DIM Estrogen Blocker Review, Benefits & Side Effects

Supplementation with an effective DIM estrogen blocker may help to prevent the onset of various hormone-sensitive conditions and diseases.

DIM is short for 3,3′-diindolylmethane; also commonly known as di-indole methane.

This compound is made from indole-3-carbinol (I3C), a phytonutrient found in cruciferous plants like cauliflower, kale, and watercress.

Research shows that diindolylmethane has certain anti-cancer effects; it is used by some as a preventive and curative treatment for cancers of the breasts, colon, uterus and cervix.

However, it has not been approved by the FDA as a cancer treatment and more research is required to validate initial findings in non-human trials.

DIM capsules are used therapeutically to treat PMS symptoms, BPH (enlarged prostate) and RRP (recurrent respiratory papillomatosis). DIM is an estrogen blocker that seems to protect against hormonal imbalances. It naturally stimulates the synthesis of “good” estrogen forms, and simultaneously downregulates synthesis of “bad” estrogens.

Current large-scale human trials studying the effects of DIM on estrogen regulation are underway, sponsored by the US NCI (National Cancer Institute) and other healthcare authorities.

DIM

Hormone Supplement

Estrogen

Testo- sterone

Body- building

How It Works:

• Aids healthy hormone balance for men & women
• Mitigates some effects of excess estrogen
• Anti-oxidant & anti-inflammatory benefits

Dosage:

Between 100 - 600 mg per day

Safety:

Rated Possibly Safe

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DIM Estrogen Blockers: How They Work

The body’s endocrine system works best when all hormones are in balance and being efficiently utilized.

When one or more hormones are out of balance, various potential symptoms, conditions and/or diseases may onset.

The most common hormonal irregularity is estrogen imbalance.

When there is too much “bad” estrogen, and not enough progesterone can be synthesized to counteract its effects, estrogen dominance develops in many women past the age of 35.

This can lead to weight gain and additional health consequences.

Other factors may also contribute to the development of estrogen dominance including, but not limited to:

• Environmental xenoestrogen exposure;

• Use of hormone replacement therapies and/or birth control pills;

• No ovulation during menstruation (anovulation);

• Inefficient estrogen detoxification by the liver, sometimes caused by improper digestive capacities;

• Poor stress management which taxes the thyroid and the adrenal glands;

• Poor dietary choices and inadequate hydration;

• Tobacco use and/or excessive alcohol consumption;

Several factors that may contribute to high estrogen levels can be improved by making positive lifestyle modifications.

Following a healthy diet with lots of on water-rich options like organic vegetables and fruits, exercising daily, quitting smoking, managing stress effectively and minimizing exposure to toxins can significantly improve hormonal balance.

A supplement like DIM or I3C can help, but these lifestyle choices should always come first.

DIM, Excess Estrogen and Cancer Development

The relationship between estrogen and cancer continues to be investigated. There are various forms of estrogen – more than two dozen – and some have stronger effects than others.

The three most researched and understood estrogen forms are 2-hydroxy (“good”) estrogen, and 4-hydroxy and 16-hydroxy estrogens (both “bad”).

Every form of estrogen is used by the body for various purposes and every organ in the body possesses estrogen receptor sites. When there are too many bad estrogens circulating in the bloodstream, excessive amounts may get stored in adipocytes (fat storage cells).

These forms of estrogen are difficult for the body to detoxify, and their prolonged storage may increase susceptibility to disease, especially hormone sensitive cancers.

Cells utilize a complex series of actions to detoxify themselves from harmful estrogen accumulations. Intermediates are generated when the cells attempt to rid themselves of carcinogenic estrogens which can generate free radical agents.

These oxygenating radicals may cause damage to proteins, fats and DNA. Damaged DNA can mutate and cause cancerous cells to develop.

DIM estrogen blockers may inhibit the development of various cancers by suppressing tumor cellular proliferation.

Also, excessive estrogen in the body can lead to various other adverse conditions, possibly including:

• Allergic reactions, asthma and chronic bronchitis;
• Decreased sex drive (libido);
• CFS (chronic fatigue syndrome);
• Headaches and/or irritability;
• Infertility;
• Increased fat storage in the abdominal region and thighs;
• Cervical dysplasia;
• Symptoms of menopause;

Supplementation with a DIM estrogen blocker supplement may help to support men’s and women’s health in a natural way by restoring proper balance to the hormones.

Safety of DIM Estrogen Blockers

DIM estrogen blocking supplements are effective at more than helping to regulate estrogen levels. Diindolylmethane may also act as an antioxidant, anti-inflammatory, antitumor, antiproliferative, antiparasitic, antiviral and antibacterial.

Diindolylmethane supplementation for periods less than twelve weeks, and with dosage amounts less than 25 milligrams daily are classified as likely safe. No serious side effects have been noted at these supplementation levels.

DIM usage at doses between 25 and 299 milligrams daily is considered to be possibly safe when implemented for less than twelve consecutive weeks.

Using a DIM supplement at doses over 300 milligrams daily is associated with hyponatremia, a condition where sodium levels become depleted to unsafe levels. This supplementation level is categorized as possibly unsafe.

There are drug contraindications associated with taking DIM for estrogen regulation. Cytochrome P450 1A2 substrates prescription medications, diuretics and hormone replacement agents should not be stacked with diindolylmethane.

Always speak with a doctor first before beginning any supplementation program with DIM supplements.

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