Kyo-Dophilus is a probiotic supplement manufactured by Kyolic. This product is a combination probiotic formula with Lactobacillus gasseri, Bifidobacterium bifidum and Bifidobacterium longum.
Every capsule contains 1.5 billion Colony Forming Units of viable probiotic cells. This is a lower dosage than many other probiotic products on the market.
This probiotic formula is non-dairy, heat-stable and is stomach acid resistant so it reaches the gut. According to the manufacturers, a lower dosage may be required when taking a supplement that is stomach acid resistant.
The manufacturer guidelines state this product is good for use after taking anti-biotics, when traveling, to boost everyday immunity, to promote a health intestinal function as well as for general well-being.
Studies have shown that the probiotic bacteria strains found in the Kyo-Dophilus supplement combination are effective for lessening the duration of the common cold.
According to clinical studies Kyo dophilus is also good for restoring microflora balance in older adults.



- Supports a healthy immune system & microflora
- Promotes digestion & nutrient absoprtion
- Combats pathogenic bacteria; Improves metabolism
Kyo-Dophilus Probiotic Review
Related Topics
- What are Probiotics?
- Probiotic Benefits
- Best Probiotic Strains
- Probiotic Side Effects
- Probiotic Supplements
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- Probiotics for Children
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- Lactobacillus Acidophilus
- Lactobacillus Bulgaricus
- Lactobacillus Rhamnosus
- Bifidobacterium Bifidum
- Bifidobacterium Infantis
- Bifidus Regularis
Kyolic also produce a probiotic product for children, Kyolic Kids Kyo-Dophilus chews. This product contains the same three probiotic strains, L. gasseri, B. bifidum and B. longum, in a chewable tablet with 1 billion CFUs per serving.
Kyolic also manufacturers a nine-strain probiotic complex Kyo-Dohilus ® 9 which has a proprietary probiotic blend of L. gasseri B, L. rhamnosus, L. gasseri M, B. bifidum, B. longum M, B. longum, B. infantis, B. breve and B. lactis.
A Kyo dophilus with Digestive Enzymes formula is also available. This supplement also contains Protease, which is a digestive enzyme to process protein. It is also a source of Lactase, which is essential for the complete digestion of whole milk and helps breaks down lactose. Lactose intolerant people cannot break down this sugar.
This supplement also includes the digestive enzyme Amylase, which is involved in the hydrolysis (breakdown) of starch into sugars, and Lipase, which is involved in the hydrolysis of lipids (fats). These enzymes help digest protein, fat and carbohydrates.
Environmental toxins, inadequate diets, over-refined foods, and poor health can cause people to lack these digestive enzymes. Symptoms of bloating, constipation, diarrhea, heartburn, intestinal gas, heartburn are also signs of microflora imbalance and enzyme deficiency.
Allergies, chronic fatigue, headaches, stomach aches, nutritional deficiencies as well as yeast infections are also symptoms of these deficiencies. Kyo-Dophilus probiotic supplements may help with these symptoms and improve digestive health and function.
Kyo-Dophilus Supplement Benefits
Kyo-Dophilus is recommended to support health intestinal function, boost the immune system and to combat the growth of pathogenic bacteria that can cause harmful effects on the body. Research shows this supplement may generally improve well-being and improve resistance to the common cold.
A clinical study published in Clinical Nutrition in August 2005 showed the effect of taking Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3 and B. bifidum MF 20/5 on common cold episodes. These strains are the same as the ones used in the Kyo-Dophilus supplement formula
Four hundred and seventy-nine healthy adults from age 18 to 67 were given daily vitamins and minerals that had probiotic bacteria. The other group was given the supplements without the probiotic bacteria.
A significantly higher enhancement of cytotoxic plus T suppressor cells (CD8+) and T helper cells (CD4+) was observed in the probiotic-treated group. Fecal lactobacilli and bifidobacteria also increased notably with the probiotic supplementation.
The clinical study concluded taking the probiotic formula for at least three months considerably shortened common cold episodes by almost 2 days and also reduced the severity of symptoms.
Positive Effects on the Immune System
A clinical study published in the Journal of the American College of Nutrition in April 2015 showed taking Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2 resulted in a less inflammatory cytokine profile (method used to test for inflammatory markers in the body) and a produced a beneficial shift in gut microbiota in older adults.
The probiotic combination formula, which is similar to that found in Kyo-Dophilus probiotic capsules, was given twice daily for 3 weeks.
Blood and stool samples were collected. The percentage of circulating CD4 (white blood cell that fights infection) lymphocytes and ex vivo (outside the body) mitogen stimulated cell cytokine production were all measured. Mitogens are often used to stimulate lymphocytes to assess immune function.
In stool samples the specific bacterial targets were measured via quantitative polymerase chain reaction (qPCR) (monitors the amplification of a targeted DNA molecule in real time) and the probiotic community composition was determined via pyrosequencing (DNA sequencing).
With the probiotic group there was an increase in fecal bifidobacteria (48% versus 30% in placebo group) and lactic acid bacteria (55% versus 43% in the placebo group).
There was also decrease in Escherichia coli in the probiotic group. The clinical study concluded the probiotic maintained CD4+ lymphocytes and produced a less inflammatory cytokine profile. Also there were changes in the microbial communities which more closely resembled those seen in healthy younger populations.
Kyo-Dophilus Side Effects
Kyo-dophilus is safe for both adults and children. The manufacturer’s dosage recommendations for Kyo-dophilus for infants is to sprinkle half a capsule on food. Adults can take one capsule with a meal, twice daily.
The probiotic strains in Kyo-dophilus supplements are generally well tolerated with a low risk of side effects. However, there are reports of probiotic bacteria causing flatulence, bloating or diarrhea when first starting to use these products.
Some individuals should not take Kyo dophilus or other oral probiotic capsules or tablets without first consulting with their doctors. Probiotics should not be taken by those with impaired immune systems or by those with open surgical wounds or using a catheter. People with SBS (Short Bowel Syndrome) should also avoid probiotics.
Kyo dophilus is dairy free and Kyo dophilus with Digestive Enzymes also has lactose enzymes added. This supplement may be suitable for lactose intolerant individuals, but you should check with your doctor before taking either of these products.
Unless otherwise directed by a medical care professional probiotics should not be taken whilst pregnant. Probiotics do interact with anti-biotics and should be taken at least two hours apart from each other.
Kyolic Kyo dophilus is a well-rated probiotic supplement on Amazon. It is considered to be a good choice for helping to support the immune system and for balancing the microflora of the intestine for better digestive health.
- Spaiser SJ, Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2 Ingestion Induces a Less Inflammatory Cytokine Profile and a Potentially Beneficial Shift in Gut Microbiota in Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. J Am Coll Nutr 2015;34(6):459-69. doi: 10.1080/07315724.2014.983249. Epub 2015 Apr 24.
- de Vrese M, Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: a double blind, randomized, controlled trial. Clin Nutr 2005 Aug;24(4):481-91. Epub 2005 Apr 21.
- Larsen N, Predominant genera of fecal microbiota in children with atopic dermatitis are not altered by intake of probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07. FEMS Microbiol Ecol 2011 Mar;75(3):482-96. doi: 10.1111/j.1574-6941.2010.01024.x. Epub 2011 Jan 11.
- Reuter G. The Lactobacillus and Bifidobacterium microflora of the human intestine: composition and succession. Curr Issues Intes Microbiol 2001 Sep;2(2):43-53.
- Jin HZ, Analysis of the probiotic Bifidobacterium and Lactobacillus community in child intestinal flora]. Wei Shen Wu Xue Bao 2005 Aug;45(4):567-70.
Article last updated on: April 6th, 2018 by Nootriment