GABA’s popularity as a nutritional supplement continues to grow despite the contradictions regarding its potential benefits.
The ongoing controversy centers around whether or not GABA supplements are able to effectively cross the blood-brain barrier or not. If it cannot, then it said to not be able to provide benefit to our brains.
Researchers tell us these supplements are unable to penetrate the barrier with any degree of effectiveness and therefore cannot be instrumental in increasing the levels of the GABA neurotransmitter in our brains.
User reports and GABA reviews, however, often directly contradict the scientific reports about the supplement, leaving researchers searching for a mechanism which could be causing the effects.
As it currently stands, some users continue to experience a better sense of well-being, better sleep, improved focus and more satisfaction with life in general when supplementing with GABA. It has been suggested that the growing number of users with positive reviews may be due entirely to the placebo effect, but there are other alternative theories as well.
One theory about why GABA supplements seems to cause effects for some people is related to the area of current research regarding blood-brain barrier hyperpermeability. It has been hypothesized that personal differences in blood-brain barrier permeability (whether naturally or possibly due to conditions such as chronic inflammation) may allow compounds like supplemental GABA into the brains of some people.
Another theory states that GABA may not have to directly cross over the blood-brain barrier to cause effects there. While the exact connection is still being studied, it is believed that the network of neurons in the gastrointestinal system (the enteric nervous system) has a connection with our brain and may actually play a role in our mental state. The theory therefore is that GABA supplements may interact with GABA receptors in the gut to then cause mental effects.
Either of these theories could reconcile the current scientific knowledge about GABA and the blood-brain barrier. At this time neither of these theories have been proven or even thoroughly studied though, and both would be good areas for future research.
The debate over efficacy aside, this article is intended to offer insight directed toward potential users of GABA supplements. The GABA reviews selected here have been chosen because they tend to reflect many other users experiences in a general sense.
GABA is available as a dietary supplement only, and the FDA has not approved GABA as a drug to prevent or treat any conditions.



- Anxiolytic effects to reduce stress
- May improve sleep & anxiety
- Supports fat loss & increases HGH
GABA Reviews for Calm & Relaxation
Related Topics
GABA is used most frequently for anxiety or panic attacks. It is unknown why some people experience anxiety relief and others do not.
GABA supplements have been used by some people as a natural alternative to prescription medications. However, it is important to note that GABA is not a drug, and it should not be used in the place of prescribed medications without doctor approval.
One user shared:
I’ve taken 750mg, 1500mg, and so on multiple times in trying to gain relief with this supplement. I believe every time I did there was absolutely no effect, if not some slight placebo effect.
Compared to many other supplements I have to agree with the science and say this one is kind of a waste of money and has little benefit, if any.
Alternatively, another reviewer suffering with social anxiety shared the following GABA review:
This GABA supplement is working better than I could have expected. It’s not as good as a benzo, but it is working for me. It took about two weeks of taking a 500mg pill four times a day before I started to notice the effects.
Now, I definitely feel calmer and more sociable. I’d say the only negative aspect of it is that usually twice a day I feel high. It’s not a bad feeling by any means, but I’ve never gotten any kind of high off a benzo.
GABA Reviews for Depression
GABA supplements are not an antidepressant however some individuals have reported relief from certain depressive symptoms when taking GABA supplements. Whether this is due to a placebo effect or not is unknown.
A man reports his experience thus:
This stuff is fantastic, puts me in a good mood every day, it’s seems to make me feel kind of euphoric in a odd way for about 5 minutes, might be surprised if you where not expecting it.
Others, who have tried it with hopes of relieving some of their symptoms but experience no relief, also weigh in:
GABA is produced naturally in your brain, not in a pill. This did not work for me. I took up to 4 of these at once and still nothing. And no I’m not a drug addict. I don’t blame the manufacturers because I use their other supplements and love them. This simply did not work to help my depression.
GABA Reviews for Better Sleep
Sleep regulation may be the effect which has the highest number of positive reports from users, though there are a fair share of those whose sleep showed no improvement.
A woman writes about her husband’s experience:
GABA does everything that it’s suppose to, after suffering a stroke my husband was having difficulty sleeping, this supplement has allowed him to get the first full nights rest since.
Most people who take GABA for sleep disturbances take between 750mg-1000mg right before going to bed. Because GABA may make you drowsy, this is a good time for anyone planning to experiment with this supplement.
GABA Reviews Summarized
GABA reviews are often positive despite the lack of scientific evidence supporting the use of this nootropic. Although it has been shown that GABA is unable to cross the blood-brain barrier, it is possible there is some other mechanism at work.
Because everyone’s brain chemistry is unique, nootropics and other mind enhancing supplements or medications may affect individuals differently.
Until more is known about GABA supplements, there are other GABAergic supplements which are suitable replacements. Two popular supplements are L-Theanine and Lemon Balm, both of which are capable of crossing the blood-brain barrier and interacting with GABA receptors in the brain.
- Silveri MM. GABAergic contributions to alcohol responsivity during adolescence: insights from preclinical and clinical studies. Pharmacol Ther. 2014
- Schousboe A, Madsen KK, Barker-Haliski ML, White HS. The GABA synapse as a target for antiepileptic drugs: a historical overview focused on GABA transporters. Neurochem Res. 2014
- Stokes PR, Myers JF, Kalk NJ, Watson BJ, Erritzoe D, Wilson SJ, Cunningham VJ, Riano Barros D, Hammers A, Turkheimer FE, Nutt DJ, Lingford-Hughes AR. Acute increases in synaptic GABA detectable in the living human brain: a [¹¹C]Ro15-4513 PET study. Neuroimage. 2014
- Plante DT, Jensen JE, Schoerning L, Winkelman JW. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder? Neuropsychopharmacology. 2012
- Uetake K, Okumoto A, Tani N, Goto A, Tanaka T. Calming effect of orally administered γ-aminobutyric acid in Shih Tzu dogs. Anim Sci J. 2012
- Borisenko SA, Tolmacheva NS, Burov IuV, Blinkova NF. [Permeability of the blood-brain barrier to 3H-GABA during alcoholic intoxication]. Biull Eksp Biol Med. 1982
- Vanini G, Lydic R, Baghdoyan HA. GABA-to-ACh ratio in basal forebrain and cerebral cortex varies significantly during sleep. Sleep. 2012
Article last updated on: March 13th, 2018 by Nootriment
2 Comments
I took a tablet of Phenibut and had a hell of a sleep. I could not wake up and thought I would die at work. Then I took L-Tyrasine with coffee and I am running all day full of energy.
I’ve been taking meds for depression for years and wanting to get OFF them; I decided to try GABA ( NOW brand ) and they work great! I’ve been off the pharma meds for a few weeks & my mood is good. I highly recommend, but hey, everyone is different.