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Noopept and Phenibut are nootropics that are purported to improve mood, चिंता का मुकाबला, छूट और समर्थन संज्ञानात्मक समारोह को बढ़ावा देना.
Both have been used clinically to address symptoms of neurological disorders including cerebrovascular disorder, अल्जाइमर रोग, बूढ़ा डिमेंशिया, as well as mood disorders.
In addition to their medical uses, Noopept and Phenibut are taken for their “ऑफ-लेबल” लाभ. User reviews and some scientific research points to positive effects for those dealing with lack of focus, चिंता, तनाव, or emotional mood swings.
Both Noopept and Phenibut are Russian-developed nootropics and most of the research available on these substances was conducted in Russia. While they have some similarities in terms of their range of uses, the effects and mechanisms involved are very different.
Phenibut is significantly more powerful as an anxiolytic agent than Noopept and poses a higher risk of side effects. Noopept exhibits more benefits for mental performance, स्मृति, focus and awareness.
Some users elect to take a Noopept Phenibut Stack to experience the benefits of both of these substances in combination. Before using this nootropic stack, it is important to learn about the effects of these drugs, how they should be used responsibly and the dangers of overuse.
मानसिक ऊर्जा
स्मृति
मस्तिष्क स्वास्थ्य- स्मृति का समर्थन करता है, फोकस & मूड
- मानसिक सतर्कता बढ़ाती है & energy
- बढ़ता बीडीएनएफ & मस्तिष्क स्वास्थ्य को बढ़ावा देता है
Noopept vs. Phenibut
संबंधित विषय
- क्या है Noopept?
- उपयोगकर्ता समीक्षाएँ
- सूचना दी लाभ
- यह कैसे काम करता है
- नकारात्मक पक्ष प्रभाव
- विशिष्ट अनुभवों
- की सिफारिश की खुराक
- सबसे अच्छा तरीका है लेने के लिए
- Choline के साथ स्टैकिंग
- अनुशंसित Nootropic ढेर
- क्रय गाइड
- बल्क Noopept पाउडर
- खरीदें Noopept कैप्सूल
- Noopept कानूनी है?
- Piracetam करने के लिए तुलना
- Aniracetam की तुलना
- Oxiracetam की तुलना
- Pramiracetam की तुलना
Comparisons between Noopept vs. Phenibut may help to clarify a number of questions consumers have when it comes to choosing one over the other.
Noopept and Phenibut are synthetic nootropics or “स्मार्ट ड्रग्स” – an umbrella term defining substances that have the reputation of enhancing cognition, फोकस, स्मृति, साथ ही प्रेरणा.
Studies regarding the efficacy of nootropics have been ongoing since the mid-1970s. Several of today’s popular nootropics, including Noopept and Phenibut, were developed in Russia as early as the mid-1960s.
Usage of nootropics in the United States has begun to gain wider acceptance, especially in regard to increased knowledge and research about them.
One area of ongoing study begun in the 1970s is the potential use of nootropics in the alleviation of symptoms of dementia and age-related memory loss. [1]
Individuals tend to use Noopept as a support for cognitive function, while Phenibut is commonly used as an anti-anxiety medication or a depressant for the central nervous system.
Testimonials and experience logs from users suggest that both have mood-lifting and calming properties, however Phenibut is significantly stronger than Noopept for the alleviation of anxiety and stress.
Noopept Overview
Noopept is the Russian brand name for a synthetic chemical (N-phenylacetyl-L-prolyglycine ethyl ester or Omberacetam) that has been studied for its capability to provide some protection to neurofunction and ameliorate cognitive impairments.
Noopept is defined as a “स्मार्ट ड्रग” that has garnered interest for its potential to stimulate certain receptors in the brain that are involved with cognition, स्मृति, और ध्यान. It appears to facilitate cholinergic neurotransmission, which plays a role in short-term memory, ध्यान स्विचन, impulse control and learning.
The actual mechanism of action of Noopept in this regard is not yet fully understood. Several potential mechanisms of action have been identified in animal studies.
Noopept is also believed to stimulate two primary “उत्तेजक” neurotransmitter receptors and receptor pathways that facilitate thought processes, स्मृति, और ध्यान.
It appears to selectively increase activation of AMPA and NMDA receptors in the glutamate family. Glutamate is the primary excitatory neurotransmitter in the brain.
Ionotropic receptors such as AMPA and NMDA have the potential to turn on or turn off channels that facilitate neurotransmissions. Noopept is perceived to have the capability of opening these channels, stimulating greater communication between neurons or transmission of signals that mediate focus and thought processes. [3]
These glutamate receptors are also involved in Long-Term Potentiation, which is the mechanism involved in encoding memories in the brain for long-term storage.
Research also shows benefits for symptoms of anxiety, चिड़चिड़ापन, apathy and fatigue in patients with vascular cerebral damage or traumatic brain injury. One study found that Noopept enhanced mood, daytime wakefulness and sleep quality in patients diagnosed with organic brain disorders. [13]
Research in animal models also suggests benefits for depression. The mechanisms involved in Noopept’s anti-anxiety and anti-depression effects are not well understood. This nootropic has been shown to increase the frequency of Inhibitory Post-Synaptic Currents (IPSCs) in Hippocampal pyramidal cells.
User reviews often cite mood boosting effects from taking Noopept. Some users describe feeling “उज्जवल”, स्पष्ट नेतृत्व, more confident in social settings, less susceptible to irritation over minor hassles, and general positivity and well-being.
Not everyone experiences these effects and compared to Phenibut, the anxiolytic effects are much subtler.
- 1000x Piracetam से अधिक शक्तिशाली
- स्मृति का समर्थन करता है, ध्यान और मूड
- मानसिक सतर्कता और ऊर्जा को बढ़ा देता है
Phenibut अवलोकन
Phenibut has been utilized in clinical settings in Russia since the 1960s. It is widely prescribed for mood disorders and insomnia under the brand names Anvifen, Fenibut, and Noofen.
Phenibut has a long history of use in Russia and former Soviet countries like Ukraine and Latvia as an anti-anxiety formula that triggers a calming effect on users without the sedation commonly found in other modern anti-anxiety and antidepressant medications.
It has been used to enhance quality sleep in neurotic patients as well as those displaying psychosomatic fears and anxieties. आज, it’s commonly used as a treatment for the relief of symptoms of PTSD and for alcohol withdrawal syndrome. [7]
Phenibut has not been approved for used a medical drug in the United States, but is commonly taken off-label as a nootropic agent or for recreational purposes.
अध्ययन में, Phenibut shows the potential to ‘imitate’ GABA-like influences on GABA-B receptors, encouraging relief of anxiety. It has also been studied for its potential to stimulate dopamine receptors and its ability to antagonize beta-phenethylamine. [8]
The chemical structure of Phenibut is similar to that of gamma-aminobutyric acid (GABA) – an inhibitory chemical in the brain. GABA is an amino acid that behaves as a neurotransmitter in the central nervous system, required for regulating normal brain function.
GABA’s mechanism of action is to decrease the activity of neurons and prevent nerve cells from getting “overexcited”. It counteracts excitatory signals and reduces the rate of stimulation in neurons.
सरल शब्दों में, GABA reduces the number of stress or anxiety-causing “messages” the brain receives in response to internal and external stimulus.
Phenibut is a selective GABA receptor agonist, which means that it can bind to GABA-B receptors and promote the same response as the neurotransmitter gamma-aminobutyric acid.
Because if it’s similar chemical structure to GABA, it can promote calming sensations. Phenibut is more powerful than taking a GABA supplement because it has a higher degree of bioavailability and can better cross the blood-brain barrier.
जानवरों के अध्ययन में, Phenibut has been shown to decrease anxiety. Modern human studies are lacking, but there is ample evidence from user reviews showing an anxiolytic effect of this substance.
Phenibut was originally considered to be a nootropic agent because it could calm the mind without causing excessive sedation and impairment cognitive abilities.
Some early studies conducted in Russia suggest benefits for mental function, but there is limited data available to evaluate its broader effects on memory, ध्यान और अनुभूति.
While a small number of users claim that this substance has nootropic effects of its own, most say that any cognitive benefits are linked to a reduction in anxiety. Noopept is a better choice for users who want to achieve cognitive enhancement.
Phenibut has a long history of clinical use, but can be dangerous if taken without appropriate medical supervision. Use of this substance at high dosages or taking it for long periods of time can result in serious side effects including overdose, लक्षण, a psychosis-like condition and may necessitate hospitalization.
Phenibut works on similar receptors in the brain as alcohol, benzodiazepines and baclofen. The same GABAergic side effects that are possible with these agents could occur if Phenibut is misused.
चिंता
मूड
सो & अनिद्रा- तनाव में कमी के लिए शक्तिशाली anxiolytic
- उत्तेजित करता है गाबा रिसेप्टर्स & समर्थन नींद
- न्यूरोप्रोटेक्टिव & समर्थन करता है संज्ञानात्मक समारोह
Comparing Noopept and Phenibut
When comparing Noopept and Phenibut, the differences between the two should be clear. They are two different substances, one intended for use as a stimulation for cognitive function, and the other for anti-anxiety.
Both are labelled as nootropics and they are described as having some similar properties for anxiety relief and mood enhancement. हालांकि, user experiences demonstrate a clear difference between the two.
Phenibut is a significantly more potent GABA agonist that produces an anxiolytic effect and can cause sedative-like effects.
Noopept may increase inhibitory nerve signals in certain parts of the brain, but it does not appear to bind to GABA receptors and it has some stimulant-like effects.
For off-label use, Phenibut produces a more powerful experience of relaxation, मानसिक शांत, and restfulness but also carries a heightened risk of dangerous side effects.
When comparing research into Noopept vs. Phenibut, there are studies that have looked at the neuroprotective properties of these substances for the treatment of cognitive dysfunction or degenerative brain disorders.
More research is needed to evaluate the effectiveness of these drugs for dementia-related conditions, सेरेब्रल ischemia, Alzheimer’s disease and degenerative nerve damage in the brain.
A 2014 study on cellular models reported benefits of the neuroprotective effects of Noopept in its potential to inhibit oxidative damage and suppression of cellular death. [9]
जैसा कि पहले उल्लेख किया, tau and tau bundles have been linked to Alzheimer’s disease. Tau is a type of neuron protein linked to neuro fibers known as tangles in the brain of those affected by Alzheimer’s disease.
Scientific evidence has purported that disruption of tau functions and interactions can play a role in disruption in brain functions involved in dementia type disease processes. [10]
While human clinical trials, animal studies, and microbiological research are still exploring the exact cause of certain types of dementia, nootropics such as Noopept may prove beneficial in offering protection against toxicity as well as in decreasing tau phosphorylation. [11]
Because dementia patients, depending on severity and stage, often grow agitated, घबरा, suspicious, and even paranoid, study of nootropics such as Phenibut may also prove beneficial in providing calming influences.
जानवरों के अध्ययन में, Phenibut (बीटा-फिनाइल-गामा-aminobutyric एसिड एचसीएल) primarily acts as a GABA-mimetic. A mimetic is something that imitates something, meaning that it is able to imitate or mimic the effects of GABA in the brain.
1960 के दशक के बाद से, Russian doctors have used Phenibut in clinical practices for its potential to influence GABA receptors. It is popular for the relief of anxiety, डर, as well as to improve sleep patterns in neurotic patients. इस तरह, Phenibut may act much like a tranquilizer to calm severely agitated patients.
Some studies have also established neuroprotective effects of R-Phenibut in experimental models of stroke un animals. But there is no evidence that Phenibut can cure these conditions.
Use of Phenibut or Noopept as a broad range treatment of Alzheimer’s symptoms and degenerative conditions have not been fully explored nor studied in large, नियंत्रित, नैदानिक परीक्षण. पशु, laboratory and cell line experiments and studies continue.
There are no comparative studies available to evaluate the efficacy of Noopept vs. Phenibut as nootropic agents for cognitive enhancement.
- तनाव में कमी के लिए शक्तिशाली anxiolytic
- नींद में सुधार और अनिद्रा को कम कर सकते हैं
- न्यूरोप्रोटेक्टिव और cardioprotective इफेक्ट
Noopept Phenibut Stack
A number of users on Reddit and Longecity report their experiences with taking a Noopept Phenibut Stack.
According to one review, “The Noopept Phenibut stack is an interesting one! This may actually be a highly effective stack for improving sociability, सतर्कता, and mood.” [14]
Reviewers claim that the enhanced mental clarity and focus of Noopept pair well with the positive mood and pro-social effects of Phenibut. Noopept contributes to memory performance, cognition and alertness while Phenibut prevents the feeling of over-stimulation that can occur.
If taking these nootropics in a stack, it is recommended to start with lower dosages due to the potential for synergistic effects.
खुराक
Noopept supplements are available in a variety of milligram strengths and dosage recommendations will vary depending on product. Always take Noopept and other nootropics like Phenibut according to usage instructions.
In regard to safety issues, personal tolerance and sensitivity may influence the potential for side effects and adverse reactions.
Noopept is available as a tablet and is also sold in powdered form. Noopept capsules are available में 10 mg, 20 mg, और 30 mg options. Serving size for the supplement regardless of milligram strength is typically one capsule daily.
Nasal sprays and sublingual use of the powder have also become popular options recently. Some users do not experience benefits when taking this nootropic orally, but find it to be effective if used sublingually or administered as a spray to the nosel.
Phenibut, due to its potency, as well as potential for dependency, is not recommended as a daily supplement. के लिए सबसे, taking Phenibut twice a week is adequate and prevents the potential of tolerance as well as possible withdrawal symptoms for those who use it more than recommended.
Dosage recommendations for Phenibut range 250 करने के लिए मिलीग्राम 1000 mg of the supplement in capsules or powdered form on a daily basis, although some individuals may take as much as 3000 दैनिक मिग्रा.
Use of higher dosages increases the risk of serious side effects. Long-term use could cause tolerance to develop and result in dependence or withdrawal symptoms.
Those new to use of Noopept as well as Phenibut should start with even lower dosages to gauge how the body reacts to it.
Consult with a doctor before taking these substances. Do not use Phenibut if you have a pre-existing medical condition without first checking with your doctor.
Combining Phenibut with other medications that affect GABA receptors could exacerbate side effects. Do not drink alcohol when taking this nootropic drug.
नोट:: The US Food and Drug Administration has deemed nootropics, at least currently, as unregulated supplements. Some claims regarding use of nootropics have not been fully researched and studied, nor approved by the FDA.
- अब फोकस, & स्पष्ट मस्तिष्क कोहरे और अधिक प्रेरित लग रहा है
- ऊर्जा बूस्ट, alertnes & स्मृति
- जिसमें है 12 सुरक्षित और प्राकृतिक nootropic अवयवों
साइड इफेक्ट
In regard to safety considerations, Noopept does present with some side effects that can include but are not limited to:
- सिर दर्द
- Change in appetite
- Potential irritability
- A sense of restlessness
- मस्तिष्क कोहरे
Noopept is generally well tolerated and most users do not experience serious side effects. If you do develop adverse effects, using a lower dosage or taking a choline supplement can mitigate these.
Learn about safe use of Noopept and potential side effects इस आलेख में.
A number of side effects are also associated with use of Phenibut, इस तरह के रूप में:
- पेट में ऐंठन
- चक्कर आना
- सुस्ती
- Potential dependence
?
Serious adverse effects can occur when taking high dosages, especially if consuming this nootropic drug in combination with other substances.
A 2013 case study of possible dependents to Phenibut emphasizes the importance of caution with users. The case presented a patient self-medicating to treat insomnia, चिंता, and cravings for alcohol.
The individual developed tolerance to the point where he began to experience withdrawal symptoms within three to four hours of use. He was treated with baclofen as a substitution of Phenibut, and after approximately nine weeks was successfully tapered off. [12]
के बारे में अधिक जानें risks and side effects of Phenibut here as well as ways to reduce potential negative effects through responsible use.
मुफ़्त शिपिंग
- C.D. Nicholson, Pharmacology of nootropics and metabolically active compounds in relation to their use in dementia. Psychopharmacology. (1990)
- Chen-YiWu et al, The Effects of Anti-Dementia and Nootropic Treatments on the Mortality of Patients with Dementia: A Population-Based Cohort Study in Taiwan. एक और. 2015; 10(6):e0130993.
- Firstoba Lulu et al, [चूहे मस्तिष्क में ग्लूटामेट रिसेप्टर्स पर nootropic दवाओं के विशिष्ट प्रभावों का अध्ययन]. Eksp Klin Farmakol. 2011;74(1):6-10
- Brust पी, nootropics piracetam और pramiracetam द्वारा रक्त मस्तिष्क बाधा भर में choline परिवहन के scopolamine प्रेरित परिवर्तन के उत्क्रमण. Arzneimittel-Forschung (1989)
- डॉ.. Karl Kruszelnicki, How does the blood-brain barrier work? ABC Science (2013)
- Rita U. Ostrvskaya et al, The nootropic and neuroprotective proline-containing dipeptide Noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model. Psychopharmacology के जर्नल (2007)
- a href="https://www.ncbi.nlm.nih.gov/pubmed/1183076"1 लक्ष्य ="_ blank" रिलायंस एनर्जी ="nofollow">Lapin I, Phenibut (बीटा-फिनाइल-गाबा): एक ट्रैंक्विलाइज़र और nootropic दवा. सीएनएस ड्रग रेव. 2001 शीतकालीन;7(4):471-81.
- Ibid.
- Óstrovskaya RU et al, Neuroprotective effect of novel cognitive enhancer Noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. जंमू Biomed विज्ञान. 2014 अगस्त 6;21:74.
- Johnson GV, Stoothoff WH, Tau phosphorylation in neuronal cell function and dysfunction. J Cell Sci. 2004 नवम्बर 15;117(Pt 24):5721-9.
- Rita U Óstrovskaya et al, उपन्यास के न्यूरोप्रोटेक्टिव प्रभाव-विज्ञापन से संबंधित सेलुलर मॉडल पर संज्ञानात्मक बढ़ाने noopept apoptosis और ताऊ का क्षीणन शामिल है hyperphosphorylation. जंमू Biomed विज्ञान. 2014 अगस्त 6;21:74.
- Andriy Samokhvalov et al, Phenibut निर्भरता. Case Report. बीएमजे मामले की रिपोर्ट 2013
- Neznamov जीजी, Teleshova ES. संवहनी और दर्दनाक मूल के कार्बनिक मस्तिष्क रोगों में हल्के संज्ञानात्मक विकारों के साथ रोगियों के उपचार में Noopept और piracetam के तुलनात्मक अध्ययन. Neurosci व्यवहार Physiol. 2009 मार्च;39(3):311-21. doi: 10.1007/s11055-009-9128-4.
- Our Top 5 Noopept पोट - What To Stack It With And What To Expect? Liftmode.
आलेख अंतिम बार अद्यतन किया गया: 16 जुलाई, 2018 द्वारा Nootriment