- CholineCholinergic SupplementMemoryBrain HealthCognition
How It Works:
Top Choline Products* ❯View User Ratings* ❯*Affiliate LinksOVERVIEW: Choline is an essential brain nutrient related to B-complex vitamins. It is consumed in the diet and synthesized in the body by the liver. READ MORE...USED FOR: Memory, Focus, Brain Health, Mood, Depression, Lucid Dreaming, Liver Health, NAFLD.MECHANISM: Increases choline availability in the brain needed to synthesize acetylcholine. READ MORE...DOSAGE: 250mg to 1,000mg per day; Taken once daily with food.SIDE EFFECTS: Likely safe when used orally and at appropriate dosages. High doses may cause low blood pressure, nausea, vomiting, salivation, diarrhea, constipation, anorexia, dizziness (vertigo), sweating, insomnia, and headache. READ MORE...INTERACTIONS: Atropine; No Known Supplement Interactions.RELATED SUPPLEMENTS: Alpha GPC, Citicoline, Phosphatidylcholine, DMAE, Lecithin, Centrophenoxine, Phosphatidylserine, UridineTop Choline Supplements
- Supports memory and synaptic plasticity
- Raises acetylcholine levels
- Promotes brain health and focus
What should my dose of Alpha GPC be if I use that as my choline source?
Most people will take between 400 – 800 mg of Alpha GPC per day, but it has been used safely in studies at a dose of up to 1,200 mg per day. This higher dosage is generally reserved for the treatment of cognitive decline and Alzheimer’s disease. You can find out more about using this supplement at https://nootriment.com/alpha-gpc-dosage/
I use choline every day and its definitely helped my memory. But not sure what the best form of choline is.
Is the choline in eggs bioavailable or would it be the same as choline bitartrate? I can’t find what the actual type of choline is in eggs. Are there any studies looking at the increase in choline in the blood after eating eggs?
The choline found in eggs is bound to a phospholipid and is in the form of phosphatidylcholine and not choline bitartrate. There is no tartaric acid in eggs which is the additive that makes it a “bitartrate” :)
I have yet to come across a study looking at the bioavailability of choline from eggs unfortunately. According to this reference “No estimates are available for percentage absorption of the various forms of choline in humans.”
“Choline is an essential nutrient..”
Not “essential” in the sense that it must be provided whole from diet … choline is bio synthesized in normal metabolism. Not that supplementation is without effect, but it isn’t “essential”.
que cantidad o cuantas pastas debe tomar una persona que sufre de alzheimer etapa leve?
Choline Chloride, is absorbed directly into the body more efficiently, and therefore, is harder to find on the shelves because of general greed and evil. However, Feed quality, Choline Chloride, can be purchased on E Bay. Keep in mind, , it is hydroscopic, so have a sealable container that is air tight, and take a quarter of a teaspoon every few days.
All this praise of choline overlooks some serious dangers. Michael Greger, M.D., in his book, “How not to Die,” points out conclusive evidence that the choline in eggs greatly raises the risk of lethal prostate cancer in men (see pages 215, 216). The choline in eggs and meat is converted into a toxin called trimethylamine, which increases the risk of heart attack and stroke as well as of prostate cancer and other cancers–and of premature death generally.
Hi Dr. Benjamin,
Thanks for your comment. I recently finished reading Michael Greger’s book and looked into the choline research when I saw those claims being made.
There have been some studies in which a higher dietary intake of choline was correlated with an increased risk of aggravation of already diagnosed prostate cancer in men. This study is the one most frequently cited: https://www.ncbi.nlm.nih.gov/pubmed/22952174 – In this study, men who were diagnosed with prostate cancer and consumed the highest amount of choline-rich foods saw a 70% increased risk of lethal prostate cancer.
It’s very important to note that this is a correlation and not definitive evidence of causation. The top 5 choline-contributing food sources consumed in this study included “whole eggs, beef, skim milk, reduced-fat milk, and poultry without skin.” We know that consumption of these foods is already associated with greater prostate cancer risk. This study does not tell use whether it is the choline content that is mechanistically responsible for increasing the risk of lethal prostate cancer. Instead, it may be other compounds in these foods that are often found together with choline.
It would be valuable to get data on how the use of choline supplements effects prostate cancer risk, because then we could examine the effects of choline in isolation.
ND Jacob Schor has a good discussion of this in the Natural Medicine Journal http://www.naturalmedicinejournal.com/journal/2013-03/dietary-choline-increases-prostate-cancer-deaths
“While the link between choline and fatal prostate cancer is becoming clear, the risk-benefit analysis remains murky. Choline is an essential nutrient and is associated with a number of positive health effects, including possibly preventing fatty liver disease and cognitive decline in the elderly. We cannot and probably should not put all of our patients on choline-free diets.”
Men who have been diagnosed with prostate cancer should definitely consult with their doctors or oncologists before taking a choline supplement. But given the important roles that choline plays in the body as a methyl donor and precursor to acetylcholine, it would not be wise to cut out all choline from your diet.
[I strongly recommend that you remove all you DL-choline bitartrate ads if this is correct.]
Can you please mention differences between DL-choline bitartrate and L-choline bitartrate in https://nootriment.com/choline/#bitartrate.
“DL-Choline Bitartrate should not be used in pharma or food applications although the price is normally more attractive. Studies have that shown the DL-form has nefrotoxic effects (1). In Europe, according to the CODEX and European Union, only L-Choline Bitartrate is allowed because it is mentioned in DAB and in the USP monograph. The DL form does not comply with these monographs. Moreover, according to the FDA, L-Choline Bitartrate is considered GRAS affirmed (21CFR182.8250_2010) but not the DL-form.” – http://www.geelawsonnutritional.com/news/gee-lawson-news/42-what-you-are-buying-might-not-be-the-right-source-of-choline.html
“Urolithiasis in rats consuming a dl bitartrate form of choline in a purified diet.” – https://www.ncbi.nlm.nih.gov/pubmed/16158911 — Urolithiasis = Kidney stone disease
Can DL-choline bitartrate and L-choline bitartrate be disgusting by their characteristics:
* Smell: ?
* Taste: ?
* Smell: ?
* Taste: ?
You might want to mention the differences between the DL and L form of choline bitartrate at https://nootriment.com/choline-bitartrate/ as well.
Thanks for your comment :). I will get an article prepared on this topic!
Hola, compre bitartrato de colina 99% de pureza calidad ups fabricada en China, compre medio kilo para ir probando… a los 5 días de consumir 1,5 gramos diarios, me salieron sarpullidos en la cara, eso es normal? debería bajar la dosis?? son sarpullidos chicos, pegaditos uno a lado del otro, no son rojos, a simple vista no se ven, pero al tacto si.
Some people do experience rashes when they use Choline bitartrate supplements. If the rash persists, you may want to lower the dose, try a different brand of supplement or switch to another higher quality form of choline like Phsophatidylcholine, CDP Choline or Alpha GPC. I hope that information helps!
My chiropractor suggested I take Choline for my liver – since I have been taking Choline faithfully for three weeks my liver counts have dropped – a nice noticeable. drop.
Great to hear Dawn!
It would be excellent to know what type of choline supplement you’re using, info on the brand and what dosage you are taking.
Thanks for sharing your experience.