Lactobacillus Acidophilus dds-1 is a substrain of the L. Acidophilus species of probiotic bacteria. This proprietary strain was developed by a researcher at the University of Nebraska and has been studied for its benefits for digestive health and immunity.
Probiotics are good forms of bacteria that naturally reside in the intestines and colon. These good bacteria are important for preventing the spread of bad or “pathogenic” bacteria. They also play a role in digestion and help the body synthesize important compounds like vitamins.
The Lactobacillus family of probiotics are Lactic-Acid producing bacteria and they help to preserve the health pH balance of the digestive tract. There are over 400 different species of probiotic bacteria that have been identified in the human biome.
Lactobacillus Acidophilus is one of the most prevalent and is widely available in probiotic supplements.
The Lactobacillus Acidophilus dds-1 strain is manufactured according to specific quality-control standards and stabilizing techniques. Each capsule of this probiotic provides a minimum of 2.5 billion colony forming units (CFUs).



- Supports a healthy immune system & microflora
- Promotes digestion & nutrient absoprtion
- Combats pathogenic bacteria; Improves metabolism
Lactobacillus Acidophilus dds-1
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- Probiotic Benefits
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- Probiotic Supplements
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- Lactobacillus Acidophilus
- Lactobacillus Bulgaricus
- Lactobacillus Rhamnosus
- Bifidobacterium Bifidum
- Bifidobacterium Infantis
- Bifidus Regularis
Lactobacillus Acidophilus dds-1 is a probiotic strain discover in the 1950’s by Dr. Khem Shahani at the University of Nebraska. Dr. Shahani started Nebraska Cultures in 1981 to manufacture probiotics.
This probiotic is available as a loose powder, as a capsule or tablets. Lactobacillus Acidophilus dds-1 is stomach and bile resistant so it is viable when it reaches the gut.
Another manufacturer of L. acidophilus DDS-1 (UAS Labs) produces a culture that is stable for up to two years at ambient temperature (23°C) when blended with a low water activity microcrystalline cellulose.
This probiotic is used to inhibit the Heliobacter pylori bacterium that causes stomach ulcers and helps to regulate the stools to prevent diarrhea and constipation. This probiotic strain produces B-vitamins and folic acid and helps reduce lactose intolerance.
Clinical studies have shown it helps to inhibit 23 toxic microorganisms and helps relieve dermatitis and is used for acute respiratory infections.
Lactobacillus Acidophilus dds-1 Benefits
The Lactobacillus Acidophilus dds-1 probiotic produces enzymes that help to breakdown proteins and fats. Fermented dairy products with this probiotic have higher levels of B12 and folic acid.
In animal clinical studies with rats, L. Acidophilus DDS-1 was shown to have a cholesterol lowering effect. Lactobacilli bind bile acids to cholesterol which increases the bile acid cholesterol excretion.
This probiotic also increased the fatty acid production in the intestine. This action decreases circulatory fatty acid concentrations by inhibiting hepatic cholesterol synthesis or by redistributing cholesterol from the plasma to the liver.
Lactobacillus Acidophilus dds-1 has also been shown to have anti-carcinogenic properties when tested in rat animal studies with induced colon tumors. The DDS-1 fed rats clinical group had significantly reduce cases of tumor incidence compared to the control group.
Another clinical animal studies with mice showed that DDS-1 was able to stimulate the production of immune components (interleukin-1? and tumor necrosis factor-?) that are known inhibitors of tumor cells.
Lactobacillus Acidophilus dds-1 is effective for treating Traveler’s diarrhea. Two capsules of this probiotic were taken with a CFU (Colony forming units) of one billion one week prior to travel and during the entire time travelled in high risk areas of Guatemala, Mexico or Nepal. The average diarrhea rate was 3% for those taking the probiotic supplement compared to the usual expected rate of 25 to 30%.
Lactobacillus Acidophilus dds-1 has been shown to be effective in treating atopic dermatitis in a clinical study published in the American Journal of Clinical Dermatology in 2010. Preschool children taking DDS-1 were significantly improved in the SCORAD (Scoring atopic dermatitis) values compared to the placebo group.
Immune Boosting Effects of L. Acidophilus dds-1
Lactobacillus Acidophilus dds-1 also has antibacterial and anti-pathogenic effects.
This probiotic produces an antibacterial compound acidophlin which inhibits Bacillus subtilis, Clostridium botulinum, Clostridium perfringens, and Escherichia coli, which can all cause food poisoning.
Proteus mirabilis can cause kidney stones as well as wound infections, septicemia, and pneumonia especially in hospitalized patients.
Salmonella enteritidis and Salmonella typhimurium infections are being seen more in HIV and malaria patients and immune compromised individuals.
Staphylococcus aureuscauses MRSA and Staphylococcus faecalis is found in diseased teeth and causes endocarditis (inflamed heart valve).
Lactobacillus Acidophilus dds-1 Side Effects
Lactobacillus Acidophilus dds-1 is well tolerated, but mild side effects have been reported when first using this supplement. This probiotic may cause intestinal gas initially when taken and this symptom usually lessens as the body adjusts to taking the probiotic.
While probiotics are generally safe for healthy adults, there is a risk of side effects if taken by individuals who are immunocompromised in some way. Probiotics should not be taken by those with impaired immune systems such as organ donor recipients or those on immunosuppressive medication.
Those with SBS (Short Bowel Syndrome) or those using a catheter should avoid taking probiotics. Probiotics do interact with anti-biotics and should be taken at least two hours apart from each other.
Unless otherwise directed, probiotics should not be taken whilst pregnant or while breastfeeding. Some strains may be appropriate for pregnant or nursing mothers. You should speak to your doctor to learn about recommended products and dosages during pregnancy or lactation.
Lactobacillus Acidophilus dds-1 has applications for inhibiting infections, in the treatment of dermatitis and skin disorders and allergic conditions. It is also useful in regulating stools for relieving diarrhea and constipation. This probiotic strain is also being studied for its anti-tumor properties in the treatment of cancer.
- Gerasimov SV, Role of short-term use of L. acidophilus DDS-1 and B. lactis UABLA-12 in acute respiratory infections in children: a randomized controlled trial. Eur J Clin Nutr 2015 Oct 14. doi: 10.1038/ejcn.2015.171. [Epub ahead of print]
- Gerasimov SV, Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial. Am J Clin Dermatol 2010;11(5):351-61. doi: 10.2165/11531420-000000000-00000
- Rangavajhyala N, Nonlipopolysaccharide component(s) of Lactobacillus acidophilus stimulate(s) the production of interleukin-1 alpha and tumor necrosis factor-alpha by murine macrophages. Nutr Cancer 1997;28(2):130-4.
- Chatterjee A, The bactericidal effects of Lactobacillus acidophilus, garcinol and Protykin compared to clarithromycin, on Helicobacter pylori. Mol Cell BiochemSee comment in PubMed Commons below 2003 Jan;243(1-2):29-35.
- Kim MS, A study on the prevention of salmonella infection by using the aggregation characteristics of lactic Acid bacteria. Toxicol Res See comment in PubMed Commons below2013 Jun;29(2):129-35. doi: 10.5487/TR.2013.29.2.129.
Article last updated on: March 25th, 2018 by Nootriment