Does Arginine Pyroglutamate Increase HGH Synthesis

Arginine pyroglutamate is the combination of the amino acid arginine with a molecule of pyroglutamate.

The L-form of arginine (L-arginine) is a known precursor to NO (nitric oxide) production and is under continuing research for its potential to elicit a wide array of human-healthy benefits.

Nitric oxide is a vasodilator and useful for athletic performance enhancement and treating many diseases and conditions. Increasing levels of NO can improve diabetic complications like cold hands and feet, to more serious conditions like cardiovascular disease.

Pyroglutamate is not nearly as common as arginine, yet is still readily available in meats, vegetables, fruits and dairy products.

Strength athletes like bodybuilders use arginine pyroglutamate for its dual ability to increase intravenous blood flow and enhance production of anabolic hormones, like human growth hormone (HGH).

L-Arginine

Amino Acid

Pre-Workout

Muscle Growth

Sexual Health

How It Works:

• Boosts nitric oxide production for workouts
• Reduces fatigue & promotes muscle growth
• Supports immune function & sexual health

Dosage:

Between 3 - 6 g per day

Safety:

Rated Possibly Safe

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Arginine Polyglutamate for Athletic Performance

L-arginine encourages and accommodates NO synthesis, resulting in increased vasodilation effects.

As nitric oxide travels through the blood vessels, it works to relax endothelium.

The endothelium is the inner lining of the blood vessels, and when it relaxes, the blood vessels are able to open wider in diameter, allowing for greater amounts of blood to circulate without elevating intravenous blood pressure.

With increased blood volume coursing through the blood vessels, more nutrients, proteins, and hormones, like HGH, are delivered throughout the body.

In the case of athletes, their muscles are flooded with significant amounts of these substances, accommodating long-lasting muscular “pumps”.

Arginine may also bring about increases in muscle size, endurance, strength and healing abilities. While research studies have found inconclusive results in the application of l-arginine on its own, stronger evidence exists when stacking this amino acid with other compounds that can contribute to increase NO levels.

Arginine Pyroglutamate and Cognitive Functioning

As the vasodilation effects of nitric oxide are experienced over the entire body, blood flow to the brain is likewise enhanced.

For this reason, nitric oxide is being studied for its potential roles as a neuroprotectant and as a treatment for degenerative mental disorders, like Parkinson’s and Alzheimer’s.

High intensity physical activity can deplete energy reserves needed by the brain for efficient functioning. Although the brain comprises only about 2% of the body’s total mass, it requires roughly 20% of the body’s oxygen and energy in order to function correctly.

Therefore, when athletes use up high amounts of these reserves to make it through their workouts; sometimes their brains suffer from lacking nutrients and fuel.

As arginine pyroglutamate is capable of crossing the brain-blood barrier, it is able to stimulate energetic inner-brain functions, and thus enhance cognitive functioning on many levels. It may be able to act as a cerebrovasodilator, targeting an increase in circulation within the brain.

Research continues showing promising results for using arginine pyroglutamate as a general neural enhancer. Arginine pyroglutamate has been shown treat the brain-degrading effects of long-term alcoholism and general senility. It is also used successfully as a therapy for memory disorders.

More Benefits of Arginine Pyroglutamate

Arginine pyroglutamate is known to stimulate increased HGH synthesis, as well as the synthesis of several other hormones.

This occurs naturally, safely, within the body, and is therefore preferred over taking HGH treatments.

HGH is one of the most powerful hormones that our bodies produce to accommodate the development, strength, healing and endurance of lean protein muscle tissues.

Increasing HGH can also result in decreased body fat as nutrients are directed away from lipid storage and towards muscle maintenance and growth.

For most people with typical diets throughout their lives, HGH synthesis decreases with age, leading to less muscle, less strength, difficulty healing, decreased athletic endurance and more fat mass. Clinical trials are addressing the capacity of arginine pyroglutamate to reverse these effects of aging by maintaining increased lean muscle into elderly years.

In one clinical trial that lasted five weeks, arginine pyroglutamate supplementation was shown to promote generalized fat loss.

And in 1981, an Italian physician, A. Isidori, M.D., from the University of Rome, discovered that arginine pyroglutamate oral supplementation yielded a 7X increase in HGH levels in the blood. This data was generated in comparison with results from a separate trial with the exact same study parameters, yet in which only arginine (no pyroglutamate) was administered.

This result shows a synergistic mode of operation occurs when these two substances are combined. More clinical research is necessary and warranted to discern exact recommendations for supplementation.

Arginine Pyroglutamate Side Effects

There are no reported serious side effects of arginine pyroglutamate supplementation, even at high doses. The only side effect reported to date is gastronomic upset.

Both arginine and pyroglutamate are naturally occurring substances. Arginine is manufactured within the body by our kidneys as well. It is also readily available in food sources. However, there are some individuals for whom this supplement is contraindicated.

Although negative side effects and interactions are rare, you should still always speak with your doctor before beginning any arginine pyroglutamate supplementation programs.

Sometimes, even natural substances like amino acids can cause health complications if improperly administered.

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