Inositol is a psuedovitamin that is used as a brain supplement for enhancing the mood and energy levels. It is similar structurally to the B-family of vitamins, and is sometimes even called vitamin B8 (although it is not technically a vitamin).
This natural nootropic compound is found in a number of foods such as grains, nuts, beans, and fruits. It is also produced by the human body and was originally discovered as a component of human spinal fluid.
Humans consume about a gram of Inositol each day and the kidneys make about another 2 grams. It is believed that there are a number of brain benefits from taking Inositol supplements, including improved mood, more focus, and better thought processing.
This naturally occurring chemical is also implicated in many other physiological functions and plays a vital role in the firing of your neurons. People have used it for depression, anxiety, OCD, and boosting mental productivity.
This article will provide an in-depth review of what Inositol is, how it works in the body, the range of benefits delivered, as well as dosage, usage, and side effect information.



- Supports brain & liver health
- Involved in mood regulation & nerve signalling
- Improves insulin sensitivity for PCOS, fertility & weight loss
What Is Inositol?
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Inositol is a type of carbohydrate sugar alcohol and an isomer of glucose.
There are actually nine different varieties of this supplement which are mainly found within cell membranes. The most common form is called myo-inositol, and is typically the form that is referred to when discussing inositol in general.
The primary uses of this natural chemical is for transporting fat throughout the body. This nutrient also helps the neurons within the central nervous system produce energy and communicate via neurotransmitters.
Inositol is a substrate or a building block that is used to help synthesize a number of different compounds necessary for your cells to function. It is transmuted inside the body into many different forms and transported throughout the body.
Inositol functions together with Choline which is why you will often find products for sale containing choline and inositol stacked together.
How Inositol Works in the Body
This supplement works in several different ways. The first of these is the facilitation of the opening of calcium channels within the brain. These stores are critical for neurotransmitters to be released and take effect.
One of these neurotransmitters that sees greater activity when taking Inositol is Serotonin. This neurochemical is involved in the regulation of your mood and sleep patterns. Inositol is also critical in gene expression although the exact routes and methods are unclear.
Finally, this pseudovitamin aids in the process of neurogenesis, or the creation of neurons within the brain. In this respect it is thought that Inositol may be able to contribute to long-term brain health and prevent cognitive decline with age.
Benefits Of Inositol
Some of the main benefits of Inositol are related to improved brain efficiency and enhanced mood. Low levels of Inositol are implicated in cases of depression and supplementation is believed to improve your mental outlook. As negative feelings and anxiety are reduced, this can also often lead to greater levels of productivity.
Having proper levels of this compound in the body is thought to also lessen the characteristic symptoms of fatigue associated with depression, giving you better energy metabolism. Many reviews also report that this nootropic makes their brain feel like it is working at a faster firing rate with better intellectual processing and computations.
Other benefits include lower cholesterol levels and less accumulation of fat in the heart, arteries and brain. When Inositol combines with Choline it produces lecithin which is integral in the breakdown of fats within the body. There have also been a number of studies showing that this supplement may actually improve the strength and health of your hair as well as aiding in its growth.
Inositol has been formally studied for some of its mental effects, including effects on obsessive compulsive disorder (OCD), panic disorder, and depression.
One study found that OCD patients who took 18 g of inositol orally for 6 weeks had significant improvement compared to when they took a placebo based on their Yale-Brown Compulsive Scale scores. The trial, while robust in its methodology, was relatively small in its sample size (13 patients) and larger trials are needed to confirm these results.
In research studies, inositol seems to reduce the severity and rate of panic attacks and the severity of agoraphobia (fear of not being able to escape certain situations or places) over 4 weeks of treatment. There has been some research done that even indicates that insitol may be as effective as fluvoxamine (Luvox) for the treatment of panic disorder.
Research on inositol use for depression has been somewhat contradictory. One research study found that the overall improvement in scores on the Hamilton Depression Rating Scale was significantly greater for depressed patients given inositol than for placebo patients after 4 weeks.
Another study on inositol use for depression found similar results, with inositol patients having better scores than placebo patients during the trial period. However the researchers also continued to monitor the patients after cessation of the treatment with inositol or placebo.
The researchers found that half of the patients who had responded well to inositol relapsed rapidly after inositol discontinuation whereas none of those who responded to placebo relapsed rapidly after placebo cessation. More research is still needed to fully understand the use of inositol for depression, and repetition of these results is crucial.
The Natural Medicines database has rated Inositol as Possibly Effective for improving lithium-induced side effects, OCD, panic disorder, polycystic ovary syndrome, and respiratory distress syndrome. While research has been promising, more large-scale double-blind placebo-controlled studies are still needed to confirm the results of smaller studies.
At this time, Inositol is available as a dietary supplement only, and the FDA has not approved Inositol as a drug to prevent or treat any conditions.
Inositol Dosage Levels
Depending on your intended reason for taking this nootropic, there are different Inositol dosages recommended. Most users take anywhere between 500 mg and several grams a day. This can be split into several different administrations throughout the day. It is recommended that you speak with your doctor to help determine the best dosage for your personal needs.
It is common practive to determine your personal dosage level based on some trial and error. You can begin with a lower dose and then work your way up from there. The main thing is to pay close attention to how your body responds and the effects which are felt.
Since there is a lot of evidence for the use of Inositol in conjunction with Choline, a great potential stack would be using both of these supplements together. You may want to stack Inositol with one of the higher quality choline sources such as CDP Choline (Citicoline) or Alpha GPC for the best results.
It is often advised to use these compounds in a 1:1 ratio, though again you should determine what works best for you with some controlled experimentation.
Inositol Side Effects
While Inositol is generally very well-tolerated with few side effects being reported, there are some to watch out for. These are generally very mild and can include headache, nausea, diarrhea, fatigue, nervousness, and some additional GI issues.
If you experience any of these Inositol side effects, the best course of action is to reduce the dosage. If the side effects do not improve, then consider taking a few days off and start up again later (albeit at a reduced dosage level).
There are no known interactions with Inositol and any medications or other supplements, however it is always recommended that you speak with your doctor to determine if any new supplement is right for your needs.
- Schneider S. Inositol transport proteins. FEBS Lett. 2015
- Dinicola S, Chiu TT, Unfer V, Carlomagno G, Bizzarri M. The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome. J Clin Pharmacol. 2014
- Billcliff PG, Lowe M. Inositol lipid phosphatases in membrane trafficking and human disease. Biochem J. 2014
- Unfer V, Porcaro G. Updates on the myo-inositol plus D-chiro-inositol combined therapy in polycystic ovary syndrome. Expert Rev Clin Pharmacol. 2014
- Greenberg EF, Lavik AR, Distelhorst CW. Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment. Biochim Biophys Acta. 2014
- Ivanova H, Vervliet T, Missiaen L, Parys JB, De Smedt H, Bultynck G. Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival. Biochim Biophys Acta. 2014
- Adams GG, Imran S, Wang S, Mohammad A, Kok MS, Gray DA, Channell GA, Harding SE. The hypoglycemic effect of pumpkin seeds, Trigonelline (TRG), Nicotinic acid (NA), and D-Chiro-inositol (DCI) in controlling glycemic levels in diabetes mellitus. Crit Rev Food Sci Nutr. 2014
- Mukai T, Kishi T, Matsuda Y, Iwata N. A meta-analysis of inositol for depression and anxiety disorders. Hum Psychopharmacol. 2014
- Henry SA, Gaspar ML, Jesch SA. The response to inositol: regulation of glycerolipid metabolism and stress response signaling in yeast. Chem Phys Lipids. 2014
- Fedorenko OA, Popugaeva E, Enomoto M, Stathopulos PB, Ikura M, Bezprozvanny I. Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors. Eur J Pharmacol. 2014
- Dessì A, Fanos V. Myoinositol: a new marker of intrauterine growth restriction? J Obstet Gynaecol. 2013
- Scioscia M, Nigro M, Montagnani M. The putative metabolic role of d-chiro inositol phosphoglycan in human pregnancy and preeclampsia. J Reprod Immunol. 2014
- Croze ML, Soulage CO. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie. 2013
- Wilson MS, Livermore TM, Saiardi A. Inositol pyrophosphates: between signalling and metabolism. Biochem J. 2013
- Kim YJ, Hernandez ML, Balla T. Inositol lipid regulation of lipid transfer in specialized membrane domains. Trends Cell Biol. 2013
- Barker CJ, Berggren PO. New horizons in cellular regulation by inositol polyphosphates: insights from the pancreatic β-cell. Pharmacol Rev. 2013
- Sylvia LG, Peters AT, Deckersbach T, Nierenberg AA. Nutrient-based therapies for bipolar disorder: a systematic review. Psychother Psychosom. 2013
- Shears SB, Weaver JD, Wang H. Structural insight into inositol pyrophosphate turnover. Adv Biol Regul. 2013
- Lee JY, Kim YR, Park J, Kim S. Inositol polyphosphate multikinase signaling in the regulation of metabolism. Ann N Y Acad Sci. 2012
- Ma K, Thomason LA, McLaurin J. scyllo-Inositol, preclinical, and clinical data for Alzheimer's disease. Adv Pharmacol. 2012
- Saiardi A. How inositol pyrophosphates control cellular phosphate homeostasis? Adv Biol Regul. 2012
- Dailey MJ, Kim S. Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase. Biochem Biophys Res Commun. 2012
- Parys JB, De Smedt H. Inositol 1,4,5-trisphosphate and its receptors. Adv Exp Med Biol. 2012
- Howlett A, Ohlsson A, Plakkal N. Inositol for respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev. 2012
- Saiardi A. Cell signalling by inositol pyrophosphates. Subcell Biochem. 2012
- Shears SB, Ganapathi SB, Gokhale NA, Schenk TM, Wang H, Weaver JD, Zaremba A, Zhou Y. Defining signal transduction by inositol phosphates. Subcell Biochem. 2012
- Unfer V, Carlomagno G, Dante G, Facchinetti F. Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials. Gynecol Endocrinol. 2012
- Carlomagno G, Unfer V. Inositol safety: clinical evidences. Eur Rev Med Pharmacol Sci. 2011
- Carlomagno G, Nordio M, Chiu TT, Unfer V. Contribution of myo-inositol and melatonin to human reproduction. Eur J Obstet Gynecol Reprod Biol. 2011
- Kerr WG, Colucci F. Inositol phospholipid signaling and the biology of natural killer cells. J Innate Immun. 2011
- Camfield DA, Sarris J, Berk M. Nutraceuticals in the treatment of obsessive compulsive disorder (OCD): a review of mechanistic and clinical evidence. Prog Neuropsychopharmacol Biol Psychiatry. 2011
- Galazis N, Galazi M, Atiomo W. D-Chiro-inositol and its significance in polycystic ovary syndrome: a systematic review. Gynecol Endocrinol. 2011
- Larner J, Brautigan DL, Thorner MO. D-chiro-inositol glycans in insulin signaling and insulin resistance. Mol Med. 2010
- Barker CJ, Berggren PO. The role of inositol and the principles of labelling, extraction, and analysis of inositides in mammalian cells. Methods Mol Biol. 2010
- Tsui MM, York JD. Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes. Adv Enzyme Regul. 2010
- Papaleo E, Unfer V, Baillargeon JP, Chiu TT. Contribution of myo-inositol to reproduction. Eur J Obstet Gynecol Reprod Biol. 2009
- Deranieh RM, Greenberg ML. Cellular consequences of inositol depletion. Biochem Soc Trans. 2009
- Burton A, Hu X, Saiardi A. Are inositol pyrophosphates signalling molecules? J Cell Physiol. 2009
- Ooms LM, Horan KA, Rahman P, Seaton G, Gurung R, Kethesparan DS, Mitchell CA. The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. Biochem J. 2009
- Michell RH. Inositol derivatives: evolution and functions. Nat Rev Mol Cell Biol. 2008
- Vucenik I, Shamsuddin AM. Protection against cancer by dietary IP6 and inositol. Nutr Cancer. 2006
- Bennett M, Onnebo SM, Azevedo C, Saiardi A. Inositol pyrophosphates: metabolism and signaling. Cell Mol Life Sci. 2006
- Bezprozvanny I. The inositol 1,4,5-trisphosphate receptors. Cell Calcium. 2005
- Kim H, McGrath BM, Silverstone PH. A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI-cycle) to psychiatric disorders--focus on magnetic resonance spectroscopy (MRS) studies. Hum Psychopharmacol. 2005
- Silverstone PH, McGrath BM, Kim H. Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings. Bipolar Disord. 2005
- Harwood AJ. Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited. Mol Psychiatry. 2005
- Taylor MJ, Wilder H, Bhagwagar Z, Geddes J. Inositol for depressive disorders. Cochrane Database Syst Rev. 2004
- Vucenik I, Shamsuddin AM. Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. J Nutr. 2003
- Howlett A, Ohlsson A. Inositol for respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev. 2003
- Agam G, Shamir A, Shaltiel G, Greenberg ML. Myo-inositol-1-phosphate (MIP) synthase: a possible new target for antibipolar drugs. Bipolar Disord. 2002
- Agranoff BW, Fisher SK. Inositol, lithium, and the brain. Psychopharmacol Bull. 2001
- Fisher SK, Novak JE, Agranoff BW. Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance. J Neurochem. 2002
- Harvey BH, Brink CB, Seedat S, Stein DJ. Defining the neuromolecular action of myo-inositol: application to obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2002
- Larner J. D-chiro-inositol in insulin action and insulin resistance-old-fashioned biochemistry still at work. IUBMB Life. 2001
- York JD, Guo S, Odom AR, Spiegelberg BD, Stolz LE. An expanded view of inositol signaling. Adv Enzyme Regul. 2001
- van Calker D, Belmaker RH. The high affinity inositol transport system--implications for the pathophysiology and treatment of bipolar disorder. Bipolar Disord. 2000
- Einat H, Belmaker RH. The effects of inositol treatment in animal models of psychiatric disorders. J Affect Disord. 2001
- Irvine RF, McNulty TJ, Schell MJ. Inositol 1,3,4,5-tetrakisphosphate as a second messenger--a special role in neurones? Chem Phys Lipids. 1999
- Colodny L, Hoffman RL. Inositol--clinical applications for exogenous use. Altern Med Rev. 1998
- Fukuda M, Mikoshiba K. The function of inositol high polyphosphate binding proteins. Bioessays. 1997
- Belmaker RH, Bersudsky Y, Agam G, Levine J, Kofman O. How does lithium work on manic depression? Clinical and psychological correlates of the inositol theory. Annu Rev Med. 1996
- Communi D, Vanweyenberg V, Erneux C. Molecular study and regulation of D-myo-inositol 1,4,5-trisphosphate 3-kinase. Cell Signal. 1995
- Woodcock EA. Inositol phosphates in the heart: controversy and consensus. J Mol Med (Berl). 1995
- Shamsuddin AM. Inositol phosphates have novel anticancer function. J Nutr. 1995
- Benjamin J, Agam G, Levine J, Bersudsky Y, Kofman O, Belmaker RH. Inositol treatment in psychiatry. Psychopharmacol Bull. 1995
- Belmaker RH, Bersudsky Y, Benjamin J, Agam G, Levine J, Kofman O. Manipulation of inositol-linked second messenger systems as a therapeutic strategy in psychiatry. Adv Biochem Psychopharmacol. 1995
- Kofman O, Belmaker RH. Ziskind-Somerfeld Research Award 1993. Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression. Biol Psychiatry. 1993
- Gani D, Downes CP, Batty I, Bramham J. Lithium and myo-inositol homeostasis. Biochim Biophys Acta. 1993
- Eichberg J, Abe S, Berti-Mattera LN, Day NS, Lowery JM, Zhu X, Peterson RG. Inositol and phospholipid metabolism in diabetic nerve. Diabet Med. 1993
- Irvine RF. Inositol lipids in cell signalling. Curr Opin Cell Biol. 1992
- Downes CP, Macphee CH. myo-inositol metabolites as cellular signals. Eur J Biochem. 1990
- Berridge MJ. The Albert Lasker Medical Awards. Inositol trisphosphate, calcium, lithium, and cell signaling. JAMA. 1989
- Putney JW Jr, Takemura H, Hughes AR, Horstman DA, Thastrup O. How do inositol phosphates regulate calcium signaling? FASEB J. 1989
- Michell RH. Inositol lipids and phosphates in growing, stimulated and differentiating cells. Biochem Soc Trans. 1989
- Hanley MR, Jackson TR, Vallejo M, Patterson SI, Thastrup O, Lightman S, Rogers J, Henderson G, Pini A. Neural function: metabolism and actions of inositol metabolites in mammalian brain. Philos Trans R Soc Lond B Biol Sci. 1988
- Dillon SB, Murray JJ, Uhing RJ, Snyderman R. Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes. J Cell Biochem. 1987
- Holub BJ. The cellular forms and functions of the inositol phospholipids and their metabolic derivatives. Nutr Rev. 1987
- Williamson JR. Role of inositol lipid breakdown in the generation of intracellular signals. State of the art lecture. Hypertension. 1986
- Greene DA. Sorbitol, myo-inositol and sodium-potassium ATPase in diabetic peripheral nerve. Drugs. 1986
- Holub BJ. Metabolism and function of myo-inositol and inositol phospholipids. Annu Rev Nutr. 1986
- Williamson JR, Cooper RH, Joseph SK, Thomas AP. Inositol trisphosphate and diacylglycerol as intracellular second messengers in liver. Am J Physiol. 1985
- Holub BJ. The nutritional significance, metabolism, and function of myo-inositol and phosphatidylinositol in health and disease. Adv Nutr Res. 1982
Article last updated on: March 13th, 2018 by Nootriment