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Jako kanadský, smíte legálně koupit Provigil?
This drug is one of the best regarded treatments for serious sleep disorders such as narcolepsy, práce na směny poruchy spánku, and obstructive sleep apnea/hypoponea syndrome. It is commonly used off-label for ADHD, daytime fatigue, certain types of cognitive decline, a as a general cognitive enhancing smart drug.
Je známo, pro posílení mozkové funkce související s pozornost, koncentrace, logické myšlení, učení, stejně jako ukládání a načítání vzpomínky. Z těchto důvodů, many Canadians are interested in taking Provigil to sharpen their mental faculties and boost their productivity or level of success at work or school.
I když Provigil se široce používá v USA, je obtížné najít v Kanadě, primarily because the name brand version of Modafinil sold in Canada is Alertec.
Jaký je právní status Provigil v Kanadě a jste oprávněni kupovat z jiných zemí jej importovat?
Bdělosti
Duševní bystrost
Zaměření- Stimuluje bdělost v mozku
- Podporuje duševní čilosti & zpracování
- Zvyšuje zaměření, motivace & energie
Provigil
Příbuzná témata
- Co je Modafinil? (Provigil)
- Jak Provigil funguje?
- Účinky a výhody
- Uživatelské recenze
- Typické zkušenosti
- Doporučené dávky
- Jak se přípravek
- Provigil využití
- Použití pro ADHD
- Účinky na hubnutí
- Negativní vedlejší účinky
- Zneužití varování & nebezpečí
- Srovnání s Adrafinil
- Srovnání s Armodafinil
- Srovnání k Adderall
- Kde koupit
- Obecný Modafinil značky
- Je Modafinil právní?
- Jak se dostat Modafinil
- Přehled zdrojů Online
Přípravek Vigil je jedním z obecné obchodní značky pro lék Modafinil which is sold worldwide by Cephalon (a subsidiary of Teva Pharmaceutical Industries since 2011).
To byly značkové pod různými jmény v různých zemích.
Provigil je obchodní název pro Modafinil prodaný v Belgii, Irsko, Itálie, Jižní Korea, Velká Británie, Spojené státy, Jihoafrická republika a Izrael.
V Kanadě, Modafinil se prodává pod Značka Alertec, takže lékaři a lékárníci jsou často obeznámeni s obchodním názvem Provigil.
Pro kanadské občany, Provigil will most often be the brand you will encounter if you research Modafinil from an online source located in the United States nebo ve Spojeném království.
Provigil (Modafinil) je lék vyvinutý speciálně k léčbě narkolepsie, poruchy spánku pracovní směny a nadměrné denní únava z důvodu obstrukční spánkové apnoe.
Tento lék se používá off-label pro many purposes including ADHD, zlepšení vnímání, ztráta hmotnosti, vylepšení výkonu pro sportovce, únava, Některé Psychiatrické poruchy, neurodegenerativních onemocnění, roztroušená skleróza, depersonalizace poruchy a kokain závislost.
Vláda Spojených států má značně experimentoval s modafinilem, většinou v souvislosti s řešením problému únavu vojáků a piloti, kteří se ocitnou v situacích, ve kterém musí zůstat obezřetní a vzhůru déle než 24 hodin.
Historie modafinilu
Modafinil byl nejprve vyvinut ve Francii v 1976 od Michel Jouvet, an experimental medicine professor working for Lafon Laboratories (Singgjä byla koupena Cephalon v 2001). The discovery of Modafinil came about because of testing done on a compound called Adrafinil.
Adrafinil and Modafinil have very similar molecular structures, with the only difference being that Modafinil does not have a hydroxyl group that Adrafinil has on its terminal amide. The reason for this high degree of similarity is because Adrafinil je ve skutečnosti proléčivo Modafinil.
Po požití, Adrafinil cestuje přes krevní řečiště jater, where it is metabolized and fully broken down into its component parts, konkrétně modafinilic kyselina a Modafinil. In testing to determine Adrafinil’s mechanism of action in the body, Modafinil was found to be the primary active compound that is the cause of Adrafinil’s effects.
Both compounds are considered eugeroics, or compounds that promote wakefulness. Má podobné povzbuzující účinky, however they are not chemically related to traditional amphetamine based stimulants, and they work differently in the body.
After the discovery of Modafinil, research on Adrafinil still continued for a while. Adrafinil was first tested for use in humans as a drug to treat narcolepsy sleep disorder. It was approved for this use in France in 1986.
Once Modafinil could be produced on its own without conversion from Adrafinil, and after it had gone through animal testing of its own, production of Adrafinil was slowed. Modafinil was more potent and faster acting then its predecessor, and therefore commanded more research and funding. Eventually Cephalon stopped production of Adrafinil and focused solely on Modafinil. Adrafinil is produced again today by other manufacturers however.
Provigil for Sleep Disorders
Like its predecessor Adrafinil, Modafinil was first tested as a treatment for narcolepsy in humans. Narcolepsy is a neurologically based sleep disorder that causes excessive sleepiness during the day that is unrelated to quality and quantity of nighttime sleep. Narcoleptics also can fall asleep randomly multiple times per day, často bez varování.
Modafinil has been tested in many different double-blind placebo-controlled clinical trials, a to bylo vidět significantly improve wakefulness and decrease excessive daytime sleepiness when compared against a placebo. V jedné studii, ve srovnání s placebem, Provigil was seen to improve the mean sleep latency time by up to 54%, měřeno pomocí udržování bdělosti.
Modafinil is approved as a prescription treatment for narcolepsy in Canada. It has also been approved as a treatment for two other serious sleep disorders, shift-work sleep disorder and obstructive sleep apnea/hypoponea syndrome.
Shift-work sleep disorder is caused by disturbances to the normal circadian rhythm that our bodies follow. Lidé jsou přirozeně vypařováním, awake during the day, sleeping at night. Because of needing to work overnight or very late night work shifts, some people must be awake at night, a pak spát přes den.
This switching of the natural bodily schedule can cause excessive sleepiness while awake at night, and insomnia when trying to sleep during the day. V hodnoceních, Provigil has been seen to improve work performance and decrease lapses in attention as measured by the Psychomotor Vigilance test better than a placebo.
Obstructive sleep apnea/hypopnea syndrome is a condition that affects breathing during sleep. Hypopnea refers to labored, shallow breathing that is caused by a partial blockage of the upper airway, while apnea refers to the temporary cessation of breathing due to complete airway blockage.
These episodes of interrupted breathing can occur multiple times per hour during sleep, leading to poor quality sleep, and subsequently excessive sleepiness during the day. The most common treatment for this condition is wearing a continuous positive airway pressure (CPAP) machine while sleeping to help keep the airway open and unobstructed.
I s touto léčbou pro podmínku, Někteří lidé stále přetrvávají reziduální Nadměrná denní spavost. V těchto případech, Provigil has been seen to be an effective treatment for the excessive sleepiness, and improves scores on the Epworth Sleepiness Scale significantly compared to placebo.
- Zvýšení energie, bdělost a motivace
- Zvyšuje duševní výkonnost a zaměření
- Podporuje paměť a poznávání
Modafinil pro ADHD
Jak již bylo zmíněno dříve, Provigil is officially approved as a treatment for narcolepsy, práce na směny poruchy spánku a syndrom obstrukční spánkové apnoe/hypopnoe. Any other uses of Provigil are technically off-label uses.
Modafinil has been used off-label for a large number of uses, including for disease related fatigue associated with depression, roztroušená skleróza, fibromyalgie, a Parkinsonova nemoc; schizofrenie; ztráta hmotnosti; ADHD; a jako kognitivní enhancer.
One of the most popular off-label uses of Provigil is as a treatment for the symptoms of attention-deficit disorder (PŘIDAT) a pozornost deficit nepořádek hyperaktivity (ADHD). In multiple different studies, Provigil has been seen to significantly improve the symptoms of ADHD compared to placebo, as measured by a variety of tests including the ADHD Rating Scale-IV School and Home Versions, Klinické globální dojmy-zlepšení měřítko, the Conners Rating Scales, and the Teacher and Parent ADHD Rating Scale-IV.
Provigil has even been tested against a conventional ADHD medication to show its efficacy. Ve studii, Provigil was compared to dextroamphetamine (Dexedrin) and a placebo. It was observed that both active medications improved scores on the DSM-IV ADHD Behavior Checklist for Adults significantly over placebo. Provigil was seen to perform similarly compared to the dextroamphetamine.
There are some doctors who will consider writing prescriptions for Provigil for their patients with ADHD. This most commonly happens in situations where previous use of conventional amphetamine or methylphenidate stimulants like Adderall and Ritalin have either not worked as well as wanted, nebo způsobit vážné vedlejší účinky (amphetamine can have negative cardiovascular effects).
Use of Provigil for ADHD is not currently recommended for pediatric patients due to a single case of a negative reaction in a research trial. A doctor diagnosed the child with Stevens-Johnson syndrome, and even though the diagnosis was later recanted, use in children has not been approved since that time. Tato podmínka, while quite serious, is considered a very rare possibility, and is believed to only affect certain people (more information in the Side Effects section below).
Using Provigil as a Nootropic
The other most popular off-label use of Provigil is as a nootropic smart drug. A large variety of people from university students to business executives have reported using Modafinil as a way to give themselves a mental edge.
In addition to helping relieve fatigue and give a boost of energy throughout the day, Provigil has been said to zlepšit schopnost učit se, zaměření, koncentrace, motivace, a paměť. Thoughts are said to flow more easily, and information is retained better. Users report being highly motivated and focused on their tasks, often working for many hours straight without distractions.
One literature review of studies done on Modafinil found that there was a trend across the research showing that the drug may help improve memory, specifically in the areas of working memory and episodic memory. Another literature observed that Modafinil may help improve executive function (řízení času, řešení problému, plánování) when completing difficult and complex tests and tasks.
One research study had participants take a series of cognitive tests and assessments before being given either a placebo or Provigil, and then also completing the same tests at 90 a 180 minut po požití. Provigil was seen to significantly improve scores from baseline on reakční čas, motivace, bdělost, and fatigue levels, compared to any improvements seen between baseline and placebo scores.
In one randomized double-blind, between-subjects study, participants were given either Provigil or a placebo and then asked to complete a battery of neuropsychological tests that assessed memory and attention. Compared to scores from placebo patients, scores from patients given Provigil were significantly improved on tests of digit span memory and visual pattern recognition memory, as well as a spatial planning task and a test of stop-signal reaction time.
There was also seen a small increase in response time on a few tests, including a decision-making task, opožděné porovnávání vzorku testu, as well as the spatial planning task. The researchers believe that this delay allowed for the inhibition of prepotent responses (responses that are habitual or ingrained, but are counter to the task at hand), and therefore may show beneficial effects for people with ADHD, even though this study was conducted in neurotypical participants.
Proto, Provigil is not thought to increase the speed of thoughts and reasoning, but instead may help to control impulsive responding, allowing for overall improvements to performance.
Provigil vs. Alertec
V Kanadě, Provigil se není regulovaná látka which means that it is legal to possess this drug. Je to, Nicméně, classified as a Schedule I prescription-only medication, and is listed on the Prescription Drug List (který nahradil F plán pro výživu a léky).
Therefore you must have a doctor’s prescription to buy this medication in Canada legally.
Došlo k určité nejasnosti, zda Alertec obecný Provigil, ale to není. Je to simply a different brand name for the same product. Provigil a Alertec jsou prostě různé obchodní značky na stejný lék (Modafinil). Není žádný rozdíl mezi nimi.
Pokud jste kanadským občanem a chcete hovořit s lékařem o předpis pro Modafinil, Váš recept bude zapsán pro “Alertec”.
V některých případech může lékař obsahovat frázi Generické substituce OK, aby bylo možné pro Modafinil za jiné obchodní název pro vyplnit váš recept.
Lidé hlásili dovážet Modafinil v mnoha různých značek, jako Provigil, Modalert, Modiodal a Modavigil úspěšně, s i bez lékařského předpisu.
Ve většině případů, Uživatelé se raději objednat obecné formy Modafinil namísto nákupu Provigil droga značkou v Kanadě. Důvodem je, že generics are much cheaper but still contain the same active ingredient.
To bylo řečeno, objednávání Provigil (nebo některé alternativní Modafinil) z online lékárna based in another country is not a straightforward proposition. There are a few factors to to be aware of before you consider doing this.
The first issue surrounds the legality of importing medications. While it is legal to import prescription medication in the United States with proof of a prescription, laws in Canada do not allow the importation of prescription drugs by individuals even when a doctor’s prescription is present.
Dovoz regulovaných léků bez lékařského předpisu může vést k zabavení zásilky na hranicích celními orgány. Tyto předpisy jsou známé pro nekonzistentně prosazena; jen proto, že někdo, koho znáte mohl objednat Provigil do Kanady z jiné země však neznamená, že budete mít stejné štěstí.
Legal repercussions which could ensue, i když v současné době jsme neslyšeli o některou s ohledem na dodávky v malých množstvích obvykle vyhrazena pro osobní použití. Osobní potřebu množství jsou tvořeny 30-60 denní nabídky.
Can I Buy Provigil in Canada Without a Prescription?
Rychlé vyhledávání na Google vám poskytne více on-line prodejci Provigil. Any legitimate pharmacies will be operating according to the regulations of both their own country, as well as the ones they ship to, and will require proof of a prescription.
Nicméně, in addition to these pharmacies, Existuje mnoho online obchody nabízí prodej Provigil nebo jiné značky Modafinil bez lékařského předpisu. Slyšeli jsme dobré i špatné zprávy o těchto typech prodejců. There is always a risk when dealing with an individual or a company who is working outside the regulations of the law.
Jedním z rizik v tom tak zahrnuje vaše finanční údaje, pokud vyžadují platbu pomocí kreditní karty. Druhé riziko je, že vaše zásilka může nikdy odeslána. A third risk is that your shipment could be seized in customs, because as described earlier, importation of prescription drugs is not legal in Canada, i s předpisem.
Nakonec, if you do receive your order you will be unable to determine if you have received real Provigil or not. There are typically not good manufacturing procedures in place, or quality assurance standards set by the distributors. Some legitimate online pharmacies will be able to provide Certificates of Analysis for their products, but most grey market online pharmacies will not.
Existují laboratoře, které můžete poslat vzorek k testování čistoty, but this would be quite costly to do for every shipment you get. Navíc, if your results are not good and the product is not pure or actually Modafinil, nemáte žádný způsob využití.
Legal Non-Prescription Provigil Alternatives
Buying prescription medications from online pharmacies can be tempting, as prices are cheap online. However if you try to buy Provigil or buy Modafinil online as a Canadian, it comes with many inherent risks. Many people are unwilling to take these risks, and therefore turn to non-prescription alternatives such as Adrafinil or one of the Racetams.
With Adrafinil, you will be able to experience the same effects of Modafinil, but without needing a prescription. Jak je popsáno výše, Adrafinil je proléčivo Modafinil. Je to broken down in the liver into the active Modafinil.
Adrafinil není tak silný jako Modafinil, as not all of the compound is directly converted into Modafinil; Proto, you will need a higher dosage to get similar effects of a normal Modafinil dosage. Také, Adrafinil takes longer to take effect, as it must be metabolized in the liver. But after that initial delay, users say that the effects are quite comparable to Modafinil.
Another non-prescription nootropic option that some people use as a Provigil substitute is one of the Racetam group of compounds. This family of nootropics is based off of Piracetam, considered the first nootropic.
Vyvinut v roce 1960, Piracetam has been seen in many different studies to have positive effects on the neurotransmitter Acetylcholine. Elevated levels of Acetylcholine is associated with improved formování paměti, uchování, a odvolání, as well as enhanced overall cognition.
Since the developement of Piracetam, byly vyvinuty účinnější deriváty, that often have even more specialized effects. Například, Aniracetam and Oxiracetam are considered 3-6 times more powerful than their parent compound, while Phenylpiracetam is thought to be as much as 50-60 stejně silný jako Piracetam krát. Pramiracetam – 30 stejně silný jako Piracetam krát – is said to increase mental energy levels and alertness for up to 8 hodin, making it an ideal alternative to Provigil.
Adrafinil and the Racetams are categorized as unscheduled, unregulated compounds in the Canada and many other countries, včetně Spojených států. The sale of compound like this is somewhat restricted, making it hard to find them sold domestically, however they are entirely legal to buy and are available from many online nootropic stores.
Provigil vedlejší účinky
If you end up buying Provigil from an international online pharmacy and receive your product, it is possible you may have a product that is not entirely pure. Contaminants in the product could cause unwanted side effects, which is one of the key risks inherent in buying from these places.
If you do receive legitimate Modafinil, or if you are taking the drug legally with a prescription, then there are still some common side effects to be aware of. While generally well tolerated in adults, there have been reports from research studies and user reviews of the following common side effects: bolesti hlavy, nevolnost, úzkost, nervozita, zažívací potíže, pálení žáhy, zvracení, průjem, bolest zad, sucho v ústech, suchá kůže, a nespavost.
Some people need a little while for their bodies to adjust to new medications. Side effects caused by this often subside within a couple weeks. If you are still experiencing side effects after that then speak with your doctor.
One common side effect, insomnie, is often caused by dosage timing. The half-life of Provigil is between 12-15 hodin. If you take a dosage of this drug too late in the day, then you may still experience its stimulating effects late into the evening/night. It is recommended to take your dosage in the morning before noon if you have experienced sleep disturbances.
Jak již bylo zmíněno, certain serious skin and mucous membrane reactions are possible when taking Provigil, včetně Stevens - Johnsonova syndromu, toxická epidermální nekrolýza (DESET), a léková reakce s eosinofilií a systémovými příznaky (ŠATY). There has been strong evidence suggesting that some people may have a genetic predisposition to develop these conditions if you take certain medications, včetně Provigil.
Stevens - Johnsonův syndrom, while considered the least serious, but still potentially fatal, is the most likely reaction to occur (although no documented cases have been seen in research studies in adults, and the one pediatric case was retracted). Mezi příznaky patří horečka, bolest v krku, ucpaný nos, body aches/pains, a červená/fialová vyrážka u ústí, nos, oči, a pohlavní orgány, that spreads and blisters.
Pokud máte některý z těchto příznaků, it is imperative that you stop taking Provigil immediately, and go to an emergency room or contact your doctor to determine a treatment plan.
Provigil v Kanadě Shrnutí
Přípravek Vigil je obchodní název pro Modafinil v několika zemích než Kanada. V Kanadě, Modafinil je prodáván pod značkou Alertec. It is an approved treatment for a number of serious sleep disorders. Další použití Provigil jsou považovány za off-label.
There are some doctors who will write off-label prescriptions for Provigil for uses such as ADHD, however it can be hard to find these doctors. Z tohoto důvodu, some Canadians will turn to the internet grey market to buy generic Provigil online, however this proposition has a number of risks involved.
Pokud nejste schopni získat předpis pro Modafinil, another option is to look for Adrafinil which is not regulated in Canada and produces largely similar effects compared to Provigil.
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Doprava zdarma
- Chapman JL, Kempler L, Čang CL, Williams SC, Ľubica S, Wong KK, Yee BJ, Grunstein RR, Marshall NS. Modafinil zlepšuje denní spavost u pacientů s mírnou až středně obstrukční spánková apnoe není pomocí standardní léčby: randomizované placebem kontrolované zkřížené studii. Hrudník. 2014
- Rabkin JG, McElhiney MC, Rabkin R, McGrath PJ. Modafinil léčba únavy v HIV/AIDS: randomizované, placebem kontrolované studii. J Clin Psychiatry. 2010
- Parnell H, Ucholub G, Farmář S, Hana S, Varney V. Úspěšná léčba hypercapnic respirační selhání s ústní modafinil. Int J Chron bránit Pulmon Dis. 2014
- Generali JA, Cada DJ. Modafinil: Parkinsonova choroba související ospalost. Hosp Pharm. 2014
- Kalechstein AD, Mahoney JJ 3., Yoon JH, Bennett R, De la Garza R 2.. Modafinil, ale ne escitalopram, zlepšuje pracovní paměť a trvalá pozornost v dlouhodobé, Uživatelé vysokých dávek kokainu. Neurofarmakologie. 2013
- Joos L, Goudriaan AE, Schmaal L, Fransen E, Van den Brink W, Sabbe BG, Dom G. Účinek na impulzivity a recidivy u pacientů závislých na alkoholu: randomizované, placebem kontrolované studii. EUR Neuropsychopharmacol. 2013
Článek naposledy aktualizován: 12. dubna, 2018 od Nootriment