptors and may cause more Dopamine receptors to be generated. This is likely the reason why many people experience enhanced mood and feelings of well-being when taking Arcalion. Additionally, this nootropic compound can lead to heightened motivation, energy, stamina, and resistance to mental fatigue.
In some countries of the world, Arcalion is considered a prescription drug. In these places it is used in the treatment of asthenia, chronic fatigue, hypothyroidism, depression, and other conditions that can cause lethargy or weakness.
In other places, including the United States, Arcalion and generic Sulbutiamine are sold as supplements. The FDA has not approved Sulbutiamine as a drug to prevent or treat any conditions, and it is available as a dietary supplement only.
Arcalion Dosage & Use
The dosage for Arcalion may differ slightly depending upon your reason for use. Proper dosage is dependent on many different factors, and it is always recommended that you speak to your doctor before beginning any new supplements. The following dosage recommendations are general guidelines only, and your personal dosage may be different.
For example, someone who is simply looking for the Nootropic (or cognitive enhancing) benefits of Arcalion might want to stay within the 400 to 600 mg range per day. Others who are looking for help to improve their moods and increase energy and stamina may even want to use a little more, up to 850 mg.
The generally accepted dosage range is between 250 and 850 mg per day. Users may break this up into several (two or three) equally divided administrations throughout the day. For the most accurate advice regarding dosages, you should speak to your doctor or a knowledgeable health professional.
As with any supplement, it is important to start with the lowest effective dose. Only work your way up once fully familiar with the effects since everyone will have a different experience.
Arcalion should be taken with meals to increase the rate of absorption since it is fat-soluble. Arcalion is typically sold in 200 mg tabs, but you can also buy it in as cheaper Sulbutiamine bulk powder which allows you to measure out your desired dose.
Potential Arcalion Stacks
Using Arcalion dosages on their own can improve your energy levels and ability to concentrate, but most people prefer to stack it with other compounds for better results. Arcalion has the interesting potential to help make other supplements even more effective.
This is particularly true for another nootropic supplement family known as the Racetams. Stacking Racetams together with Arcalion serves to increase the effectiveness of both supplements, resulting in stack synergy.
Taking Arcalion together with Aniracetam is a popular stack. Aniracetam is one of the most popular nootropics, noted for both improving memory as well as reducing feelings of stress and anxiety.
Another stack that you might wish to try is Arcalion together with caffeine. This nootropic stack should help to increase your stamina and motivation even further, but without the caffeine related side effects such as nervousness and jitters.
When stacking supplements together, you might find that you can reduce your Arcalion dosage and still achieve the same results due to the fact that nootropics often potentiate each other at smaller doses.
- Trovero F, Gobbi M, Weil-Fuggaza J, Besson MJ, Brochet D, Pirot S. Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain. Neurosci Lett. 2000
- Litvinovich EF, Langeman TI, Litvinovich SF. [The use of sulbuthiamine (enerion) in the combined therapy of patients with symptomatic focal epilepsy]. Zh Nevrol Psikhiatr Im S S Korsakova. 2006
- Ollat H, Laurent B, Bakchine S, Michel BF, Touchon J, Dubois B. [Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer disease]. Encephale. 2007
- Ahmed MA, Elbeshlawy MM. Potentiometric sensors for the selective determination of sulbutiamine. J Pharm Biomed Anal. 1999
Article last updated on: March 13th, 2018 by Nootriment
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