Lactobacillus delbrueckii is a lactic acid producing probiotic bacteria, commonly used in probiotic supplements and in the dairy industry.
Lactobacillus delbrueckii ssp. Lactis and Lactobacillus delbrueckii subsp. bulgaricus play an important role in in cheese-making and yogurt production.
These bacteria strains are often combined with Streptococcus thermophilus to make a starter for yogurt production. Both probiotic strains are LAB (Lactic Acid Bacteria).
Lactic acid gives yogurt a tart flavor and helps preserve the yogurt as well as lowering the pH to coagulate the milk proteins that thickens the yogurt.
Lactic acid also plays an important role in supporting digestive health and in the immune system, helping to inhibit the growth of pathogenic bacteria that can cause diseases or digestive imbalances.
Taking a Lactobacillus delbrueckii probiotic supplement may therefore improve digestive function and support the immune system.
Lactobacillus delbrueckii is beneficial to lactose intolerant individuals who lack the enzymes to breakdown lactose to simpler sugars that can be digested. Clinical studies have also shown that Lactobacillus delbrueckii helps reduce the risk of developing the common cold and flu during human clinical trials.



- Supports a healthy immune system & microflora
- Promotes digestion & nutrient absoprtion
- Combats pathogenic bacteria; Improves metabolism
Lactobacillus Delbrueckii Yogurt Benefits
Related Topics
- What are Probiotics?
- Probiotic Benefits
- Best Probiotic Strains
- Probiotic Side Effects
- Probiotic Supplements
- Probiotic Foods
- Best Probiotic Yogurt
- Probiotics for Children
- Probiotics for Women
- Yeast Infections
- What are Prebotics?
- Lactobacillus Acidophilus
- Lactobacillus Bulgaricus
- Lactobacillus Rhamnosus
- Bifidobacterium Bifidum
- Bifidobacterium Infantis
- Bifidus Regularis
Lactobacillus delbrueckii is found naturally in yogurt products and was one of the first strains used in the commercial manufacturing of yogurt and other fermented food products.
This strain of probiotic organism was first isolated in 1905 by Dr. Stamen Grigorov in Bulgaria. Dr. Grigorov noted that this strain of bacteria helped to break down lactose and other sugars into lactic acid within the gastrointestinal tract.
This mechanism may have benefits for individuals who are lactose intolerant and who are not naturally able to break down the lactose sugar. By increasing the acidity of the gastrointestinal tract, Lactobacillus delbrueckii may also boost the body’s natural defenses against harmful bacterial organisms.
Pathogenic bacteria like E. Coli and Salmonella cannot survive in the human gastrointestinal tract when the pH is too low. By inhibiting the spread of these bad bacteria, Lactobacillus delbrueckii and other probiotic supplements are said to boost immune function.
Lactobacillus Delbrueckii Yogurt Benefits
A clinical study published in the Journal of Dairy Science in February 2016 showed that yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 reduces risks of catching the common cold and flu.
It is believed this is because of the immunostimulatory exopolysaccharide (EPS) that is produced from Lactobacillus delbrueckii. EPS establishes the functional and structural integrity of biofilms, which is a group of microorganisms that stick together and adheres to a surface.
Consuming yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 (with EPS) and Streptococcus thermophilus OLS3059 (in the OLL1073R-1 yogurt) supplemented natural killer (NK) cell activity.
These NK cells provide rapid responses to viral-infected cells as part of the innate immune system. The OLL1073R-1 yogurt treatment also induced IFN-gamma (Interferon gamma) production in spleen cells in mice. Interferon gamma is part of the innate and adaptive immunity system against viral and bacterial infections in the human body.
The study concluded traditional Bulgarian yogurt production exerts immunostimulatory effects on IFN-gamma inducible EPS produced from L. delbrueckii ssp. bulgaricus.
Lactobacillus Delbrueckii Medicinal Uses
A clinical study published in the Journal of Microbiology and Biotechnology in August 2015 showed LAB from yogurt with Lactobacillus delbrueckii subsp. Bulgaricus significantly induced TNF-alpha (tumor necrosis factor-alpha) and IL-1 beta (Interleukin-1 beta, mediator of the inflammatory response) production.
TNF-alpha is a pleiotropic (producing or having multiple effects from a single gene) inflammatory cytokine, (protein) that regulates inflammatory response. The clinical study concluded this probiotic strain had potential for use in treating immune deficiency disorders.
A clinical study published in the Asian Pacific Journal of Cancer Prevention in 2015 showed pre-treatment with probiotic containing yogurt can improve Helicobacter pylori eradication rates with tailored triple therapy.
In this particular study, the addition of probiotics did not reduce the side effects of the Helicobacter pylori medication. Eradication results were measured by negative histology as well as a negative rapid urease test that was given four weeks after the treatment.
In the tailored triple therapy plus pretreatment with probiotic containing yogurt group, there was a significant higher (89%) success rate than in the tailored triple therapy with placebo group.
Lactobacillus Delbrueckii Side Effects
Lactobacillus delbrueckii subsp. Bulgaricus is safe to use as an oral probiotic supplement and it is also found naturally in many yogurt products. At appropriate dosages, side effects are not likely and are generally mild when they do occur.
However, some individuals are recommended against using all probiotic supplements to prevent migration of the bacteria into other parts of the body. Even though probiotic bacteria are healthy when they are present in the gut, there could be negative side effects if they were to travel into the blood stream or other parts of the body.
Probiotics should not be taken by those with impaired immune systems, those using a catheter or those with open surgical wounds. Unless otherwise advised by a medical professional, probiotic supplements with Lactobacillus delbrueckii subsp. Bulgaricus should not be taken while pregnant or while breastfeeding.
This particular strain of probiotics has been shown to help lactose intolerant individuals and may be beneficial to this condition. However, individuals who are allergic to dairy products are advised to avoid milk-based probiotics.
Lactobacillus delbrueckii is beneficial for improving the immune system and helping to prevent colds and flu and is beneficial to those with lactose intolerance.
- Makino S, Enhanced natural killer cell activation by exopolysaccharides derived from yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1. J Dairy Sci 2016 Feb;99(2):915-23. doi: 10.3168/jds.2015-10376. Epub 2015 Dec 10.
- Zheng H, Strand-specific RNA-seq analysis of the Lactobacillus delbrueckii subsp. bulgaricus transcriptome. Mol Biosyst 2016 Jan 26;12(2):508-19. doi: 10.1039/c5mb00547g.
- Li C, Effect of the absence of the CcpA gene on growth, metabolic production, and stress tolerance in Lactobacillus delbrueckii ssp. bulgaricus. J Dairy Sci 2016 Jan;99(1):104-11. doi: 10.3168/jds.2015-10321. Epub 2015 Nov 14.
- Tongtawee T, Effect of Pretreatment with Lactobacillus delbrueckii and Streptococcus thermophillus on Tailored Triple Therapy for Helicobacter pylori Eradication: A Prospective Randomized Controlled Clinical Trial. Asian Pac J Cancer Prev 2015;16(12):4885-90.
- Hong YF, Immune Regulatory Effect of Newly Isolated Lactobacillus delbrueckii from Indian Traditional Yogurt. J Microbiol Biotechnol 2015 Aug;25(8):1321-3. doi: 10.4014/jmb.1501.01057.
- Liu W, Relationships between functional genes in Lactobacillus delbrueckii ssp. bulgaricus isolates and phenotypic characteristics associated with fermentation time and flavor production in yogurt elucidated using multilocus sequence typing. J Dairy Sci 2016 Jan;99(1):89-103. doi: 10.3168/jds.2015-10209. Epub 2015 Nov 5.
Article last updated on: April 6th, 2018 by Nootriment
1 Comment
Je viens de recevoir les résultats d’un prélèvement vaginal qui mentionne 1.000.000 de lactobacilles delbruecki mon médecin me dit que cela ne se soigne pas le laboratoire ne pense pas la même chose c’est quoi ce truc .