Many people buy Phosphatidylserine for its well-known memory and mental focus benefits. However, we are seeing the natural compound recommended more and more as an antidote to common stress and anxiety.
Phosphatidylserine, commonly abbreviated as PS, is a phospholipid manufactured by the body for use in metabolism and cellular communication. It has been consumed safely as a supplement for decades.
However, PS is still considered somewhat obscure by the general public, and its many uses have not been widely written about. Now, new research indicates that buying Phosphatidylserine may be a useful tool for balancing mood and cutting stress.
Here’s a quick guide to how Phosphatidylserine works, with recommendations for the most safe and effective forms for you to purchase.



- Supports memory function & cognition
- Boosts neuron health & communication
- May improve mood, sleep & relaxation
How Phosphatidylserine is Used by the Body
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The cell membrane is the home of all natural Phosphatidylserine, a phospholipid, in the body.
More than in any other area of the body, the membranes of brain nerve cells are comprised of as much as 10 percent Phosphatidylserine (as well as the other common phospholipid known as phosphatidylcholine).
Here, the compound is used as a sort of “gatekeeper,” facilitating the transfer of raw materials and biochemical messages into and out of the cell.
The compound makes these cell membranes permeable, healthy, and able to communicate. It also assists in the metabolism process, making use of glucose and fueling natural energy throughout the systems of the body. Phosphatidylserine is involved in synthesizing the available amounts of the important neurotransmitters acetylcholine and dopamine in the brain.
The combined effect of these mechanisms is to facilitate cognition, and provide the brain with the energy it needs to process information and give instructions at peak efficiency. But when people buyPhosphatidylserine for use as a stress reliever, the most important role it plays is as a regulator of cortisol, which we will discuss below.
The Cortisol Connection
Though most of us think of stress as the result of hectic life conditions or emotional imbalance, stress does have a chemical root. The adrenal cortex is a hormone producing organ which is a part of the adrenal gland, found near the kidneys.
When we perceive stress, this gland releases a chemical known as cortisol. Cortisol in turn stimulates high intensity functions which the body needs in times of physical danger, including increased metabolism and the burning of both muscle and fat.
For most people, excessive mental stress can trigger this cortisol reaction when it is not needed, causing problems like high blood pressure and inflammation. Phosphatidylserine is one of the body’s natural methods for curbing runaway cortisol production. But the amount of PS we can generate naturally is no match for the flood of cortisol that modern life delivers to most people.
When you buy Phosphatidylserine capsules as a dietary supplement, it’s possible to maintain balanced levels of cortisol every day, no matter what stress triggers are experienced. For this reason, some form of Phosphatidylserine pill is recommended as a healthy daily stress fighter.
But the cost and expense of adding PS to one’s daily vitamin regimen may be too much effort for most people. That’s why many popular cognitive health combo stack products like Alpha Brain incorporate a dose of Phosphatidylserine into every pill.
Phosphatidylserine Benefits for Mood
Phosphatidylserine’s cortisol control can deliver excellent daily stress relief for everyone. However, some form of Phosphatidylserine supplementation can also assist in treating more intense emotional imbalances. Patients suffering from mild to severe depression can benefit greatly from the positive effect of PS on mood. For people who live with anxiety, including panic attacks and social anxiety, PS can help soothe scattered and hyperactive thoughts.
Its proven boosts to cognitive effects like memory power and learning ability have a complementary effect upon anxiety symptoms, making it easier to process information, recall facts, and prioritize stressful stimulus before it is perceived as overwhelming. These factors strongly make the case to buy Phosphatidylserine.
Phosphatidylserine for Athletes and Bodybuilders
One of the most frequently advised solutions for stress and anxiety is exercise. There is no better way to naturally bring chemical balance to the brain and distribute energy stores before they trigger the perception of stress. Phosphatidylserine is an excellent supplement to this end, preventing the over-production of exercise-induced hormones like cortisol, and making athletic training more productive.
Phosphatidylserine’s regulation of metabolism can even improve muscle performance, lower post-workout soreness, and assist in fat-burning. For these reasons, it is commonly used in pre-workout supplement stacks for athletes and bodybuilders. Taking this supplement with a moderate level of activity will help to restore balance to your physical well-being. The stress relieving benefits of regular exercise will be enhanced significantly.
Is Phosphatidylserine Safe? Dosage Info
Phosphatidylserine is naturally produced by the body and as such is very well-tolerated by almost all people. Supplementing within recommended dosage guidelines is widely considered to be very safe and will not cause any major side effects.
In rare cases, Phosphatidylserine can generate sensitivities such as upset stomach or sweating, but these effects will be temporary and mild if experienced at all.
The standard Phosphatidylserine dose that most people react favorably to lies between 100 to 500 mg per serving. This dose can be repeated multiple times per day if desired, with food. A full stomach will prevent any unwanted stomach sensitivity to the supplement.
If you buy Phosphatidylserine in bulk, perhaps start with a small dose in the 100 – 200 mg range, and then gradually increase the amount if necessary, such as in times of acute stress.
Best Way to Buy Phosphatidylserine
Many people do not wish to buy Phosphatidylserine in bulk because the relatively small doses required for stress relief do not warrant large purchases. The typical Phosphatidylserine bulk product is sold in units of 50 grams or more, constituting hundreds of doses. This is far more than the average user will need, especially if they are just curious about sampling a small amount of PS in conjunction with other supplements.
For this reason, Phosphatidylserine is most popularly consumed as a part of combined nootropic stack products like Alpha Brain. A nootropic is any compound which is taken to improve various facets of cognitive and mood health.
Often we find synergistic combinations among various nootropics. In the case of Alpha Brain, Phosphatidylserine is added as a potent stress reliever to known cognitive enhancers such as choline boosting Alpha GPC and the rainforest herb AC-11.
Phosphatidylserine mixes particularly well with L-Tyrosine, the amino which stimulates mood-lifting dopamine production. For about $1 per day, Alpha Brain provides a broad range of full-spectrum cognitive benefits, with the perfect pre-calculated dose of Phosphatidylserine for stress relief. This method constitutes the optimum method for buying Phosphatidylserine for stress and anxiety relief.
- Kingsley M. Effects of phosphatidylserine supplementation on exercising humans. Sports Med. 2006
- Araujo JA, Landsberg GM, Milgram NW, Miolo A. Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine. Can Vet J. 2008
- Tietjen GT, Gong Z, Chen CH, Vargas E, Crooks JE, Cao KD, Heffern CT, Henderson JM, Meron M, Lin B, Roux B, Schlossman ML, Steck TL, Lee KY, Adams EJ. Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4. Proc Natl Acad Sci U S A. 2014
- Fünfgeld EW, Baggen M, Nedwidek P, Richstein B, Mistlberger G. Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer's type (SDAT). Prog Clin Biol Res. 1989
- Lee B, Sur BJ, Han JJ, Shim I, Her S, Lee YS, Lee HJ, Hahm DH. Oral administration of squid lecithin-transphosphatidylated phosphatidylserine improves memory impairment in aged rats. Prog Neuropsychopharmacol Biol Psychiatry. 2015
- Scapagnini U, Guarcello V, Triolo G, Cioni M, Morale MC, Farinella Z, Marchetti B. Therapeutic perspectives in psychoneuroendocrinimmunology (PNEI): potential role of phosphatidylserine in neuroendocrine-immune communications. Int J Neurosci. 1990
- Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geriatr Cogn Disord. 2014
- Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010
Article last updated on: April 29th, 2018 by Nootriment
1 Comment
Thanks alot