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Fasoracetam (NS-105, LAM-105) was initially developed for the treatment of Alzheimers by Nippon Shinyaku.
A member of the racetam family, a class of compounds famed for their cognition enhancing properties, it also shows promise as an antidepressant and anxiolytic.
Dr. Hakonarson, who specializes in genome medicine, is exploring the drug’s usefulness as an ADHD drug for a particular genetic subset of the population.
Fasoracetam works on three different types of receptors in tandem: the cholinergic, GABA and glutamate.
These receptors are all associated with the formation and retention of new memories. This has been proven in the laboratory.
Memory
Mental Function
Brain Health- Upregulates GABA(B) receptor sensitivity
- Increases acetylcholine & glutamate activity
- Boost cAMP to support memory
What is Fasoracetam?
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- Fasoracetam Review
Fasoracetam is a powerful Racetam compound with a chemical structure of (5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-one.
Primarily it has attracted the interest of nootropics enthusiasts searching for ever stronger analogues of the original racetam, Piracetam.
Fasoracetam improves general intelligence while attacking anxiety and apathy, which, as much as a lack of ability, can stand in the way of reaching one’s full potential.
These are also frequent concerns for patients diagnosed with ADHD which explains the interest in researching its effects for this disorder.
Fasoracetam prevents learned helplessness. In animal trials, rats given the drug were substantially less likely to remain immobile when submersed in water than those who were not. They were also more motivated to rescue themselves from merciless electrical shocks on their feet.
While human studies have yet to be conducted in this area, it was found to increase “the number of GABAB receptors in rat cerebral cortex without affecting the binding properties of adrenoceptors and 5-HT2 receptors.”
- Promotes mood and stress relief
- Supports memory formation and learning
- Boosts focus and attention
Effects of Fasoracetam
This is remarkable. This means the brain does not, as several recreational users have reported, build a tolerance to fasoracetam; each dose is as or more effective at alleviating depression and anxiety as the last. Its mechanism of action is not like Prozac’s.
Nor does it affect monoamine uptake or its circulating concentration within tissues. Its short term safety has been established, but it is not certain whether it is as well tolerated long term as Piracetam or Aniracetam.
Fasoracetam Dosages and Where to Buy
For now, the use of Fasoracetam is limited as a nootropic supplement. It is fairly hard to track down and comparatively costly.
You can buy it from several nootropic research compound suppliers, but remember that it has yet to be approved for human use in the USA and this carries some inherent risk.
Its antidepressant effects are most prominent at large doses and a standard dose has not yet been agreed upon. In human trials, 100mg a day has been given to subjects with no observed consequences, but some psychonauts use only 10mg a day sublingually.
This puts its potency level in line with nootropics like Noopept which are said to be 1000x stronger than Piracetam.
- Focus longer, clear brain fog & feel more motivated
- Boost energy, alertnes & memory
- Contains 12 safe and natural nootropic ingredients
Comparisons with Coluracetam
The reported effects of Fasoracetam do have some commonalities with another powerful Racetam nootropic known as Coluracetam.
Coluracetam received a great deal of attention thanks to its positive impact on the high affinity choline uptake system, which can increase the speed at which acetylcholine is produced.
Yet it is not alone. Its sister substance shares these powers with it. This means it may also share the unique mood and memory enhancement benefits that sets Coluracetam apart from its illustrious relatives.
Rats given fasoracetam “showed [an] increase of ACh release from the cerebral cortex and the enhancement of HACU both in the cerebral cortex and hippocampus” Coluracetam mitigates learning deficits after a single dose and, even more fascinating, the improvements do not disappear with sudden cessation. This may be the result of comparatively long lasting alterations to HACU.
Fasoracetam inhibited baclophen-induced memory loss in rats whereas the other drugs used did not. This further suggests it has a potent influence on cholinergic and GABA systems, both of which, in varied and complex ways, retaining new information.
This, combined with its inducement of resiliency, suggests it makes an excellent study aid.
User Experiences with Fasoracetam
Recreational users on Longecity report having more motivation, improved mental clarity and less anxiety while under its influence. This corresponds perfectly with what has been established in animal studies.
While it would be preferable to have more human research trials with Fasoracetam, one needn’t doubt the results of animal trials since lab rats, as far as anyone can tell, do not experience placebo effects.
Information about this promising pharmaceutical is still scant compared with older racetams, but with what is available it is safe to conclude it bolsters memory, melts away procrastination, improves focus, relieves depression and enhances learning.
Although it is young, Fasoracetam will likely become a beloved members of many nootropic stacks.
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- Bessho, Tomoko, et al. "MKC-231, a choline-uptake enhancer:(1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats." Journal of Neural Transmission 115.7 (2008): 1019-1025.
- Gualtieri, Fulvio, et al. "Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs." Current pharmaceutical design 8.2 (2002): 125-138.
- Kumagai, Y., et al. "Comparison of pharmacokinetics of NS-105, a novel agent for cerebrovascular disease, in elderly and young subjects." International journal of clinical pharmacology esearch 19.1 (1998): 1-8.
- Murai, S., et al. "MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice." Journal of Neural Transmission/General Section JNT 98.1 (1994): 1-13.
- Ogasawara, Takashi, et al. "Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer." Pharmacology Biochemistry and Behavior 64.1 (1999): 41-52.
- Shimidzu, Takako, et al. "Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: Possible involvement of GABA< sub> B receptor up-regulation after repeated treatment." European journal of pharmacology 338.3 (1997): 225-232.
Article last updated on: April 25th, 2018 by Nootriment
2 Comments
Profound, thank you for the great enlightening review.
“Fasoracetam prevents learned helplessness. In animal trials, rats given the drug were substantially less likely to remain immobile when submersed in water than those who were not.”
“Disappointment is my daily bread,but I thrive on it.” – Dr. Oswald Theodore Avery ( en.wikipedia.org/wiki/Oswald_Avery )
en.wikipedia.org/wiki/Learned_helplessness
“Learned helplessness is a mental state in which an organism forced to endure aversive stimuli, or stimuli that are painful or otherwise unpleasant, becomes unable or unwilling to avoid subsequent encounters with those stimuli, even if they are escapable, presumably because it has learned that it cannot control the situation.”
10-100mg is quite a dose range!
I opted for the higher-mid range, and scooped perhaps 60+mgs under my tongue. I could start to feel some effect right away. I even spat a fair bit out, thinking I didn’t want to overdo it the first time out.
I’d say it was one of the most effective noots I ever tried. The anti-anxiety and anti-depressant effects was only comparable to my early trials of Pramiracetam. The rest of the day went by incredibly smooth, energetic and motivated. (IOW…NOT typical for me :-) ).
I read there is no drop off or tolerance with continued use of this. if that’s the case, that would be a near miracle. I would still cycle it’s use and use some natural multi-anti-oxidants formulas along with it, just to make sure nothings gets burnt out.