What is the best Hordenine dosage to take? Hordenine is a natural stimulant found in barley and bitter orange extract.
This compound is an alkaloid related to phenylethylamine that exhibits adrenergic effects.
It is similar to tyramine (found in cheese), and is derived from N-methyltyramine.
Hordenine is used as an athletic performance enhancer and weight loss aid due to its ability to increase blood flow and energy. It isĀ also sometimes used as a nootropic supplement to promote mental focus and concentration.
However, there is very limited clinical research into the effects and safety of this supplement. It may not be appropriate for all users, due to the potential for increased blood pressure.
Furthermore, there are no standard recommended dosages for Hordenine supplements. Information currently available is primarily based on animal studies and anecdotal evidence. The following is a summary of Hordenine’s effects plus dosages commonly used.



- Natural MAO inhibitor for enhanced mood
- Stimulates metabolism for weight loss
- Boosts focus, energy & motivation
Does Hordenine Burn Fat?
Related Topics
Hordenine is marketed as an exercise supplement for bodybuilders and athletes. Taking a Hordenine dosage is purported to improve weight loss and fat burning results.
As a natural stimulant, it may increase the body’s metabolic rate, but there are insufficient human research studies to determine the efficacy of this compound.
Hordenine is an MAO inhibitor. MAO (monoamine oxidase) is a natural chemical in the body that regulates hormonal secretion by destroying androgens such as dopamine or norepinephrine.
When MAO levels rise, the body can become depleted of these substances, leading to significant problems with central nervous system function. Hordenine protects the levels of these critical hormones, and aids in their delivery to cell receptors.
The result is the stimulation of cellular metabolism, the engine which fires all energy in the body. Simultaneously, Hordenine is known to release fatty acids to be destroyed by oxidation.
Finally, Hordenine’s stimulatory effects tend to quash appetite. In combination, these effects are the perfect basis for high energy workout which burn a lot of fat, even after the workout is done. This is why fitness sites promote the supplement.
Hordenine Cognitive Effects
In addition to its uses as a fat burner, Hordenine has also become popular for use as a cognitive enhancing nootropic supplement. This class of natural nutrients are known as “smart drugs” which boost intelligence, memory, mood and other mental functions. Hordenine’s metabolic interaction with the adrenal system produces a wealth of mental energy to go along with physical effects.
It may boost concentration, make focusing upon tasks or logic problems easy, and boost sensitivity to stimulus. Users report that Hordenine generates a confident, euphoric mood and banishes symptoms of depression. Normal functions at work or during daily activities are not impaired, but are infused with enthusiastic energy and clarity, raising productivity. Hordenine may also increase libido and sexual function.
Hordenine is commonly used with PEA (phenylethylamine). These compounds exhibit a synergistic effect.
Hordenine Dosage
There is insufficient clinical evidence to determine the optimal dosage for Hordenine. No safe dosing ranges have been established so far. Before taking Hordenine supplements, you should speak to your doctor to determine whether this product is appropriate for you. A doctor that is familiar with your medical history will be in the best position to recommend a dosage to you.
As reported by user reviews, Hordenine dosages typically range from 20 – 50 mg per day. For new users, it is recommended to start with a low dosage to determine sensitivity and gauge any negative side effects. Some individuals may be more sensitive to this compound than others.
Hordenine is often stacked with other stimulants, including caffeine. When used alongside other stimulants, it may be necessary to take a smaller dosage of both substances. Use with other supplements may increase the risk for side effects.
As a pre-workout supplement, Hordenine doses are consumed 30-45 minutes before exercise.
Check with a doctor to find out if this supplement is safe for you to take during exercise. Due to its ability to increase blood pressure, it may put added strain on the heart during periods of intense exercise.
For some users, taking Hordenine dosages late in the day may result in sleep disturbances. Do not take dosages in the evening when first using this supplement or insomnia may result.
If stacking Hordenine with Phenylethylamine, a ratio of 30 mg to 250 mg of PEA is typical. These supplements have synergistic mechanisms of action, meaning that they potentiate the effects of each other. By combining the two, there may be a greater effect on circulation, energy and mood.
Hordenine Side Effects
In low dosages, Hordenine use is not linked to a risk of serious side effects for healthy individuals. However, this compound does exhibit stimulant effects which may interact with other drugs or supplements or with pre-existing medical conditions.
If you are taking medication for blood pressure or any conditions relating to heart function, do not use Hordenine. Speak to your doctor for a full list of contraindications and drug and supplement interactions.
Side effects that may occur after taking a Hordenine dosage include sleeplessness, fast or irregular heart beat, dizziness, stomach issues, and anxiety. Some individuals may experience mood disruptions as well.
In some users, Hordenine can cause an “energy crash” after the effects of this supplement wear off.
These side effects are more likely when taking higher dosages of this supplement. If you experience mild adverse effects, a smaller dosage may improve the tolerability for this supplement. If you experience serious side effects, you should discontinue use and seek medical attention.
Summary
Hordenine is used by bodybuilders, athletes and bio-hackers to increase energy, physical performance, weight loss and cognitive function. There has been limited research into the effects of this supplement. While it is a natural compound, users may experience side effects, particularly at high dosages.
There is insufficient research available to determine the appropriate dosage for Hordenine supplements. While 20 – 50 mg per day is common among users, this dose may not be safe for all individuals depending on personal sensitivity, medical history or drug and supplement interactions.
- Kim SC, Lee JH, Kim MH, Lee JA, Kim YB, Jung E, Kim YS, Lee J, Park D. Hordenine, a single compound produced during barley germination, inhibits melanogenesis in human melanocytes. Food Chem. 2013
- Schweitzer A, Wright S. Action of hordenine compounds on the central nervous system. J Physiol. 1938
- TASHIRO G. Effects of hordenine sulfate and methiodide on the receptors for the sweating axon reflex and on the sweat glands in the human skin. Arch Int Pharmacodyn Ther. 1960
Article last updated on: March 29th, 2018 by Nootriment
1 Comment
is hordenine legal to put in supplements and sell under UK law