Arginine aspartate is a commercially available health supplement manufactured by combining the two amino acids: arginine and aspartate (aspartic acid).
Although no clinical evidence is available in clear support of it, many believe arginine aspartate to be effective at enhancing general metabolic functioning.
Further, it is commonly used by those suffering from symptoms of erectile dysfunction.
Arginine aspartate is the subject of clinical study for its possible effectiveness in treating burns, diabetes mellitus, angina, cancer, hyperlipidemia and much more.
It is considered safe for general human usage as it is created from common natural substances. However, not enough information is currently available to rule out adverse side effects.



- Boosts nitric oxide production for workouts
- Reduces fatigue & promotes muscle growth
- Supports immune function & sexual health
Arginine Aspartate
Related Topics
- L-Arginine
- L-Arginine Benefits
- Benefits for Men
- Benefits for Bodybuilding
- Effects on Blood Pressure
- Arginine Aspartate
- Arginine Alpha-Ketoglutarate
- Arginine Pyroglutamate
- Arginine Ornithine and Lysine
- Suggested Dosages
- Food Sources
- Comparison to L-Citrulline
- Best Supplement
- Topical Cream
- 500 mg Tablets
- Arginine Extreme
- Buy L-Arginine Powder
- Side Effects
The L-form of the amino acid arginine is very common in nature and is known as a precursor to the synthesis of nitric oxide (NO).
Nitric oxide is a substance well documented to exhibit vasodilation effects.
As such, it is used by doctors and strength training athletes to accommodate increased blood flow and nutrient delivery.
L-arginine plays various other vital biological roles as well, including assisting in cell division, healing and detoxification.
Aspartate is believed to support the absorption of minerals including magnesium, calcium and potassium, to name a few. By combining the vasodilation precursor properties of L-arginine with aspartate, it is believed that the two will accentuate each other’s effects within the body.
Possible Benefits of Arginine Aspartate
The possible benefits of arginine aspartate for human health are a question of on-going research.
Currently, arginine aspartate is being studied for all of the following treatment possibilities:
- Enhancing athletic performance via vasodilation and increased mineral absorption;
- Reducing hepatic encephalopathy (brain damage as a result of liver cirrhosis);
- Reversing erectile dysfunction symptoms when used in conjunction with pycnogenol;
- Increasing production of human growth hormone (HGH);
- Preventing and reversing the development and spreading of cancerous cells;
- Alleviating chest pains and treating heart disease, coronary artery disease, and other cardiovascular conditions;
- Reversing the symptoms of hypercholesterolemia, hyperlipidemia and atherosclerosis
Arginine Aspartate Dosing Instructions
There are several variables to consider when determining optimal dosages for Arginine Aspartate. These include individual body weight, reason for using Arginine Aspartate, dietary considerations and sensitivity to the two compounds.
Amonts between 400mg to up to 6000 mg per day have been used in studies with no reported negative side effects.
The following dosages have been used in clinical trials with positive results:
- 200 mg three times daily for long-flight altitude sickness;
- One dose equalling 50 mg per kilo of body weight to treat asthma;
- 30 grams every day for three days as an enhancer for certain chemotherapy drugs;
- 4 mg cream applied to hands and feet to combat consistent coldness due to poor blood flow in diabetic patients;
- 3 grams three times daily to help to alleviate complications associated with type II diabetes mellitus;
- 5 grams daily for 6 weeks to combat ED symptoms;
- 6 grams twice daily to enhance generalized athletic performance;
Who Should Not Use Arginine Aspartate
Arginine aspartate is a supplement made by combining two natural substances which are already present in the human body.
Supplementing with arginine and aspartate together may bring about various additional health benefits.
However, because of lacking clinical data to this point, it is not recommended for use by those under 18 years of age. Also, pregnant woman and nursing mothers should not use it.
Arginine aspartate may also not be suitable for those who have liver or kidney disease, low blood pressure and/or recent heart failure. Men using sexual enhancement products, like Viagra, should not use this supplement.
Also, anyone taking antihypertensive medications, or those would low blood pressure issues, should not use arginine aspartate. Speak to your doctor before purchasing this supplement to decide whether it is safe for you.
Possible Arginine Aspartate Side Effects
Arginine aspartate may have negative effects when used in conjunction with agents to lower cholesterol and/or insulin production.
It may increase the strength of effects brought on by nitric oxide donors, like isosorbide mononitrate, sodium nitroprusside and glyceryl trinitrate to name a few.
Possible side effects of improper arginine aspartate supplementation include metabolic acidosis, lessened urea cycle efficiency, increased ammonia toxicity and brain damage at the most extreme end. More commonly experienced side effects are milder, like nausea, vomiting, bloating, gas, headaches, flushing and irritability.
All supplementation programs should be discussed with your primary healthcare provider beforehand. While it is true that arginine aspartate is a natural supplement, like other natural products, it may induce mild-to-severe side effects in various medical scenarios.
- Scott JA, Grasemann H. Arginine metabolism in asthma. Immunol Allergy Clin North Am. 2014
- Jabecka A, Ast J, Bogdaski P, Drozdowski M, Pawlak-Lemaska K, Cielewicz AR, Pupek-Musialik D. Oral L-arginine supplementation in patients with mild arterial hypertension and its effect on plasma level of asymmetric dimethylarginine, L-citruline, L-arginine and antioxidant status. Eur Rev Med Pharmacol Sci. 2012
- Alizadeh M, Safaeiyan A, Ostadrahimi A, Estakhri R, Daneghian S, Ghaffari A, Gargari BP. Effect of L-arginine and selenium added to a hypocaloric diet enriched with legumes on cardiovascular disease risk factors in women with central obesity: a randomized, double-blind, placebo-controlled trial. Ann Nutr Metab. 2012
- Lucotti P, Monti L, Setola E, La Canna G, Castiglioni A, Rossodivita A, Pala MG, Formica F, Paolini G, Catapano AL, Bosi E, Alfieri O, Piatti P. Oral L-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass. Metabolism. 2009
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- Alves GN, Tavares AM, Vieira PJ, Sprinz E, Ribeiro JP. Oral L-arginine modulates blood lactate and interleukin-6 after exercise in HIV-infected men. Int J Sports Med. 2014
- Luiking YC, Ten Have GA, Wolfe RR, Deutz NE. Arginine de novo and nitric oxide production in disease states. Am J Physiol Endocrinol Metab. 2012
- Riccioni G, Bucciarelli V, Verini M, Consilvio NP, Gallina S, Martini F, Aceto A, Scotti L, Bucciarelli T. ADMA, SDMA, L-Arginine and nitric oxide in allergic pediatric bronchial asthma. J Biol Regul Homeost Agents. 2012
Article last updated on: May 13th, 2018 by Nootriment
1 Comment
where can I buy l-arginine aspartate. Its different than the garden variety arginine supps out there