Grape seed extract supplements are being used for a wide variety of uses from reducing inflammation to antioxidant benefits to increased stamina and energy as well as improved brain health.
The grape seed extract dosage that you use will depend on your reasons for taking this supplement. It will also depend on the quality of product you are using as measured by the proanthocyanidin content found in the extract.
Grape seed extract is considered to be a safe supplement with few known side effects or contradincations.
In the US, the Muscadine grape has been cultivated since the early 16th century. It has been used in cooking and as a traditional medicine, taken as either a preventative or to cure certain ailments.
The properties of grape seed extract are now being investigated by science. Researchers are trying to establish what properties and compounds the red grape contains and how its effects may be utilized in medicine.



- Supports brain health & alertness
- Improves heart health & cholesterol levels
- Potent anti-oxidant & procyanidins source
Supplementing with Grape Seed Extract
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Grape seed extract is a by-product of the wine industry.
The grape seeds used come only from the red grape and even then only from certain varieties.
The Muscadine red grape is observed to have greater proportions of bioactive plant compounds in both the skin and the seed.
Red wine is seen to be more beneficial, health wise, than white wine. When making red wine, the skins of the grape are left to ferment for longer than the white or green grape. This allows for more of the compounds – such as resveratrol – to be transferred into the fluid.
Historically the vine and all its constituent parts played a major traditional role in natural cures and preventions. Vine leaves were used to treat inflammation and bodily injuries. Other parts were used to treat skin and eye conditions, sore throats, and even constipation. It was believed that grapes taken regularly would act as a preventative and keep a person healthy.
Grape Seed Extract Reviews and Health Benefits
Today science is investigating how the grape and its component parts may produce positive effects for health. It is now understood that the seeds of grapes contain a high level of oligomeric proanthocyanidin complexes or OPCs.
The grape seed usually holds a higher level than other parts of the fruit or plant. OPCs are a polyphenol which assist in helping the body produce glutathione.
This is an antioxidant which plays a significant role in helping to keep damaging free radicals under control. Free radicals are major contributors to causing damage to cells and therefore the human body as a whole. They are implicated in illnesses such as cancer, high blood pressure and dementia.
It is also clear from reviews that people take grape seed extract dosages for a broad variety of conditions, whether based on scientific evidence or not. These range from on-going serious clinical problems to health maintenance and illness prevention.
Observations from user reviews include that grape seed extract has been used for:
- Joint and muscle pain
- Inflammation
- Chilblains
- Pain relief associated with varicose veins
- Skin conditions
- Mood enhancer
- Libido
- Stamina
- Respiratory problems
- Reduction of allergy symptoms
- Arthritis
Scientific research continues to investigate the use of Grape Seed extract for many of these conditions. While research is considered to be limited at present, there is some good data regarding Chronic Venous Insufficiency. ocular stress, and other conditions.
At this time, grape seed extract is available as a dietary supplement only, the FDA has not approved grape seed extract as a drug to prevent or treat any conditions.
Grape Seed Extract Use
The difference between grape seed extract liquid and grape seed oil is that the oil is a preparation used in food, cooking, and sometimes skin care. The oil is extracted as the seed is being processed and in many cases does not prove to contain the same compounds in the same proportions as the seed itself.
The extract also has a very high fiber content. This is not only useful when taking the supplement in isolation but is also why it is added to some health foods. Nutritional food bars often contain grape seed extract as part of their ingredient list to increase the fiber content.
Some people are being directed to take grape seed extract doses by their doctors. In particular people with high or raised blood pressure are suggested to try the supplement. This is in an effort to control the problem and avoid prescription drugs which may have side effects.
There is some recent scientific evidence which supports the use of grape seed extract in lowering blood pressure. This could be the reason some doctors are willing to encourage low risk patients to try the supplement and monitor effects.
Grape Seed Extract Dosage
Proper dosage is dependent on many different factors, and it is always recommended that you speak with your doctor to help determine the best dosage for your needs. The following dosage recommendations are general guidelines only, and your personal dosage may be different.
The standard daily dose of grape seed extract is between 100mg and 300mg per day for most conditions. As with many supplements, it is usually recommended that the lower dose is taken to start and increased as required.
Some products do suggest values of up to 600mg per day and some research studies have used up to 900mg per day. While dosages of this amount have not produced an increased risk of serious side effects, it is not recommended to take more than 300 mg unless advised to do so by your doctor.
These dosages are based on an active dosage of 50 mg – 250 mg per day of OPCs. Oligomeric proanthocyanidin complexes are the active components found in grape seed extract, but not every product will contain the same concentration of these antioxidant compounds.
Look for products that provide at least 80% proanthocyanidin content specified in the ingredients list to ensure you are purchasing a high quality product.
There are no recorded significant side effects relating to grape seed extract. High tolerable doses have not yet been established, but research suggests doses of up to 900mg per day are well tolerated.
This supplement should not be given to individuals who are allergic to grapes. Pregnant or breastfeeding women should consult with a doctor prior to taking the product, as safety information in these groups is limited.
Purchasing Grape Seed Extract
Buying Grape Seed Extract in capsule form will cost approximately $10-20 per bottle of 60 capsules. Tablets come in dosage sizes of between 100 – 300 mg each. You can expect to pay between $0.15 – $0.25 per serving for a single ingredient grape seed extract dosage.
Some products may combine this supplement with other antioxidant ingredients to promote anti-aging effects. These products will typically cost more, but may offer additional health benefits.
- Bagchi D, Swaroop A, Preuss HG, Bagchi M. Free radical scavenging, antioxidant and cancer chemoprevention by grape seed proanthocyanidin: an overview. Mutat Res. 2014
- Sapwarobol S, Adisakwattana S, Changpeng S, Ratanawachirin W, Tanruttanawong K, Boonyarit W. Postprandial blood glucose response to grape seed extract in healthy participants: A pilot study. Pharmacogn Mag. 2012
- Cheah KY, Howarth GS, Bastian SE. Grape seed extract dose-responsively decreases disease severity in a rat model of mucositis; concomitantly enhancing chemotherapeutic effectiveness in colon cancer cells. PLoS One. 2014
- Sano A, Tokutake S, Seo A. Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting. J Sci Food Agric. 2013
- Khoshbaten M, Aliasgarzadeh A, Masnadi K, Farhang S, Tarzamani MK, Babaei H, Kiani J, Zaare M, Najafipoor F. Grape seed extract to improve liver function in patients with nonalcoholic fatty liver change. Saudi J Gastroenterol. 2010
- Zhen J, Qu Z, Fang H, Fu L, Wu Y, Wang H, Zang H, Wang W. Effects of grape seed proanthocyanidin extract on pentylenetetrazole-induced kindling and associated cognitive impairment in rats. Int J Mol Med. 2014
- Tyagi A, Raina K, Shrestha SP, Miller B, Thompson JA, Wempe MF, Agarwal R, Agarwal C. Procyanidin B2 3,3(″)-di-O-gallate, a biologically active constituent of grape seed extract, induces apoptosis in human prostate cancer cells via targeting NF-κB, Stat3, and AP1 transcription factors. Nutr Cancer. 2014
Article last updated on: May 12th, 2018 by Nootriment
5 Comments
What is the recommended dosage of grape seed capsule for cancer patients given 6 months to live
:( I am sorry to hear that. I will keep you or whoever it is in my thoughts. Honestly I would take a bunch of it. Like two pills 3-4xper day. I would also add circumin, saments, cats claw, fucoidan, and EAT cbd/thc found in a syringe (looks thick and black).
Jessica, I stumbled across this page and saw your comment and got the impression you are well versed in natural cancer fighting alternatives. I have a recent diagnosis of squamous cell carcinoma in my right tonsil and lymph nodes. Would you suggest this same array of items for me?
I just came across this site and I’m so sorry to hear of your situation. I hope you have found healing and I will pray for you!
Jessica, you sound very knowledgeable about alternative, natural remedies for cancer. I have recently been diagnosed with squamous cell carcinoma in my right tonsil and lymph nodes and was wondering if the list of items you recommended Kenyetta would be appropriate for me. What training or experience do you have with these natural remedies? I’m trying to quickly learn as much as I can. Thank you!