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Ampakines are considered to be the most potent among all of the different types of nootropic supplements available today. Ampakines have a stimulative effect on Glutamate receptors in the brain.
They actually get their name from being positive allosteric modulators of AMPA receptors (hence AMPAkines), but they are also NDMA receptor agonists.
What this means is that taking Ampakines increases the level of glutamate – a neurotransmitter which is very important for learning, memory, and focus. Glutamate is intimately connected with neuroplasticity and long-term potentiation between neurons.
Using Ampakines as part of your nootropic stack can cause an improvement in concentration, attention span, better comprehension of new information, improved reasoning skills and give you a more powerful memory. What are the best Ampakine nootropics that you can use?
Memory
Mental Energy
Concentration- Stimulate AMPA receptors in the brain
- Supports memory & learning
- Promotes alertness & concentration
Best Ampakines
Related Topics
There are a few different types of Ampakines – some of which have a long history of being used as nootropics and some of which are relatively new and still undergoing testing.
Two of the most well-known and best Ampakines are Sunifiram and Unifiram. Sunifiram in particular is estimated to be 1,000 times stronger than Piracetam.
Other compounds such as Aniracetam and Pramiracetam are technically classified as Racetams but also work as weak Ampakines.
A lot of the new nootropics like CX-516 (Ampalex), CX-614, CX-546, CX-717 and LY-404187 are Ampakines being researched as potential treatments for mental decline and other brain disorders.
Cost Of Ampakines
Right now these compounds are all very expensive making the cost prohibitive for most nootropic users.
However, as these drugs become more popular you can expect the price to drop steadily. In the future we may find Ampakine supplements and drugs used to treat Parkinson’s disease, Alzheimer’s, depression and other mental illnesses such as schizophrenia.
How Ampakines Work In The Body
With all of the nootropics available out there now, why are Ampakines being so heavily sought-after by users of nootropics?
Ampakine drugs are actually the very first type of external drugs tested to increase excitatory responses in certain synaptic receptors in the brain.
By stimulating these receptors, Ampakine nootropic actually improve the ability of the brain to communicate, causing more connections to be formed and faster connections to occur between neurons.
Ampakines like Sunifiram and Unifiram are also able to facilitate Long Term Potentiation which is the process by which memories are formed and stored in the brain.
Taking Ampakine Drugs
Ampakine cognitive enhancement research have also become a point of interest for the American military.
Ampakines like Aniracetam and Sunifiram seem to have the same stimulant properties as the amphetamine class of drugs without the same risk of negative side effects.
In fact, Aniracetam and Sunifiram are generally considered to be very safe with extremely low risk of dangerous side effects.
Taking Ampakine drugs and supplements can increase your energy levels and help you focus intensely on one task at a time. Ampakines have also shown benefits with regards to mood enhancement and treatment of various psychological disorders.
Even though at present Ampakines are not widely available and tend to be much more expensive than more common nootropics like Piracetam and Noopept, we can expect this to continue to be one of the most exciting areas of nootropic development in the future.
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- Cepeda C, Cummings DM, Hickey MA, Kleiman-Weiner M, Chen JY, Watson JB, Levine MS. Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 Mouse Model of Huntington's Disease: Exercise, Adenosine Receptors and Ampakines. PLoS Curr. 2010
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Article last updated on: March 13th, 2018 by Nootriment
3 Comments
Hello.
Is it already sold, or another stage of the test?
Thank you.
Svajunas K.
Hi Svajunas,
The Ampakine Sunifiram is available for sale. All of these nootropics continue to be tested and are research compounds at this point. Here is more information on Sunifiram: https://nootriment.com/sunifiram-review/
Ampakines do not increase the amount of glutamate released. They bind to a site on the AMPA receptor and, when glutamate binds to the channel, slow the closure of that channel. This means that there will be a prolonged current flow of Na+ ions in the cell, making it more likely that a strong depolarization will occur.