Bioresponse DIM is one popular brand of diindolylmethane supplements providing 150 mg of active ingredient per pill.
This product is currently rated as Amazon’s Choice for the best DIM supplement. It features a patented microencapsulated form of DIM that is said to have greater oral bioavailability.
Diindolylmethane is a compound derived from cruciferous vegetables like turnips, cabbage, kale and Brussels sprouts.
DIM is being researched for its potential as a natural anti-cancer agent.
It may have certain benefits for hormone-sensitive cancers that develop in the breasts, prostate, uterus, colon and cervix.
It is also undergoing much clinical research and experimentation addressing its various apparent therapeutic capacities.
Diindolylmethane supplements like Bioresponse DIM have also demonstrated antioxidant, antiviral, anti-inflammatory, and antibacterial properties.
Of particular note are its anti-androgenic and cardioprotective traits, which are believed to cause the majority of its apparent health benefits.
DIM supplements may be able to promote a healthy hormone balance and prevent excessive levels of estrogen in both men and women.
It is used by physicians to treat patients with painful premenstrual syndrome (PMS) symptoms, recurrent respiratory papillomatosis (RRP) and enlargement of the prostate. Bioresponse DIM is also recommended by some for female acne, heavy or irregular menstrual cycles, PCOS, and weight loss.



- Aids healthy hormone balance for men & women
- Mitigates some effects of excess estrogen
- Anti-oxidant & anti-inflammatory benefits
Bioresponse DIM Review
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Bio Response Nutrients says that their DIM product is the only microencapsulated Diindolylmethane supplement on the market.
This company states that their DIM has a higher bioavailability compared to other products due to its Absorption-enhanced microencapsulation process.
Bio Response also says that DIM cannot be absorbed naturally by the human body when taken on its own as an oral supplement.
This is the primary form of DIM used in research studies and clinical trials, and it has been well-established as the industry standard.
However, other manufacturers do offer microencapsulation tablets now that may also have a high degree of bioavailability to the human body.
Bioresponse DIM and Estrogen Balancing
Bioresponse DIM is frequently used by women to regulate health levels of estrogen in the body. Estrogen imbalances are the most common type of endocrine system problem.
There are more than two dozen known estrogens; some are known to be “good”, and some not. “Bad” estrogens, like 16-hydroxy estrogen, are known to be carcinogenic when they accumulate in excess within fat storage centers throughout the body.
Harmful estrogens are difficult to metabolize, but are still necessary for numerous biological purposes.
Both men and women require estrogenic compounds in every organ system of the body. If carcinogenic estrogens remain accumulated for too long, estrogen-sensitive colorectal, breast, prostate, cervical and uterine cancers can develop.
Also, estrogen dominance may develop, in both sexes, and cause an array of secondary symptoms to develop. Bioresponse DIM promote certain anti-androgenic effects which help to naturally balance estrogen, progesterone, testosterone and other hormonal levels.
Women take DIM to help them lose weight, alleviate symptoms associated with painful menstrual cycles, improve PMS symptoms and to support reproductive health.
While research on DIM for many of these women’s health conditions is lacking, user reviews cite benefits that include normalized menstrual cycle lengths, reduction in period pain, improved weight management, better moods and fewer hunger cravings.
Some women say that it can improve conditions related to uterine fibroids, infertility and PCOS, though large-scale human trials are lacking in these areas.
Male Benefits of Bioresponse DIM Supplementation
For men, routine supplementation with Bioresponse DIM may help to naturally restore proper testosterone balance. More men than ever are experiencing the debilitating effects of low testosterone (“Low-T”).
As a result, more men are also electing to use testosterone replacement therapies (TRTs). These may include injections, tablets, skin creams and other forms.
Despite the potential benefits, they can also cause side effects including, but not restricted to:
- Benign prostatic hypertrophy;
- Prostate cancer;
- Congestive heart failure;
- Deep-vein thrombosis;
- Pulmonary embolism;
- Irritability and/or hostility;
- Muscle weakness and/or fat gains;
- Fatigue and/or depression;
While TRTs may cause adverse side effects, Bioresponse DIM may help to naturally moderate testosterone synthesis and utilization; causing no known side effects when used at low doses over short time periods.
Additional Bioresponse DIM Benefits
Bioresponse DIM may also help to reduce the risk of heart disease due to inflammation. Bad estrogens and xenoestrogens are known to cause widespread inflammation within the body.
Chronic inflammation is associated with nearly all preventable diseases; including heart disease, the top killer in the US and in many other countries worldwide.
Because diindolylmethane is known to help to balance estrogens in the body, it may be effective at protecting the heart from some hormone-related diseases.
Estrogens affect the entire body, including the heart muscle and circulatory vessels. The effects of estrogens on cardiovascular health are well-established.
Bioresponse DIM supplementation may:
- Decrease bad (LDL) cholesterol;
- Decrease total cholesterol levels;
- Increase good (HDL) cholesterol;
- Strengthen blood clotting capacities;
- Smooth and dilate blood vessels and capillaries;
- Increase blood volume displacement without elevating blood pressure;
- Decrease free radical damages to circulatory vessels and the heart muscle;
By improving cholesterol balance and upregulating blood delivery, diindolylmethane supplementation can help to protect the cardiovascular system and lessen the risks of developing high cholesterol, hyperlipidemia, high triglycerides, atherosclerosis, coronary artery disease and/or heart disease.
How Much Bioresponse DIM Should Be Used?
Every individual has a unique set of biological and psychological variables to cater to. In order to maximize the effectiveness of diindolylmethane supplementation, it is necessary to experiment with different doses.
To begin, start out at ¼ of the manufacturer’s recommended amount. If this causes no side effects after several consecutive days of usage, then increase the dosage to ½ of the manufacturer’s recommendation.
Continue in this manner until reaching the full dosing recommendation. If any gastrointestinal issues develop, cease increasing the amount and consider slight decreases in dosing.
Although Bioresponse DIM is accepted as safe for human use generally, it’s always best to talk with a doctor before beginning supplementation.