D-aspartic acid (DAA) is an acid that is often used to boost testosterone levels.
The supplement is commonly taken by men who seek to increase testosterone for improved sexual performance or athletic endurance.
DAA has been observed to serve a number of functions in the body related to sexual health.
It has been connected to testosterone production, which is why it is often claimed to be an effective testosterone boosting supplement.
In clinical trials, DAA has been observed to increase testosterone levels in males who already suffer from low hormone levels, but has not been observed to have a significant effect on active individuals with normal testosterone levels.
Despite the limited research data, DAA Test Booster supplements are commonly used among bodybuilders. This supplement is also a common ingredient in supplement stacks designed to promote male sexual function and muscle growth.
What do you need to know before deciding to take a DAA testosterone boosting supplement?



- Shown to increase testosterone production
- Supports athletic performance, fat loss & strength
- Boosts sexual health & libido
DAA Powder Review
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DAA is a non-essential amino acid, which means it is naturally produced by the human body and does not need to be consumed in food.
Supplementing with D-Aspartic acid from foods and other sources may increase levels of this substance in the body. This is purported to have benefits for testosterone levels, strength, energy, mood, athletic performance and more.
Because DAA is a “natural” substance, many consider it safe for supplementation. However, there is little clinical evidence available on the long-term effects of DAA supplementation. Most studies have been relatively short in duration (often around three months) and have reported few side effects.
The majority of research on DAA has focused on the role of the amino acid within the body and not the effects of supplementation. More clinical research is needed to demonstrate the efficacy of DAA as a testosterone booster.
DAA vs. Testosterone Replacement Therapy
Some men take DAA as a natural test booster alternative to testosterone replacement therapy (TRT). Nearly five percent of American males over the age of 40 are thought to regularly use TRT.
These TRTs effectively elevate testosterone levels, but come with a variety of possible adverse side effects. Adverse results can include androgenic alopecia (hair loss), gynecomastia (male breast growth), aggression, irritability, acne, shrunken testicles, infertility, kidney failure, low sperm quality, loss of sperm motility, fat gains, muscle loss and many others.
Regulators are also becoming increasingly concerned that TRT elevates the risk of cardiovascular disorders, such as heart attack and stroke. These risks sometimes lead to men looking for alternative products, including DAA. However, there are no comparative studies examining the risk of side effects from DAA versus TRTs.
Testosterone is a primary androgenic hormone important for sexual development and function, among its many other roles. When a man with low testosterone levels elects to undergo testosterone replacement therapy, he is relying on external sources of testosterone to be delivered via tablets, gels, transdermal patches or injections.
Some are concerned that heightened levels of synthetic testosterone causes the body to stop producing testosterone. This is some concern that chronic TRT will result in dependence.
These concerns may also occur with DAA usage. For this reason, most bodybuilders and athletes will take DAA powders or tablets for a maximum of three weeks at a time. This is followed by at least a one week break to allow the body to reset before commencing use again.
DAA and Testosterone Biosynthesis
Like every steroidal hormone, testosterone is manufactured from cholesterol. In males, testosterone is produced mainly in the Leydig cells, which are located inside the testicles.
The quantity and function of Leydig cells is regulated by follicle stimulating hormone (FSH) and luteinizing hormone (LH).
The hypothalamic-pituitary-testicular axis is responsible for regulating testosterone synthesis in the following manner:
- Accumulated DAA is recognized in the anterior pituitary gland (adenohypophysis).
- DAA accumulation is a sign to the brain that testosterone levels are running low.
- When the brain reads testosterone levels as low, it signals the synthesis and secretion of gonadotropin releasing hormone (GnRH).
- GnRH stimulates the pituitary gland to secrete LH and FSH.
- LH and FSH travel to the Leydig cells and stimulate testosterone synthesis.
- A negative feedback loop is used to inform the hypothalamus and the pituitary to cease signaling for GnHR synthesis and release.
- Cessation of GnRH synthesis stops the synthesis of LH and FSH, ending the testosterone production cycle.
Uses of DAA Testosterone Booster Supplements
DAA supplements are claimed to give the body the raw materials it needs to naturally increase testosterone synthesis. When the body produces testosterone, a number of positive biological and psychological effects follow, including:
- Increased energy and improved moods;
- Improved muscle size and strength;
- Enhanced fat metabolism;
- Strengthened sex drive;
- Improvements in spermatogenesis, such as increased sperm motility, volume and quality;
- Supported bone density and strength.
Elevated testosterone levels may have benefits for individuals with low testosterone. We also know that DAA is involved in the synthesis of testosterone.
However, there have not been sufficient studies looking at the effects of taking DAA to boost testosterone levels. It is unclear what effects orally administered D-Aspartic Acid will have for healthy men with normal levels of this hormone.
Side Effects of DAA
DAA plays a number of roles in the human body and many argue that its ‘natural’ origin makes it safe for supplementation. While low dosages are not linked to side effects, it is unclear whether negative effects may occur at higher dosages or with prolonged use.
Mild side effects, such as stomach upset, diarrhea, vomiting and nausea, have been reported. These symptoms are usually mild and temporary. Additionally, there are no known drug contraindications associated with D-aspartic acid supplementation.
DAA Supplement Dosages
Most clinical research conducted on DAA supplementation has used dosages between two and three grams per day. Speak with your doctor before taking DAA testosterone boosters to make sure the supplement will be safe and effective for you.
- Willoughby DS, Leutholtz B. D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men. Nutr Res. 2013 Oct;33(10):803-10.
- D'Aniello A. D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role. Brain Res Rev. 2007 Feb;53(2):215-34. Epub 2006 Nov 21.
- Melville GW, Siegler JC, Marshall PWM. Three and six grams supplementation of D-aspartic acid in resistance trained men. J Int Soc Sports Nutr. 2015; 12: 15.
- Ota N, Ting S, and Sweedler JV. D-aspartate acts as a signaling molecule in nervous and neuroendocrine systems. Amino Acids 43.5 (2012): 1873–1886.
Article last updated on: March 31st, 2018 by Nootriment
1 Comment
Can I take DAAMax along with Raw HGH and Black Antler?