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Provigil (Modafinil, Modalert) spadá do skupiny Eugeroic léků, používá ke stimulaci mysli a zvýšit bdělost.
It is prescribed clinically in the treatment of sleep disorders with millions of users worldwide.
Provigil is also taken as a nootropic supplement by individuals who want to “Hack” their brain to become more productive and achieve greater cognitive abilities.
While this nootropic is considered safer and better tolerated than traditional stimulants which can become addictive of cause withdrawal symptoms, Existují nějaké vedlejší účinky, být si vědom.
Ve většině případů, Provigil side effects will be mild and will only last for a short period of time i když tam bylo pár vážnější nežádoucí účinky hlášené.
Tam jsou také některé lékové interakce být si vědom a každý, kdo se již existujícího zdravotního stavu, poraďte se svým lékařem před použitím tohoto léku.
Bdělosti
Duševní bystrost
Zaměření- Stimuluje bdělost v mozku
- Podporuje duševní čilosti & zpracování
- Zvyšuje zaměření, motivace & energie
Jak Provigil funguje
Příbuzná témata
- Co je Modafinil? (Provigil)
- Jak Provigil funguje?
- Účinky a výhody
- Uživatelské recenze
- Typické zkušenosti
- Doporučené dávky
- Jak se přípravek
- Provigil využití
- Použití pro ADHD
- Účinky na hubnutí
- Negativní vedlejší účinky
- Zneužití varování & nebezpečí
- Srovnání s Adrafinil
- Srovnání s Armodafinil
- Srovnání k Adderall
- Kde koupit
- Obecný Modafinil značky
- Je Modafinil právní?
- Jak se dostat Modafinil
- Přehled zdrojů Online
Přípravek Vigil je bdělost a ostražitost posílení lék užívaný k léčbě nadměrná únava v průběhu dne, Narkolepsie, spánkové apnoe, a práci na směny poruchy.
Mnoho uživatelů hodnocení říci, že při užívání tohoto léku, to zcela eliminuje potřebu spánku a činí je soustředěnější a energický.
Jako off-label chytré drogy, získala přízeň mezi podnikateli, studenti a další lidé pracující ve vysoce konkurenčních odvětvích, pomoci jim dostat dopředu.
Je to obvykle zakoupeny jako obecných Modafinil od online lékárny nebo jako Adrafinil, což je právní předpis, bez alternativní, ve skutečnosti převede na Modafinil v játrech.
Clinical trials have demonstrated that Provigil has a positive effect on mental performance in areas such as memory, analytické uvažování, uchovávání informací, a koncentrace.
This pharmaceutical works by stimulating the central nervous system, though not with the same mechanism of action of typical stimulants like Adderall or even caffeine. Provigil increase the release of catecholamines such as Norepinephrine and Dopamine in the brain. These neurotransmitters are both involved in our energy levels as well as attention-assigning functions in the brain.
Provigil also raises levels of the neuropeptide Orexin by strongly activating Orexin-secreting neurons. Orexin stimuluje uvolňování neurotransmiteru histaminu v hypothalamu. This increase in Histamine leads to higher levels of wakefulness and perceptual awareness.
The hypothalamus is the system in your brain that regulates sleep cycles and fatigue. Podle rostoucí histaminovým činností, Provigil v podstatě blokuje pocit únavy a umožňuje zůstat produktivní více hodin za den.
Uses of Provigil
Modafinil byl nejprve testovány pro použití u lidí jako léčba pro narkolepsii porucha spánku. V mnoha různých dvojitě zaslepených placebem kontrolovaných klinických studiích provedeno v letech, Modafinil byla zjištěna být úspěšná léčba narkolepsie. To bylo vidět výrazně snížit nadměrné denní spavosti a zvýšit bdělost nad placebo.
Provigil byl také testovány a schváleny jako léčba nadměrné spavosti spojené s poruchou spánku práce na směny (SWSD). Někteří lidé rozvíjet tuto podmínku, když jsou nuceni pracovat noční směny v zaměstnání. Při užívání modafinilu, lidé s SWSD byly pozorovány na lepší pracovní výkon, nad jejich účaří a oproti placebu.
Modafinil byl také schválen jako doplněk léčby pro syndrom obstrukční spánkové apnoe/hypopnoe (OSAHS). U některých lidí, tradiční léčba pro tuto podmínku (pomocí CPAP stroj v noci) ještě jim ponechává nadměrná spavost během dne, a bylo vidět, že Provigil úspěšně snížit tuto ospalost.
Modafinil je klasifikována FDA v Spojené státy jako rozvrh IV jen předpis léku. Provigil je oficiálně schválený na label použití jsou pro výše popsané poruchy spánku.
Nicméně, Existuje mnoho více off-label použití, které Modafinil byla přijata pro. Odhaduje se, že až 90% ze všech receptů napsal jsou přijímána pro off-label použití. Některé off-label použití týkají zpět na Provigil je schváleno použití, jako, když je přijata ke snížení únavy spojené s určitými, včetně roztroušená skleróza, deprese, fibromyalgie, a Parkinsonova nemoc.
Jeden velmi časté užívání vztahuje k si Provigil stimulující, koncentraci zvýšit účinky: často se používá pro zlepšení příznaků pozornost deficit nepořádek hyperaktivity (ADHD). V mnoha různých studiích, Provigil byla zjištěna snížit symptomy ADHD, měřeno počtem testů včetně kontrolního seznamu chování ADHD DSM-IV, Učitel a rodič ADHD hodnocení stupnice IV, a klinické globální dojmy-zlepšení rozsahu.
Provigil se také velmi často používá off-label jako kognitivní zlepšení chytré drogy, nebo nootropní. Širokou škálu lidí z vysokoškoláků do podnikatelé používají tento lék na zlepšení jejich koncentrace, zaměření, motivace, a paměť.
Bylo provedeno několik studií použití Provigil jako kognitivní enhancer. Jedna studie zjistila, že ve srovnání placebem, Modafinil snižuje únavu úrovně, Vylepšené bdělost, Snížená doba náběhu, a zlepšení motivace. Another study saw that compared to a placebo, Provigil patients had improved performance on a spatial planning task, signál stop test reakční doba, and memory tests of visual pattern recognition and digit span.
Provigil vedlejší účinky
Provigil is considered to be one of the strongest nootropics available and with great strength there usually comes some chance of side effects.
Zatímco Provigil is regarded as safe by the medical community, there have been reports of some negative reactions to this drug.
Most of the side effects commonly encountered when using this wakefulness promoter are benign and only cause some temporary discomfort. The most frequently reported side effects include headaches and nausea.
Less frequently reported effects can consist of nervousness, ztráta chuti k jídlu, úzkost, točení hlavy, sucho v ústech, and insomnia especially when taken late in the day.
Ve velmi vzácných případech, Přípravek Vigil je spojováno s bolestí na hrudi, hypertenze, tachykardie, parestezie, zánět hltanu, a poruchy příjmu potravy.
Vedlejší účinky mohou být zvláště patrné, když jste nejprve začíná Provigil a obvykle zmizí nebo odezní po několika dnech. Tyto vedlejší účinky může být také snížena nebo potenciálně nemůže zůstat dobře hydratované a použitím multivitaminový doplněk.
Další jedinci říkají, že výkonu nebo pomocí dopaminu posílení dodatek na konci jeho poločas pomáhá snižovat negativní dopady tohoto stimulant.
Devět z nejčastěji hlášených mírné Provigil nežádoucí účinky jsou uvedeny níže, s všechny známé způsoby, jak pomoci zabránit nebo zmírnit.
- Zvýšení energie, bdělost a motivace
- Zvyšuje duševní výkonnost a zaměření
- Podporuje paměť a poznávání
1. Bolesti hlavy
Bolesti hlavy jsou nejčastěji uváděné Provigil vedlejší účinek. V několika recenzích bylo odhadnuto, že až polovina všech uživatelů, Provigil zkušenosti bolesti hlavy v určitém okamžiku, když se vezme drogu.
Přesná příčina těchto bolestí hlavy je stále neznámý, jako to nebylo zkoumáno přímo, ale to dá rozum, že zvýšená hladina histaminu může být ve hře. Patofyziologie za ním je stále předmětem studia, ale bylo zjištěno, že zvýšené hladiny histaminu může způsobit bolesti hlavy clusteru.
Jiná teorie, že někteří uživatelé mají je, že vzhledem intenzivní soustředění a zaměření, které mohou způsobit Provigil, Ať zapomenete pít správné hladiny vody po celý den, vedoucí k dehydrataci a následné bolesti hlavy. Nastavení budíků po celý den na ni nezapomněli zůstat hydratované mohl pomoci.
Pro některé lidi, the headaches are present only when they begin taking the drug, and subside after a few weeks as their bodies adjust. Nicméně, if your headaches persist, and you want to/need to keep taking Provigil, then you may want to consider using an over-the-counter pain reliever NSAID, například ibuprofen.
Users have reported that this can significantly reduce Provigil headaches. However some people may not want to have to take these drugs on a long-term basis due to concerns of elevated hepatotoxic enzymes, and this a personal choice you must make.
2. Digestive Upsets
Nausea is often the second most reported Provgil side effect, typically second only to headaches. Some people also report having heartburn, zažívací potíže, bolesti žaludku, and even in some cases vomiting. Other users have reported that Provigil does not cause them issues when they initially take it, but that they later have diarrhea.
The exact cause of these symptoms can vary from person to person. For some people it just comes down to their physiology and not being able to handle the drug properly. Sometimes a lower dosage may help, but this isn’t the case for everyone.
One theory suggests that dehydration may be the cause of some digestive issues. Users report that large amounts of water should be consumed while taking Modafinil, over and above normal water consumption levels even for well hydrated people.
It has also been suggested that due to its stimulating effects that Modafinil may cause increased rates of digestion, leading to indigestion and diarrhea; similar effects have been reported from people who take amphetamine based stimulants.
Keeping well hydrated is one of the key suggestions for avoiding or minimizing many digestive upsets with Provigil. Users have suggested that a divided dose can help relieve some digestion issues.
One of the key suggestions is to take a lower dosage for a while and see if effects subside. What is considered a “normální” dosage for most people is simply too much for others, and a lower dosage can help.
3. Nervozita/úzkost
Some people have reported feeling anxiety and/or nervousness when taking Provigil. Users report that they can simply have a “fluttery” feeling in their chest or stomach or have symptoms as severe as a full panic attack.
While people who have existing anxiety issues may be slightly more likely to experience this, there are many user reports from people who do not have existing anxiety conditions also report this side effect occurring.
It has been suggested that these effects may be due to the fact the Provigil may affect the neurotransmitter GABA in the brain. V výzkum na zvířatech, Modafinil has been seen to decrease levels of GABA. It stands to reason that this effect would be seen in humans as well.
GABA is the primary inhibitory neurotransmitter known to counteract the excitatory neurotransmitter Glutamate; decreased levels of GABA have been observed in people with anxiety disorders in research studies.
Some suggestions for improving the anxious feelings including taking a lower dosage for a while and seeing if the symptoms improve. It has also been recommended by users to avoid taking caffeine with Provigil if you have this side effect. Taking the supplement L-Theanine has also been suggested by some users.
4. Loss of Appetite and Weight
Some users have reported having a significantly decreased appetite when taking Provigil. They report that they simply do not feel hungry while taking the drug. Others report that they become so focused on their work or studies that they simply forget to eat.
This loss of appetite can in turn lead to weight loss. While weight loss may be considered a benefit to some, it is not to others. Some people will even use Modafinil as a weight loss drug, but they typically take it as a diet aid, along with exercise and a calorie deficit. Losing weight through simply not eating is not a safe and healthy way to sustainably lose weight, a je nutno.
The cause of the appetite loss associated with Provigil may be due to increases in the neurotransmitter Dopamine. Modafinil has been seen to increase Dopamine levels in the brain. When Dopamine levels are elevated, satiety is often high as well, and people don’t feel the need to seek out food. It is thought that Histamine may also play a role, as this neurotransmitter is involved in the regulation of appetite and metabolism.
Ways to help combat this loss of appetite are to schedule small frequent meals throughout the day. Setting alarms for yourself throughout the day to take breaks to eat and drink can be very helpful for eating properly and keeping hydrated.
5. Dizziness/Lightheadedness
Another common side effect that some people get while on Provigil is dizziness, točení hlavy, or vertigo. Some users report that they can feel very dizzy shortly after taking Provigil, and that the effect diminishes throughout the day and goes away, while others report continuing to feel dizzy for hours.
The exact cause of this side effect is not known. Je to possibly due to changes in blood pressure; while it is rare, Modafinil has been observed to cause low blood pressures in some patients. The most common theory is that it is related to dehydration. Jak je uvedeno před, it is very important to stay very well hydrated when taking Provigil, as it can be easy to become dehydrated and have a variety of side effects related to it.
6. Back Pain
Some users have reported having back, krk, and shoulder pain when taking Provigil. Tension in the neck and shoulders has been reported, as well as lower back pain.
This side effects does not appear to be a physiological response to the drug itself, although that has not been tested and cannot be ruled out. The most accepted theory has to do with the immense concentration and focus that Modafinil can cause in users.
Many users report that when they take a dose of Provigil that they can easily sit down and work non-stop for hours with high levels of focus and motivation. While this can be great for getting lots of work done, it can have physical effects on the body.
Sitting for long periods of time can cause muscles to become cramped and sore, especially if you are sitting with poor posture, or in a seat that is not ergonomic. On the other side, if you take Modafinil and then are very active, it is possible that the stimulating effects of the drug allows you to push harder and longer than you normally do, and possibly strain yourself.
Making sure you have proper lumbar support in your desk chair may help if you are sitting for long periods of time. Trying to take short breaks where you get up and move can help with this type of strain on the neck and back.
7. Rýma
When taking Provigil, a small number of people have reported developing rhinitis. This is irritation and inflammation of the mucous membranes of the nose, causing stuffy nose, rýma, and/or post-nasal drip (mucus accumulation at the back of the nose or throat that drips down the throat, causing sore throat and/or throat clearing).
The exact cause of this side effect has not been studied, however there is a theory that it could be due to the elevated levels of Histamine that Modafinil causes. Histamin, in addition to regulating appetite and wakefulness, also plays a role in mediating the body’s allergen response. People with allergic rhinitis (seasonal or pet allergies) are familiar with the effects of elevated histamine levels and subsequent allergic reaction nasal issues.
If you have rhinitis caused by Provigil, then you can try taking a lower dosage for a while and see if this side effects subsists. Some people have reported using antihistamine allergy drugs to reduce rhinitis symptoms.
For other people though, this either does not truly help, or seems to dull the effects of Provigil. It may take some testing to figure out what works best for you in reducing this side effect and maximizing Progvigil’s benefits.
8. Cardiovascular Issues
Traditional amphetamine and methylphenidate based stimulant drugs are known for having a relatively high incidence of cardiovascular side effects. Many users have reported feeling heart palpitations and a racing heartbeat at times, and there have been serious cases of blood pressure changes occurring.
Initially it was thought that Provigil didn’t cause any negative cardiovascular effects because it causes its stimulating effects in the body in a different method than traditional stimulants. It has been determined thought that while much less common, some cardiovascular side effects can be experienced when taking Modafinil.
Provigil has been seen to increase blood pressure and heartrate, and it is thought to do this through altering autonomic function.
If you have any cardiovascular issues when taking Provigil – bušení srdce, rychlý tep, bolest na hrudi – then speak with your doctor as soon as possible. They may recommend a lower dosage, or possibly a different dosage schedule.
9. Insomnie
Insomnia is a common side effect of Provigil. Many people have reported having problems falling asleep and staying asleep while taking this medication.
Pro mnoho lidí, this side effect is normally just caused by poor timing of their dosage. Modafinil has a very long half-life of between 12-15 hodin. This means that it can still be active in the body at amounts that can cause can effect for many hours after it was ingested.
Taking your dosage early in the morning is important for avoiding sleep disturbances. It has been recommended that Modafinil be taken first thing in the morning after waking up. Some users with sleep disorders have even said that they will wake up earlier than they need to to take their dosage (před 7 am) and then fall back asleep for up to a few hours as it kicks in.
When you first begin taking Provigil, insomnia can be a common side effect, regardless of when you take it. Many users have said that as their bodies adjusted to the drug the insomnia subsided and they no longer had issues. If you have just started taking Provgil, or are taking a new higher dosage, then give your body time to adjust.
If you still are experiencing insomnia after an initial adjustment period and when taking your dosage early in the morning, then speak with your doctor about lowering your dosage and other options.
Provigil vážné vedlejší účinky
One of the most serious Provigil side effects that can occur is dermatological in nature and may be recognizable first as a simple skin rash. Mezi tyto podmínky patří Stevens - Johnsonův syndrom, Toxická epidermální nekrolýza (DESET), and Drug Rash with Eosinophilia and Systemic Symptoms (ŠATY).
These side effects are considered very rare. There has been strong scientific evidence that indicates that some people may have a genetic predisposition that makes them more susceptible to developing these skin rash conditions when they take some medications that are processed in the body a certain way – včetně Provigil.
These conditions typically are only seen after multiple months of prolonged use of this drug, but in some cases it is known to develop faster. If you notice any distinct changes to your skin while using this drug, it is important that you stop taking it immediately and speak to a medical professional.
Stevens-Johnson syndrome is the most common of these conditions to develop, and symptoms include a fever, body aches and pains, bolest v krku, rýma, and a red or purple rash typically near the mouth, nos, oči, a/nebo genitálie, které šíří a nakonec blistrech.
While these instances are highly rare in the general population, in these certain individuals with the predisposition it is slightly more likely to be brought on by Provigil use. You may be able to lessen the risk of this condition by using Provigil only on an occasional basis as opposed to every day.
Provigil Safety, Dávkování, and Contraindications
Provigil is approved as a prescription drug for adults. Use in children is often limited to severe narcolepsy cases. Pregnant women and breastfeeding mothers should not be using this drug due to a lack of conclusive research trials.
If you are on any other medication, it is best to consult your doctor to find out if Provigil is right for you. The following is a non-exhaustive list of some of the medications that are known to interact with Provigil:
- cyklosporinu
- midazolamu
- triazolam
- fenytoin
- diazepam
- klomipramin
- omeprazol
- propranolol
- SSRI
- IMAO
- Warfarinu
It is also not advised to take oral steroidal birth control pills and other hormone-based contraceptives such as IUDs, patches or implants when using Provigil. One of the side effects of Provigil is that it can lessen the effectiveness of birth control while taking both together, and for up to one month after you stop using this drug.
V nejčastěji recommended dosage for Provigil je 200 mg / den pro poruchy spánku. It is recommended to take the drug first thing in the morning for people with narcolepsy and obstructive sleep apnea/hypopnea syndrome.
People with shift-work sleep disorder are typically advised to take a dosage of 200 mg between 30-60 minutes before a night shift, although sometimes an additional 100 mg dosage is taken during the shift. This higher dosage is not necessary for some people, but they do find they function better if they split their 200 mg dosage into two administrations during their shift.
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Doprava zdarma
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Článek naposledy aktualizován: 12. dubna, 2018 od Nootriment