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Centrophenoxine is a nootropic supplement sold in many different countries under the brand name Lucidril.
It is a well-known and widely used supplement to combat aging and age related side effects.
Centrophenoxine is also thought to be able to help protect the brain against many forms of damage caused by toxic environmental chemicals.
As a choline source, it is also a frequent component of nootropic stacks with Racetams and Noopept.
There are a full range of cognitive benefits related to this interesting and exciting nootropic. Learn how it works and what some of the side effects of Centrophenoxine Powder might be, then decide for yourself if it is right for you.
Brain Health
Memory
Neuro- plasticity- Supports memory & heightens acetylcholine
- May reduce lipofuscin & beta-amyloid residue
- Boosts brain health & fights aging
Centrophenoxine Effects and Benefits:
Related Topics
The main effects of Centrophenoxine relate to its ability to treat brain damage due to old age, stroke, chemicals or drugs (including excessive alcohol consumption).
It is a very strong neuroprotectant which means it can help keep your neurons healthy and free of damage.
Prolonged administration of Centrophenoxine dosages has been shown in animal studies to significantly reduce waste products (lipofuscin) that build up in aged cells within the heart and brain. It has also been shown to help reverse the accumulation of potassium within the brain.
As we age, potassium is accumulated in the brain impairing its function and many researchers consider this as one of the reasons for age-related cognitive decline. Centrophenoxine could become one of the best nootropics for longevity of life.
Centrophenoxine also helps to cause an increase in the production of chemicals which are both helpful and essential to the proper functioning of the brain. These chemicals include various types of protein and RNA (Ribonucleic Acid).
Glucose uptake to the brain is also increased when using Centrophenoxine powder. The supplement is actually marketed in many areas as a powerful anti-oxidant, helping to rid the brain of toxins and poisons.
Medical uses include helping with Alzheimer’s disease (in many cases this supplement is combined with existing treatments and medicines to improve effectiveness), dementia and just overall general cognition improvements.
A great amount of research is ongoing into the effectiveness of Centrophenoxine on improving mood and possibly also treating ADHD.
How Centrophenoxine Works:
The main mechanism of action for Centrophenoxine is still unclear. However, most researchers seem to be in general agreement that the substance does lead to higher Acetylcholine levels.
This may be due to a higher level of choline (an actual precursor) and certain phospholipids being converted into Acetylcholine as a result of Centrophenoxine supplementation.
Of course, not all the choline will be converted and there are a number of different processes which occur. But in general Centrophenoxine is considered to be a good acetylcholine next to Alpha GPC and Citicoline.
Another interesting theory about Centrophenoxine’s mechanism of action has to do with the increased production of RNA. This is actually shown to help cells carry out protein synthesis at a higher rate. It also leads to an increased rate of protein turnover which can help to explain most of the anti-aging benefits of Centrophenoxine.
A third potential theory regarding how Centrophenoxine actually works has been called the “membrane theory of aging.” As cells age, according to this theory, they have limited ability to remove the mineral potassium and it tends to accumulate in the cells.
There are actually little pumps in the side of the nerve cell walls that will pump potassium out of the cell to ensure proper concentrations, but these pumps can become less effective with aging. This also leads to lipofuscin build up. Centrophenoxine comes to the rescue by slowing down the rate of these ‘age deposits’ within the brain and helps to remove those that have already formed.
Centrophenoxine Side Effects:
Centrophenoxine is very safe, with almost zero toxicity and it is also very well-tolerated when used at safe doses.
Despite this, there still may be a number of possible Centrophenoxine side effects. Most of these occur in higher doses and when combined with other substances (almost like an interaction, although none are known).
Of course, if you are taking any prescription drugs or medications, speak to a doctor before beginning Centrophenoxine use.
Commonly reported side effects include headache, nausea, dizziness, gastrointestinal issues, jaw clenching, and irritability. If any of these occur discontinue use immediately and speak to a doctor.
This nootropic drug is not safe for pregnant women or women trying to become pregnant. Because of its DMAE content, it has the potential to cause teratogenicity and should be avoided.
Centrophenoxine As A Choline Source:
This supplement is also considered an excellent source of choline and Acetylcholine. Obviously there are any number of such sources and which one works best really comes down to a personal decision. Of course, the additional benefits of buying Centrophenoxine might outweigh other choline sources such as Alpha GPC and CDP Choline.
Especially if you are a little older and concerned about fighting the effects of aging, Centrophenoxine might be an excellent place to start with anti-aging nootropics. Then again, feel free to try each one on its own and test their respective merits for yourself.
- Ramirez A, Vial H, Barailler J, Pacheco H. [Effects of levophacetoperane, pemoline, fenozolone, and centrophenoxine on catecholamines and serotonin uptake in various parts of the rat brain]. C R Acad Sci Hebd Seances Acad Sci D. 1978
- Al Moutaery AR. Effect of centrophenoxine on water-immersion restraint stress- and chemically-induced gastric ulcers in rats. Res Commun Mol Pathol Pharmacol. 2003
- Nandy K, Baste C, Schneider FH. Further studies on the effects of centrophenoxine on lipofuscin pigment in neuroblastoma cells in culture: an electron microscopic study. Exp Gerontol. 1978
- Nandy K, Bourne GH. Effect of centrophenoxine on the lipofuscin pigments in the neurones of senile guinea-pigs. Nature. 1966
- Nagy K, Nagy V, Bertoni-Freddari C, Nagy I. Alterations of the synaptosomal membrane 'microviscosity' in the brain cortex of rats during aging and centrophenoxine treatment. Arch Gerontol Geriatr. 1983
- Nehru B, Bhalla P, Garg A. Further evidence of centrophenoxine mediated protection in aluminium exposed rats by biochemical and light microscopy analysis. Food Chem Toxicol. 2007
- Nehru B, Verma R, Khanna P, Sharma SK. Behavioral alterations in rotenone model of Parkinson's disease: attenuation by co-treatment of centrophenoxine. Brain Res. 2008
- Petkov VD, Stancheva SL, Tocuschieva L, Petkov VV. Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats). Gen Pharmacol. 1990
- Mistry SD, Tripathi CG, Bhavsar VH, Kelkar VV. The effect of centrophenoxine at the skeletal neuromuscular junction. Indian J Physiol Pharmacol. 1985
Article last updated on: March 13th, 2018 by Nootriment
2 Comments
I am 51 and have been a daily alcohol user for 30 years. I’m taking centrophenoxine in pill form currently… As of 2 days. I’m taking “complete hgh” and other good nootrophic vitamins… Including Gabe. Trying to reverse damages to my brain and body. Just ordered noopept… And am excited. Do you also have powder forms of paracetamol, aniracetam, oxiracetam, pramiracetam, phenylpiracetam, and noopept? What else do you suggest to use more of my brain and to reverse time. Thank you so much!!!
For powdered nootropics & many other ranges (natural supplements, range choline sources (don’t start/continue dosing various racetams without also taking choline sources either extra specific foods (raw eggs, sardines) or adding choline doner to your Stack; analogous to: if you work out blend & ratio that repairs withered synapses & forms new “pathways” in brain atrophied & degenerated from daily soaking it in poison (booze is technically a poison, not a drug. When people consume too much for body to endure while liver processes it you hear of “Alcohol poisoning” not “OD’d on Stolichniya”) & brain is firing as hasn’t for decades the nootopics being reconditioning the head on motor; valves reseated & new valve springs, tighter angle camshaft, to allow valves which “tighter” open/close at increased time w/ more overlap to allow whole function better; “create more power” well the racetams & noopept being “worked over motor” the choline is part fuel that allows various improved functions, part race grade lubricant that enables it’s functioning without creating piles of metal shavings.
For powders nootropicsdepot.com. if your in US the $ amount need spend to get free shipping isn’t overly high, for free shipping internationally one need spend >$200USD.
They have huge range but don’t just dose willy nilly or turn into blithering muppet
If looking to implement regime to increase brain function over long term & keep it as well as undo damage but also combat “natural aging process/cognitive decline”; there’s no such thing anymore with new studirs & effects
Consider starting with modafinil &/or armodafinil. As in cease any/all other racetams & noopept & start fresh again.
Start with Modafinal, 1st thing & armidafinal an hr or 2 later, or if they hit too hard take 1/2 Modafinil 1st thing then other 1/2 2hrs later. They ought be all need them per day, if going long days maybe, MAYBE an Armidafinal at 3-5pm. When taking Modafinils crush or Break them into as many pieces as can & drink with at least litre of fluid.
Then, carefully, layer small doses of your Stack on the Modafinil.
If not had it before, alone it’s like Oxiracetam on steroids then x10 but ladts 3-4 times longer.
That’s important to beaware of: “half life” & “length of effect” of various things take; Modafinil goes all day, Oxiracetam next longest at 8hrs 1/2 life but really want to redose at 6hr mark.
You list Noopept, it’s not a racetam but is nootropic & cognitive enhancer
Layer everything, bit by bit, CAREFULLY, Adding noopept do so at low dose (10mg), the ubiquitous base Piracetam (the grandaddy everything else sprouted from) & this can be upped libberally (unlike others) without fear of frying brain.
Oxiracetam IS excellent but I STRESS; alter/lower doses when combine it to stack; in initial “kick start” taking 4-500mg twice a day for 2 wks is considered brutal/hardcore. A gradual, constant 200mg is ample.
Despite Oxiracetam “on own” in capsule dose is 750, 800 or 1000mg depending on where read, in stack like I’m describing, on going, 200mg ought be enough. Because it has own distinctive “feel” & if you later wanna go higher, increase in stack, do it gradually & be careful.
Pramiracetam is good for firing up brain, increasing memory & function, & a MUST is SMALL amount, NEVER >100mg, in stack stay 270days on Mir space station said “It acts like ‘comb’ on brain, casting out random impulse & annoyance/frustration: both a product & enemy of working in space, leaving calm mind that feel functioning better” & is actually sold over counter in pill form in Russia. “On its own” it’s 100mg dose, in a stack 20mg is fine, never go over 50mg whatever you do.
Pramiracetam is good to include not for any mental effect you may feel straight away but exactly for your stated intention physical repair/healthy brain & keep it up everyday & the effects, benifit will get more & more & better & better over your initial 2 4 & 8 weeks (keep at it & don’t let up)
Pramiracetam helps with blood flow & brain function at biological, “physical” level.
Aniracetam is an odd 1 in that on its own it has rather short effect (~2hrs) but in a Stack ongoing it sorta “swells” after initial dip, the perfect counterpoint to others that take effect & have “straightline” wear off” Aniracetam best summed as “holistic”, the whole, you’ll notice other things as well as what usually doing or example can “mentally multitask” with clarity, your mind/focus on what doing but also adding up costs of doing up a car or bike done before, be able mentally compile work need do, parts need buy, keep running totals of costs in money & man hours, even effects in performance of work all the while you are installing security system, wiring, sensors, cameras & access control, lift security & gates not of an apartment but 107 apartment building.
A must in your case is Centrophenoxine as it is not only Choline source but recent studies showing it repairs existing damage but literally undoes/stops the biomechanism that we know as “brain slowing with age”; it undoes the biological function that causes that as well as showing great promise in treating ADHD without dosing kids on amphetamines
Coluracetam is another you may want to add LATER as it’s shown promise in longterm treatment of undoing damage
REMEMBER CHOLINE, include fuel to feed your better functioning brain
AND
ALCAR; that stuff isn’t racetam, it’s natural occurring molecule, that the more the better, few tea spoons a few times a day independent of your racetam Stack.
When you’ve got the Modafinil length you want, your Racetam Stack will last, feel effect & sure as shit feeel it wear off; they all have bit different times but dose 1st thing, spoon if peanut butter (a couple are fat soluble to work better) & dose again 5-6 hrs later. If you know you’ll be at home, cool, although pre weighing (buy digital scales to 0.000) isn’t bad idea (just keep it capped), if out and about being caught at shopping center as brain goes from firing on all 12 cylinders that’ve been ported polished & low boost, Immediate turbocharger fitted, various racetams wear iff 1st, fortunately Oxiracetam lasts longest but in aircon shopping center, lost track of time, you may wonder why sweating like sauna or look like junkie except brain’s still firing “Dafuq’s going on? Oh bugger”.
A 3rd dose of only 2-3 ‘tams, +ALCAR & choline is ok to do if you are working, mentally, up to 16hrs.
With Modafinal you may have trouble sleeping but even if sleep isn’t option make yourself lie in bed for min 3-4hrs per night; you won’t feel it day 1 or 2 but eventually you will; anticipate what body needs & give it; many people leading ultra productive, successful lives & having 5hrs sleep/night, while doing 3 different jobs, vocations/projects any 1 of which might leave person knackered & needing 8-9hrs sleep.
Ensure you rest “the organism” (your body & brain) even if “the consciousness” is functioning fine.
Be sure to eat right foods for what doing too. And stsrting psyllium husks, 1 teasoon in decent size glass water, + always 2nd glass water is must; is great thing to add too.
The objective of most biohackers from student doing exams to Elon Musk is to get the blend, components & ratio right for each person’s own NZT 48
Fairly recent stadies been into exactly what you said your intention is; repair degradation &;damage & have brain firing as was before damage; the biohack isn’t just for SuperLife but cure Alzheimers, rectify problems used to either have kids dosed on speed (what can go wrong?) or those that 20yrs ago saw jids drop out at 13, undo “cure” senility, have mind as sharp at 90 as dick was hard at 19 as well as assist those “on the spectrum” allowing more inclusion, increased shared learning especially important in world that is becoming more & more isolating & detatchment of world increadingly managed online, even for those who don’t go online.
Biohacking is unlocking our brains, bioengineering is giving us ability to either grow own new organs needed, 3D bio printing making/repairing bodies there’s just the pesky ethical prudes to overcome growing new bodies as each wears out & transfer consciousness into new 19yr old body developed like original doing 25hrs swimming a week & competing at National level, but wisdom of years to enjoy the fuck iutta that bidy, each time
What could go wrong?
Martin Bryant was sentenced to ~5000yrs jail for Port Arthur. Tasmania has proud history of no qualms at pushing envelope of what person or a people can be made do (just ask any Tasmanian Aboriginal) Bryant is guinea pig for human indefinite life!!
Nootropicsdepot.com
Be careful
Good luck