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Artvigil is a generic brand of the drug Armodafinil (Nuvigil, Waklert) manufactured by HAB Pharmaceuticals & Research Ltd. In India.
Each tablet of Artvigil contains 150mg of Armodafinil, which is composed of the (?)-(R)-enantiomer of the popular smart drug Modafinil (Provigil, Modvigil, Modalert).
Generic drugs are identical replications of brand-name drugs with the same pharmaceutical dosage, intended use and potency. Generics tend to be significantly cheaper than brand-name drugs.
Armodafinil is an FDA-approved drug for the treatment of excessive daytime sleepiness linked to narcolepsy and shift work sleep disorder. It is prescribed as an adjuvant therapy for obstructive sleep apnea.
It is also used off-label in the treatment of Major Depressive Disorder, Chronic Fatigue Syndrome (CFS) and Attention Deficit Hyperactivity Disorder (ADHD). It is so
In comparison to Modafinil, Artvigil is believed to have a longer duration of efficacy in the human body and to have a more rapid onset of effects. A smaller dosage is required to achieve the same positive effects on memory and mental alertness.
Energy
Cognition
Motivation- Wakefulness-boosting stimulant
- Enhances motivation and focus
- Shown to boost mental performance
Artvigil Review
Related Topics
- What is Armodafinil?
- What is Nuvigil?
- Armodafinil vs. Modafinil
- User Review
- Typical Nuvigil Experiences
- How it Works
- Nuvigil for ADHD
- Effects on Depression & Anxiety
- Dosage Recommendations
- How to Take
- Reported Side Effects
- Withdrawal & Tolerance
- Prescription Information
- Buying Nuvigil
- Generic Nuvigil Brands
- Is Armodafinil Legal?
- Is Nuvigil Safe?
- Comparison to Adderall
Artvigil is made by HAB Pharmaceuticals Ltd. In India and is sold in blister pages of 10 tablets. Each pill contains 150 mg of the active ingredient modafinil.
It is the second most-popular generic form of Armodafinil on the market, after Sun Pharma Waklert, which is also manufactured in India.
According to one website, Artvigil sells for less than 1/10th the price of the trade name Nuvigil product, made by Cephalon. Many US consumers who have a prescription for this drug from their doctor will opt to buy generics from India due to the cost savings. [7]
Armodafinil was first approved for sale in the United States in June 2007. In 2016, the FDA gave pharmaceutical company Mylan approval to begin marketing a generic version of this drug. Since that time, several brands of generic Armodafinil have been introduced.
User reviews of Artvigil suggest that it provides the same effects as other generic brands of this drug. It is commonly used to boost alertness, promote motivation and to support increased productivity.
How Does Artvigil Work?
Artvigil is composed of the (R)-enantiomer of the pharmaceutical drug Modafinil (Provigil). The standard Modafinil drug contains an equal mixture of R-(?)- and (S)-(+)-modafinil), but research shows that it is only the (R)- version that is effective.
In pharmacology, enantiomers refer to different chiral forms of a molecule. Two molecules might have the same chemical structure, but based on their orientation, they may have different effects on the body and bind differently to receptors. [1]
This is the case with the R-(?)- and (S)-(+)- enantiomers of Modafinil. Because the physiological effects of this drug are attributed to the (R)- form, an enantiopure version of this compound was introduced to the market to improve potency and reliability.
Armodafinil requires a smaller dosage than modafinil, is reported to start working faster and has a duration of effects of between 6-12 hours, which is longer than for modafinil. Other than the pharmacodynamic differences, the pharmacological effects are similar.
Researchers have not yet fully identified the mechanism of action involved in Artvigil’s effects. Studies show that it binds to the dopamine transporter (DAT), which is a protein found on the membrane of neurons that pumps dopamine from the synaptic cleft back into the cell.
By binding to the dopamine transporter, Artvigil blocks the re-uptake of dopamine into the cytosol. This results in more dopamine being present in the synaptic cleft. [2]
This indirectly causes greater activation of dopamine receptors as the neurotransmitter chemical is given greater opportunity to activate receptors on the post-synaptic neuron. Dopamine is linked to mood regulation, thinking, planning behavior, motivation, attentional control and executive function.
Not all of the effects of Artvigil are mediated by dopamine receptors. When modafinil was administered alongside dopamine receptor antagonist drug called haloperidol in rats, an increase in locomotor activity was still observed.
Other neurological systems that may be affected by armodafinil and modafinil include the orexin system and histamine receptors. More studies are needed to better understand its mechanism of action.
- Increases energy, wakefulness and motivation
- Boosts mental performance and focus
- Supports memory and cognition
Artvigil 150mg Benefits & User Experiences
Modafinil is well-researched for its ability to boost wakefulness, arousal, attention and to support memory performance in certain conditions. Armodafinil is also well-supported by research and has been shown to improve vigilance in healthy adults as well as in people with medical conditions.
In clinical trials, these drugs have demonstrated “beneficial effects on cognitive performance processes such as attention, learning, and memory.” [6]
Users who take Artvigil say that it helps them to feel more focused, awake and clear-headed when engaging in mentally demanding work. Some find it to produce fewer side effects than Modafinil.
Many users who purchase generic forms of Armodafinil from offshore pharmacies do so because the cost is significant cheaper than purchasing in the United States. Below are some user reviews of this product posted online:
Safety & Side Effects
Artvigil is typically taken at a dosage of 150 mg or 250 mg in the morning. It is sometimes split into two dosages, with the second dose being given early in the afternoon. Using this smart drug late in the evening can disrupt sleep schedules and cause insomnia. [2]
Adverse effects can include dizziness, nervousness, anxiety, diarrhea, trouble sleeping, stomach pain, nausea, dry mouth, chest pain or muscle weakness.
Stop taking this drug and consult with a doctor if you experience numbness, tingling, pain, mouth sores, itching, difficulty swallowing, easy bruising, hallucinations, aggression, unusual changes in mood, heart arrhythmias or dark urine.
More serious but rare side effects can include fever, headache or pressure in the head, sore throat, a skin rash or vomiting. This list of potential negative effects is not exhaustive; check with your doctor to learn more about possible health risks. [5]
This drug can cause adverse reactions in people with certain medical conditions. Consult with your doctor if you have heart disease, high blood pressure, mental health issues, a history of substance addition, or liver or kidney disease.
Armodafinil may interact with other medications such as antidepressants, sedatives, seizure medications, HIV medications, cyclosporine (Neoral, Sandimmune, Gengraf), propranolol (Inderal), omeprazole (Prilosec), nefazodone, clomipramine (Anafranil), butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), phenobarbital (Solfoton), and rifampin. Let your prescribing doctor know about any other drugs or supplements you are currently using.
Armodafinil (Nuvigil, Waklert) is not appropriate for everyone. It is a controlled substance and a prescription-only medication in the United States. Consult with a doctor to determine whether this drug is appropriate for you.
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- Ariëns, E. J. (1984). "Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology". European Journal of Clinical Pharmacology. 26 (6): 663–668. doi:10.1007/BF00541922. PMID 6092093.
- Nuvigil Prescribing Information.
- Armodafinil. Wikipedia.
- Ballon JS, Feifel D (April 2006). "A systematic review of modafinil: Potential clinical uses and mechanisms of action". The Journal of Clinical Psychiatry. 67 (4): 554–66.
- Nuvigil Patient Information Including Side Effects. RXList.com
- Mereu M, Bonci A, Newman AH, Tanda G (October 2013). "The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders". Psychopharmacology. 229 (3): 415–34. doi:10.1007/s00213-013-3232-4. PMC 3800148?Freely accessible. PMID 23934211.
- Artvigil. ModaPharma.
Article last updated on: July 6th, 2018 by Nootriment
1 Comment
Love this stuff. It is one’s greatest ally when working 12 hour overnight shifts. Cut my coffee intake in half once I got ahold of these little guys. And dirt cheap too. $1 a pop.