Using DIM for bodybuilding may help to balance hormonal activity, improve lipid profiles, decrease fat levels, increase muscle mass and enhance cardiovascular.
DIM is short for diindolylmethane, a naturally-synthesized compound that is created from the breakdown of indole-3-carbinol (I3C) via the digestive process.
I3C is found in cruciferous vegetables from the Brassicaceae plant family.
Both I3C and DIM have been implicated in various clinical trials as anticancer agents. Recently, research shows that supplementing DIM for bodybuilding purposes may offer various other health benefits as well.
By naturally balancing estrogen and testosterone levels, in both women and men, diindolylmethane may promote athletic performance, muscle building and fat loss.
This supplement is also believed by some health experts to significantly reduce the chances of developing various degenerative diseases and conditions.



- Aids healthy hormone balance for men & women
- Mitigates some effects of excess estrogen
- Anti-oxidant & anti-inflammatory benefits
DIM for Bodybuilding:
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Bodybuilders often use supplements to boost testosterone levels.
This male sex hormone is associated with increases in muscle mass, decreased fat mass, improvement of lipid profiles, strengthening bone tissue and decreasing healing times between workouts.
Testosterone levels in men are integrally related to estrogen levels. Men manufacture estrogen by converting testosterone with the aromatase enzyme.
An overabundance of aromatase in the system will cause free testosterone to decrease as it is converted to estrogen.
Elevated estrogen levels can lead to estrogen dominance, which in turn may cause an array of side effects including gynecomastia, low sex drive, hair loss, mood swings and more.
Further, clinical data shows that men with even slight surpluses of estrogen triple their risks for stroke incidences and significantly increase their chances of developing coronary artery disease.
On the other hand, if men have low estrogen levels, they increase their chances of developing osteoporosis and bone fractures. Using DIM for bodybuilding helps to balance hormones, fortify the bones and improve cardiovascular disease risk factors.
id=”dangers”The Dangers of Testosterone Replacement Therapy
Statistics show that the sales of testosterone replacement products and therapies have risen more than two thousand percent in recent years. Research suggests that low testosterone is associated with a myriad of diseases and adverse health conditions.
However, administration of synthetic testosterone products is associated with a long list of adverse side effect possibilities. These include loss of vision, prostate cancer, erratic mood swings, hostility and death.
Supplementing DIM for bodybuilding purposes stimulates natural testosterone elevations with low risk of side effects.
Certain men develop estrogen deficits because they lack adequate levels of aromatase to convert available testosterone. Other males do not generate enough testosterone to be able to synthesize estrogen via aromatase.
In this case, both testosterone and estradiol levels can drop to unsafe levels. Using DIM for bodybuilding seems to effectively suppress aromatase actions and thereby normalize testosterone and estradiol levels.
In one clinical study, more than 3000 men between 69 and 80 years of age had their serum estradiol and testosterone levels quantified during a 4.5-year mean follow-up.
It was determined that men with deficient testosterone were 65% more likely to die than men with adequate testosterone.
In the same study, it was determined that men with low estrogen were 54% more likely to die than those with normal levels. And in men with both low testosterone and low estradiol, there was a 96% increase in all-cause mortality when compared with men with balanced hormonal levels.
How Safe Is DIM for Bodybuilding?
Supplementation with diindolylmethane is known to be likely safe when administered at 24 mg daily or less over a 12-week maximum time frame.
DIM is used clinically to treat various hormone-sensitive cancers and other conditions.
For doses up to 300 mg daily, supplementation is considered possibly safe, with only mild and temporary side effects like headaches and stomach upset being noted.
In doses over 300 mg daily, usage is considered possibly unsafe. This level of dosing should only be administered by doctors or clinicians in controlled environments.
What Do Bodybuilders Say about Diindolylmethane?
Most of the clinical research and experimentation on diindolylmethane has addressed its anticancer and chemopreventive effects. There is one study that seems to show that gut-injected DIM attenuates fat gains expected with a high-calorie food intake program. V
arious studies seem to be showing positive effects on lipid metabolism, cholesterol synthesis in the liver and overall improvements in the risks factors for obesity, weight gain, heart disease and more. Many of these cardioprotective effects seem to be brought on because DIM stimulates vasodilation.
Review of consumer purchasing trends and satisfaction ratings seems to indicate that DIM for bodybuilding may be effective at generating muscle mass increases and fat mass decreases.
Male bodybuilders often experiment with stacking DIM and L-creatine. For women, there seems to be benefits for alleviating PMS symptoms and reversing uterine fibroids.
As diindolylmethane is known to exhibit estrogen-modulating effects, it seems to help to balance overall hormone levels in both men and women. Supplementing DIM for bodybuilding may present an array of health benefits in addition to improving fat metabolism and maintaining ideal weight levels.
Always speak to your physician about supplementing DIM for bodybuilding beforehand. Dosing is sensitive. Small increments can lead to strong changes in biological effects.
- Kula K1, Slowikowska-Hilczer J, Walczak-Jedrzejowska R, Kula P, Oszukowska E, Marchlewska K, Wranicz JK. [Physiological significance of estrogens in men--breakthrough in endocrinology]. Endokrynol Pol. 2005 May-Jun;56(3):314-21.
- Kula K1, Walczak-Jedrzejowska R, S?owikowska-Hilczer J, Wranicz JK, Kula P, Oszukowska E,Marchlewska K. [Important functions of estrogens in men--breakthrough in contemporary medicine]. Przegl Lek. 2005;62(9):908-15.
- Xuemin Qian, Jung Min Song, Tamene Melkamu, Pramod Upadhyaya and Fekadu Kassie Chemoprevention of lung tumorigenesis by intranasally administered diindolylmethane in A/J mice. Carcinogenesis. 2013 Apr; 34(4): 841–849.
- Gregory A. Reed, Jean M. Sunega, Debra K. Sullivan, John C. Gray, Matthew S. Mayo, James A. Crowell, and Aryeh Hurwitz Single-Dose Pharmacokinetics and Tolerability of Absorption-Enhanced 3, 3?-Diindolylmethane in Healthy Subjects Cancer Epidemiol Biomarkers Prev. 2008 Oct; 17(10): 2619–2624.
- Barrett, JR. "Good Estrogen Bad Estrogen." Environmental Health Perspectives 108.9 (2000): A416–A417.
- Shishinn Sun, Jing Han, Walter M. Ralph, Jr., Alamelu Chandrasekaran, Kai Liu, Karen J. Auborn and Timothy H. Carter Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro. Cell Stress Chaperones. 2004 Mar; 9(1): 76–87.
- Johnson IT Glucosinolates: bioavailability and importance to health. Int J Vitam Nutr Res. 2002 Jan;72(1):26-31.
- Zaidi MR, Merlino G. The two faces of interferon-? in cancer. Clin Cancer Res. 2011 Oct 1;17(19):6118-24. doi: 10.1158/1078-0432.CCR-11-0482. Epub 2011 Jun 24.
- A Castañon, A Tristram, D Mesher, N Powell, H Beer, S Ashman, G Rieck, H Fielder, A Fiander and P Sasieni Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 2012 Jan 3; 106(1): 45–52.
- Prabodh K. Kandala and Sanjay K. Srivastava Diindolylmethane-mediated Gli1 Protein Suppression Induces Anoikis in Ovarian Cancer Cells in Vitro and Blocks Tumor Formation Abilityin Vivo* J Biol Chem. 2012 Aug 17; 287(34): 28745–28754.
- Mohan, Sumit et al. "Prevalence of Hyponatremia and Association with Mortality: Results from NHANES." The American journal of medicine 126.12 (2013): 1127–37.e1. PMC. Web. 24 July 2015.
- Fan, Saijun et al. "Low Concentrations of Diindolylmethane, a Metabolite of Indole-3-Carbinol, Protects against Oxidative Stress in a BRCA1-Dependent Manner." Cancer research 69.15 (2009): 6083–6091. PMC. Web. 24 July 2015.
- Chinnakannu, Kannagi et al. "Cell Cycle-Dependent Effects of 3,3?-Diindolylmethane on Proliferation and Apoptosis of Prostate Cancer Cells."Journal of cellular physiology 219.1 (2009): 94–99. PMC. Web. 24 July 2015.
- Dent P. Crosstalk between ERK, AKT, and cell survival. Cancer Biol Ther. 2014 Mar 1;15(3):245-6. doi: 10.4161/cbt.27541. Epub 2014 Jan 14.
- Ye Q, Cai W, Zheng Y, Evers BM, She QB. ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer. Oncogene. 2014 Apr 3;33(14):1828-39. doi: 10.1038/onc.2013.122. Epub 2013 Apr 29.
- Prabodh K Kandala1 and Sanjay K Srivastava 1 Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3) BMC Med. 2012; 10: 9.
Article last updated on: April 29th, 2018 by Nootriment