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Ergoloid mesylates is also known as Hydergine. It is made from combining together methanesulfonate salts of three dihydrogenated ergot alkaloids.
It was developed by Albert Hoffman (who also discovered LSD) for the Sandoz (now part of Novartis) company.
As a pharmaceutical drug, Ergoloid has been used for a variety of functions. This includes treating dementia and other age-related cognitive impairments. It has also been used for helping in recovery after strokes.
There are a number of users taking this drug as a Nootropic to help improve memory, cognition and brain health.
Ergoloid appears to be more effective when combined with other Nootropic agents like Piracetam.
Cognitive Enhancement
Neuron Health
Memory- Increases dopamine & acetylcholine
- Anti-oxidant for brain cell health
- Improves blood flow to the brain
Ergoloid Effects
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The mechanisms of action for Ergoloid mesylates (co-dergocrine mesilates, dihydroergotoxine mesylateremain) remains unknown. However, it is able to stimulate modulation of synaptic neurotransmission. In other words, it makes communication between neurons and even possibly different sections (hemispheres) of the brain more efficient.
This supplement is thought to stimulate the Dopamine and Serotonin receptors as well as blocking alpha-adrenoreceptors (this effects adrenaline and noradrenaline chemicals). All of these pathways also help to increase the amount of blood flow to the brain.
There is also evidence that Ergoloid can reduce MAO levels within the brain. Since these levels almost always rise as we age, helping to combat this is a major step forward in preventing brain aging. It should be noted that this mechanism of action only appears to be present in selected brain regions such as the hypothalamus, hippocampus, and the cerebellum.
Ergoloid Benefits
There are a number of key benefits of this nootropict. For starters, it helps to enhance memory and learning processes. In addition to this, many users also find that their concentration, focus, and even speed of recall is improved, sometimes significantly (although this has been known to vary considerably according to the individual).
Possibly a number of these benefits are due to the fact that Ergoloid increases blood flow to the brain as well as oxygen uptake due to its action as a mild vasodilator. Brain cell metabolism and mitochondrial metabolism are also both enhanced.
This supplement is also considered to be an extremely powerful anti-oxidant. It is capable of scavenging almost all types of free radicals and removing them from the brain and the body.
It also helps to remove a number of additional poisons and toxins like lipofuscin which is known as the aging pigment. In fact, numerous experiments have found this supplement to be the most potent anti-oxidant in the class of nootropics.
Furthermore, Ergoloid stimulates new interconnective growth between neurons. It promote the release of brain-derived neurotrophic factor (BDNF) which is used to repair damaged neurons and support the growth of neurons and neurites.
Recent studies even show this supplement can increase dendritic density in the brain which normally diminishes with age. Ergoloid restores these connections back to youthful levels.
The supplement helps to stop the blood from coagulating and may prevent blood clots in the brain. This is also partly due to the vasodilating effect that this supplement has, but Ergoloid can also promote normalization of systolic blood pressure.
Some users have even seen their levels of cholesterol drop due to supplementation. This is more prevalent in those with extremely high levels to begin with, but it is a tremendous benefit nonetheless.
Additionally, Ergoloid increase levels of Serotonin in your brain cells which has a positive effect on sleep and wake cycles. Many individuals report that their brain is more alert and awake when taking Ergoloid and that symptoms of lethargy and fatigue are reduced.
Ergoloid Dosage
There is some disagreement regarding the optimal dosage levels for this supplement. In the US, the generally accepted recommended dose is 3 mg per day. However, many European countries think this is simply too low and suggest taking up to 9 mg per day in 3 divided doses.
It should also be noted that some people may need to take the supplement for several months before they notice any significant effects or improvements. For this reason, most people will take it in a nootropic stack alongside other faster acting cognitive enhancers such as Piracetam, Aniracetam, Noopept or Pramiracetam.
Ergoloid Side Effects
Ergoloid is extremely non-toxic and has very few reported side effects. Some users do report having initial mild nausea, gastric disturbances, and bradycardia.
Those with abnormally slow heart beats and/or low blood pressure should not take this supplement.
It is also not recommended that pregnant or nursing women take this supplement, since it is not clear what additional effects it may have.
Ergoloid Review
All in all, Ergoloid can be an extremely effective nootropic supplement with positive implications for brain health and life extension. It is known to protect the brain from damage related to aging while also promoting the repair of existing damage. There are some mild cognitive enhancement benefits associated with Ergoloid in relation to memory, learning, concentration and especially alertness levels.
Another option if you cannot find Ergoloid for sale online is to purchase Centrophenoxine which offers many of the same benefits and is usually easier to buy in the United States. You may want to try using Ergoloid supplements in combination with Piracetam or other Racetams to see a stronger improvement in mental performance.
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- McHenry LC Jr, Jaffe ME, Kawamura J, Goldberg HI. Hydergine effect on cerebral circulation in cerebrovascular disease. J Neurol Sci. 1971
- McConnachie RW. A clinical trial comparing 'Hydergine' with placebo in the treatment of cerebrovascular insufficiency in elderly patients. Curr Med Res Opin. 1973
- Burian E. An ergot alkaloid preparation (Hydergine) in the treatment of presenile brain atrophy (Alzheimer's disease): case report. J Am Geriatr Soc. 1974
Article last updated on: May 15th, 2018 by Nootriment
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