Cytidine Diphosphate Choline, also known as Citicoline, is a nootropic supplement that can have a measurably positive impact on your brain power.
CDP Choline is helpful in the prevention of memory loss among the elderly, but it can also boost memory performance in healthy young adults.
This natural compound is both a source of the vitamin Choline as well as a neuromodulator, capable of changing the way neurons in your brain communicate.
You will find Cytidine Diphosphate Choline for sale online as Citicoline or under the brand names NeurAxon and Somazina.



- Supports memory, focus & mental clarity
- Increases levels of acetylcholine neurotransmitter
- Promotes brain cell health & communication
How Does It Work?
Related Topics
- What is Citicoline?
- Cytidine Diphosphate Choline
- CDP Choline Effects
- User Reviews
- Benefits for the Brain
- Comparison to Alpha GPC
- Risk of Adverse Effects
- Safe Dosage Guidelines
- How to Take
- Stacking with Piracetam
- Buy CDP Choline
- Supplement Ratings
- Ceraxon Citicoline
- Cognizin Citicoline
- Neuroaxon Citicoline
- Somazina Citicoline
- Zynapse Citicoline
CDP Choline is a unique form of choline which is a nutrient you need for proper brain function.
The FDA recommends getting at least 425 mg of choline in your diet, but most individuals do not achieve even this low amount.
For purposes of improving your memory or protecting yourself against cognitive decline and dementia, it may be necessary to get even more than 425 mg.
However, much of the choline present in foods (such as egg yolks and liver) is significantly degraded by the gut and never arrived at your brain.
Cytidine Diphosphate Choline is different; it has much better absorption into your blood and is transported to the brain at a faster rate. It also has better transit through the BBB (Blood brain barrier) and into the central nervous system.
Once the barrier has been crossed, CDP Choline turns on the synthesis of components in the cell membranes. This boosts the levels of acetylcholine and other neurotransmitters involved in memory and basic thought processing. As a result, cerebral energy metabolism is boosted as well.
Studies have shown that Cytidine Diphosphate Choline increases dopamine receptor densities in the brain which can make it easier to focus while also having a positive effect on factor related to mood.
Why is Cytidine Diphosphate Choline important?
This nootropic compound has a number of benefits both for healthy individuals who want to increase their intellect as well as in the recovery from certain medical conditions.
Patients that have suffered the effects of an acute stroke can fall victim to reduced functional impairments.
This can cause long term effects in the brain that are hard to overcome. Simple brain functions that were lost with a stroke can be at least partially recovered with the help of CDP Choline supplements.
Citicoline may also reduce brain tissue damage when a brain injury has occurred.
In tests, rats that had induced Alzheimer’s Disease in the hippocampi have been treated with this nutrient. The supplement counteracted the neuronal degeneration and increased memory retention, as well as reduced the apoptotic cells that were present. (Apoptosis is the process of cell death occurring in multicellular organisms.)
Cytidine Diphosphate Choline has been approved for treatment in many different cases, including strokes, neurodegenerative disease and other head traumas in both Europe and Japan.
The clinical outcome of patients that had suffered an ischemic stroke were improved in these cases after given the supplement.
Death and disability rates were reduced following an ischemic stroke when given CDP Choline. It was also able to improve the visual functions in patients with eye diseases, including glaucoma and amblyopia.
It isn’t only stroke victims that have found benefits from this source of choline, but recovering drug addicts have found the supplement to be fruitful, as well. A dependency to Cocaine is a result of depleted dopamine levels found in the central nervous system.
Cytidine Diphosphate Choline intake results in an increase of brain dopamine levels, and was found to decrease cravings for those that were dependent on Cocaine.
Cytidine Diphosphate Choline Benefits
Overweight and obese patients can also see great benefits from this acetylcholine precursor. This nootropic increases the brain’s response to food stimuli in the lateral orbitofrontal cortex, insula and amygdala. This results in a decreased appetite after eating a small amount.
There are many other benefits that come with the Cytidine Diphosphate Choline supplement, some of which are listed below:
- Enhanced cellular communication in the brain as a result of increasing neurotransmitter availability. These include dopamine and norepinephrine.
- Increased cerebral blood flow and glucose metabolism.
- Reduced oxidative stress.
- Prevention of excess in inflammatory response in the brain.
- Inhibited release of free fatty acids.
There is still more research to be done, so the full benefits of CDP Choline are yet to be found, but this list is sure to grow.
The side effects of this supplement have been found to be minimal in research to this point. Minor stomach pain and diarrhea are the only two reported adverse side effects with most choline supplements.
Receiving the benefits of Cytidine Diphosphate Choline is simple with the supplemental approach, and there are many benefits beyond repairing functions in the brain. It’s important to know how much to take.
2000 mg is the controlled amount that has been researched thus far, and the most effective oral dosages fall between 500 and 2000 mg.
CDP Choline is a water-soluble supplement meaning that your body will flush it out quickly. Plasma levels will peak within the first hour after oral ingestion of the supplement, with most of it excreted as Carbon Dioxide in respiration. The rest is excreted within 24 hours through urine.
If you do plan to use Cytidine Diphosphate Choline, it is important to stay current with the research that is going into this nootropic to fully understand what it can do for you.
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Article last updated on: March 17th, 2018 by Nootriment