The broad spectrum of Idebenone’s nootropic effects have only recently begun to be understood. This organic compound was originally developed for use as a treatment of one of the most pervasive neurological disorders faced by man – Alzheimer’s Disease.
In fact, Idebenone has been employed by conventional medicine as a therapy for many serious brain and body diseases, including heart disease, liver disease, the severe nervous system disorder Friedreich’s ataxia, and a host of nerve ailments known as mitochondrial encephalomyopathies.
While it has shown some limited success in those fights, the nootropic effects of Idebenone have recently taken center stage. As a powerful anti-oxidant, this little-known supplement might be the key to dramatic mental rejuvenation and longevity.



- Potent anti-oxidant for anti-aging benefits
- Supports ATP production & enegry levels
- Promotes cognitive function & memory
Idebenone’s History as an Alzheimer’s Disease Therapy
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Curing Alzheimer’s Disease, a disorder which affects as many as 50 percent of all people over the age of 85, has become one of the holy grails of neuroscience.
To this end, countless therapies for it have been explored so far, such as the use of Idebenone nootropic effects, research of which began in the late 90s.
In a recent study published by the National Institutes of Health, Idebenone was shown to slow the progression of Alzheimer’s symptoms such as memory loss and slowing of cognitive ability.
It is unclear if Idebenone can actually stop Alzheimer’s from beginning, but it can reduce the impact of the disease.
By noting the general mental improvements brought by Idebenone’s facilitation of choline transfer, it became clear that the compound could provide similar benefits – such as clear thoughts, excellent memory recall, and a sense of alert energy – to the minds of healthy people.
Idebenone and CoQ10 – Similarities and Differences
Idebenone is an analog of the energy boosting anti-oxidant Coenzyme Q10 (CoQ10), a popular supplement that many people take for heart health, muscle recovery after exercise, cancer prevention, and general anti-aging effects.
It is so similar that it is interchangeable with CoQ10 during one of its most vital processes – fueling cellular energy production. While nearly identical, Idebenone is a shorter-chain compound than CoQ10, and as a result is far more bioavailable to the brain.
Idebenone does not break down as quickly as CoQ10, and as it is able to interface directly with cell receptors, it is thought to produce far more amplified versions of CoQ10’s benefits. The primary Idebenone nootropic effects act as a super-charged anti-oxidant, shielding cells from free radicals. This anti-oxidant power acts to both protect and repair brain cells from future damage.
Idebenone Effects on Nerve Growth Factor
Idebenone is a known booster of the brain’s nerve growth factor (NGF). This substance is at the root of healthy growth of neurons and nerves within the brain.
It can repair cellular damage, while fostering an environment where new synaptic connections grow easily and freely.
Idebenone also facilitates the transfer of choline in the brain. This nutrient is necessary for memory, focus and brain cell health.
All of these structures within the brain are responsible for how we organize, access, and connect thoughts over time. Our memories, interpretations of experiences, and verbal and logical reasoning are all founded in the physical tissues of the brain.
The easier it is for neural growth to take place, the more facility we feel mentally. This is why choline-rich supplements of all kinds are known to produce clear-headed thinking and heightened ability to focus. Idebenone effects on nerve growth factor place a strong role in creating these conditions as well.
Idebenone Benefits for the Brain
By keeping choline transmission running smoothly and efficiently, an excellent slate of benefits can be achieved. Cognitive function is enhanced overall, with improved recall of facts, increased problem-solving ability, and faster response to stimuli.
The overall state of growth-positive neuroplasticity in the brain which results from cholinergics makes it easier to adapt to new conditions swiftly, formulating reasoned responses to information. That’s really just another way of describing learning.
Information is able to pass across the corpus callosum with ease, creating a channel of communication between the right and left hemisphere of the brain.
Idebenone also regulates and stimulates the release of dopamine, a known mood enhancer which delivers feelings of joy, pleasure, and optimism. Idebenone nootropic benefits are also thought to regulate serotonin release, especially as it pertains to sleep cycles.
Finally, Idebenone’s anti-aging properties at the cellular level are thought to have visibly positive effects upon skin condition, prompting cosmetics companies to use it in moisturizers.
Dosage For Best Idebenone Nootropic Benefits
No significant side effects have been reported from daily Idebenone supplementation. However, the best results for achieving Idebenone nootropic benefits are obtained by taking 500 mg to 1000 mg per day. The higher doses should be worked towards gradually and only if necessary.
Most people find that 500 mg provides the perfect balance of mental clarity, mood lift, and recall.
It is possible with the higher doses to become so hyper alert that sleep is difficult. For this reason, it is recommended to take the dose earlier in the day in general. If you can’t find the rare Idebenone for sale, look into the very similar benefits to be found in choline supplements such as Citicoline.
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Article last updated on: March 20th, 2018 by Nootriment