All-natural Inositol for depression is the latest method to gain notoriety for combatting the symptoms of this common disorder.
Feelings of depression can come and go in all humans, but for some people, this condition is rooted in chemical imbalances in the body and can become far more serious.
Scientists have found links between low levels of Inositol and a variety of mental imbalances, such as OCD, bipolar disorder, anxiety, and depression. Many people have added this supplement (one of the B vitamins) into a daily mental health regimen.
So far, the results have been good. Inositol supplements may be able to significantly lift mood and ease anxious thoughts. When it is combined with other nootropic supplements like Choline, Inositol can help lay the foundation for clear thinking, peacefulness, and even optimism.
Let’s find out if Inositol is truly an alternative to prescription anti-depression and anti-anxiety meds. If so, this nutrient could represent a breakthrough for depression sufferers.



- Supports brain & liver health
- Involved in mood regulation & nerve signalling
- Improves insulin sensitivity for PCOS, fertility & weight loss
The Connection between B Vitamins and Mood
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B-vitamins like Inositol have been a remedy for stress for generations.
Lately, they have become an interest among the nootropic community as a viable way to enhance mental energy, lift mood, and fight more serious cognitive disorders.
The B Vitamins are comprised of at least 9 separate compounds, each with its own chemistry and mental effects. These nutrients can lower blood pressure, improve cellular health in the brain, and activate neurotransmitters relating to mood.
Taking Inositol for depression is a part of a natural regimen for improved brain health and neurotransmitter balance. This is similar to the way a daily regimen of St. John’s Wort can ease the intensity of depressive episodes.
Inositol’s Mechanism of Action
Inositol’s full-body benefits, such as lowering blood pressure, increasing good HDL cholesterol, and burning excess fats are well known. It also plays a key role in fighting emotional imbalance such as depression in two important ways.
First, taking Inositol for depression increases the activity of the neurotransmitter serotonin. This hormone generates a pervasive feeling of total mental well-being, peacefulness, and even joy. Serotonin depletion is frequently noted in cases of extreme depressive episodes.
Next, Inositol goes to work at GABAergic receptor sites, activating an inhibitory response which calms the firing of nerves. The natural compound GABA, which normally performs this function, is difficult to supplement with as pills containing GABA are not bioavailable. Inositol, when taken in the proper dosages, can cross the blood brain barrier and initiate the GABA-like calming of nervous reactions to stress.
Finally, Inositol improves the communication between neurons. The net effect of all of these mechanisms is the sensation of an energetic yet calm mental state. Users are left feeling optimistic, productive, and unburdened by typical depressive thoughts.
Inositol for Depression
In general, Inositol is regarded as a powerful yet completely natural anxiolytic agent. It can soothe distressing, overactive thoughts, either chronic or acute in nature. Many people keep a supply of Inositol on hand to counter any unexpected stress sources, such as at work or school.
Inositol cuts many of the contributing factors to depression, such as social anxiety. Increased serotonin levels can promote an overall feeling of positivity, no matter what the external factors are. Inositol banishes feelings of lethargy and listlessness, replacing them with a feeling of bright, clear mental energy. This shift is essential to overcoming the fatigue and hopelessness of a depressive episode.
Inositol is relatively fast-acting, and is no more harmful than eating a handful of almonds or a serving of eggs. For this reason, taking natural Inositol for depression seems to have almost no side effects, and is far safer than prescription anti-depression SSRIs. That being said, some research has indicated that Inositol actually enhances the efficacy of SSRIs.
Choline plus Inositol – The Ultimate Depression Fighter
Inositol is often stacked with another famous B vitamin – Choline. As the pre-cursor to the neurotransmitter Acetylcholine, Choline is one of the key building blocks of good mental health.
Choline supplements like Alpha GPC or Citicoline can lead to enhanced memory, better learning ability, and heightened concentration.
When combined with Inositol, all of the noted effects of a choline supplement are amplified.
The state of heightened mental performance, control, and brighter mood which can be achieved with the stack is an excellent antidote to the low energy and hopelessness of depression. Taking Inositol for depression combined with Choline supplements is an excellent way to not only fight depression, but also to invest in the long term healthy function of the brain.
How Do Inositol Side Effects Compare to Anti-Depressants?
Comparing the side effects of using Inositol versus conventional pharmaceutical anti-depressants like Prozac is truly no contest. Unlike those prescribed drugs, which can cause dependency, liver toxicity, and suicidal tendencies, Inositol is harmless.
It has no notable side effects over a broad range of dosages, and is water soluble, which means the body can easily discard excess amounts. When combined with other natural nootropic supplements like CDP Choline, Inositol remains safe and effective, amplifying calming effects for a peaceful, contented mind.
You can buy Inositol supplements for depression online or find it in a mood-enhancing stack for best results.
- Billcliff PG, Lowe M. Inositol lipid phosphatases in membrane trafficking and human disease. Biochem J. 2014
- Burton A, Hu X, Saiardi A. Are inositol pyrophosphates signalling molecules? J Cell Physiol. 2009
- Ma K, Thomason LA, McLaurin J. scyllo-Inositol, preclinical, and clinical data for Alzheimer's disease. Adv Pharmacol. 2012
- Sylvia LG, Peters AT, Deckersbach T, Nierenberg AA. Nutrient-based therapies for bipolar disorder: a systematic review. Psychother Psychosom. 2013
- Shamsuddin AM. Inositol phosphates have novel anticancer function. J Nutr. 1995
- Ooms LM, Horan KA, Rahman P, Seaton G, Gurung R, Kethesparan DS, Mitchell CA. The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. Biochem J. 2009
- Eichberg J, Abe S, Berti-Mattera LN, Day NS, Lowery JM, Zhu X, Peterson RG. Inositol and phospholipid metabolism in diabetic nerve. Diabet Med. 1993
- Belmaker RH, Bersudsky Y, Agam G, Levine J, Kofman O. How does lithium work on manic depression? Clinical and psychological correlates of the inositol theory. Annu Rev Med. 1996
Article last updated on: April 16th, 2018 by Nootriment
1 Comment
I’m allergic to magnesium stearate which almost every supplement on the market contains. It causes severe constipation. Is there a quality Inositol on the market that does not contain it?