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How long does it take Phenibut to work and what is the typical duration of effects?
Phenibut is a nootropic agent that is used for reducing anxiety, enhancing sociability, promoting better sleep, and improving cognitive function.
Users typically take this product to relax, combat feelings of stress and nervousness, मूड और बूस्ट फोकस बढ़ाने. Research shows that it can inhibit anxiousness and restlessness at low doses without causing a decline in mental performance.
उपयोगकर्ता की समीक्षा के अनुसार, the effects can kick in within 1 – 4 hours of oral consumption. Because this anxiolytic has a long half-life, it is important to use it responsible to reduce the risk of side effects.
Individual responses to Phenibut supplementation vary. The onset of effects and half-life can also be affected by how you take this product, what form you take it in, other substances used and differences in metabolism.
इस लेख समीक्षाएं the pharmacokinetics of phenibut,, its duration of effects in the CNS (केंद्रीय तंत्रिका तंत्र) and how to take it safely.
चिंता
मूड
सो & अनिद्रा- तनाव में कमी के लिए शक्तिशाली anxiolytic
- उत्तेजित करता है गाबा रिसेप्टर्स & समर्थन नींद
- न्यूरोप्रोटेक्टिव & समर्थन करता है संज्ञानात्मक समारोह
Phenibut कैसे काम करता है?
संबंधित विषय
- क्या Phenibut है?
- उपयोगकर्ता समीक्षा
- लाभ और उपयोग करता है
- खुराक अनुशंसाएँ
- प्रभाव & कार्रवाई के तंत्र
- अनुभव की रिपोर्ट
- विरोधी चिंता प्रभाव
- नींद के लिए Phenibut का उपयोग
- कैसे लेने के लिए
- नकारात्मक पक्ष प्रभाव
- वापसी के खतरों
- शराब संयोजन के साथ जोखिम
- Picamilon की तुलना
- Phenibut गाइड ख़रीदना
- थोक पाउडर का उपयोग कर
- Primaforce Phenibut समीक्षा
- एसएनएस Phenibut XT की समीक्षा
Phenibut was developed by Soviet scientists in the 1960s to treat PTSD (पोस्ट-दर्दनाक तनाव विकार), अनिद्रा, बड़बड़ा, depression and various other disorders.
It was initially used in Russian cosmonauts to help them deal with the stresses of space missions without impairing cognition. Studies found it to promote feelings of well-being and calm while also supporting concentration, ध्यान अवधि और स्मृति.
Phenibut (Noofen, Anvifen) is used by some people as a “स्मार्ट ड्रग” और सामांयतः में शामिल है Nootropic ढेर designed for reducing social anxiety, distractions, inhibitions and enhancing mood.
The Natural Medicines Comprehensive Database states that people use phenibut powder and capsules for improving learning capacity, स्मृति, और सामान्य अनुभूति. [3]
This nootropic has also been studied and used clinically for the following:
- Insomnia and other sleeping disorders;
- PTSD (पोस्ट अभिघातजन्य तनाव विकार);
- Fear, तनाव, चिंता, और तनाव;
- Heart arrhythmia;
- शराब;
- अवसाद;
- थकान;
It is sold as an over-the-counter medicine in Russia and certain European nations. Phenibut is sold under several brand names – सहित Noofen, Citrocard, Fenibut, and Phenybut.
कार्रवाई के तंत्र
Phenibut is a synthetic derivative of a chemical the body produces endogenously called GABA (एसिड गामा aminobutyric). GABA is an inhibitory neurotransmitter that is responsible for regulating anxiety and over-excitation in times of stress.
GABA is very important for balancing the effects of a stimulatory neurotransmitter called ग्लूटामेट. These two nerve-signaling chemicals work together to mediate numerous CNS functions.
When taken as an oral dietary supplement, GABA has a difficult time crossing the BBB (रक्त मस्तिष्क बाधा). [1] There is on-going debate about whether it is effective if consumed orally.
Phenibut was designed as a phenylated analog of GABA, capable of crossing the blood-brain barrier and acting as a direct agonist of GABA (बी) रिसेप्टर्स. By binding to GABA receptor sites, it causes similar inhibitory effects as this neurotransmitter.
Some other compounds with similar effects include GABA, Lyrica, Picamilon, Gabapentin, and Baclofen.
डबल-ब्लाइंड, placebo-controlled human research on phenibut is lacking. Much of the research was conducted in Russian in the 1960s and 1960s and is not available in English. हालांकि, पशु अध्ययन में, this compound has been shown to: [3]
- Decrease alcohol-induced behavioral disorders;
- Decrease desire to consume alcohol;
- Decrease respiratory rate;
- Increase heart rate;
- Reduce anxiety;
- Cause sedation;
- तनाव में कमी के लिए शक्तिशाली anxiolytic
- नींद में सुधार और अनिद्रा को कम कर सकते हैं
- न्यूरोप्रोटेक्टिव और cardioprotective इफेक्ट
How Long Does Phenibut Take to Work?
Each user will have a different experience with this nootropic supplement. Numerous individual factors control how long it takes phenibut to become active in the CNS.
According to a report by the New York State Office of Alcoholism and Substances Abuse Services, Phenibut has an onset of effects of 60 – 90 मिनट.
Some users say that they feel it working within one hour of taking a dose while others say it can take up to two hours for the benefits to kick in. These differences may be explained by individual tolerance and sensitivity, whether it is being consumed with a meal and other factors related to metabolism.
PsychonautWiki के अनुसार, this compound has a “come up” time of 1.5 – 3 घंटे. This refers to the amount of time between when effects are first observed and peak efficacy. This source reports that peak effects occur between 3 – 4 hours with an offset period of 4 – 6 घंटे.
According to Nootrohacker, “Many users find that it takes quite a while for the effects to take hold. It is common to feel nothing for 4-6 hours after taking Phenibut, then experiencing a nice calming effect.” [2]
Phenibut is sometimes administered via insufflation (नाक के माध्यम से) or rectally. It may work faster if taken via different methods of administration. According to an article in the Drug and Alcohol Review, this nootropic has an onset of action between 20 – 30 minutes when taken rectally.
प्रभाव की अवधि
Phenibut capsules and powder have a longer half-life than some other nootropic drugs. Most users find they only need to take a single dose of this calming nootropic daily.
Although the reported half-life of this smart drug is about 5 घंटे, the duration of its effects varies significantly between users.
Some user reviews state that the noticeable effects are short-lived and begin to fade after 4-6 घंटे. Others state that they feel effects for up to 24 hours after a single dose.
PsychonautWiki reports a total duration of effects of 10 – 16 hours and states that after-effects may be felt for between 6 – 24 घंटे.
Some factors that affect how long you will feel phenibut’s effects after taking it include:
- Use of stimulants (कैफीन की तरह) taken recently;
- Concurrent use of other GABAergic substances;
- Former use of GABAergic drugs;
- Consumption of alcohol;
- Time since last meal;
- Current health state;
- चयापचय;
- Body weight;
- Gender;
- उम्र;
- मूड में सुधार करने के लिए सबसे प्रभावी खुराक
- डोपामाइन के स्तर का अनुकूलन, सेरोटोनिन और GABA
- तनाव और चिंता के खिलाफ की रक्षा
Recommended Phenibut Dosage
Phenibut may not be safe for everyone. Using this substance in high dosages could lead to serious adverse effects.
As a result of the long period of time it takes for this nootropic to start working in the body, users should avoid re-dosing the substance multiple times a day. If taking as a sleep aid, it may be recommended to use one to two hours before bedtime.
The common phenibut dosage ranges between 250-1000 मिलीग्राम (mg) दैनिक. [1] Be careful with high doses (से अधिक 1 ग्राम दैनिक).
यह निर्धारित करने के लिए इस उत्पाद को लेने से पहले डॉक्टर से परामर्श करें कि क्या यह आपके लिए उपयुक्त है. Begin at the low end of the recommended dosage range until you observe how it affects you.
Some users take more than is commonly recommended to experience the Phenibut उच्च. Some users report a euphoric experience after taking larger doses.
The effects are said to be similar to those of other GABA agonists – शराब की तरह, barbiturates, और बेंज़ोडायज़ेपींस.
Be aware that using phenibut in doses of more than 1000 mg daily can increase the risk of developing tolerance, and some dangerous adverse side effects.
Using Long-Term
Using phenibut long-term might lead to tolerance and GABA receptor downregulation. इस वजह से, its use should be cycled on and off.
Some nootropics begin to work better as you take them for long periods of time. This is not the case with GABAergic drugs. The more you use these substances, the less effective they will become.
This nootropic drug affects the same receptors in the brain as alcohol. Just as users can become less sensitive to the effects of alcohol नियमित उपयोग के साथ, so too can sensitivity decrease with ongoing use of Phenibut.
Individuals who take this substance sometimes report feeling a need to increase the dose to continue to experience the benefits. This is strongly advised against as it could lead to serious negative reactions.
One common approach to cycling phenibut is to use it 2-3 days each week and take the other 3-4 दिन बंद.
Some users take it daily for 2 सप्ताह, and then stop taking it for 2 weeks so that they keep noticing its effects and minimize their risks for developing tolerance.
Most users who take it responsibly do not experience withdrawal symptoms, but they are possible. If you have a history of drug abuse or consuming large amounts of alcohol, you may be at greater risk for developing signs of withdrawal when you stop taking it.
Phenibut Not Working
What should you do if you do not feel any effects after taking this substance or notice the effects beginning to taper off?
Many phenibut users report positive experiences with this nootropic. Reviewers commonly cite the following effects: [4]
- Noticeable decrease in anxiety;
- Improved sexual performance;
- Feelings of extreme calmness;
- Increased prosocial behavior;
- Increased overall well-being;
- Increased motivation;
- बढ़ी हुई सतर्कता;
Phenibut seems to work in most people who try it, but not all of them. Some people experience no noticeable effects from taking this smart drug and are non-responders.
To maximize its effectiveness, it is recommended to be taken on an empty stomach, first thing in the morning. Some users claim that taking the powder or capsules with 80-160 mg of caffeine helps to “किक में” its effects.
Other users claim that it is more effective if administered intranasally. Some report feeling little to no effects with the Phenibut HCL crystals but experiencing positive benefits with the Free Amino Acid (faa) प्रपत्र.
कुछ सूत्रों के अनुसार, if you weigh more than 210 पाउंड, higher dosages of अप करने के लिए 1.5 ग्राम (1500 mg) दैनिक may be necessary to experience effects.
Those who have a tolerance to drugs like Valium (diazepam), Xanax (अल्प्राजोलम), or Klonopin (clonazepam) might not notice any effects.
If you stop noticing the effects after using it for a while, उसके बाद cycling off for 2 सप्ताह will normally restore your sensitivity.
Most users seem to have positive experiences with phenibut when they use it appropriately. हालांकि, there are some possible side effects to be aware of, सहित: [2]
- पेट की परेशानी;
- हल्कापन;
- सिर दर्द;
- थकान;
- मतली;
In rare and severe cases, extremely high doses can cause memory loss or loss of consciousness. Mixing this product with alcohol or other GABA agonists to make it work better is not recommended.
मुफ़्त शिपिंग
आलेख अंतिम बार अद्यतन किया गया: 16 जुलाई, 2018 द्वारा Nootriment