The nutritional supplement Picamilon (nicotinyl-y-aminobutyric acid) is highly touted online to normalize anxiety levels without causing lethargy or drowsiness.
In contrast to many anxiety relievers, Picamilon increases alertness and wakefulness while at the same time reducing signs of tension and stress.
It is known to work quickly to alleviate anxiousness and prevent bouts of anxiety before they happen.
Picamilon supplements are further observed to have a brain-boosting effect, leading to increased memory, planning, intelligence, reasoning, learning and attention. Some users reviews say that taking Picamilon dosages can give them heightened mental drive and motivation while making it easier to concentrate in a non-stimulator way.
You can buy Picamilon online from a small number of nootropic vendors and you do not need a prescription to purchase it in the USA.



- Consists of GABA & Niacin
- Stimulates GABA receptors in the brain
- Promotes mood, sleep & relaxation
Picamilon Introduction
Related Topics
Picamilion is a combination of the neurotransmitter GABA and the vitamin Niacin (Vitamin B3).
GABA is an important neurochemical for controlling anxiety levels in the brain and many anxiety medications work in some way on GABA receptors.
Picamilon is an example of a GABAergic compound that increases the permeability of this chemical through the blood-brain barrier.
In the Picamilon formulation, Niacin acts as a carrier that can deliver GABA across this barrier. The net effect is higher levels of GABA in the brain as well as higher levels of Niacin which can have distinct effects on its own.
These days, you will see Picamilon used clinically in Russia (where it was first developed in 1969) as well as in Japan as a prodrug version of GABA. Picamilon is currently sold in the United States as a dietary supplement that can enhance mood, lessen signs of anxiety, relieve stress and help you relax.
In addition to its anxiolytic properties, the presence of Niacin means that this supplement increases blood flow to the brain. This can lead to meaningful improvements in brain function, resulting in several nootropic effects such as increased alertness and attentiveness, better memory retention, improved communication between the two hemispheres of the brain and faster signaling between neurons.
Why Use Picamilon
In patients with mild symptoms of anxiety or social anxiety, Picamilon is observed to improve nervous system control. It can restore balance to your state of mind, by regulating neurons that are firing at an excessive rate.
Small dosages of this supplement have a sedative effect and can counteract the negative effects of emotional stressors. It has been shown to inhibit the motivated aggression response as well as tempering the orienting reaction response that animals show when disturbed by fear-inducing stimuli.
In humans, Picamilon is said to promote relaxation and feelings of calm without leading to muscle relaxation or sluggishness. User reviews say that it helps them to achieve a sense of centered focus, giving them a slight increase in mental energy and greater clarity of thought.
Picamilon is also considered to be a Nootropic which means it is capable of having positive effects on your mind and cognitive processes. Studies have found it to have anti-amnesiac properties and anecdotal evidence from experience logs demonstrates that it can improve memory and learning capacity as well as fluid intelligence.
Picamilon may help in the areas of faster memory recall, better attention span, and higher levels of awareness. There is also evidence that it can reduce impulsive actions and behavior, along with increasing motivation.
In Russia, it is commonly used as a prescription drug for improving cerebral blood flow. This mechanism of activity can be helpful in addressing a number of problems such as vasoneurosis, depression, asthenia, acute alcohol intoxication, senile psychosis, migraines, primary open glaucoma, and even certain types of cranial cerebral (brain) trauma.
Picamilon is an anti-hypoxic meaning that it can help to ensure that your brain is getting enough oxygen, primarily by increasing circulation to the cerebrum.
What it interesting is that it also has the potential to lower blood pressure throughout the rest of your body. Studies comparing it to papaverine or other blood pressure drugs have found that it works better than these well-established medications.
Finally, Picamilon can help both children and adults with urinary disorders, improving the adaptive function of the bladder.
Buy Picamilon
In spite of the wide-ranging benefits of this supplement, there are relatively few places where you can buy it online. Stores like GNC or your local pharmacy do not typically carry this product as it is still not very well known in the North American market.
Some users will turn to looking for it on Amazon or eBay, though the quality control of these products can vary greatly. Only ever purchase it from a vendor who can supply you with an authentic Certificate of Analysis.
You can buy Picamilon tablets from companies like Serious Nutrition Solutions in either 50 mg dosages or 150 mg doses. These options can be convenient, though there is a significant mark-up for buying it from a brand name supplier.
The more popular option is to purchase bulk Picamilon powder from a vendor who specializes in nootropics. You can then design your own stack around Picamilon for a very cost-effective price. At present, it is possible to buy 30 grams of Picamilon for as little as $30 giving you a price per dosage of less than 20 cents.
Depending on the format you choose to buy Picamilon in, there will be different instructions for how to use it. The suggested daily dosage range is between 100 and 600 mg. It is best to split your dosages into several administrations of up to three times per day.
You will want to take these doses in between meals on an empty stomach to help with the absorption. Some users recommend that you do not take it past 6 PM at night lest you find yourself having difficulty falling asleep later.
You might need to take Picamilon powder for several weeks before some of the cognitive enhancement effects become noticeable, but the anti-anxiety benefits should be apparent right away. Be sure to start with the lowest effective dose and increase this amount only after becoming familiar with the effects.
Among anxiolytics, Picamilon is considered one of the safest and is very well-tolerated. There are few reported side effects when it is used as an appropriate dosage. In some instances, it may cause mild negative reactions like headaches, nausea, and tingling. Most of these are short-lived and diminish over time.
There is also the potential that this supplement might interact with other medications, such as benzodiazepines. New users are advised to seek the advice of a qualified before adding this to their routine. Your doctor can help you to understand the best way to use this nootropic before you decide to buy Picamilon.
- Likhodeev VA, Spasov AA, Isupov IB, Mandrikov VB. [Effects of aminalon, fenibut, and picamilon on the typological parameters of cerebral hemodynamics in swimmers with dysadaptation syndrome]. Eksp Klin Farmakol. 2009
- Kresiun VI, RozhkovskiÄ IaV. [Molecular-biochemical mechanisms of the effects of nootropic agents]. Biull Eksp Biol Med. 1990
- Mirzoian RS, Gan'shina TS. [The new cerebrovascular preparation pikamilon]. Farmakol Toksikol. 1989
- VishnevskiÄ EL, Guseva NB. [Validation of the treatment of the neurogenic bladder in children with myelodysplasia using pikamilon]. Urol Nefrol (Mosk). 1998
Article last updated on: March 13th, 2018 by Nootriment
5 Comments
Nowhere in this post is the title question, Where To Buy Picamilon Online, answered. That is silly on the one hand and mean on the other.
Hi Bunny,
Thanks for your comment. We used to have links up to a retailer that sold Picamilon online. However, the FDA has since ruled that Picamilon does not fit the definition of a dietary supplement and this ingredient has been pulled from the market. It cannot be purchased legally as a dietary supplement anymore. There are some alternative supplements that you may want to look into, such as Valerian Root, GABA, Rhodiola Rosea, or L-Theanine.
Well, then I don’t see why you tweeted about it today if it can’t be purchased. I just spent a frustrating 5 minutes clicking into oblivion.
Hey Amy,
Thanks for letting me know. We have a system that automatically tweets out our articles. If you’re looking for an alternative to Picamilon, a few readers have told me that PharmaGABA (which is a modified form of GABA) is effective in its place.
It is still legal to buy! As long as the seller doesn’t call it a “dietary supplement”.
So please put the links back? Thanks