Famous for its energy enhancing qualities, Hordenine is a natural supplement that acts as an MAO inhibitor.
As a powerful hormone regulator, Hordenine effects include increased cellular metabolism, promoting fat burning and enhancing mental focus.
Simultaneously, this plant alkaloid balances the output of the adrenal glands, improving mood and producing an intense sense of drive and ambition.
Hordenine is commonly stacked with PEA to fight fatigue, stimulate the mind and improve symptoms of mild forms of depression.
Here is a rundown of all of the effects of Hordine supplements that can naturally improve your physical and mental productivity.



- Natural MAO inhibitor for enhanced mood
- Stimulates metabolism for weight loss
- Boosts focus, energy & motivation
Hordenine Effects and How it Works
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Hordenine is very similar in chemical structure to the neurochemical tyramine, which assists in the release of hormones such as norepinephrine, epinephrine, and dopamine.
Hodenine, an N-methyltyramine derivative, performs many of the same functions.
Hordenine crosses the blood brain barrier and functions as a monoamine oxidase (MAO B) inhibitor. Hordenine effects and benefits include balancing hormone levels and improving nerve communication.
When Dopamine levels get too low, we start to experience various disturbances in the central nervous system including stress responses, symptoms of depression, and difficulty focusing . Hordenine effects and benefits remedy these issues and lifts concentration levels while improving mood.
The adrenergic system is stimulated, creating the sensation of lasting natural energy. Cell metabolism is increased, resulting in more energy for all processes of mind and body.
Hordenine plays a role in the breakdown of fatty acids. It also has the tendency to slow digestion and gastric emptying, resulting in a lowered appetite. Together, the increased energy, lowered appetite, and increased fat burning make Hordenine particularly suited to the weight loss goals shared by many fitness enthusiasts.
Hordenine may increase blood pressure via vasoconstriction, making the passages of blood vessels more constricted. This is one reason it is sometimes prescribes as an anti-asthmatic medication.
Positive Hordenine Effects and Benefits
Most people in the nootropic community take Hordenine supplements to generate mental energy and focus. The hormonal balance it provides as an MAO inhibitor can translate to a greatly enhanced ability to focus and freedom from distraction for most people.
Any sufferers of attention-related disorders such as ADHD might benefit from the use of this supplement, which carries none of the chemical side effects of commercial products like Adderall.
Hordenine effects and benefits also include a powerful mood enhancer, giving users feelings of confidence and euphoria. These feelings are amplified and their duration is extended when Hordenine is taken in a stack with PEA (phenylethylamine).
Hordenine’s other most famous effects and benefits occur in the gym. We’ve already discussed Hordenine’s ability to super-charge workout energy and burn fats, but its important to note that the fat burning power can extend outside of the gym too.
The same mechanisms which boost metabolism while working out are in play even if no exercise is being performed. So, Hordenine can aid in fat burning around the clock, even without any exercise at all.
Of course, exercise is a very important component of total wellness for everybody and should be a part of most normal days, but Hordenine can boost your body’s natural efforts to achieve balance no matter what your activity level is in a given day.
Possible Negative Hordenine Effects
Hordenine has been consumed safely for many years. It has not yet been approved for use by the FDA, but that is more likely a result of not enough studies having been performed yet rather any serious danger to the public.
Hordenine effects can be very stimulating and affect blood pressure. As such, it should not be taken by anyone who has been already prescribed blood pressure medication. Hordenine also conflicts with other MAO inhibitors and should not be mixed with them.
Side effects are possible, but rare if used appropriately. Symptoms like rapid heart beat, arrhythmia, sweating, bad digestion have been reported. Some light anxiety is also possible if dosage is too high. All of these symptoms are on par with what might be experienced if you drank too much coffee in a given day.
By respecting dosage guidelines, most people will not experience any negative side effects from Hordenine.
Dosage Info For Best Benefits
A great conservative beginning dose of Hordenine starts at 30 mg per day. If this is tolerated well, you can increase the dosage by taking 30 mg, 2 to 3 times per day. Again, this is similar to how one might consume coffee. Depending upon your sensitivity, you will be able to tolerate more or fewer doses per day.
If effects are still not intense enough, you can safely increase the dosage to 50 mg at a time. Beyond that amount, you may start to experience side effects like sweating or sleeplessness. Taking the supplement earlier in the day will ensure normal sleep.
If you are primarily interested in the many Hordinine effects and benefits related to exercise, consume your dose at least 30 – 45 minutes before each workout. By staying within recommended dosage guidelines, Hordenine can be a great, safe source of all-day energy, excellent mental focus, and fat-burning metabolism.
- Singh AK, Granley K, Misrha U, Naeem K, White T, Jiang Y. Screening and confirmation of drugs in urine: interference of hordenine with the immunoassays and thin layer chromatography methods. Forensic Sci Int. 1992
- Hapke HJ, Strathmann W. [Pharmacological effects of hordenine]. Dtsch Tierarztl Wochenschr. 1995
- TASHIRO G. Effects of hordenine sulfate and methiodide on the receptors for the sweating axon reflex and on the sweat glands in the human skin. Arch Int Pharmacodyn Ther. 1960
Article last updated on: March 25th, 2018 by Nootriment