- PhenylalanineAmino AcidMoodFocusEnergy
How It Works:
Top Phenylalanine Products* ❯View User Ratings* ❯*Affiliate LinksOVERVIEW: Phenylalanine is an amino acid that has three forms: L-phenylalanine, D-phenylalanine, and DL-phenylalanine. Of these forms, only L-phenylalanine is an essential amino acid that is found in proteins. READ MORE...USED FOR: Depression, ADHD, Parkinson's disease, Chronic pain, Osteoarthritis, Rheumatoid arthritis, Alcohol withdrawal, Vitiligo.MECHANISM: Phenylalanine crosses the blood-brain barrier and has effects on the functioning of the central nervous system. It is also involved in the creation of various hormones and neurotransmitters including dopamine, epinephrine, and norepinephrine. READ MORE...DOSAGE: 100-5000 mg daily; average dosage 1000-2000 mg daily; Dosage varies due to reason for taking.SIDE EFFECTS: Rated as Possibly Safe when L-phenylalanine is used orally for therapeutic purposes. Normally well tolerated in individuals without preexisting conditions; mild side effects include nausea, headache, and heartburn. May cause an allergic reaction in some individuals.INTERACTIONS: Antipsychotic drugs, Baclofen, Levodopa, MAOIs. No known interactions with any herbs or supplements. Phenylalanine supplements can cause various serious adverse effects in individuals with phenylketonuria (PKU) or other phenylalanine metabolism disorders. May have negative effects in individuals with schizophrenia.RELATED SUPPLEMENTS: Mucuna Pruriens, Sulbutiamine, Phenylalanine, Phenylethylamine, 5-HTP, L-Tryptophan, L-Theanine, SAMe, GABA, Inositol, Rhodiola Rosea, St. John's WortTop Phenylalanine Supplements
- Precursor for the production of dopamine
- Supports mood & combats stress
- Boosts energy & mental focus
Is DLPA good for my hip pain??
You recommend to take 100-200 g a day, and everything is sold 500 g per capsule. Am I missing something?
Unfortunately, most of the capsules are sold in 500 mg dosages, but there are a few vendors that carry smaller dosage tablets. Dr. Mercola has a good discussion of this problem on his site. While many users see positive results at the lower dosage, a lot of supplement companies feel they need to use the industry standard of 500mg DL-PA in order to compete on the value proposition.
Generally, the 500 mg dosage is used for chronic pain management and other medical interventions whereas smaller doses can be better for mood enhancement or for use in a nootropic stack. However, each individual is different.
In this case, you have two options: Look for a supplier of bulk phenlyalanine powder so you can measure the powder yourself and get precisely the dosage you want; Or if you purchase phenylalanine capsules/tablets, you can split the pill into two to achieve an approximate dosage of 250 mg.
I notice that although the article is for DLPA, the shopping links are for L-phenylalanine; for those wishing to try it, you need the D- form for pain relief; you can use the L-phenylalanine alone to improve mood. Recommended dosage for pain is 2,000 mg/day in a divided dose, increasing weekly to a maximum of 4,500 mg/day. (As most of these supplements come in 500 mg capsules, that’s a lot of pills to swallow!) If you do not experience pain relief at that level it will not probably not work for you. If you do get relief, then you can back off 500 mg/day/wk until you experience discomfort and then stay at that dosage. It did not work for me for osteoarthritis pain but did help with mood; most of these phenylalanine supplements are affordable and there are very few side effects. As noted, lower doses can be effective for improved mood, or you can also use 5-HTP.
Hello, thanks for nice article here about DL- Phenylalanine. I wonder how the dosage of 200 or 500 could interfere with stimulants as coffe about 200mg or phenibut at 200 mg or 500 mg. Also if it has any bad side effects with medication like ritalin 5-10-15 mg.
I was wondering about constipation? Seems like since I have been taking it for back pain about a week I have noticed constipation?
My Doctor prescribed it for increasing endorphin production in the brain. This was mostly due to opiate withdrawl and just living free from synthetic opiods but if you follow his logic, an increase in endorphin production (apparently the DL version does this) you may feel opiod like side effects. Constipation being a major one as well as pain reduction which you stated. Be assured to know that the supplement won’t effect you like synthetic opiods because you are stimulating your own endorphin production and not adding synthetic endorphins (opiods) which supress the natural production.
This was taken from blue light forum, in my research about endorphin deficiency syndrome…
But you may be experiencing constipation due to how d-phenylalanine helps w EDS and pain in general.
“The body makes its own endogenous opioids (generally called endorphins, enkephalins, and dynorphins.) Each has a function in the brain/body, and in order to maintain a proper concentration, the body has enzymes responsible for breaking these molecules down and making then inactive.
One of those enzymes is carboxypepsidase-a, which is excreted by the pancreas and is responsible for endorphin degradation.
D or DL-phenylalanine, however, blocks the activation of this enzyme which will then result in a higher enkephalin concentration. This potentially therapeutic for people who have naturally low enkephalin levels. Interestingly, DL-phenylalanine may also have some anti-depressant effects via dopamine and NDMA (as it is a precursor to the synthesis of both of these.”
It’s important to note L-phenylalanine may affect mood and will not affect pain, and D-phenylalanine for pain, not for mood. So your goals should dictate which you’re taking.
I suspect too many endorphins are in play, and just like morphine (endogenous morphine I’d where the term “endorphin” comes from), this can cause OIC or opioid induced constipation. You can try loperamide (immodium AD), titrating down your d-phenylalanine dose, or both. Also be sure you’re drinking plenty of water, getting adequate fiber and exercise, as lack of any of this can cause constipation or make slight constipation much worse. Hope this helps.
I’m waiting to ask my dr about this supplement and EDS in a couple weeks, I’ve tried 20+ ssri’s/snri’s, I have general and social anxiety, major depressive disorder and irritable bowel syndrome. I’ve also tried ever ibs D med for men. DL-phenylalanine, low dose naltrexone (LDN), and kratom (which I have tried with success for 8 months and suffered 0 withdrawals after 3-5 grams 3-4x a day). The first 2 I haven’t tried, but I’m having trouble getting back on kratom because of the ibs-d and kratom is pure insoluble fiber.
I am currently withdrawing from suboxone, it’s my 4th day since the last .5 mg dose..I did a short taper from 2mg. I’ve been on subs for several months so I am anticipating a long withdrawal. I have been taking a low dose of xanax (reluctlantly) and have access to gabapentin & clonodine just to get through the first few worst days but I want to start taking this DLPA.. also to avoid taking other narcotics to get by to achieve abstinence! I don’t want to trade one addiction for another. **However I am trying to conceive and may have to go through IVF procedures to get pregnant. Is it safe for me to take the DLPA now? If not are there any other supplements with the similar benefits that are safe to take while trying to concieve/pregnant? I read that high does of liposomal vitamin c can help opiate withdrawals as well. Thanks any feedback would help, not sure if this is the right forum to ask but I will consult with my psychiatrist too..
Soweit ich das versteh ist dlpa ein Vorläufer von tyrosin? Und wann ist welches besser? Welche Form wird am besten resorbiert? Die dlpa Form oder l phenylanalin?
What is the recommended doses you should take a day (in “tea spoon messuarements”)? For example 1/5 teaspoon x 3 a day.?
Also how many hours/days does it take for you to feel any effect?