Phosphatidylcholine is a nutritional supplement that many in the health community have been promoting as one of the best natural brain supplements available.
It can both improve the health of your brain cells and boost memory performance for individuals of all ages and circumstances.
Before you buy Phosphatidylcholine, you may have some questions about the best way to use this source of Choline.
There are also many different ways that you can choose to purchase your Phosphatidylcholine supplements as well as some slightly stronger alternatives that it would be wise to consider.
Let’s first take a closer look at what Phosphatidylcholine is and how it works in the body, then discuss the practical matter of where to buy it and how to make sure you are getting the best value.



- Increases acetylcholine levels in the brain
- Supports memory & cognition
- Promotes brain cell health
Phosphatidylcholine Review
Related Topics
- What is Phosphatidylcholine?
- Benefits & Effects
- Buy Phosphatidylcholine Online
- What is Choline?
- What is Acetylcholine>
- Cholinergic Receptors
- Choline's Role in the Brain
- Using Choline Supplements
- Acetylcholinesterase Inhibitors
- Effects and Benefits
- Recommended Dosages
- Dietary Sources
- Risks of Choline Deficiency
- Possible Side Effects
- Buy Choline
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Phosphatidylcholine (sometimes written as two words like Phosphatidyl Choline) is part of a group of substances known as phospholipids.
Phosphatidylcholine is a necessary fat that contains choline in its molecular make-up and is found throughout the body in biological membranes. In fact, you can find Phosphatidylcholine in the cell membrane of every neuron in your brain.
This supplement is closely related to the lecithin group of yellow-brownish fatty substances which occur in both animal and plant tissues.
In fact, lecithin supplements that are promoted as being beneficial to brainpower get this reputation because they contain Phosphatidylcholine (although lecithin that you may buy in a store is usually a mixture of Phosphatidylcholine and other compounds).
Taking Phosphatidylcholine may provide support to many different organs and tissues throughout the body. Structurally, it differs slightly from most other phospholipids due to the fact that it contains an extra essential fatty acid.
Choline is a component that the body only produces in very small quantities and therefore it is mainly obtained from various foods. Common food sources include soy beans and eggs.
Phosphatidylcholine is also surprisingly non-toxic and has a number of additional uses including as an emulsifier or lubricant.
Why Use Phosphatidylcholine?
There are quite a few different reasons you might buy Phosphatidylcholine tablets or powder. One of the primary benefits is more efficient fat metabolism. This nutrient is essential for the metabolism of fatty acids and also the transportation of fats throughout cell membranes.
Many of the Phospholipids contained in this supplement aid in the breakdown and removal of lipids. As a source of choline, this supplement also works as a methyl provider, improving processes that transport fatty acids from the liver to other tissues.
Making sure you get enough choline in your diet is imperative to liver health. This applies not only to treatment of various liver diseases like cirrhosis, fatty liver (often due to diabetic related problems), acute and chronic hepatitis, and toxic liver damage, but also to the prevention of certain liver conditions.
This includes helping to reduce liver fibrosis, preventing the death of liver cells due to toxins like drugs and alcohol, and preventing liver cells from damage due to certain viruses. A number of studies have demonstrated that taking Phosphatidylcholine supplements can restore health in those suffering from hepatitis.
These health benefits are without a doubt solid reasons to consider taking Phosphatidylcholine. But in most cases, this natural compound is used by people who want to improve their memory capacity and intelligence.
Phosphatidylcholine contains choline which is a precursor to a brain chemical called Acetylcholine. This neurotransmitter is vital in memory formation processes in the brain. If you have trouble remembering things or want to improve your ability to recall important facts and details, getting more choline may make a big difference.
Acetylcholine is also involved in the ability to pay attention, perceive information, perform calculations and analyze incoming data. Everyone from elderly individuals to younger children are likely to see improved memory, concentration and learning capacity when Acetylcholine levels are high.
Phosphatidylcholine supplements are also used by people who want to reduce their risk of experiencing age-related memory loss as well as developing other degenerative neurological disorders. Some researchers have touted Phosphatidylcholine as a potential life extension nutrient, although more research in to its effects are still needed.
It is believed these effects are due to Phosphatidylcholine’s essential role in the repair, maintenance, and restoration of cell membranes. These cell membranes are also the primary regulatory mechanism for controlling what goes in and out of a cell and they actually play a very important role in maintaining the ability of your brain to communicate with itself.
The healthy fatty acids found in this nootropic can boost the body’s overall immune system, prevent unnecessary inflammation, repair damage to cells, and increase membrane fluidity. This supplement also helps to regulate a healthy level of cholesterol stored in the body, which may lower blood pressure and support healthy heart function.
Research on supplemental Choline sources has been very promising, however more research is still needed, especially large-scale human trials. At this time, Phosphatidylcholine is available as a health supplement only, and the FDA has not approved Phosphatidylcholine as a drug to prevent or treat any conditions.
Should you Buy Phosphatidylcholine?
As you can see, there are many reasons one might want to buy Phosphatidylcholine. But an important question to ask is, are there any other supplements that might give you better results?
While Phosphatidylcholine is one of the better options out there for Acetylcholine supplements, it is not 100% choline and it has low efficiency in reaching the brain. Additionally, the process of converting this nutrient into the Acetylcholine neurotransmitter requires more energy than certain other forms of Choline.
The determining factor for how good a Choline supplement is should be based on how well it converts into Acetylcholine.
Alpha GPC is another type of natural Choline (it stands for L-Alpha glycerylphosphorylcholine) and it is actually made by purifying Phosphatidylcholine into a more active form. Studies have also found it to be much faster acting, requiring only a few hours to notice performance changers whereas Phosphatidylcholine can take weeks to produce benefits.
Since Phosphatidylcholine has lower Acetylcholine conversion compared to Alpha GPC, scientists now view Alpha GPC as a superior supplement for memory enhancement.
Because Alpha GPC is more expensive, some people may end up deciding to purchase Phosphatidylcholine instead. However you should remember that you will need a larger dosage in order to achieve the same results.
You may buy Phosphatidylcholine in a number of different places. Many traditional health food stores and vitamin shops sell this formulation now and you can sometimes find it in supplement or vitamin stacks alongside several other brain-boosting compounds.
One of the things to check for is that your source of Phosphatidylcholine uses all-natural Lecithin. Otherwise, it is likely coming from an inferior source. Also, take a look at some of the reviews regarding the company and the particular formulation before making your purchase, especially if you are considering buying online.
Using Phosphotidylcholine
If you do decide that Phosphotidylcholine is the supplement that is right for you, the most commonly recommended dosage is between 1,500 mg to 2,000 mg per day. Proper dosage is dependent on many different factors and your personal dosage may be different. It is recommended that you speak with your doctor before beginning any new supplements.
Since this supplement is fat-based, you should take it with meals to improve its absorption into your blood. The total daily dose may be taken at once, but is usually more effective when spread out over several different administrations.
Although this supplement is considered to be safe for oral use in adults and generally well-tolerated, there still may be some side effects. These can include excessive sweating, stomach upset, and even diarrhea. However, most of these effects are generally seen when using higher than recommended doses. Often lowering the dosage helps remedy most of these effects in many users.
Stomach discomfort is common when you start taking it for the first time, so you may want to limit your dosage for the first week or two. Remember that it can take a few weeks before you notice any positive effects from this supplement, so you should make sure to get a large enough supply to adequately test it out when you first buy Phosphotidylcholine pills or powder.
- Zeisel SH. The supply of choline is important for fetal progenitor cells. Semin Cell Dev Biol. 2011
- Nagata T, Yaguchi T, Nishizaki T. DL- and PO-phosphatidylcholines as a promising learning and memory enhancer. Lipids Health Dis. 2011
- Köfeler HC, Tiboldi A, Hoeger H, Lubec G. Hippocampal lipids linked to spatial memory in the C57BL/6J mouse. Neurochem Int. 2010
- Yaguchi T, Nagata T, Nishizaki T. Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha7 nicotinic ACh receptors. Life Sci. 2009
- Troen AM, Chao WH, Crivello NA, D'Anci KE, Shukitt-Hale B, Smith DE, Selhub J, Rosenberg IH. Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine. J Nutr. 2008
- Hashioka S, Han YH, Fujii S, Kato T, Monji A, Utsumi H, Sawada M, Nakanishi H, Kanba S. Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation. Free Radic Biol Med. 2007
- Crespo D, Megias M, Fernandez-Viadero C, Verduga R. Chronic treatment with a precursor of cellular phosphatidylcholine ameliorates morphological and behavioral effects of aging in the mouse [correction of rat] hippocampus. Ann N Y Acad Sci. 2004
- McDaniel MA, Maier SF, Einstein GO. Brain-specific" nutrients: a memory cure?" Nutrition. 2003
Article last updated on: March 14th, 2018 by Nootriment
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