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Hydergine is also known as Ergoloid Mesylates, co-dergocrine mesilate, or dihydroergotoxine mesylate.
This supplement, created in the 1940’s, is derived from rye and has become one of the world’s most useful and popular ‘smart drugs’ or cognitive enhancers.
Hydergine was actually created by Albert Hofman who also discovered LSD, while working for the Sandoz pharmaceutical company in Switzerland. It is currently being used for treating age-related cognitive decline, memory enhancement, and as a powerful anti-oxidant.
It may even have benefits for stroke recovery and has been approved by the FDA for the treatment of senility and cerebrovascular insufficiency.
Cognitive Enhancement
Neuron Health
Memory- Increases dopamine & acetylcholine
- Anti-oxidant for brain cell health
- Improves blood flow to the brain
Hydergine Effects:
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Despite the facts that this drug has been around for decades (almost 80 years, in fact) and is one of the most researched of all the cognitive enhancers on the market, the exact mechanisms of action still remain somewhat mysterious.
What is generally accepted is that this supplement affects a number of different neurotransmitters along with the brain’s energy utilization systems.
Research indicates that Hydergine interacts directly with subtypes of alpha adrenoceptors, Dopamine, and Serotonin receptors. This serves to facilitate the release of Dopamine, Norepinephrine, and Acetylcholine (all powerful brain chemicals in their own right).
It is generally accepted that the effects upon these individual chemicals and systems directly lead to Hydergine’s main benefits.
Another effect is that of helping to increase levels of blood flow to the brain. The supplement also improves oxygen utilization in the brain by enhancing metabolism of the ganglion cells. Overall, it is thought that these effects may offer a slight boost to all cognitive functions.
Hydergine Benefits:
One of the most impressive benefits of Hydergine is the ability to help with stroke recovery.
If the caught in time, this supplement can even be administered prior to surgery or treatment as a method of delaying some of the damaging effects.
It has also been shown to improve the speed and magnitude of post-operative recovery as well.
Hydergine has significant benefits upon blood pressure and oxygen levels in the brain. It helps to normalize systolic blood pressure along with reducing very high cholesterol levels. There is also evidence suggesting it can decrease feelings of lethargy and optimize the amount of oxygen uptake to the brain.
Due its multitude of effects and modulations on different neurotransmitters, there are also a number of cognitive benefits associated with this supplement. Many users report a significant increase in their level of memory as well as an increased learning capacity.
Another potential benefit that is common to many Nootropics is an improvement in mental clarity and an end to so-called ‘brain fog.’ This also tends to promote an enhanced attention span and improved focus and concentration. Some users reviews report that this supplement helps to improve symptoms of mild depression.
Researchers continue to explore the possibilities of using Hydergine as a treatment for age-related cognitive decline, under the theory of this supplement acting as a neuro-protective.
Hydergine Dosage:
The recommended dosage of Hydergine is dependent on a lot of different factors and there is still quite a bit of disagreement about how much should be administered.
For example, in the USA, a common Hydergine dosage is generally considered to be 1 mg, taken up to three times daily.
In many other countries throughout Europe and also in Japan and in the United Kingdom, medical professionals regularly administer up to 12 mg of this supplement per day, all without any serious side effects.
There are a number of researchers who still contend that this recommended dose is way too low. This, they say, is an explanation for why a number of studies display lackluster results. They argue Hyderdine powder could help more people, especially those with diseases like Alzheimer’s, if the dosage was increased.
Hydergine Side Effects:
This supplement is generally considered to be very safe and most people do not encounter side effects. However, always remember that this is a powerful cognitive enhancer that can increase levels of certain neurotransmitters in your brain.
It is important to follow the recommended usage guidelines properly and take precautions to ensure that you do not experience any negative outcomes.
Serious Hydergine side effects are quite rare but approximately 3% of people in studies do experience some mild side effects including nausea, anorexia, vomiting, abdominal pain, dizziness, headaches, and sleep disorders.
Hydergine Review:
Hydergine is a unique Nootropic supplement that has been proven safe and effective in medical contexts. While some brain hackers may experiment with this drug for their own cognitive enhancement purposes, it is still not a popular as the more “mainstream” Nootropics like Piracetam and Aniracetam.
There are some health risks associated with continuous usage of Hydergine and a number of individuals say that the effects are not noticeable enough for this supplement to be worth it.
If you are looking for a proven nootropic to improve your memory, prevent brain aging and give you greater clarity of though, consider trying Noopept which is over 1,000 times stronger than Piracetam and is similar to Hydergine in terms of potency.
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- Huber F, Köberle S, Prestele H, Spiegel R. Effects of long-term ergoloid mesylates ('Hydergine') administration in healthy pensioners: 5-year results. Curr Med Res Opin. 1986
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- Datta KD, Evenson RC, Gannon PJ, Dick EP. Efficacy of oral hydergine (ergoloid mesylates) in alcohol related encephalopathy. Prog Neuropsychopharmacol Biol Psychiatry. 1987
- van Loveren-Huyben CM, Engelaar HF, Hermans MB, van der Bom JA, Leering C, Munnichs JM. Double-blind clinical and psychologic study of ergoloid mesylates (Hydergine) in subjects with senile mental deterioration. J Am Geriatr Soc. 1984
- Hollister LE, Yesavage J. Ergoloid mesylates for senile dementias: unanswered questions. Ann Intern Med. 1984
- Schran HF, McDonald S, Lehr R. Pharmacokinetics and bioavailability of ergoloid mesylates. Biopharm Drug Dispos. 1988
- Olin J, Schneider L, Novit A, Luczak S. Hydergine for dementia. Cochrane Database Syst Rev. 2000
- Schneider LS, Olin JT. Overview of clinical trials of hydergine in dementia. Arch Neurol. 1994
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- Burian E. An ergot alkaloid preparation (Hydergine) in the treatment of presenile brain atrophy (Alzheimer's disease): case report. J Am Geriatr Soc. 1974
- Jenike MA, Albert MS, Heller H, LoCastro S, Gunther J. Combination therapy with lecithin and ergoloid mesylates for Alzheimer's disease. J Clin Psychiatry. 1986
- Büyüköztürk A, Kanit L, Ersöz B, Menteş G, Hariri NI. The effects of hydergine on the MAO activity of the aged and adult rat brain. Eur Neuropsychopharmacol. 1995
- Walker C. Ergoloid mesylates vs. Alzheimer's: the latest round. Geriatrics. 1990
- [No authors listed] Hydergine for cerebral arteriosclerosis. Med Lett Drugs Ther. 1974
- Rehman SA. Two trials comparing 'Hydergine' with placebo in the treatment of patients suffering from cerebrovascular insufficiency. Curr Med Res Opin. 1973
- McHenry LC Jr, Jaffe ME, Kawamura J, Goldberg HI. Hydergine effect on cerebral circulation in cerebrovascular disease. J Neurol Sci. 1971
- Hughes JR, Williams JG, Currier RD. An ergot alkaloid preparation (Hydergine) in the treatment of dementia: critical review of the clinical literature. J Am Geriatr Soc. 1976
- Bochner F, Eadie MJ, Tyrer JH. Use of an ergot preparation (hydergine) in the convalescent phase of stroke. J Am Geriatr Soc. 1973
- Szewczykowski J, Meyer JS, Kondo A, Nomura F, Teraura T. Effects of ergot alkaloids (hydergine) on cerebral hemodynamics and oxygen consumption in monkeys. J Neurol Sci. 1970
- McConnachie RW. A clinical trial comparing 'Hydergine' with placebo in the treatment of cerebrovascular insufficiency in elderly patients. Curr Med Res Opin. 1973
- Banen DM. An ergot preparation (Hydergine) for relief of symptoms of cerebrovascular insufficiency. J Am Geriatr Soc. 1972
Article last updated on: March 13th, 2018 by Nootriment
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6 Comments
do you sell Hydergine or dihydroergotoxine mesylate? Or do you stack it in another product you sell?
I would also like to know if this website sells Hydergine?
I was curious if hydergine would help my mother who has alzymers disease, please send me some info as to which one to buy in liquid form, thanks, Jason Dorsey.
I need to know if I can buy Hydergine thru your web site, if so please tell me how. Thank you in advance
You can buy Hydergine on ************ It is absolutly miracle drug for brainfog and cfs
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