D-aspartic acid dosage guidelines typically suggest taking between 2 – 3.5 grams of this supplement per day.
Dosages are based on the amounts typically used in research trials. DAA is available as both a bulk powder and in capsule format.
D-aspartic acid is a non-essential amino acid, meaning it is naturally synthesized in the human body.
It plays a number of important biological functions, particularly as a secondary neurotransmitter in the brain. DAA is also involved in the production of testosterone. This fact has led to some using DAA as a supplement to support athletic performance, especially muscle development.
Although DAA has been observed to increase testosterone in some cases, it does not appear to effectively increase testosterone levels in already healthy male subjects.
It may result in a short-term increase in testosterone levels among men participating in intense workouts or strength training programs. These results have been reported when using 3 grams dosages of D-Aspartic Acid per day for 12 to 30 days.



- Shown to increase testosterone production
- Supports athletic performance, fat loss & strength
- Boosts sexual health & libido
Why Use D-Aspartic Acid?
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DAA remains a popular supplement for bodybuilders and is generally branded as a ‘testosterone booster‘. This fact appeals to an increasing population of men who want to raise their testosterone levels.
It is estimated that between three and five percent of American men over the age of 40 are currently undergoing at least one type of testosterone replacement therapy (TRT).
As more men rely on TRT (which can be administered via injections, gels, patches and tablets) to elevate their testosterone levels, there is mounting concern about the potential side effects.
D-Aspartic Acid has been suggested by some as a natural alternative testosterone boosting supplement. It is presumed to be safe because this is an endogenous compound that our bodies are capable of synthesizing naturally.
However, the limited clinical research history into DAA means that there is insufficient evidence to determine the safety of long-term use of this supplement. While few side effects have been reported, it is possible that higher dosages of D-Aspartic acid could cause an increased risk of adverse effects.
D-Aspartic Acid Dosage Guidelines
Most research on DAA has focused on its natural role in the body. There has been less research conducted on the effects of oral supplementation. However, there have been several human research trials using this supplement and these studies can be used to inform guidelines regarding recommended dosages.
Most well-organized studies have used doses between 2,000 mg and 3,500 mg of DAA per day. It is recommended that this supplement be used as part of a cycle and not taking for long periods of time.
A typical D-Aspartic Acid dosage cycle may include three weeks of use followed by a one week break from taking this supplement. This cycle is used to prevent tolerance from forming so that natural testosterone levels do not become too high or become supressed.
It is important to pay close attention to the manufacturer’s dosing instructions. Be sure to speak with your family doctor before beginning DAA supplementation to make sure it is a safe and effective option for you.
How to Support Testosterone Levels Naturally
Healthy testosterone levels can be supported with a healthy lifestyle. For instance, healthy lifestyle habits that include a nutritional plan, consistent and adequate hydration, effective stress management and daily semi-strenuous physical activity for at least thirty minutes can help maintain healthy testosterone levels.
Proper nutrition has a large impact on the body’s ability to manufacture and regulate hormones. Likewise, moving the lymph through the lymphatic system, which supports detoxification, requires hydration (water) and regular physical exercise.
Combined with a good diet and exercise, consistent stress management can help support healthy testosterone levels. The physiological and mental effects of stress are associated with the onset and development of preventable disease. Along with improper nutrition, dehydration and sedentary living, stress is the most prevalent cause of general ill health.
Taking a DAA supplement, or other natural testosterone boosters, is alone not enough to support good health and adequate hormone levels.
Function of DAA in the Body
DAA is a secondary neurotransmitter used in calcium-dependent signaling. This means it helps deliver the brain’s messages throughout the body.
As a neurotransmitter it is associated with a number of physiological processes, including the production of testosterone.
DAA is responsible for transporting cholesterol into cellular mitochondria, which is a crucial part of testosterone production. Cholesterol must be delivered to the mitochondria of the Leydig cells within the testicles for testosterone to be produced.
In the Leydig cells, cholesterol is acted on by several hormones (including luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin) to produce testosterone.
DAA is has also been observed to induce vasodilation. Vasodilation is characterized by the widening of blood vessels, particularly in the heart and lungs.
Vasodilation may support improved circulation and help reduce blood pressure. Good circulation and healthy blood pressure are associated with cardiovascular health.
How to Take D-Aspartic Acid Safely
DAA is naturally produced by the body and supplementation is generally well tolerated, at appropriate dosage levels. However, there is little data available on the side effects of long-term DAA supplementation.
Reported side effects include headache, nausea and fluid retention. These side effects are often temporary.
While there is limited data available on negative effects of DAA, there is significant research that the long-term use of Testosterone Replacement Therapies can cause serious side effects.
If DAA is used for long periods of time to increase testosterone levels, it theoretically could also result in some of these negative effects. This has not been demonstrated in clinical studies.
However, some of the known side effects of TRTs include:
- Cardiovascular disorders;
- Enlargement of the prostate;
- Kidney failure;
- Premature androgenic alopecia (hair loss);
- Gynecomastia (male breast development);
- Shrinking of the testicles;
- Increases in triglycerides (stored fats);
- Muscular wasting (atrophy);
- Loss of vision and/or hearing;
- Pain-causing erections (priapism).
Always speak with your doctor before beginning to use this supplement and to help you determine the best D-aspartic acid dosage for your needs.
- Melville GW, Siegler JC, Marshall PWM. Three and six grams supplementation of D-aspartic acid in resistance trained men. J Int Soc Sports Nutr. 2015; 12: 15.
- D'Aniello A. D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role. Brain Res Rev. 2007 Feb;53(2):215-34. Epub 2006 Nov 21.
- Willoughby DS, Leutholtz B. D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men. Nutr Res. 2013 Oct;33(10):803-10.
- CBC News. Heart risks from testosterone replacements flagged by Health Canada. July 15, 2014. Online.
Article last updated on: March 31st, 2018 by Nootriment
1 Comment
I would like to know if taking aspartic acid (3 – 5 g) can cause stomach hyper-acidity and in that case, how can I solve the problem.
Thank you for your help.