Sulbutiamine powder is a nootropic supplement shown to potentiate activity in key brain systems related to mood and memory.
This biosynthetic supplement is a derivative of Vitamin B1 – also known as Thiamine. As an enhanced version of this natural vitamin, Sulbutiamine is known for having more positive effects on brain function than if you were to take Thiamine itself.
This supplement has been used by individuals who suffer from depression, anxiety, and asthenia, and it also possesses powerful cognitive enhancement benefits.
If you buy Sulbutiamine powder, it may increase your energy levels, boost your memory performance, and creative positive feelings of excitement, motivation, and arousal.



- Heightened alertness, focus & energy
- Supports memory & mental performance
- Promotes mood through dopaminergic activity
How does Sulbutiamine work?
Related Topics
- What is Sulbutiamine?
- What is Arcalion?
- User Reviews
- Effects and Benefits
- Why Take Sulbutiamine?
- Sulbutiamine for Energy
- Effects on Dopamine
- Dosage Guidelines
- Sulbutiamine for Anxiety
- Possible Side Effects
- Bulk Sulbutiamine Suppliers
- Buying Sulbutiamine Online
- Arcalion Uses
- How to Take Arcalion
- Is Arcalion Safe?
- Buy Arcalion
In order to properly examine the mechanism of action for Sulbutiamine, it is important to first understand the role of Vitamin B1 in the body.
This essential compound is involved in the energy-generation system of your cells which converts carbohydrates into ATP for your many bodily functions.
Thiamine activates a coenzyme called Thiamine pyrophosphate (TPP) which is used to produce Acetyl Coenzyme A (Acetyl-CoA) from pyruvate as part of the metabolic process
Thiamine is also responsible for several functions related to the production of RNA and DNA and it is involved in the synthesis of Acetylcholine which is one of the most important neurotransmitters for memory. Low levels of Thiamine can produce oxidative stress in your neurons and can interfere with other neuronal maintenance that may lead to premature brain cell loss.
Furthermore, Thiamine has been found to prevent brain lesions and other forms of brain damage as well as environmental damage from alcohol and other lifestyle factors.
As invaluable as Thiamine is for improving mental performance, it is known that Vitamin B1 does not do a particularly good job of crossing the blood-brain barrier. This filtration system is what keeps your circulating blood separate from your brain tissue.
In order for any nutrients you consume to be taken up by your neurons and affect cognitive abilities, they must first penetrate this barrier to reach the Central Nervous System. For this reason, Japanese scientists first developed Sulbutiamine (also sold under the brand-name Arcalion) as a modified format of Thiamine that can better cross over the blood-brain barrier.
The effects of Sulbutiamine powder are similar in many regards to Thiamine, but at a higher level of potency. When Sulbutiamine reaches your brain, it is known to potentiate dopaminergic and cholinergic activity through something called upregulation.
In other words, it makes your neurons more sensitive to the Dopamine and Acetylcholine neurotransmitters when they are released from your neurons. Sulbutiamine has been shown to stimulate more activity in the reticular activating system of the brain which is the part of your mind that controls arousal and motivation levels.
Benefits of Sulbutiamine
There are many different reasons why people will buy Sulbutiamine supplements, but one of the primary goals is to heighten levels of Dopamine receptor activity in your neurons.
Dopamine is one of the most powerful good-mood hormones that your brain uses to signal moments of pleasure and reward.
Low levels of Dopamine are associated with inability to focus, lack of drive or excitement, mental fatigue, depression, and stress. Higher amounts of this neurotransmitter can improve attention and concentration, give you more energy, enhance your mood, and diminish feelings of sadness or stress.
Sulbutiamine is often taken as a mood-boosting supplement, both for ongoing mood regulation and sometimes even as a “party drug” for people who want to relax and unwind.
Buying Sulbutiamine tablets also offers a number of benefits related to intellectual capacities such as memory, learning, reasoning, and neuroplasticity. One of the fundamental reasons for this is that Sulbutiamine can increase Acetylcholine activity in the brain.
Acetylcholine is a neurotransmitter that is connected with working or short-term memory, long-term memory conversion and retrieval, fluid intelligence, and attentiveness. Many people who use this nootropic say that it makes their thoughts seem much clearer and in general makes mental tasks much easier to complete.
Research on Sulbutiamine is limited and more research is still needed to fully understand the effects of this supplement. At this time the FDA has not approved Sulbutiamine as a drug to prevent or treat any conditions.
How to Buy & Use Sulbutiamine
You can buy Sulbutiamine supplements either in pill or powder format, with the powdered versions being significantly cheaper to buy in bulk.
The main reason for this is from the high costs of actually preparing Sulbutiamine capsules which can often amount to more than the actual cost of the raw ingredient itself.
For this reason, most nootropic users prefer to purchase all of their brain supplements in bulk powder form online. You can purchase Sulbutiamine powder for $29.99 for a 50 gram supply which should last you at least 2-4 months.
The average manufacturer recommended Sulbutiamine dosage is between 400 – 1000 mg per day. However you may see results at a different dose level depending on your personal biochemistry and other supplements you are using.
It is best to test out a few different dosages to determine which gives you the most positive results. It is always recommended that you speak with your doctor before beginning any new supplements to help determine the best dosage for your personal needs.
Sulbutiamine is a fat-soluble powder which means you should ingest it either with milk, food or some other fat source such as fish oil. While it is also semi-water-soluble, absorption from your digestive system will be greatest when stacked with a source of lipids.
Another important thing to keep in mind if you plan to buy Sulbutiamine is that it may become less effective if you use it consistently for a long period of time. This is due to something called downregulation and it seems to be particularly noticeable in regards to the dopaminergic activity of this nootropic compound.
For this reason, you should cycle this supplement in such a way to prevent your receptors from becoming overly used to its effects. A common strategy is to take Sulbutiamine powder for one week and then stop taking it for another week.
You may want to stack it with other nootropics like Aniracetam or Noopept for enhanced results. The effects of Sulbutiamine may also be amplified when using it with a Choline source such as Centrophenoxine.
- Bettendorff L. The compartmentation of phosphorylated thiamine derivatives in cultured neuroblastoma cells. Biochim Biophys Acta. 1994
- Micheau J, Durkin TP, Destrade C, Rolland Y, Jaffard R. Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation. Pharmacol Biochem Behav. 1985
- Balzamo E, Vuillon-Cacciuttolo G. [Facilitation of a state of wakefulness by semi-chronic treatment with sulbutiamin (Arcalion) in Macaca mulatta]. Rev Electroencephalogr Neurophysiol Clin. 1982
- Levin OS, Slizkova IuB. [The use of enerion in the treatment of asthenic disorders in patients after mild cranio-cerebral trauma]. Zh Nevrol Psikhiatr Im S S Korsakova. 2007
- Kang KD, Majid AS, Kim KA, Kang K, Ahn HR, Nho CW, Jung SH. Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells. Neurochem Res. 2010
Article last updated on: March 13th, 2018 by Nootriment