The importance of Uridine for memory, aging, mood disorders, cardiovascular health and more is currently a subject of significant research.
This nutrient found in beer and breast milk, is a nucleotide base that has been associated with certain cognitive enhancement properties.
Users buy Uridine supplements to promote healthy brain cells and it shows synergistic benefits with Omega 3 fatty acids from Krill or Fish oil.
Deoxynucleic acid (DNA) is made up nucleotides called guanine, adenine, thymine and cytosine. Ribonucleic acid (RNA) is the messenger molecule used as a template to make cells in the body to make and rebuild tissues.
RNA is also made up of the same nucleotides as DNA except thymine is replaced with uracil. Uridine is a compound that contains a uracil ring attached to another ring structure. Uridine makes uracil available for the body to copy messages from DNA to RNA in order to repair and replace cells like neurons.
Purchasing Uridine capsules or powder online can increase the availability of this nutrient for optimal brain health.



- Increases dopamine & choline in the brain
- Supports cognition, memory & mood
- Protects the brain & promotes synapse growth
Do you Need Uridine Supplements?
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Some scientists believe they are seeing a rise in degenerative brain conditions and that dementia and Alzheimer’s threaten to squander the golden years of baby-boomers.
In America, almost one-third of adults over the age of 80 have been diagnosed with dementia. Dementia and Alzheimer’s are degenerative conditions.
While we do not yet have a cure for these conditions, middle age adults can take steps to improve their brain health. By paying attention to research and nutrition, healthy adults may decrease chances of brain degeneration and help preserve essential neurons used to transmit signals.
While there is still no recognized preventative drug for Alzheimer’s and dementia, we can lower the risk factors associated with these conditions by helping to preserve brain tissue with nutrition supplements like uridine. Buying Uridine supplements may aid in the growth and maintenance of neurons and promote brain health by replacing or repairing existing structures in the brain.
While there are several supplements that may boost brain health, uridine is one of the most favorable biological compounds for improving neural structures and increasing cognitive function.
Uridine Research Benefits
Uridine is a natural compound found in a wide range of living organisms such as humans, plants and bacteria. It is so important in the maintenance and development of the human brain that it is an essential ingredient in baby formula. Three key compounds that are often studied together for brain health are uridine, choline and omega-3 fatty acids.
All three of these biological compounds are essential for healthy brain development and have been studied for their ability to raise levels of phosphatidylcholine, significantly.
Phosphatidylcholine is an important molecule found in the nervous system that plays a role in memory recall through the maintenance of cell structures and proper breakdown, disposal and repair of degenerated cells made up of triglycerides (fatty acids).
While studying diseases of the human brain, researchers found that when levels of uridine were increased, there was more phosphatidylcholine found in biological pathways. It seems to increase the availability of phosphatidylcholine for functions such as growth and repair of nerve cells and synapses, which are important for sending signals throughout the nervous system.
Uridine supplementation also seemed to increase the amount of proteins transporters found on those synapses and nerve cells. Protein transporters, found on cells, recognize neurotransmitters and are responsible for transmitting signals from one cell to another.
It is known that patients with Alzheimer’s have less of these protein transporters and that uridine and phosphatidylcholine may help in the maintenance and repair of such structures to aid in diseases of the brain.
Uridine Promotes Growth of Neurites
If you buy uridine to raise levels through supplementation, you may be able to increase the number of neurites found in your brain.
Neurites are all the structures that project from a nerve cell to facilitate communication, such as axons and dendrites.
Axons are the long nerve fibers that projects out from a nerve cell covered in a myelin sheath – an insulated layer that protects the neuron. The axon is responsible for electrical conductions that carry signals away from the nerve cell during action potentials.
Dendrites are also nerve projections that branch out like a tree and are responsible for propagation of electrochemical stimulation from other dendrites on neighboring nerve cells.
By increasing the number of neurites, this shows potential for uridine to enhance synaptic plasticity (also known as neuroplasticity). This is linked to better memory formation and recall, helping to keep your mind sharp as you age.
Where to Buy Uridine?
If you are concerned about the possible onset of brain degenerative conditions such as dementia and Alzheimer’s, nootropics such as uridine may be an option to help you take control of your brain health. Uridine can be purchased as a supplement online, though it is not widely sold in retail stores today.
Some companies that sell uridine supplements are Jarrow Formulas, Absorb Health and Cardiovascular Research Ltd. All three supplements range from 25-250 mg of uridine per capsule. The recommended dose of urdine is 500-1000 mg per day taken in 250 mg increments.
Uridine is readily transported across all cell membranes including the blood brain barrier via protein transporters, under normal physiologically conditions. In general, uridine supplements are very safe and have little to no side effects when taken at the recommended dose.
Larger doses may cause some gastrointestinal symptoms such as bloating or mild cramping. These symptoms can usually be prevented when uridine supplements are taken with plenty of water.
In order to find the correct dose, it is good idea to experiment within the recommended range starting at the lower end of 500mg per day. Results may be improved when taken with a choline supplement. Before you buy uridine pills, it is best to speak to your doctor about whether this supplement is right for you.
- Yamamoto T, Koyama H, Kurajoh M, Shoji T, Tsutsumi Z, Moriwaki Y. Biochemistry of uridine in plasma. Clin Chim Acta. 2011
- Wurtman RJ, Cansev M, Sakamoto T, Ulus I. Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses. Nutr Rev. 2010
- Wurtman RJ, Ulus IH, Cansev M, Watkins CJ, Wang L, Marzloff G. Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res. 2006
- Cansev M, Watkins CJ, van der Beek EM, Wurtman RJ. Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res. 2005
- Richardson UI, Watkins CJ, Pierre C, Ulus IH, Wurtman RJ. Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells. Brain Res. 2003
- Ulus IH, Watkins CJ, Cansev M, Wurtman RJ. Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release. Cell Mol Neurobiol. 2006
- Walker UA, Langmann P, Miehle N, Zilly M, Klinker H, Petschner F. Beneficial effects of oral uridine in mitochondrial toxicity. AIDS. 2004
Article last updated on: May 12th, 2018 by Nootriment