Hordenine is a nootropic compound that works equally well for cognitive enhancement and athletic performance.
Not only does it increase metabolism and decrease appetite, but it also acts as a mental stimulant to help improve brain function.
It is used by people who want to achieve a serious edge in their work life because it can give you massive levels of energy, focus and motivation.
Taking Hordenine supplements can give you a significant boost to your mood, promote mental drive, help you concentrate and allow you to persevere in the face of brain strain. In addition to this, it is often used by bodybuilders as a pre-workout supplement or to promote fat loss and strength.
Why should you consider adding Hordenine to your diet and nootropic routine?



- Natural MAO inhibitor for enhanced mood
- Stimulates metabolism for weight loss
- Boosts focus, energy & motivation
What Is Hordenine?
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The first question to answer is what exactly is Hordenine?
It is a natural Phenethylamine compound that occurs in a number of different plants, but especially barley grass. It is structurally similar to the amino acid Tyramine.
It is also found naturally in bitter orange (citrus aurantium) and lophophora williamsii (peyote cactus).
It works primarily through the release of and protection of Norepinephrine, a powerful brain chemical. Hordenine powder is also an MAO inhibitor which can lead to enhanced positive feelings and sometimes even a sensation of euphoria.
Hordenine Effects:
Three of the most sought after effects of this supplement include fat loss, appetite control, and energy. It is also interesting to note that Hordenine is capable of producing an increased energy expenditure in healthy people, leading to more calories being burned even if you are not working out or engaged in other physical activity.
Hordenine is also considered to be a stimulant due to its adrenaline-like effect caused by the release of noradrenaline.
There was even a 2009 study which determined that when Hordenine is given to trained male athletes it caused a significant increase in Noradrenaline levels which reached a peak 90 minutes after ingestion. This also may cause increases in heart rate, blood pressure and blood flow.
As a stimulant, Hordenine may even be an effective thermogenic. This can increase the metabolism and overall fat loss. The Norepinephrine is also thought to help control appetite and desire for excess food.
It also may have an increase in mental energy, enhanced focus, and improved concentration due to the release of so many different neurotransmitters and powerful brain chemicals. In other words, it helps both the body and the mind.
Hordenine Benefits for your Brain:
Hordenine is used as a productivity booster often in the place of stronger nootropic drugs like Modafinil or Adrafinil.
It is known to promote greater levels of cognitive energy and many people say that it gives them a serious motivation rush whenever they take it.
According to Hordenine reviews, this compound can also lengthen your attention span, reduce brain fog and help you avoid distractions.
It is often taken by people who are highly productivity and success conscious because they say it allows them to work at mentally demanding tasks for extended periods of time. When paired with other nootropics such as Piracetam, Aniracetam, Noopept or Choline this effect may be amplified.
Pharmacological Actions:
Basically, this supplement is a dimethylated version of Tyramine (the amino acid). Commonly found in herbal supplements, it is used as an effective MAO-B inhibitor. Since it also helps to increase the levels and production of Norepinephrine it is thought to be a Norepinephrine and Noradrenaline uptake inhibitor.
As this substance crosses the blood-brain barrier it goes to work inhibiting the MAO-B enzymes in both the body and the brain. Additionally, it works by having the effect of being an antiasthmatic, antidiarrheal, antifeedant, cardiotonic, and a vasoconstrictor (closes blood vessels and other passageways).
Hordenine Safety & Side Effects:
According to the medical research conducted so far, Hordenine is considered to be generally very safe and well-tolerated in healthy adults.
We still must remember that it is also classified as a mild central nervous system stimulant. So, it is certainly not recommended for people who have heart conditions or high blood pressure.
Using Hordenine safely should mean following the recommended dosage levels. There have been some side effects associated with this supplement, but generally, these only occur at much higher doses.
Things like nausea, insomnia, dizziness, anxiety, upset stomach, mood swings, even rapid heart rate, and hallucinations have occurred. In these case, the best course of action is to discontinue supplementation completely at least for a few days until things return to normal and then stay at the recommended levels.
Hordenine Dosage:
The average dosage levels for Hordenine is up to 30 mg taken two or three times a day. If using for a workout, the best time to take this is about 30 minutes before exercise. If used as a fat burner, then take first thing in the morning and about six hours later. This is also the best routine to follow if using Hordenine for its mental benefits.
The supplement may also be stacked with others. This includes with caffeine, Acetyl L-Carnitine, and even PEA for fat reduction and helping to enhance the increased energy production as a pre-workout aid.
- Hapke HJ, Strathmann W. [Pharmacological effects of hordenine]. Dtsch Tierarztl Wochenschr. 1995
- TASHIRO G. Effects of hordenine sulfate and methiodide on the receptors for the sweating axon reflex and on the sweat glands in the human skin. Arch Int Pharmacodyn Ther. 1960
- Kim SC, Lee JH, Kim MH, Lee JA, Kim YB, Jung E, Kim YS, Lee J, Park D. Hordenine, a single compound produced during barley germination, inhibits melanogenesis in human melanocytes. Food Chem. 2013
- Lovett JV, Hoult AH, Christen O. Biologically active secondary metabolites of barley. IV. Hordenine production by different barley lines. J Chem Ecol. 1994
- KrstÃc MK. The action of hordenine on the superior cervical ganglion of the cat. Arch Int Pharmacodyn Ther. 1973
Article last updated on: March 13th, 2018 by Nootriment