Citrulline malate reviews suggest that this supplement can have benefits for bodybuilding and athletic performance, as well as positive effects on energy, weight loss and sexual performance.
Research into Citrulline malate supplements demonstrates benefits for cardiovascular health, enhancing muscle building results, boosting immunity and for improving erectile dysfunction symptoms.
Citrulline malate is the supplement form of the amino acid L-citrulline (C6H13N3O3). This natural substance is L-citrulline with added esters of malic acid (C4H6O5); a crystalline dicarboxylic acid that gives certain fruits their sour tastes.
Current medicinal uses of citrulline malate include treatment and prevention for Alzheimer’s, erectile dysfunction, heart failure, diabetes mellitus, high blood pressure (hypertension) and more.



- Shown to raise blood arginine levels
- Increases Nitric Oxide & Growth Hormone
- Delays onset of fatigue during intense training
Citrulline Malate Reviews on Athletic Performance
Related Topics
- L-Citrulline
- Citrulline Malate
- L-Citrulline Supplements
- L-Citrulline Benefits
- Citrulline Malate Effects
- L-Citrulline Dosages
- Citrulline Malate Dosages
- L-Citrulline Foods
- Potential Side Effects
- Citrulline for Bodybuilding
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- Citrulline Malate Reviews
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- L-Arginine vs. L-Citrulline
Athletes including bodybuilders use citrulline malate as a pre-workout supplement to improve exercise performance and power output.
Along with L-ornithine and L-arginine, L-citrulline is an intermediate in the urea cycle.
This set of biochemical reactions converts ammonia (NH3) into urea ((NH2)2CO). Lactic acid is also released as a byproduct of the arginine urea cycle.
Accumulations of lactic acid and ammonia cause changes in intramuscular pH levels. When muscle become acidic (muscular acidosis), contractility is diminished. Muscular weakness and fatigue result.
Citrulline malate reviews show that it helps to clear ammonia and lactic acid out of the system.
Routine supplementation with citrulline malate has been shown to:
- Decreasing onset times and severity of delayed onset muscle soreness (DMS);
- Upregulating NO (nitric oxide) production and stimulating vasodilation;
- Improve the body’s elimination of nitrogenous substances;
- Improve usage of amino acids during exercise sessions;
- Facilitate more rapid recoveries from intense workouts;
- Increase growth hormone levels after physical activity;
- Suppressing insulin spikes after workouts;
Citrulline malate is a common ingredient in preworkout formulas. Some bodybuilders use doses between 6 and 8 grams about an hour before intense workouts to enhance performance.
Citrulline malate reviews show that it improves recovery times; both between sets and between workouts.
Citrulline Malate Reviews on Cardiovascular Health
Cardiovascular disease is the top killer in many countries. In the US, more than 785,000 people suffered heart attacks in 2009 alone. According to the CDC, every minute, at least one person dies in the US from a coronary event
Blood vessel endothelial vasodilation may play beneficial roles in preventing and/or treating clogged arteries (atherosclerosis), angina (severe chest pains), coronary artery disease – and the subsequent development of heart disease.
L-citrulline is an L-arginine precursor. In fact, supplementing the diet with L-citrulline increases L-arginine levels more than supplementing with L-arginine.
During the urea cycle, L-citrulline is converted into L-arginine which is then released into the blood. Some of the available arginine in the system is converted to nitric oxide.
Nitric oxide is a potent vasodilator. Vasodilation relaxes smooth muscle tissue and helps to increase blood flow to areas of the body which need it most.
A given tissue may not be receiving adequate supplies of lipids, glucose and/or other nutrients. When L-arginine is converted to NO inside the endothelium of blood vessels, they open up and accommodate increased blood delivery.
By increasing the delivery of blood to certain muscles, tissues and organs throughout the body, more oxygen, nutrients, proteins, hormones and enzymes are also delivered.
This is helpful for:
- Promoting healthy modulation of blood pressure, especially in those already within normal blood pressure range;
- Promoting cardiovascular health via improved endothelial functioning;
- Supporting improved endothelial vascular functioning;
Citrulline malate reviews suggest that this supplement can decrease blood pressure, improve energy levels and promote health benefits that are linked to increased circulation.
Citrulline Malate Reviews for ED
ED (erectile dysfunction) is marked by the inability to achieve and maintain firm erections in men. It is most often caused by restricted blood flow to the corpus cavernosum.
The Corpus cavernosum are the shafts inside a penis which fill with blood when sexual stimuli are experienced. When blood cannot enter these shafts, hard erections are not possible.
Citrulline malate reviews show that it works to increase erection hardness in men with mild-to-moderate ED.
It does not act as strongly as common PDE-5 inhibitors like Viagra and Levitra. However, these prescription drugs are associated with multiple serious side effect potentials. Some of these include rage, hearing loss, stroke and testicular cancer.
Citrulline malate is a natural substance which is not associated with any adverse effects. Some citrulline malate reviews have reported on the psychological benefits associated with supplementation for ED treatment.
Subjects reported strong increases in psychological well-being concerning the safety of citrulline malate relative to mainstream PDE-5 inhibitors. They state that they feel more relaxed because they are not concerned about the potential adverse effects.
Conclusions
Citrulline malate reviews show that routine supplementation can yield various benefits. The majority of its positive effects stem from its capacity to indirectly upregulate nitric oxide synthesis and availability.
Using citrulline malate supplements in conjunction with medications with antihypertensive potentials is not recommended.
Some of these include nitrates, PDE-5 inhibitors and blood pressure medications. This can increase risks for excessive drops in blood pressure (hypotension).
To be sure that citrulline malate is safe for you, speak with a doctor before beginning supplementation. Make sure he understands your health history, as well as any pharmaceuticals and/or herbal supplements you may be taking.
- Yudkoff M. Urea Cycle. In: Siegel GJ, Agranoff BW, Albers RW, et al., editors. Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 6th edition. Philadelphia: Lippincott-Raven; 1999.
- Cunniffe B1, Papageorgiou M, O'Brien B, Davies NA, Grimble GK, Cardinale M. Acute Citrulline-Malate supplementation and high-intensity cycling performance. J Strength Cond Res. 2016 Jan 19. [Epub ahead of print]
- Sureda A1, Córdova A, Ferrer MD, Pérez G, Tur JA, Pons A. L-citrulline-malate influence over branched chain amino acid utilization during exercise. Eur J Appl Physiol. 2010 Sep;110(2):341-51. doi: 10.1007/s00421-010-1509-4. Epub 2010 May 25.
- Thibault R1, Flet L, Vavasseur F, Lemerle M, Ferchaud-Roucher V, Picot D, Darmaun D. Oral citrulline does not affect whole body protein metabolism in healthy human volunteers: results of a prospective, randomized, double-blind, cross-over study. Clin Nutr. 2011 Dec;30(6):807-11. doi: 10.1016/j.clnu.2011.06.005. Epub 2011 Jul 5.
- Pérez-Guisado J1, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 2010 May;24(5):1215-22. doi: 10.1519/JSC.0b013e3181cb28e0.
- Cormio L1, De Siati M, Lorusso F, Selvaggio O, Mirabella L, Sanguedolce F, Carrieri G. Oral L-citrulline supplementation improves erection hardness in men with milderectile dysfunction. Urology. 2011 Jan;77(1):119-22. doi: 10.1016/j.urology.2010.08.028.
- Bendahan D1, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med. 2002 Aug;36(4):282-9.
- Cormio L1, De Siati M, Lorusso F, Selvaggio O, Mirabella L, Sanguedolce F, Carrieri G. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. 2011 Jan;77(1):119-22. doi: 10.1016/j.urology.2010.08.028.
- Pérez-Guisado J1, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 2010 May;24(5):1215-22. doi: 10.1519/JSC.0b013e3181cb28e0.
- Figueroa A1, Trivino JA, Sanchez-Gonzalez MA, Vicil F Oral L-citrulline supplementation attenuates blood pressure response to cold pressor test in young men. Am J Hypertens. 2010 Jan;23(1):12-6. doi: 10.1038/ajh.2009.195. Epub 2009 Oct 22.
- Ochiai M1, Hayashi T, Morita M, Ina K, Maeda M, Watanabe F, Morishita K. Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men. Int J Cardiol. 2012 Mar 8;155(2):257-61. doi: 10.1016/j.ijcard.2010.10.004. Epub 2010 Nov 9.
- Orozco-Gutiérrez JJ1, Castillo-Martínez L, Orea-Tejeda A, Vázquez-Díaz O, Valdespino-Trejo A, Narváez-David R,Keirns-Davis C, Carrasco-Ortiz O, Navarro-Navarro A, Sánchez-Santillán R. Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction. Cardiol J. 2010;17(6):612-8.
Article last updated on: March 12th, 2018 by Nootriment