L-Tyrosine has been gaining a lot of attention recently in anxiety support forums as a natural way to reduce stress, prevent panic attacks and increase social behavior.
This natural amino acid is observed to decrease symptoms of anxiety while improving mood and helping you to maintain a positive outlook.
Tyrosine is considered to be a non-essential amino acid, since the body is capable of producing this supplement from Phenylalanine.
Even though it is rare for a body to be deficient in Tyrosine, getting additional amounts of this nutrient in your diet or from supplements can increase levels of dopamine in the brain.
Not only can this alleviate signs of depression and other mood disorders, it also works to prevent anxiety and help treat cases of social anxiety.
What is the right way to use L-Tyrosine for Anxiety?



- Supports energy & motivation
- Promotes focus & mental clarity
- Improves mood & stress response
L-Tyrosine Review
Related Topics
The amino acid L-Tyrosine can be found in food sources such as chicken, turkey, fish, soy and dairy products, peanuts, almonds, avocados, bananas, milk, cheese, yogurt, lima beans, pumpkin seeds, sesame seeds, etc.
If you do not get enough Tyrosine or Phenylalanine in your diet, it can result in deficiency.
Milder cases of L-Tyrosine deficiency may result in less activity of certain neurotransmitter systems in the brain.
Tyrosine is converted by dopaminergic neurons in the brain into levodopa which is a precursor to dopamine. This neurotransmitter is a major part of the pleasure, mood and reward regulation system of the brain.
Dopamine is further converted into catecholamines which control levels of excitement and arousal in the brain. Because of its wide-ranging effect on brain function, there are a number of clinical uses for Tyrosine supplements.
L-Tyrosine for Anxiety
Recently, L-Tyrosine has been promoted as an effective treatment for individuals who experience General Anxiety Disorder.
Users have found that taking a small dosage of this supplement every day can help them cope with their anxiety symptoms and counteract some of the negative effects of other anxiolytics like 5-HTP.
There are several different neurotransmitters at work when anxiety levels are high. One of these is the excitatory neurotransmitter glutamate that is involved in much of our cognitive processing. Too much glutamate activity can cause over-stimulation and over-excitement of your neurons.
Not only is this linked to anxiety, it can also result in nerve damage due to excitotoxicity of your neural receptors. The neurotransmitter dopamine is observed to lessen signs of anxiety by limiting the amount of glutamate excitation that occurs in the brain.
L-Tyrosine influences the synthesis of a number of neurotransmitters and hormones within the brain that control stress levels. Since Tyrosine is known to increase dopamine levels in the brain, it is theorized that this is one of the mechanisms of action by which it is able to control anxiety symptoms.
Another pathway that Tyrosine interacts with is the norepinephrine communication circuit in the brain. Norepinephrine is a stress hormone that is also called noradrenaline. According to the University of Maryland Medical Center, this hormone helps your neurons transmit signals effectively and dictates the bodily response to stress.
It is one of the neurotransmitters intimately involved in determining your mood, motivation level and how you generally feel. It has been postulated that impairments in the norepinephrine communication system in your brain can result in the increase of stress and anxiety levels.
If too much Norepinephrine is present in the synaptic cleft, it can quickly generate feelings of anxiety or in extreme cases a panic attack.
L-Tyrosine facilitates the reabsorption or reuptake of Norepinephrine back into the neurons so that your synaptic receptors are not over-exposed to this compound. This has the effect of preventing overreactions to external or internal stressors, allowing you to better deal with anxiety-inducing situations.
L-Tyrosine & Social Anxiety:
A number of individuals also report that L-Tyrosine supplementation is useful in combatting social anxiety. This is a condition marked by sometimes extreme anxiety when being thrust into unfamiliar social situations. In certain cases, this reaction can be caused by normal, everyday situations such as talking to a stranger over the phone or speaking to more than one person at a time.
Studies have found that Dopamine2 receptor activity tends to be lower in individuals with social phobias. Those suffering from social anxiety notice that keeping their Dopamine levels raised is one of the keys to being able to function in social settings. As we have seen above, L-Tyrosine is capable of increasing the levels the dopamine neurotransmitter in the brain.
Since this helps to support mood and feelings of well-being, it can be a very effective anxiety reducer in all of its different forms. Also, by potentially increasing the stimulation of D2 receptors, it may be possible to target the underlying neurological basis for social anxiety with Tyrosine.
Other Benefits Of L-Tyrosine:
Tyrosine is known to have a variety of additional benefits related to motivation, executive function, attention control, and clear-headedness. It can help you better focus at work or school and prevent some of the distractions that make it more likely for feelings of anxiousness to occur. Tyrosine is further observed to regulate levels of hormones that can affect your mood and susceptibility to anxiety.
Research has shown that constant fluctuations in hormones raise the probability of anxiety in women to twice that of men. The gradual drop in progesterone, which is the primary female sex hormone, tends to mark the onset of general anxiety for many women.
L-Tyrosine supplements may help to ease this transition by contributing to better functioning of adrenal, pituitary, and thyroid glands that control hormone levels. This helps to regulate the release of progesterone, ensuring a more normalized schedule of delivery into your blood stream. Over time, this could lessen signs of anxiety especially in older women.
L-Tyrosine Dose & Use Guidelines:
Taking L-Tyrosine for anxiety requires proper consideration to dosages and safety concerns. Studies show that a safe daily dose for L-Tyrosine supplements is anywhere from 200 mg up about 5,000 mg (5 grams).
The best course of action is to begin by finding your own lowest effective dose. From here, you can adjust until you begin to see some of the desired effects.
Many user reviews report that taking between 200 and 500 mg of this supplement once to three times per day gives the best results for anxiety. Some people will use between 1 to 1.5 grams of Tyrosine per dosage, but this amount may be too much for you.
It is also recommended that you talk with your doctor before adding a new supplement to your routine. Your physician can offer you the most informed advice by examining what you are already taking and giving suggestions about any potential interactions or things to look out for.
Tyrosine can be taken with or without food (although many say it is more effective when taken with carbohydrates). However, you will want to try and avoid taking it after the early or midafternoon, since it might interfere with sleep patterns.
Using L-Tyrosine for anxiety is very safe and well-tolerated in healthy adults. The most commonly reported (although still fairly rare in the overall scheme of things) side effects include headaches, occasional nausea, diarrhea, vomiting, and insomnia.
Most of these effects are only reported when using high doses, so simply cutting back your intake should help. At very high dosages, it can exacerbate anxiety symptoms and cause an increase in your heart rate. If you experience any of these events, stop using Tyrosine and speak to your doctor for advice.
- Parker G, Brotchie H. Mood effects of the amino acids tryptophan and tyrosine: 'Food for Thought' III. Acta Psychiatr Scand. 2011
- Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T. Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour. EMBO J. 2009
- Sharman R, Sullivan K, Young RM, McGill J. Depressive symptoms in adolescents with early and continuously treated phenylketonuria: associations with phenylalanine and tyrosine levels. Gene. 2012
- Soontornniyomkij B, Everall IP, Chana G, Tsuang MT, Achim CL, Soontornniyomkij V. Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder. J Affect Disord. 2011
- Tiemann L, Heitmann H, Schulz E, Baumkötter J, Ploner M. Dopamine precursor depletion influences pain affect rather than pain sensation. PLoS One. 2014
- Colzato LS, Jongkees BJ, Sellaro R, van den Wildenberg WP, Hommel B. Eating to stop: tyrosine supplementation enhances inhibitory control but not response execution. Neuropsychologia. 2014
- Felger JC, Li L, Marvar PJ, Woolwine BJ, Harrison DG, Raison CL, Miller AH. Tyrosine metabolism during interferon-alpha administration: association with fatigue and CSF dopamine concentrations. Brain Behav Immun. 2013
Article last updated on: March 13th, 2018 by Nootriment
36 Comments
Only thing that has helped me with withdrawal symptoms from marijuana (sleeplessness, anxiety,cravings)
Good thing to know. I was also researching various things that could help ease a person off of MJ, alcohol, etc.
Wow. Alcohol to withdraw from m.j. Your research must be superb. Idiot.
I don’t believe the individual was suggesting the use of alcohol for marijuana withdrawal. I believe they were stating that they were researching ways to ease withdrawal from marijuana AND alcohol AND etc. Correct me if I’m wrong, Kush.
Can I take l-tyrosine with green tea and coconut oils. Kathy
Yes you can. I do, feel great.
Does anyone know if it’s ok to take 5-htp and L-tyrosine at the the same time? I take 5-htp in the evening before bed to help with low mood and have just bought some L-tyrosine which I plan to take in the morning to help me through a stressful work situation. I’m not planning to take these two long term, just for stressful situations. If it’s not advised to take both, I won’t. If anyone can help that would be great.
Hi Rachal,
Yes it’s safe to use these together and it is often recommended to stack 5-HTP with a catecholamine precursor like l-Tyrosine when used over long durations. We have an article on this stack at https://nootriment.com/tyrosine-5-htp/
Both of these supplements destroy (literally) libido. So if you want double destruction of your libido, take them both
Your libido will only be destroyed when overdosing 5-htp (serotonins pre-cursor). I’ve tried and tested this.
My newly married daughter is struggling with her husband having a seemingly low libido. Would this supplement help with that? I have been reading about low dopamine levels as a contributing factor- Also, his testosterone is at a normal level so it’s not that– Thanks
You might look into L-Carnatine. It gives a boost in the gym and the bedroom. Plus the name sounds like a flesh eating dinosaur.
I take 500mg of tyrosine daily, usually in between meals to give it better access to the brain, works great for reducing anxiety and getting out of a “stuck” mood.
I love to take l-tyrosine but today I took some and i got diarrhea is this normal?
Hi Athena,
Here is the information provided by the Natural Medicines database: “According to secondary sources, in high doses, nausea, diarrhea, vomiting, or nervousness have been reported.” It may be recommended to reduce your dosage to prevent diarrhea. Gastrointestinal side effects like diarrhea may also be caused by other additives in the supplement. Do you know what fillers or additives are present in the supplement you are taking?
Hi,
Can I take L tyrosine 400 mg with 7- keto dhea 50 or 100 mg?
Thanks,
Karan
Hi, I have hypertension and am currently taking coversyl hd ( hydrochlorothiazide and perindopril) are you aware of any interactions between this and L-tyrosine?
l-thyrosine increases blood pressure
I was told not to have any protein with L-Tyrosine. How long after I take it, may I have – as example – an Odwalla Protein shake? Taking it to offset the backing off of pain meds from back surgery.
That’s a bit silly since it’s one of the main amino acids in Hemp Protein Powder. I think you need to do your own research.
@Piper – This is not silly, as zlataray has stated. Yes, when using specific amino acids for therapeutic reasons, it is generally advised to take them alone as amino acids are known to “compete” for transport to the brain. When digesting a complete protein containing all 21 amino acids – you are introducing many other competing amino acids and therefore diluting the one that you may be looking to supplement. It is generally suggested to wait about 2 hours after a meal to supplement.
Taking it together with other amino acids found in protein may diminish its uptake due to the competition between amino acids. Best taken an hour or so before protein.
I am taking Parnate along with Xanax for several years. Yesterday, I went to my nutritionist and told her that I was trying to eliminate Xanax. She prescribed L-Tyrosine to take instead. I am leery for some reason. Is it safe to take L-tyrosine with Parnate?
Hi Colleen,
I just saw your post, I hope that you get this… I took xanax for years also. Most doctors do not know how to properly taper this drug; there lack of knowledge can be devastating and dangerous. Be very careful and learn as much as you can. Go to a site like benzobuddies dot com get prepared for what this entails.
Cold turkeying xanax is a recipe for disaster, tyrosine will do little good at all.
You can PM me from there and I will help you if you’d like… My screen name is Buhbyebenzos …
Best of luck,
BBB
Hi Brad, I’m trying to taper off Xanax and was also prescribed L-Tyrosine. I am on Benzo Buddies but can’t find your screen name there to PM you. My screen name is Faith2020. Can you PM me? Thank you, Lisa
Can I take l-tyrosine to replace xanex
Hey Angela,
Thanks for your question! Under FDA guidelines, dietary supplements like L-Tyrosine cannot be promoted as alternatives to prescription medications like Xanax. You should consult with the doctor who prescribed you with Xanax if you are interested in finding out about alternatives.
hey. am not sure that can apply to you but here is what happened to me. i quit xana , fluxtine 2 month ago, yeah its unpleasent. till i found 5-htp this stuff works miracle to my depression , anexity , couldnt feel l-tyrosine many doctors told me it takes like 3 -4 weeks to notice effects ,
if you suffering from depression like me. this one amazed me in very short time and couldnt feel the horrific withdrawal symptoms i read everywhere.
it contains the followings.
.Vitamine B complex [specially b6,b12] the daily value not the regular suplements.
.Magnesium supplement.
.5-htp 200mg .
wishing you fast and healthy recovery.
thanks.
Hi Wael,
Thanks for your feedback. If you happen to have recommendations on which brands of products you used, that would be much appreciated to hear about!
Hi, ive never taken this stuff before and i read the instructions wrong and measured wrong! I ended up taking 5000mg at once.. im scared. Im only small and 46kg female. How long until it leaves my system? Is there anything i can do? Thanks !
Hi Candice,
Thanks for writing in. If you are experiencing ANY side effects, it is recommended to seek out medical attention. However, there have been research studies in which dosages of up to 10 g of L-Tyrosine have been administered in a single serving without a significant risk of side effects.
Hii!! Do you know if its ok to take L-Tirosyne along with p5p(vitamin b6)
Hey Francisco,
Thanks for your question! L-Tyrosine and P5P are often used together and they may have a synergistic benefit. It’s always best to consult with a doctor before you start taking any new supplement, but there are no known side effects linked to combining L-Tyrosine and P5P.
I am currently taking 5-htp, L-theanine, Taurine, and Orinthine for insomnia purposes. The combo has helped me fall asleep but waking in the middle of the night is still an issue. I am debating adding tyrosine and glutamine to the mix but am concerned that all the different supplements might start to overwhelm my body or take over each other.
Thoughts on what supplements are safe to take together and how to find the right mixture for me are greatly appreciated!
Hi Jennifer,
All of the supplements you mentioned are forms of amino acids, which are generally well tolerated when stacked together. In terms of finding the best combination to address your specific health goals, it would be wise to consult with a doctor or Naturopath on what works best.
Glutamine is purported to improve sleep quality, but taking tyrosine late in the day can make it harder to fall asleep for some people.
Melatonin is well-established to improve sleep quality. I hope that information helps! Let me know if you have any further questions based on this.
me gustaría saber si l-tyrosine es buena para el vitiligo tengo una niña de 13 años y padece de poquito vitiligo alrededor de su ojo y si funciona que dosis darle al dia o cuántas píldoras darle al día o que otra cosa me pueden recomendar