Lactobacillus Sporogenes Probiotic Benefits & Side Effects

Lactobacillus sporogenes is a heat stable, gastric acid resistant strain of probiotic bacteria. It was the original name of the Bacillus Coagulans probiotic strain.

It has since been reclassified and renamed because it is no longer considered to be a member of the Lactobacillus family of probiotics.

B. coagulans is a spore-forming probiotic that produces lactic acid. B. coagulans probiotics are used to improve the immune system and to treat diarrhea and constipation.

Lactobacillus sporogenes is used in the treatment of Vancomycin (antibiotic) Resistant Enterococcus (VRE) and also helps reduce Fusarium (fungal) infections.

Lactobacillus sporogenes is an active ingredient in treatments for Menopause. This supplement also helps improve symptoms in Type II Diabetes.

According to Thorne Research, B. coagulans helps to promote a healthy gut flora and is a unique, stable probiotic organism that promotes gastrointestinal health.

Probiotics

Digestive Supplement

Gut Health

Digestion

Immune Function

How It Works:

• Supports a healthy immune system & microflora
• Promotes digestion & nutrient absoprtion
• Combats pathogenic bacteria; Improves metabolism

Dosage:

Between 1 - 10 Billion CFUs per day

Safety:

Rated Likely Safe

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Lactobacillus Sporogenes Benefits

Bacillus coagulans reduce pathogenic bacteria colonization due to the production of coagulin and lactic acid, which have antibacterial properties. Clinical trials using animal model research suggests that consuming the Bacillus coagulans increases immune response.

This probiotic strain has also been shown in clinical trials to reduce colonization of some strains of Vancomycin-Resistant Enterococcus (VRE). In vitro, Bacillus coagulans also reduces fungal growth of Fusarium.

Fusarium is a pathogen that cause allergic diseases such as sinusitis in immunocompetent individuals. It can also cause mycotoxicosis following ingestion of food contaminated by toxin-producing Fusarium. Lactobacillus sporogenes exhibits a prophylactic effect and may prevent infections associated with this pathogen.

Lactobacillus Sporogenes Uses

Orally, Bacillus coagulans is used to treat diarrhea. These include infectious types such as rotaviral diarrhea in children, traveler’s diarrhea, and Clostridium difficilecolitis (antibiotic-associated diarrhea).

A clinical study in the Journal of Research in Medical Science in February 2013 showed adding the synbiotic Lactol® (contains Lactobacillus Sporogenes) to mineral oil can improve the constipation symptoms of children without specific side-effects.

Bacillus coagulans is also used in the treatment of Irritable Bowel Syndrome (IBS), and Inflammatory Bowel Disease (IBD, Crohn’s disease, ulcerative colitis). Bacillus coagulans is also used to treat bacteria imbalance in short bowel syndrome (SBS) and infection due to the ulcer-causing bacterium Helicobacter pylori.

Some people use Lactobacillus sporogenes to prevent respiratory infections and to improve the immune system. It is also being researched to prevent the formation of cancer-causing agents, but is not approved as a treatment or prevention for cancer. It is also being researched for use as an additive (adjuvant) to vaccines to improve their effectiveness.

Lactobacillus Sporogenes Research

A clinical study published in the European Journal of Clinical Nutrition in April 2011 showed Lactobacillus sporogenes helped increase the feeding tolerance of low weight infants with necrotizing enterocolitis (NEC).

A clinical study published in the Journal of the American College of Nutrition looked at the effects of this probiotic on levels of oxidative stress.

This research trial showed that consuming Lactobacillus sporogenes and Inulin enriched synbiotic bread for 8 weeks could improve markers of oxidative damage in the body.

The combination was given to patients with Type 2 diabetes mellitus. Those taking the probiotic and prebiotic bread experienced beneficial effects on plasma nitric oxide (NO) levels, liver enzymes and MDA (malondialdehyde) levels. These are biomarkers of oxidative stress and indicators of free radical activity.

A clinical study published in Gynecological Endocrinology involved 12 months of treatment with a nutraceutical compound based on isoflavones and Lactobacillus sporogenes.

It was concluded that at the recommended doses of soy isoflavones 60 mg and Lactobacillus sporogenes 1 billion spores it is safe for endometrium, mammary gland, and liver function in postmenopausal women. The menopausal symptoms were gradually and significantly reduced in severity and frequency during the treatment compared to calcium plus vitamin D.

A clinical study published in Minerva Ginecol in February studied the combination formula of magnolia bark extract added to isoflavones and Lactobacillus sporogenes in menopausal women.

These women had typical menopausal symptoms and concomitant borderline psychoaffective and/or sleep alterations that did not require psychopharmacological therapy.

Isoflavones are effective in improving the classical menopause symptoms. The clinical activity of magnolia bark extract on the relevant psycho-affective symptoms, particularly anxiety, irritability and insomnia, was evident. More research is needed to determine the efficacy of Lactobacillus sporogenes for improving menopause symptoms

Lactobacillus Sporogenes Side Effects

Probiotics are generally well tolerated and there are few side effects when used appropriately. Upon starting to take Lactobacillus sporogenes supplements, individuals may experience diarrhea or changes to bowel movement patterns. These changes typically subside after a few days of use.

While probiotics are safe for most heathy individuals, there are some who should not use these supplements without first speaking to their doctors. Lactobacillus sporogenes is contraindicated for those individuals with impaired immune systems.

Probiotics should not be taken with immunosuppressant medication. This is due to the immunomodulating activity of this probiotic. These drugs include medications taken to prevent organ rejection such as azathioprine (Imuran), basiliximab (Simulect), and cyclosporine (Neoral, Sandimmune).

Other medications not to take with this supplement include daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), and mycophenolate (CellCept.). The medications tacrolimus (FK506, Prograf), sirolimus (Rapamune) as well as the steroid prednisone (Deltasone, Orasone) and corticosteroids (glucocorticoids) should also be avoided.

Conclusions

Lactobacillus sporogenes has many useful applications for health benefits for treating bowel conditions and menopause. This particular strain of probiotics is used to treat the bacteria imbalance typically seen in patients with SBS (Short Bowel Disease).

More human studies are being done to investigate additional benefits of this particular strain of the B. Coagulans probiotic.

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